WO2009014203A1 - (1,3,5/2,4,6)-1-フルオロ-2,3,4,5,6-シクロヘキサンペントールの製造方法 - Google Patents
(1,3,5/2,4,6)-1-フルオロ-2,3,4,5,6-シクロヘキサンペントールの製造方法 Download PDFInfo
- Publication number
- WO2009014203A1 WO2009014203A1 PCT/JP2008/063369 JP2008063369W WO2009014203A1 WO 2009014203 A1 WO2009014203 A1 WO 2009014203A1 JP 2008063369 W JP2008063369 W JP 2008063369W WO 2009014203 A1 WO2009014203 A1 WO 2009014203A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- producing
- cyclohexanepentol
- fluoro
- general formula
- protecting group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/005—Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
- C07C29/10—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
(1,3,5/2,4,6)-1-フルオロ-2,3,4,5,6-シクロヘキサンペントールの製造方法であって、
(A)次の一般式(I)で表される化合物[式(I)中、R1は水酸基の保護基を示し、R2は脱離基を示す]を、Fイオンを含む試薬と反応させ、一般式(II)の化合物[式(II)中、R1は保護基を示す]を製造する工程と、次いで
(B)上記化合物(II)の保護基を除去する工程と、を含む。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009524518A JPWO2009014203A1 (ja) | 2007-07-26 | 2008-07-25 | (1,3,5/2,4,6)−1−フルオロ−2,3,4,5,6−シクロヘキサンペントールの製造方法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007194369 | 2007-07-26 | ||
JP2007-194369 | 2007-07-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009014203A1 true WO2009014203A1 (ja) | 2009-01-29 |
Family
ID=40281450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/063369 WO2009014203A1 (ja) | 2007-07-26 | 2008-07-25 | (1,3,5/2,4,6)-1-フルオロ-2,3,4,5,6-シクロヘキサンペントールの製造方法 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPWO2009014203A1 (ja) |
WO (1) | WO2009014203A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013150117A1 (fr) | 2012-04-04 | 2013-10-10 | Universite De Lorraine | Radiotraceur notamment pour la maladie d'alzheimer |
JP2014177457A (ja) * | 2008-03-21 | 2014-09-25 | General Hospital Corp | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
AU2013248197B2 (en) * | 2008-03-21 | 2016-05-12 | The General Hospital Corporation | Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders |
US10058625B2 (en) | 2004-02-24 | 2018-08-28 | The General Hospital Corporation | Catalytic radiofluorination |
US10098974B2 (en) | 2004-02-24 | 2018-10-16 | The General Hospital Corporation | Catalytic radiofluorination |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06157572A (ja) * | 1992-08-05 | 1994-06-03 | General Electric Co <Ge> | 2−[18f]フルオル−2−デオキシ−d−グルコースの製造法 |
WO2007063940A1 (ja) * | 2005-12-02 | 2007-06-07 | Nihon Medi-Physics Co., Ltd. | 放射性フッ素標識化合物の製造方法 |
-
2008
- 2008-07-25 WO PCT/JP2008/063369 patent/WO2009014203A1/ja active Application Filing
- 2008-07-25 JP JP2009524518A patent/JPWO2009014203A1/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06157572A (ja) * | 1992-08-05 | 1994-06-03 | General Electric Co <Ge> | 2−[18f]フルオル−2−デオキシ−d−グルコースの製造法 |
WO2007063940A1 (ja) * | 2005-12-02 | 2007-06-07 | Nihon Medi-Physics Co., Ltd. | 放射性フッ素標識化合物の製造方法 |
Non-Patent Citations (1)
Title |
---|
LOWE G. ET AL.: "Synthesis of [3H]-Labelled and Unlabelled 2-Deoxy-2-fluoro-myo-inositol and 1-Deoxy-1-fluoro-scyllo-inositol for Use in Studies of the Phosphoinositide Cycle", J. CHEM. SOC. PERKIN TRANS. 1, 1991, pages 1249 - 1253 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10058625B2 (en) | 2004-02-24 | 2018-08-28 | The General Hospital Corporation | Catalytic radiofluorination |
US10098974B2 (en) | 2004-02-24 | 2018-10-16 | The General Hospital Corporation | Catalytic radiofluorination |
US10695449B2 (en) | 2004-02-24 | 2020-06-30 | The General Hospital Corporation | Catalytic radiofluorination |
JP2014177457A (ja) * | 2008-03-21 | 2014-09-25 | General Hospital Corp | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
AU2013248197B2 (en) * | 2008-03-21 | 2016-05-12 | The General Hospital Corporation | Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders |
US10857247B2 (en) | 2008-03-21 | 2020-12-08 | The General Hospital Corporation | Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders |
WO2013150117A1 (fr) | 2012-04-04 | 2013-10-10 | Universite De Lorraine | Radiotraceur notamment pour la maladie d'alzheimer |
FR2989088A1 (fr) * | 2012-04-04 | 2013-10-11 | Univ Lorraine | Radiotraceur pour la maladie d'alzheimer |
Also Published As
Publication number | Publication date |
---|---|
JPWO2009014203A1 (ja) | 2010-10-07 |
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