JP2017031194A - 磁気双極子安定化溶液の使用を含む疾患を処置または改善する方法および行動を向上させる方法 - Google Patents
磁気双極子安定化溶液の使用を含む疾患を処置または改善する方法および行動を向上させる方法 Download PDFInfo
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Abstract
Description
本出願は、2010年7月22日付で出願された米国特許仮出願第61/366,845号、2010年7月22日付で出願された米国特許仮出願第61/366,852号、2010年7月22日付で出願された米国特許仮出願第61/366,853号、および2010年7月22日付で出願された米国特許仮出願第61/366,844号に対する優先権を主張するものであり、これらの全てが参照により本明細書に組み入れられる。
本発明は、皮膚状態、糖尿病状態、心血管状態、がんおよび感染症を処置もしくは改善するため、対象における金属をキレートするため、その量を低減するため、もしくは対象からの金属排泄量を増大させるため、栄養補給を提供するため、または行動を向上させるための、それを必要とする対象への磁気双極子安定化溶液を含む組成物の投与を伴う、方法に向けられる。
電気活性化水でありうる磁気双極子安定化溶液は、無菌かつ発熱物質陰性であり、しっかりと隔離され完全に密封された反応器空間中で強力な電(磁)界力に水を曝露することによって作製される。これは陰性(陰極)および陽性(陽極)の両方の電気活性化水流を生成することができる。
[本発明1001]
以下の段階を含む、それを必要とする対象において皮膚状態、糖尿病と関連する状態、心血管機能障害と関連する状態、がん、感染症または金属中毒を処置または改善する方法:
磁気双極子安定化溶液を含む組成物の治療的有効量を注射によって対象に投与する段階であって、該磁気双極子安定化溶液が、約-990〜約-0.0001 mVの負電位を有しかつH2O、O2、H2O2、Cl2OおよびH3Oからなる群より選択される安定化された酸化種を含む、電気活性化水である、段階。
[本発明1002]
前記皮膚状態が、皮膚老化、しわ、にきび、光損傷、酒さ、瘢痕、湿疹、脱毛症、肥厚性瘢痕、ケロイド、伸展線もしくは皮膚伸展線条、乾癬、掻痒症、エーラース・ダンロス症候群、強皮症、炎症後色素過剰、黒皮症、脱毛症、シヴァット多形皮膚萎縮症、白斑症、皮膚癌、皮膚色素異常症、火傷、およびしみだらけの色素形成からなる群より選択される、本発明1001の方法。
[本発明1003]
前記糖尿病と関連する状態が、肥満、高血圧症、高脂血症、脂肪肝疾患、腎症、神経障害、腎不全、網膜症、糖尿病性潰瘍、白内障、インスリン抵抗症候群、悪液質、糖尿病性足部潰瘍および糖尿病性下腿潰瘍からなる群より選択される、本発明1001の方法。
[本発明1004]
前記心血管機能障害と関連する状態が、冠動脈性心疾患、脳血管疾患、高血圧症、末梢動脈疾患、閉塞性動脈疾患、狭心症、リウマチ性心疾患、先天性心疾患、心臓麻痺、心不全、動悸、上室性頻拍症、細動、失神型めまい、動揺性めまい、疲労、片頭痛、高レベルの血中総コレステロールおよび/もしくはLDLコレステロール、低レベルのHDLコレステロール、高レベルのリポタンパク質、心炎および心内膜炎のような心臓感染症、糖尿病性潰瘍、血栓性静脈炎、レイノー病、跛行、壊疽、アテローム性動脈硬化症および末梢動脈疾患からなる群より選択される、本発明1001の方法。
[本発明1005]
前記中毒が急性である、本発明1001の方法。
[本発明1006]
前記金属が、カルシウム、アルミニウム、ベリリウム、カドミウム、銅、鉄、鉛、ウラン、プルトニウム、ヒ素、モリブデン、および水銀からなる群より選択される重金属である、本発明1001の方法。
[本発明1007]
前記組成物が、ビタミン、塩、酸、ビタマー、アミノ酸、およびこれらの混合物からなる群より選択される1つまたは複数の成分をさらに含む、本発明1001の方法。
[本発明1008]
前記組成物が、ジメチルアミノエタノールならびにエリスロマイシンおよびゲンタマイシンからなる群より選択される抗生物質をさらに含む、本発明1001の方法。
[本発明1009]
前記組成物が、約250 mgの量でリポ酸およびその塩または混合物をさらに含む、本発明1001の方法。
[本発明1010]
前記組成物が約400 mgの量で葉酸をさらに含む、本発明1001の方法。
[本発明1011]
前記投与する段階が、約1分間から約1時間の期間にわたって注入により前記組成物を導入することを含み、該注入が、約1週間から約1年間より選択される期間にわたって必要に応じて繰り返される、本発明1001の方法。
[本発明1012]
