JP2017075173A5 - - Google Patents
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- Publication number
- JP2017075173A5 JP2017075173A5 JP2016249232A JP2016249232A JP2017075173A5 JP 2017075173 A5 JP2017075173 A5 JP 2017075173A5 JP 2016249232 A JP2016249232 A JP 2016249232A JP 2016249232 A JP2016249232 A JP 2016249232A JP 2017075173 A5 JP2017075173 A5 JP 2017075173A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound
- amyloidosis
- condition associated
- pathological condition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 206010002023 Amyloidosis Diseases 0.000 claims 5
- 206010002022 Amyloidosis Diseases 0.000 claims 5
- 230000001575 pathological Effects 0.000 claims 5
- 206010001897 Alzheimer's disease Diseases 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 0 *C(C1*)[C@](*)C(*)C(*)[C@]1O Chemical compound *C(C1*)[C@](*)C(*)C(*)[C@]1O 0.000 description 14
- PXKXMLOHKWCCGD-XNIMQTFVSA-N O[C@@H](C(C(C(OCc1ccccc1)=C1OCc2ccccc2)OCc2ccccc2)OCc2ccccc2)C1O Chemical compound O[C@@H](C(C(C(OCc1ccccc1)=C1OCc2ccccc2)OCc2ccccc2)OCc2ccccc2)C1O PXKXMLOHKWCCGD-XNIMQTFVSA-N 0.000 description 1
Claims (11)
-
- 医薬として許容される担体、及び、
- 化合物が、
- アミロイドーシスに関連する病的症状を治療するための、
- 化合物が、
- アミロイドーシスに関連する病的症状に罹患している対象をアミロイド画像化するための、
- アミロイドーシスに関連する病的症状がアルツハイマー病である、請求項４から６のいずれか一項に記載の医薬組成物。
- アミロイドーシスに関連する病的症状を治療するための医薬の製造における、
- 化合物が、
- アミロイドーシスに関連する病的症状がアルツハイマー病である、請求項８または９に記載の使用。
- 治療が斑の形成を阻害する、請求項８から１０のいずれか一項に記載の使用。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3857108P | 2008-03-21 | 2008-03-21 | |
| US61/038,571 | 2008-03-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014046341A Division JP6140090B2 (ja) | 2008-03-21 | 2014-03-10 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017075173A JP2017075173A (ja) | 2017-04-20 |
| JP2017075173A5 true JP2017075173A5 (ja) | 2017-11-24 |
| JP6370361B2 JP6370361B2 (ja) | 2018-08-08 |
Family
ID=41091569
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501009A Active JP5501339B2 (ja) | 2008-03-21 | 2009-03-23 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
| JP2014046341A Active JP6140090B2 (ja) | 2008-03-21 | 2014-03-10 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
| JP2016249232A Active JP6370361B2 (ja) | 2008-03-21 | 2016-12-22 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501009A Active JP5501339B2 (ja) | 2008-03-21 | 2009-03-23 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
| JP2014046341A Active JP6140090B2 (ja) | 2008-03-21 | 2014-03-10 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US8450466B2 (ja) |
| EP (2) | EP2268647B1 (ja) |
| JP (3) | JP5501339B2 (ja) |
| CN (2) | CN102046638B (ja) |
| AU (1) | AU2009225407B2 (ja) |
| CA (2) | CA2718035C (ja) |
| HK (2) | HK1157323A1 (ja) |
| MX (1) | MX2010010314A (ja) |
| WO (1) | WO2009117728A2 (ja) |
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| US9017724B2 (en) | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
| US8257680B1 (en) | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
| AU2009225407B2 (en) * | 2008-03-21 | 2013-09-05 | The General Hospital Corporation | Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders |
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| US9220403B2 (en) * | 2010-08-16 | 2015-12-29 | Cognoptix, Inc. | System and method for detecting amyloid proteins |
| WO2012099904A1 (en) * | 2011-01-18 | 2012-07-26 | General Atomics | Hydrolase enzyme substrates and uses thereof |
| CN109846862A (zh) * | 2012-10-25 | 2019-06-07 | 通用医疗公司 | 治疗阿尔茨海默病及相关疾病的组合疗法 |
| US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| AU2014340182B2 (en) | 2013-10-22 | 2019-05-23 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| WO2015143185A1 (en) * | 2014-03-19 | 2015-09-24 | Amydis Diagnostics | Amyloid targeting agents and methods of using the same |
| CN116889562A (zh) | 2016-08-31 | 2023-10-17 | 通用医疗公司 | 与神经退行性疾病相关的神经炎症中的巨噬细胞/小胶质细胞 |
| WO2018062588A1 (ko) | 2016-09-29 | 2018-04-05 | 한국원자력연구원 | 커큐민 유도체, 이의 제조방법 및 이를 포함하는 베타-아밀로이드 플라크 검출용 광음향 영상화제 |
| WO2019017995A1 (en) | 2017-07-20 | 2019-01-24 | Aztherapies, Inc. | FORMULATIONS OF CROMOLYNE SODIUM POWDER AND IBUPROFEN |
| KR20210071943A (ko) | 2018-07-02 | 2021-06-16 | 더 제너럴 하스피탈 코포레이션 | 크로몰린 소듐 및 α-락토스의 분말화된 제형 |
| CN112638944A (zh) | 2018-08-23 | 2021-04-09 | 西进公司 | 抗tigit抗体 |
| IL314660A (en) * | 2022-02-07 | 2024-09-01 | Martin J Moskovitz | Cryosurgical device and materials and methods for its use |
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-
2009
- 2009-03-23 AU AU2009225407A patent/AU2009225407B2/en active Active
- 2009-03-23 CN CN200980119032.0A patent/CN102046638B/zh active Active
- 2009-03-23 US US12/933,139 patent/US8450466B2/en active Active
- 2009-03-23 CA CA2718035A patent/CA2718035C/en active Active
- 2009-03-23 CA CA2978149A patent/CA2978149C/en active Active
- 2009-03-23 WO PCT/US2009/037928 patent/WO2009117728A2/en active Application Filing
- 2009-03-23 EP EP09723502.2A patent/EP2268647B1/en active Active
- 2009-03-23 JP JP2011501009A patent/JP5501339B2/ja active Active
- 2009-03-23 CN CN201510221345.4A patent/CN104974024B/zh active Active
- 2009-03-23 EP EP17152886.2A patent/EP3231804B1/en active Active
- 2009-03-23 MX MX2010010314A patent/MX2010010314A/es active IP Right Grant
-
2011
- 2011-10-24 HK HK11111431.1A patent/HK1157323A1/xx unknown
-
2013
- 2013-05-28 US US13/903,362 patent/US9005578B2/en active Active
-
2014
- 2014-03-10 JP JP2014046341A patent/JP6140090B2/ja active Active
- 2014-12-15 US US14/569,855 patent/US20150098903A1/en not_active Abandoned
-
2016
- 2016-04-11 HK HK16104068.1A patent/HK1217100A1/zh unknown
- 2016-12-22 JP JP2016249232A patent/JP6370361B2/ja active Active
-
2019
- 2019-08-29 US US16/555,290 patent/US10857247B2/en active Active
-
2020
- 2020-12-08 US US17/115,344 patent/US20210338849A1/en not_active Abandoned
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