JP2016519107A5 - - Google Patents
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- Publication number
- JP2016519107A5 JP2016519107A5 JP2016507634A JP2016507634A JP2016519107A5 JP 2016519107 A5 JP2016519107 A5 JP 2016519107A5 JP 2016507634 A JP2016507634 A JP 2016507634A JP 2016507634 A JP2016507634 A JP 2016507634A JP 2016519107 A5 JP2016519107 A5 JP 2016519107A5
- Authority
- JP
- Japan
- Prior art keywords
- hypoxia
- predetermined value
- cancer
- degree
- administering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010021143 Hypoxia Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 230000001146 hypoxic Effects 0.000 claims 5
- 238000003384 imaging method Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
Claims (2)
- [18F]-HX4 PET画像化を使用して癌の低酸素状態の程度を得る工程；および
得られた低酸素状態の程度と、予め決定された値を比較する工程；
ここで、前記程度が、前記予め決定された値以上である場合、患者に治療有効量のTH-302を投与するか、またはかかる程度レベルが、前記予め決定された値を超えない場合、TH-302の投与を含む治療以外の治療有効量の癌治療を施す、
を含む、患者において癌を治療する方法を決定するための情報の提供方法。 - 癌の低酸素状態が、[18F]-HX4 PET画像化を使用して測定され、得られた低酸素状態の程度が、予め決定された値と比較され、前記低酸素状態の程度が、前記予め決定された値以上である患者を対象とする、TH-302を含む癌の治療剤。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361810643P | 2013-04-10 | 2013-04-10 | |
| US61/810,643 | 2013-04-10 | ||
| PCT/US2014/033491 WO2014169035A1 (en) | 2013-04-10 | 2014-04-09 | Predictive and response biomarker for th-302 anti-cancer therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016519107A JP2016519107A (ja) | 2016-06-30 |
| JP2016519107A5 true JP2016519107A5 (ja) | 2017-06-01 |
Family
ID=51689977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016507634A Pending JP2016519107A (ja) | 2013-04-10 | 2014-04-09 | Ｔｈ−３０２抗癌療法のための予測および応答のバイオマーカー |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20160296538A1 (ja) |
| EP (1) | EP2983591A4 (ja) |
| JP (1) | JP2016519107A (ja) |
| WO (1) | WO2014169035A1 (ja) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015069489A1 (en) | 2013-11-06 | 2015-05-14 | Merck Patent Gmbh | Predictive biomarker for hypoxia-activated prodrug therapy |
| WO2016090174A1 (en) * | 2014-12-03 | 2016-06-09 | Auckland Uniservices, Ltd. | Kinase inhibitor prodrug for the treatment of cancer |
| US11504075B2 (en) * | 2017-12-20 | 2022-11-22 | University Health Network | System, methods, and devices for calculating hypoxic fraction and equilibration rate of small molecular weight tracers using dynamic imaging |
| JP2024531479A (ja) | 2021-08-27 | 2024-08-29 | アセンタウィッツ ファーマシューティカルズ リミテッド | 凍結乾燥製剤溶液および凍結乾燥製剤、ならびにそれらの方法および使用 |
| KR20240051965A (ko) | 2021-08-27 | 2024-04-22 | 아센타위츠 파마슈티컬즈 리미티드 | Th-302를 이용한 parp 억제제에 내성이 있는 환자의 치료 |
| CN118829436A (zh) | 2022-03-15 | 2024-10-22 | 深圳艾欣达伟医药科技有限公司 | 治疗brca突变癌症患者的方法 |
| WO2024179467A1 (zh) * | 2023-02-27 | 2024-09-06 | 深圳艾欣达伟医药科技有限公司 | 溶液、冻干制剂、冻干制剂单位包装、注射液及注射液配制方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1372717A2 (en) * | 2001-03-23 | 2004-01-02 | Aphton Corporation | Combination treatment of pancreatic cancer |
| US20070117784A1 (en) * | 2005-03-04 | 2007-05-24 | Novacea, Inc. | Treatment of hyperproliferative diseases with anthraquinones |
| EP2350664B1 (en) * | 2008-10-21 | 2021-05-19 | ImmunoGenesis, Inc. | Treatment of cancer using the hypoxia activated prodrug th-302 in combination with docetaxel or pemetrexed |
| US20130296273A1 (en) * | 2010-06-28 | 2013-11-07 | Threshold Pharmaceuticals, Inc. | Treatment of blood cancer |
| ES2649340T3 (es) * | 2010-07-12 | 2018-01-11 | Threshold Pharmaceuticals, Inc. | Administración de fármacos activados por hipoxia y agentes antiangiogénicos para el tratamiento del cáncer |
| EP2593796A4 (en) * | 2010-07-16 | 2016-07-27 | Auckland Uniservices Ltd | BACTERIAL NITROREDUCTASE ENZYMES AND ASSOCIATED METHODS |
-
2014
- 2014-04-09 WO PCT/US2014/033491 patent/WO2014169035A1/en active Application Filing
- 2014-04-09 JP JP2016507634A patent/JP2016519107A/ja active Pending
- 2014-04-09 EP EP14783066.5A patent/EP2983591A4/en not_active Withdrawn
- 2014-04-09 US US14/783,776 patent/US20160296538A1/en not_active Abandoned
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