前記組成物が、リグノカイン、ブピバカイン、ジブカイン、プロカイン、クロロプロカイン、プリロカイン、メピバカイン、エチドカイン、テトラカイン、リドカインおよびキシロカイン、ならびにその塩、誘導体および混合物からなる群より選択される麻酔薬をさらに含む、本発明1001の方法。
[本発明1013]
前記組成物がヘパリンをさらに含む、本発明1001の方法。
[本発明1014]
前記組成物が、アスコルビン酸ナトリウム、塩化マグネシウム2 H2O、2ジメチルアミノエタノールHCl、チアミン、リボフラビン、ニコチンアミド、ピリドキシン、パントテン酸カルシウム、シアノバラミン、および電気活性化水を含む、本発明1001の方法。
[本発明1015]
磁気双極子安定化溶液を含む組成物を注射によって対象に投与する段階を含む、対象において金属の量を低減する方法であって、該金属が、カルシウム、アルミニウム、ベリリウム、カドミウム、銅、鉄、鉛、ウラン、プルトニウム、ヒ素、モリブデン、および水銀からなる群より選択される、+1、+2または+3の酸化状態を有する重金属であり、かつ該磁気双極子安定化溶液が、約-990〜約-0.0001 mVの負電位を有しかつH2O、O2、H2O2、Cl2OおよびH3Oからなる群より選択される安定化された酸化種を含む、電気活性化水である、前記方法。
[本発明1016]
前記溶液が、約250 mgの量でリポ酸およびその塩または混合物を含む、本発明1015の方法。
[本発明1017]
前記金属が遷移状態または遷移後状態の金属である、本発明1015の方法。
[本発明1018]
前記金属が二価陽イオンである、本発明1015の方法。
[本発明1019]
前記投与する段階が、約1分間から約1時間の期間にわたって注入により前記溶液を導入することを含み、該注入が、約1週間から約1年間より選択される期間にわたって必要に応じて繰り返される、本発明1015の方法。
[本発明1020]
前記組成物が、麻酔薬および1種もしくは複数種のアミノ酸またはそれらの塩をさらに含む、本発明1015の方法。
[本発明1021]
以下の段階を含む、それを必要とする対象からの金属または1種もしくは複数種の毒素の排泄を増大させる方法:
i. 磁気双極子安定化溶液の有効量を注射によって対象に投与する段階であって、該磁気双極子安定化溶液が、約-990〜約-0.0001 mVの負電位を有しかつH2O、O2、H2O2、Cl2OおよびH3Oからなる群より選択される安定化された酸化種を含む、電気活性化水である、段階。
[本発明1022]
以下の段階を含む、それを必要とする対象において運動行動、認知行動または注意行動を向上させる方法:
磁気双極子安定化溶液の有効量を注射によって対象に投与する段階であって、該磁気双極子安定化溶液が、約-990〜約-0.0001 mVの負電位を有しかつH2O、O2、H2O2、Cl2OおよびH3Oからなる群より選択される安定化された酸化種を含む、電気活性化水である、段階。
[本発明1023]
前記投与する段階が、約1分間から約1時間の期間にわたって注入により前記溶液を導入することを含み、該注入が、約1週間から約1年間より選択される期間にわたって、前記行動の約24時間以内に、約1週間以内に、または約1ヶ月間以内に必要に応じて繰り返される、本発明1022の方法。
[本発明1024]
磁気双極子安定化溶液が、
アスコルビン酸ナトリウム、
塩化マグネシウム2 H2O、
2ジメチルアミノエタノールHCl、
チアミン、
リボフラビン、
ニコチンアミド、
ピリドキシン、
パントテン酸カルシウム、
シアノバラミン、および
電気活性化水
を含む、本発明1022の方法。
[本発明1025]
磁気双極子安定化溶液が、
約100 mg〜約500 mgのアスコルビン酸ナトリウム、
約100 mg〜約500 mgの塩化マグネシウム2 H2O、
約100 mg〜約500 mgの2 ジメチルアミノエタノールHCl、
約1 mg〜約100 mgのチアミン、
約1 mg〜約100 mgのリボフラビン、
約1 mg〜約300 mgのニコチンアミド、
約1 mg〜約100 mgのピリドキシン、
約1 mg〜約100 mgのパントテン酸カルシウム、
約100 μg〜約500 μgのシアノバラミン、および
電気活性化水
を含む、本発明1022の方法。
[本発明1026]
以下の段階を含む、それを必要とする対象に栄養補給を提供する方法:
磁気双極子安定化溶液の有効量を注射によって対象に投与する段階であって、該磁気双極子安定化溶液が、約-990〜約-0.0001 mVの負電位を有しかつH2O、O2、H2O2、Cl2OおよびH3Oからなる群より選択される安定化された酸化種を含む、電気活性化水である、段階。
[本発明1027]
