JP2016537012A5 - - Google Patents
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- JP2016537012A5 JP2016537012A5 JP2016542333A JP2016542333A JP2016537012A5 JP 2016537012 A5 JP2016537012 A5 JP 2016537012A5 JP 2016542333 A JP2016542333 A JP 2016542333A JP 2016542333 A JP2016542333 A JP 2016542333A JP 2016537012 A5 JP2016537012 A5 JP 2016537012A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- nucleic acid
- seq
- encoded
- calreticulin gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000007523 nucleic acids Chemical class 0.000 claims description 404
- 108020004707 nucleic acids Proteins 0.000 claims description 379
- 102000039446 nucleic acids Human genes 0.000 claims description 379
- 108090000623 proteins and genes Proteins 0.000 claims description 296
- 102000004169 proteins and genes Human genes 0.000 claims description 277
- 239000002773 nucleotide Substances 0.000 claims description 165
- 125000003729 nucleotide group Chemical group 0.000 claims description 165
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 118
- 108090000549 Calreticulin Proteins 0.000 claims description 96
- 238000000034 method Methods 0.000 claims description 91
- 108700028369 Alleles Proteins 0.000 claims description 68
- 230000000295 complement effect Effects 0.000 claims description 49
- 230000002068 genetic effect Effects 0.000 claims description 47
- 229920001184 polypeptide Polymers 0.000 claims description 33
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 33
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 33
- 239000003112 inhibitor Substances 0.000 claims description 30
- 231100000221 frame shift mutation induction Toxicity 0.000 claims description 29
- 230000037433 frameshift Effects 0.000 claims description 29
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 27
- 102000004082 Calreticulin Human genes 0.000 claims description 26
- 150000001413 amino acids Chemical class 0.000 claims description 25
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 19
- 108020004414 DNA Proteins 0.000 claims description 7
- 238000003364 immunohistochemistry Methods 0.000 claims description 6
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims description 5
- 108020004999 messenger RNA Proteins 0.000 claims description 5
- 208000032027 Essential Thrombocythemia Diseases 0.000 claims description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 4
- 210000001185 bone marrow Anatomy 0.000 claims description 4
- 206010028537 myelofibrosis Diseases 0.000 claims description 4
- 208000003476 primary myelofibrosis Diseases 0.000 claims description 4
- 238000012163 sequencing technique Methods 0.000 claims description 4
- 108091034117 Oligonucleotide Proteins 0.000 claims description 3
- 238000003753 real-time PCR Methods 0.000 claims description 3
- 238000012340 reverse transcriptase PCR Methods 0.000 claims description 3
- 229960005486 vaccine Drugs 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 108091023037 Aptamer Proteins 0.000 claims description 2
- 208000009527 Refractory anemia Diseases 0.000 claims description 2
- 206010072684 Refractory cytopenia with unilineage dysplasia Diseases 0.000 claims description 2
- 208000005485 Thrombocytosis Diseases 0.000 claims description 2
- 230000000692 anti-sense effect Effects 0.000 claims description 2
- 230000027455 binding Effects 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
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- 239000003814 drug Substances 0.000 claims description 2
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- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims description 2
- 238000003018 immunoassay Methods 0.000 claims description 2
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- 229910052742 iron Inorganic materials 0.000 claims description 2
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- 230000009149 molecular binding Effects 0.000 claims description 2