前記対象が、栄養障害、悪液質、糖尿病、重症食物アレルギー、短腸症候群、嚢胞性線維症、膵臓病、胃腸炎、炎症性腸疾患、難治性下痢症、タンパク質消化不良症、壊死性腸炎、感染症、代謝亢進、外傷、好酸球性胃腸炎、および胃食道逆流症からなる群より選択される疾病を患っており、かつ前記磁気双極子安定化溶液が、Zn、Se、Cu、MnおよびFeからなる群より選択される1種または複数種の微量金属を含む、本発明1026の方法。
[本発明1028]
前記対象は、運動競技者、小児、肥満対象、がんに対する化学療法を受けている対象、AIDS患者、栄養障害の対象、または昏睡状態にある対象に関連する特別食の必要性を有する、本発明1027の方法。
[本発明1029]
前記磁気双極子安定化溶液が、Zn、Se、Cu、MnおよびFeからなる群より選択される1種または複数種の微量金属を含む、本発明1026の方法。
[本発明1030]
前記磁気双極子安定化溶液が、
約100 mg〜約500 mgのアスコルビン酸ナトリウム、
約100 mg〜約500 mgの塩化マグネシウム2 H2O、
約100 mg〜約500 mgの2 ジメチルアミノエタノールHCl、
約1 mg〜約100 mgのチアミン、
約1 mg〜約100 mgのリボフラビン、
約1 mg〜約300 mgのニコチンアミド、
約1 mg〜約100 mgのピリドキシン、
約1 mg〜約100 mgのパントテン酸カルシウム、
約100 μg〜約500 μgのシアノバラミン、
約1 mg〜約20 mgのZn、
約1 mg〜約100 mgのSe、
約1 mg〜約1000 mgのCu、
約0.01 mg〜約10 mgのMn、および
約1 mg〜約20 mgのFe
を含む電気活性化水である、本発明1026の方法。
[本発明1031]
前記磁気双極子安定化溶液が、
約395 mgのアスコルビン酸ナトリウム、
約255 mgの塩化マグネシウム2 H2O、
約200 mgの2-ジメチルアミノエタノールHCl、
約36 mgのチアミン、
約7.3 mgのリボフラビン、
約100 mgのニコチンアミド、
約18.2 mgのピリドキシン、
約18.2 mgのパントテン酸カルシウム、
約320 μgのシアノバラミン、
約10 mgのZn、
約45 mgのSe、
約400 mgのCu、
約0.3 mgのMn、
約8 mgのFe、および
電気活性化水
を含む、本発明1026の方法。
[本発明1032]
ビタミン、塩、酸およびビタマー、ならびにそれらの混合物からなる群より選択される1つまたは複数を含む溶液を含有する、第1のバイアル;
電気活性化水を含む磁気双極子安定化溶液を含有する第2のバイアル; ならびに
使用説明書
を含み、
該磁気双極子安定化溶液が正電位を有し、かつ
該磁気双極子安定化溶液が、該第1および第2のバイアルを混ぜ合わせた後に負電位を有する、
キット。
[本発明1033]
第1のバイアル中の前記溶液が、アスコルビン酸ナトリウム、塩化マグネシウム2 H2O、2ジメチルアミノエタノールHCl、チアミン、リボフラビン、ニコチンアミド、ピリドキシン、パントテン酸カルシウム、およびシアノバラミンを含む、本発明1032のキット。
[本発明1034]
電気活性化水と、ヘパリン、ビタミン、塩、酸、リポ酸、葉酸、抗生物質およびビタマー、ならびにそれらの混合物からなる群より選択される1つまたは複数とを含む磁気双極子安定化溶液を含有する第1のバイアル;
磁気双極子安定化溶液を含有する第2のバイアル; ならびに
使用説明書
を含む、キット。
[本発明1035]
第1のバイアル中の前記溶液が約10 mg〜500 mgの量のリポ酸を含む、本発明1034のキット。
[本発明1036]
前記リポ酸が約100 mg〜400 mgの量で存在する、本発明1035のキット。
[本発明1037]
前記リポ酸が約250 mgの量で存在する、本発明1036のキット。
[本発明1038]
第1のバイアル中の前記溶液が、
アスコルビン酸ナトリウム、
塩化マグネシウム2 H2O、
2ジメチルアミノエタノールHCl、
チアミン、
リボフラビン、
ニコチンアミド、
ピリドキシン、
パントテン酸カルシウム、
シアノバラミン、
リポ酸、
葉酸、および
抗生物質
を含む、本発明1034のキット。
これから本発明を以下でさらに十分に記載する。しかしながら、先の記載のなかで提示された教示の恩典を有する、本発明に関連のある当業者には、本明細書に記載される本発明の多くの修正および他の態様が思い浮かぶであろう。それゆえ、本発明は、開示される特定の態様に限定されるべきではないこと、ならびに修正および他の態様は添付の特許請求の範囲の範囲内に含まれると意図されることが理解されるべきである。
式中、R1がアルキル、カルボキサミドまたはアミノカルバミル部分であり; かつR2がメチル、エチル、メトキシまたはカルボニル部分である。薬学的組成物は、2.5%〜3.5%の有効成分を含んでもよく、約2.5〜約3.5のpHを有してもよい。
容器1はバイアルであり、これは無機物、単一アミノ酸、アミノ-酢酸および局所麻酔薬(リドカイン)との総合ビタミン剤の組み合わせを含む多成分注射として本明細書に記載される、MDSSを含有する。容器2は、容器1と混ぜ合わされた場合に、生体相への効果的な送達に向けて成分を安定化する生理学的緩衝液中での成分の溶解に使われる、担体溶液/溶媒系を含む。この溶媒系は、NaHCO3に由来する炭酸を少量含有する滅菌注射用液(WFI)から調製される。この溶媒は、用途のために選択された、強力な正電荷または負電荷を帯びている。電荷は、少なくとも800ミリボルトであるように精確な電位測定によってモニタリングされうる。電荷は、注射液の溶解および充填中に、約-400〜約-700ミリボルトに減弱される可能性があり、貯蔵および保存可能期間中に、さらに約-70ミリボルトに減弱する可能性があるが、それでもなお、これは十分かつ有効と考えられる。局所麻酔作用は、ナトリウムチャネルの封鎖および血管壁弛緩の提供によって血管内皮細胞の膜を安定化するために利用される。どちらの容器も使用の前に希釈される。最終用量は200 mlであり、0.9%塩化ナトリウム注射液を含有する。最終用量は輸液バッグ中で提供することができる。
患者3人に最低でも10週間、REV-1を週1回または2回注入した。結果から、以下が明らかになっている:
患者1人は4回目の処置の直後ににきびの状態が改善していた。
患者1人はにきびによる明らかな瘢痕化が少なくなった。
患者1人は顔色が改善していた。
患者2人で皮膚の水和が改善された。結果として、湿潤剤はあまり必要とされなかった。
患者2人は処置中および処置後にしわがさらに少なくなった。
以下は、金属イオンを除去するMDSS組成物の能力について記載する。24歳から63歳の男性および女性個体20人を年齢、身体活動、および体格指数(BMI)に基づいて、処置のために無作為に選択した。心血管疾患、糖尿病またはがんの家族歴を有する対象を処置に含めた。個体を完全な身体検査、血液および尿検査、カルシウム・スコア測定および放射線検査に供した。
硫酸マグネシウム六水和物 60.2 g/L
2-ジエチルアミノアセト、キシリダイド 30.0 g/L
ナイアシンアミド 9.90 g/L
ピリドキシンHCL 9.90 g/L
リボフラビン-5-リン酸ナトリウム 0.19 g/L
チアミンHCL 6.05 g/L
シアノコバラミン結晶 0.18 g/L
電気化学的に活性化された水 + 997.50 ml
1.0リットルの溶液Bは、以下の塩および無機物を溶解することによって調製される。
炭酸水素ナトリウムUSP 86.70 g/L
硫酸マグネシウム六水和物 20.2 g/L
電気化学的に活性化された水 + 998.5 ml
硫酸マグネシウム六水和物 0.5〜10%
炭酸水素ナトリウム 0.5〜10%
アスコルビン酸 5.0〜20%
ナイアシンアミド 0.2〜2.0%
ピリドキシンHCl 0.005〜0.2%
Dパントテン酸カルシウム 0.01〜2.0%
チアミンHCl 0.1〜1.0%
リボフラビン 0.01〜0.1%
シアノコバラミン 0.001〜0.1%
磁気双極子安定化液 5.0〜500 ml
2-ジメチルアミノエタノール 1.0〜3.0%
以下では、栄養障害症状を処置するMDSS組成物の能力について記載する。上記のREV-1+配合を含んだ週に注入1回の用量を投与した。試験は10週続いた。対象データ: 対象は栄養障害の問題を有していた。II型糖尿病の症状を呈する対象もいた。結果: 患者の1人は処置後にとても気分が良いと述べた。処置の前に、足首の皮膚色は青色であった。処置の後、色はピンク色である。別の患者は眼の水和の改善を呈し(電気活性化水を同様に点眼薬として用いた)、血液循環が増大した。別の患者は手の損傷域への血液供給の改善によってとても気分が良いと報告した。別の患者は同じ体重での全身的な健康および改善を報告し、好ましい栄養学的効果を示唆している。他の患者は、より元気になった感じがすると報告している。患者の1人は、より元気になった感じがして、かかとの部分の疼痛が改善したと報告した。
製剤REV-1を対象に投与した。対象はイベントの最大2週間前まで週1回の処置を受け、イベントの時点で、対象はイベントまでに週あたり2回の処置を受けた。わずか4回の処置の後、対象は、91 kmのランニングタイムが処置前のタイムと比べて向上したことに気付いた。経過観察試験において、対象は1年後に6回の処置を受け、同じく対象は、競技中の活力レベルがより高かったと報告した。
Claims (58)
- 注射用の磁気双極子安定化溶液を含む、そのような処置または改善を必要とする対象において皮膚状態、糖尿病と関連する状態、心血管機能障害と関連する状態、がん、感染症または金属中毒を処置または改善するための薬学的組成物であって、
該磁気双極子安定化溶液が、約−990〜約−0.0001mVの負電位を有し、かつH2O、およびHOClを含む、電気活性化水であり、
該組成物は、
(i)アスコルビン酸ナトリウム、塩化マグネシウム2H2O、チアミン、リボフラビン、ニコチンアミド、ピリドキシン、パントテン酸カルシウム、シアノバラミン、および
(ii)ビタミン、塩、酸、アミノ酸またはその塩、ビタマー、2ジメチルアミノエタノールHCl、1種または複数種の麻酔薬、安定化された酸化種、ヘパリン、およびリポ酸、リポ酸塩またはその混合物からなる群より選択される、1種または複数種の成分
をさらに含む、薬学的組成物。 - 前記皮膚状態が、皮膚老化、しわ、にきび、光損傷、酒さ、瘢痕、湿疹、脱毛症、肥厚性瘢痕、ケロイド、伸展線もしくは皮膚伸展線条、乾癬、掻痒症、エーラース・ダンロス症候群、強皮症、炎症後色素過剰、黒皮症、シヴァット多形皮膚萎縮症、白斑症、皮膚癌、皮膚色素異常症、火傷、およびしみだらけの色素形成からなる群より選択される、請求項1記載の薬学的組成物。
- 前記糖尿病と関連する状態が、肥満、高血圧症、高脂血症、脂肪肝疾患、腎症、神経障害、腎不全、網膜症、糖尿病性潰瘍、白内障、インスリン抵抗症候群、悪液質、糖尿病性足部潰瘍および糖尿病性下腿潰瘍からなる群より選択される、請求項1記載の薬学的組成物。
- 前記心血管機能障害と関連する状態が、冠動脈性心疾患、脳血管疾患、高血圧症、末梢動脈疾患、閉塞性動脈疾患、狭心症、リウマチ性心疾患、先天性心疾患、心臓麻痺、心不全、動悸、上室性頻拍症、細動、失神型めまい、動揺性めまい、疲労、片頭痛、高レベルの血中総コレステロールおよび/もしくはLDLコレステロール、低レベルのHDLコレステロール、高レベルのリポタンパク質、心炎および心内膜炎のような心臓感染症、糖尿病性潰瘍、血栓性静脈炎、レイノー病、跛行、壊疽、アテローム性動脈硬化症および末梢動脈疾患からなる群より選択される、請求項1記載の薬学的組成物。
- 前記金属中毒が急性である、請求項1記載の薬学的組成物。
- 前記金属中毒が、カルシウム、アルミニウム、ベリリウム、カドミウム、銅、鉄、鉛、ウラン、プルトニウム、ヒ素、モリブデン、および水銀からなる群より選択される重金属に関連する、請求項1記載の薬学的組成物。
- 抗生物質をさらに含む、請求項1〜6のいずれか一項記載の薬学的組成物。
- 1種または複数種の成分が、リポ酸およびその塩である、請求項1〜7のいずれか一項記載の薬学的組成物。
- 葉酸をさらに含む、請求項1〜8のいずれか一項記載の薬学的組成物。
- 前記組成物が約1分間から約1時間の期間にわたって注入により導入されるように用いられ、該注入が、約1週間から約1年間より選択される期間にわたって必要に応じて繰り返される、請求項1〜9のいずれか一項記載の薬学的組成物。
- リグノカイン、ブピバカイン、ジブカイン、プロカイン、クロロプロカイン、プリロカイン、メピバカイン、エチドカイン、テトラカイン、リドカインおよびキシロカイン、ならびにその塩、誘導体および混合物からなる群より選択される、1種または複数種の麻酔薬をさらに含む、請求項1〜10のいずれか一項記載の薬学的組成物。
- 1種または複数種の成分がヘパリンである、請求項1〜11のいずれか一項記載の薬学的組成物。
- 硫酸マグネシウム六水和物、2−ジエチルアミノアセチルキシリダイド、および葉酸の1種または複数種を含む、請求項1記載の薬学的組成物。
- 注射用の磁気双極子安定化溶液を含み、対象において金属の量を低減するための薬学的組成物であって、
該金属が、カルシウム、アルミニウム、ベリリウム、カドミウム、銅、鉄、鉛、ウラン、プルトニウム、ヒ素、モリブデン、および水銀からなる群より選択される、+1、+2または+3の酸化状態を有する重金属であり、かつ
該注射用の磁気双極子安定化溶液が、約−990〜約−0.0001mVの負電位を有しかつH2O、およびHOClを含む、電気活性化水であり、
該組成物は、
(i)アスコルビン酸ナトリウム、塩化マグネシウム2H2O、チアミン、リボフラビン、ニコチンアミド、ピリドキシン、パントテン酸カルシウム、シアノバラミン、および
(ii)ビタミン、塩、酸、アミノ酸またはその塩、ビタマー、2ジメチルアミノエタノールHCl、1種または複数種の麻酔薬、安定化された酸化種、ヘパリン、およびリポ酸、リポ酸塩またはその混合物からなる群より選択される、1種または複数種の成分
をさらに含む、薬学的組成物。 - 1種または複数種の成分が、リポ酸、リポ酸塩またはその混合物である、請求項14記載の薬学的組成物。
- 前記金属が遷移状態または遷移後状態の金属である、請求項14または15記載の薬学的組成物。
- 前記金属が二価陽イオンである、請求項16記載の薬学的組成物。
- 治療的有効量の組成物が、約1分間から約1時間の期間にわたって注入により対象に導入されるように用いられ、該注入が、約1週間から約1年間より選択される期間にわたって必要に応じて繰り返される、請求項14〜17のいずれか一項記載の薬学的組成物。
- 1種または複数種の成分が、1種もしくは複数種の麻酔薬および1種もしくは複数種のアミノ酸またはそれらの塩である、請求項14記載の薬学的組成物。
- 注射用の磁気双極子安定化溶液の有効量を含み、そのような排泄の増大を必要とする対象からの金属または1種もしくは複数種の毒素の排泄を増大させるための薬学的組成物であって、
該磁気双極子安定化溶液が、約−990〜約−0.0001mVの負電位を有しかつH2O、およびHOClを含む、電気活性化水であり、
該組成物は、
(i)アスコルビン酸ナトリウム、塩化マグネシウム2H2O、チアミン、リボフラビン、ニコチンアミド、ピリドキシン、パントテン酸カルシウム、シアノバラミン、および
(ii)ビタミン、塩、酸、アミノ酸またはその塩、ビタマー、2ジメチルアミノエタノールHCl、1種または複数種の麻酔薬、安定化された酸化種、ヘパリン、およびリポ酸、リポ酸塩またはその混合物からなる群より選択される、1種または複数種の成分
をさらに含む、薬学的組成物。 - 注射用の磁気双極子安定化溶液の有効量を含み、そのような向上を必要とする対象において運動行動、認知行動または注意行動を向上させるための薬学的組成物であって、
該磁気双極子安定化溶液が、約−990〜約−0.0001mVの負電位を有しかつH2O、およびHOClを含む、電気活性化水であり、
該組成物は、
(i)アスコルビン酸ナトリウム、塩化マグネシウム2H2O、チアミン、リボフラビン、ニコチンアミド、ピリドキシン、パントテン酸カルシウム、シアノバラミン、および
(ii)ビタミン、塩、酸、アミノ酸またはその塩、ビタマー、2ジメチルアミノエタノールHCl、1種または複数種の麻酔薬、安定化された酸化種、ヘパリン、およびリポ酸、リポ酸塩またはその混合物からなる群より選択される、1種または複数種の成分
をさらに含む、薬学的組成物。 - 前記磁気双極子安定化溶液が、約1分間から約1時間の期間にわたって注入により対象に導入されるように用いられ、該注入が、約1週間から約1年間より選択される期間にわたって、前記行動の約24時間以内に、約1週間以内に、または約1ヶ月間以内に必要に応じて繰り返される、請求項21記載の薬学的組成物。
- 磁気双極子安定化溶液が、硫酸マグネシウム六水和物、2−ジエチルアミノアセチルキシリダイド、および葉酸の1種または複数種を含む、請求項21または22記載の薬学的組成物。
- 磁気双極子安定化溶液が、
約100mg〜約500mgのアスコルビン酸ナトリウム、
約100mg〜約500mgの塩化マグネシウム2H2O、
約100mg〜約500mgの2ジメチルアミノエタノールHCl、
約1mg〜約100mgのチアミン、
約1mg〜約100mgのリボフラビン、
約1mg〜約300mgのニコチンアミド、
約1mg〜約100mgのピリドキシン、
約1mg〜約100mgのパントテン酸カルシウム、
約100μg〜約500μgのシアノバラミン、および
電気活性化水
を含む、請求項21記載の薬学的組成物。 - 注射用の磁気双極子安定化溶液の有効量を含み、それを必要とする対象に栄養補給を提供するための薬学的組成物であって
該磁気双極子安定化溶液が、約−990〜約−0.0001mVの負電位を有しかつH2O、およびHOClを含む、電気活性化水であり、
該組成物は、
(i)アスコルビン酸ナトリウム、塩化マグネシウム2H2O、チアミン、リボフラビン、ニコチンアミド、ピリドキシン、パントテン酸カルシウム、シアノバラミン、および
(ii)ビタミン、塩、酸、アミノ酸またはその塩、ビタマー、2ジメチルアミノエタノールHCl、1種または複数種の麻酔薬、安定化された酸化種、ヘパリン、およびリポ酸、リポ酸塩またはその混合物からなる群より選択される、1種または複数種の成分
をさらに含む、薬学的組成物。 - 前記対象が、栄養障害、悪液質、糖尿病、重症食物アレルギー、短腸症候群、嚢胞性線維症、膵臓病、胃腸炎、炎症性腸疾患、難治性下痢症、タンパク質消化不良症、壊死性腸炎、感染症、代謝亢進、外傷、好酸球性胃腸炎、および胃食道逆流症からなる群より選択される疾病を患っている、請求項25記載の薬学的組成物。
- 前記対象は、運動競技者、小児、肥満対象、がんに対する化学療法を受けている対象、AIDS患者、栄養障害の対象、または昏睡状態にある対象に関連する特別食の必要性を有する、請求項25または26記載の薬学的組成物。
- 前記注射用の磁気双極子安定化溶液が、Zn、Se、Cu、MnおよびFeからなる群より選択される1種または複数種の微量金属を含む、請求項25〜27のいずれか一項記載の薬学的組成物。
- 前記磁気双極子安定化溶液が、
約100mg〜約500mgのアスコルビン酸ナトリウム、
約100mg〜約500mgの塩化マグネシウム2H2O、
約100mg〜約500mgの2ジメチルアミノエタノールHCl、
約1mg〜約100mgのチアミン、
約1mg〜約100mgのリボフラビン、
約1mg〜約300mgのニコチンアミド、
約1mg〜約100mgのピリドキシン、
約1mg〜約100mgのパントテン酸カルシウム、
約100μg〜約500μgのシアノバラミン、
約1mg〜約20mgのZn、
約1mg〜約100mgのSe、
約1mg〜約1000mgのCu、
約0.01mg〜約10mgのMn、および
約1mg〜約20mgのFe
を含む電気活性化水である、請求項25〜28のいずれか一項記載の薬学的組成物。 - 前記磁気双極子安定化溶液が、
約395mgのアスコルビン酸ナトリウム、
約255mgの塩化マグネシウム2H2O、
約200mgの2−ジメチルアミノエタノールHCl、
約36mgのチアミン、
約7.3mgのリボフラビン、
約100mgのニコチンアミド、
約18.2mgのピリドキシン、
約18.2mgのパントテン酸カルシウム、
約320μgのシアノバラミン、
約10mgのZn、
約45mgのSe、
約400mgのCu、
約0.3mgのMn、
約8mgのFe、および
電気活性化水
を含む、請求項25記載の薬学的組成物。 - ビタミン、塩、酸およびビタマー、ならびにそれらの混合物からなる群より選択される1つまたは複数の成分を含む溶液を含有する、第1のバイアル;
電気活性化水を含む注射用の磁気双極子安定化溶液を含有する第2のバイアル;ならびに
使用説明書
を含み、
該磁気双極子安定化溶液が正電位を有し、かつ
該第1および第2のバイアルのそれぞれの内容物を混ぜ合わせた後、該磁気双極子安定化溶液は、約−990〜約−0.0001mVの負電位を有し、かつH2O、およびHOClを含む、電気活性化水であり、
該溶液は、
(i)アスコルビン酸ナトリウム、塩化マグネシウム2H2O、チアミン、リボフラビン、ニコチンアミド、ピリドキシン、パントテン酸カルシウム、シアノバラミン、および
(ii)ビタミン、塩、酸、アミノ酸またはその塩、ビタマー、2ジメチルアミノエタノールHCl、1種または複数種の麻酔薬、安定化された酸化種、ヘパリン、およびリポ酸、リポ酸塩、またはその混合物からなる群より選択される、1種または複数種の成分
をさらに含む、キット。 - 第1のバイアル中の前記溶液が、アスコルビン酸ナトリウム、塩化マグネシウム2H2O、2ジメチルアミノエタノールHCl、チアミン、リボフラビン、ニコチンアミド、ピリドキシン、パントテン酸カルシウム、およびシアノバラミンを含む、請求項31記載のキット。
- 電気活性化水と、ヘパリン、ビタミン、塩、酸、リポ酸、リポ酸塩またはその混合物、葉酸、抗生物質およびビタマー、ならびにそれらの混合物からなる群より選択される1つまたは複数の成分とを含む注射用の磁気双極子安定化溶液を含有する第1のバイアル;
磁気双極子安定化溶液を含有する第2のバイアル;ならびに
使用説明書
を含み、
該第1および第2のバイアルのそれぞれの内容物を混ぜ合わせた後、該磁気双極子安定化溶液は、約−990〜約−0.0001mVの負電位を有し、かつH2O、およびHOClを含む、電気活性化水であり、
該溶液は、
(i)アスコルビン酸ナトリウム、塩化マグネシウム2H2O、チアミン、リボフラビン、ニコチンアミド、ピリドキシン、パントテン酸カルシウム、シアノバラミン、および
(ii)ビタミン、塩、酸、アミノ酸またはその塩、ビタマー、2ジメチルアミノエタノールHCl、1種または複数種の麻酔薬、安定化された酸化種、ヘパリン、およびリポ酸、リポ酸塩、またはその混合物からなる群より選択される、1種または複数種の成分
をさらに含む、キット。 - 第1のバイアル中の前記溶液が約10mg〜500mgの量のリポ酸、リポ酸塩、またはその混合物を含む、請求項33記載のキット。
- 前記リポ酸、リポ酸塩、またはその混合物が約100mg〜400mgの量で存在する、請求項34記載のキット。
- 前記リポ酸、リポ酸塩、またはその混合物が約250mgの量で存在する、請求項35記載のキット。
- 第1のバイアル中の前記溶液が、
アスコルビン酸ナトリウム、
塩化マグネシウム2H2O、
2ジメチルアミノエタノールHCl、
チアミン、
リボフラビン、
ニコチンアミド、
ピリドキシン、
パントテン酸カルシウム、
シアノバラミン、
リポ酸、リポ酸塩、またはその混合物、
葉酸、および
抗生物質
を含む、請求項33〜36のいずれか一項記載のキット。 - がんの処置用であり、該がんが膵臓癌である、請求項1〜13のいずれか一項記載の薬学的組成物。
- 磁気双極子安定化溶液が、カリウムを含む、請求項1〜13のいずれか一項記載の薬学的組成物。
- 磁気双極子安定化溶液が、アルギニンを含む、請求項1〜13のいずれか一項記載の薬学的組成物。
- 磁気双極子安定化溶液が、3.2〜7.6のpHを有する、請求項1〜13のいずれか一項記載の薬学的組成物。
- 抗生物質が、テトラサイクリン、オキシテトラサイクリン、メタサイクリン、ドキシサイクリン、ミノサイクリン、エリスロマイシン、リンコマイシン、ペニシリンG、クリンダマイシン、カナマイシン、クロラムフェニコール、フラジオマイシン、ストレプトマイシン、ノルフロキサシン、シプロフロキサシン、オフロキサシン、グレパフロキサシン、レボフロキサシン、スパルフロキサシン、アンピシリン、カルベニシリン、メチシリン、セファロスポリン、バンコマイシン、バシトラシン、ゲンタマイシン、フシジン酸、シプロフロキシンおよび他のキノロン、エリスロマイシン、ゲンタマイシン、スルホンアミド、トリメトプリム、ダプソン、イソニアジド、テイコプラニン、アボパルシン、シナシッド、バージニアマイシン、ピペラシリン、チカルシリン、セフェピム、セフピロム、リファンピシン、ピラジナミド、エンロフロキサシン、アミカシン、ネチルマイシン、イミペネム、メロペネム、イネゾリドセフロキシム、セフトリアキソン、セファドロキシル、セファゾリン、セフタジジム、セフォタキシム、ロキシスロマイシン、セファクロル、セファレキシン、セフォキシチン、アモキシシリン、コアモキシクラブ、ムピロシン、クロキサシリン、コトリモキサゾール、薬学的に許容されるそれらの塩、ならびにそれらの組み合わせからなる群より選択される、請求項7記載の薬学的組成物。
- 抗生物質が、エリスロマイシン、およびゲンタマイシンからなる群より選択され、かつ組成物がジメチルアミノエタノールを含む、請求項42記載の薬学的組成物。
- リポ酸、リポ酸塩、またはその混合物が約250mgの量で存在する、請求項8記載の薬学的組成物。
- 葉酸が約400mgの量で存在する、請求項9記載の薬学的組成物。
- アスコルビン酸ナトリウム、塩化マグネシウム2H2O、2ジメチルアミノエタノールHCl、チアミン、リボフラビン、ニコチンアミド、ピリドキシン、パントテン酸カルシウム、シアノバラミン、および電気活性化水を含む、請求項13記載の薬学的組成物。
- アスコルビン酸ナトリウム、塩化マグネシウム2H2O、2ジメチルアミノエタノールHCl、チアミン、リボフラビン、ニコチンアミド、ピリドキシン、パントテン酸カルシウム、シアノバラミン、および電気活性化水を含む、請求項22記載の薬学的組成物。
- 第1のバイアルに含まれる溶液が、ビタミンK2を含む、請求項31記載のキット。
- 第1のバイアルに含まれる磁気双極子安定化溶液が、ビタミンK2を含む、請求項33記載のキット。
- 磁気双極子安定化溶液が、ビタミンK2を含む、請求項38記載の薬学的組成物。
- がんを処置または改善するための薬剤である、請求項1記載の薬学的組成物。
- 磁気双極子安定化溶液が、ビタミンK2を含む、請求項51記載の薬学的組成物。
- 安定化された酸化種の1種または複数種の成分が、O2、O3、H2O2、Cl2OおよびH3Oからなる群より選択される、請求項1〜30、および38〜47のいずれか一項記載の薬学的組成物。
- 該第1および第2のバイアルのそれぞれの内容物を混ぜ合わせた後、磁気双極子安定化溶液がO2、O3、H2O2、Cl2OおよびH3Oからなる群より選択される、安定化された酸化種をさらに含む、請求項31〜37のいずれか一項記載のキット。
- 1種または複数種の成分が、一種または複数種のアミノ酸またはその塩を含む、請求項1〜30、および38〜47のいずれか一項記載の薬学的組成物。
- 1種または複数種の成分が、ビタミン、塩、酸、1種または複数種のアミノ酸もしくはその塩、ビタマー、2ジメチルアミノエタノールHCl、1種もしくは複数種の麻酔薬、安定化された酸化種、ヘパリン、およびリポ酸、リポ酸塩またはその混合物を含む、請求項1〜30、および38〜47のいずれか一項記載の薬学的組成物。
- 1種または複数種の成分が、一種または複数種のアミノ酸またはその塩を含む、請求項31〜37のいずれか一項記載のキット。
- 1種または複数種の成分が、ビタミン、塩、酸、1種または複数種のアミノ酸もしくはその塩、ビタマー、2ジメチルアミノエタノールHCl、1種もしくは複数種の麻酔薬、安定化された酸化種、ヘパリン、およびリポ酸、リポ酸塩またはその混合物を含む、請求項31〜37のいずれか一項記載のキット。
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