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- 239000003795 chemical substances by application Substances 0.000 claims 6
- 230000002163 immunogen Effects 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 230000009261 transgenic effect Effects 0.000 claims 2
- 108020004491 Antisense DNA Proteins 0.000 claims 1
- 108020005544 Antisense RNA Proteins 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
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- 238000010367 cloning Methods 0.000 claims 1
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- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 description 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- 108091027967 Small hairpin RNA Proteins 0.000 description 1
- 108091060271 Small temporal RNA Proteins 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 108091070501 miRNA Proteins 0.000 description 1
- 239000002679 microRNA Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000005257 nucleotidylation Effects 0.000 description 1
- 239000004055 small Interfering RNA Substances 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13184632 | 2013-09-16 | ||
| EP13184632.1 | 2013-09-16 | ||
| EP13186939.8 | 2013-10-01 | ||
| EP13186939 | 2013-10-01 | ||
| US201361909313P | 2013-11-26 | 2013-11-26 | |
| US61/909,313 | 2013-11-26 | ||
| PCT/EP2014/069638 WO2015036599A1 (en) | 2013-09-16 | 2014-09-15 | Mutant calreticulin for the diagnosis of myeloid malignancies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020022378A Division JP2020109092A (ja) | 2013-09-16 | 2020-02-13 | 骨髄性悪性腫瘍の診断のための突然変異体カルレチクリン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016537012A JP2016537012A (ja) | 2016-12-01 |
| JP2016537012A5 true JP2016537012A5 (enExample) | 2017-11-02 |
| JP6745220B2 JP6745220B2 (ja) | 2020-08-26 |
Family
ID=51795161
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016542333A Active JP6745220B2 (ja) | 2013-09-16 | 2014-09-15 | 骨髄性悪性腫瘍の診断のための突然変異体カルレチクリン |
| JP2022177306A Active JP7646221B2 (ja) | 2013-09-16 | 2022-11-04 | 骨髄性悪性腫瘍の診断のための突然変異体カルレチクリン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022177306A Active JP7646221B2 (ja) | 2013-09-16 | 2022-11-04 | 骨髄性悪性腫瘍の診断のための突然変異体カルレチクリン |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US9371570B2 (enExample) |
| EP (5) | EP4733417A2 (enExample) |
| JP (2) | JP6745220B2 (enExample) |
| KR (1) | KR102433548B1 (enExample) |
| CN (3) | CN113564254A (enExample) |
| AU (2) | AU2014320262B2 (enExample) |
| BR (1) | BR112016005611B1 (enExample) |
| CA (1) | CA2924370C (enExample) |
| DK (3) | DK2808338T3 (enExample) |
| ES (1) | ES2577289T3 (enExample) |
| MX (1) | MX348980B (enExample) |
| PL (2) | PL3494985T3 (enExample) |
| PT (1) | PT2808338E (enExample) |
| RU (1) | RU2668808C2 (enExample) |
| SG (1) | SG11201601193TA (enExample) |
| WO (1) | WO2015036599A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014320262B2 (en) | 2013-09-16 | 2019-06-13 | Cemm - Forschungszentrum Fur Molekulare Medizin Gmbh | Mutant calreticulin for the diagnosis of myeloid malignancies |
| US10550435B2 (en) | 2014-11-12 | 2020-02-04 | Neogenomics Laboratories, Inc. | Determining tumor load and biallelic mutation in patients with CALR mutation using peripheral blood plasma |
| WO2016087514A1 (en) * | 2014-12-02 | 2016-06-09 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Anti-mutant calreticulin antibodies and their use in the diagnosis and therapy of myeloid malignancies |
| WO2016160858A1 (en) * | 2015-03-30 | 2016-10-06 | Loh Jeffrey Thomas | Methods for producing modified red blood cell compositions, compositions and uses thereof |
| BR112017022779B1 (pt) * | 2015-04-23 | 2024-04-30 | Quest Diagnostics Investments Incorporated | Método para detectar uma mutação de deleção in-frame no éxon 9 do gene da calreticulina |
| KR101953092B1 (ko) * | 2015-11-11 | 2019-06-13 | 가톨릭대학교 산학협력단 | Ｂｃｒ／ａｂｌ 음성 골수증식종양 관련 유전자변이 다중검출용 펩티드핵산 프로브, 이를 포함하는 유전자변이 다중검출 조성물, 다중검출 키트 및 유전자변이 다중검출방법 |
| ITUA20162858A1 (it) * | 2016-04-26 | 2017-10-26 | Univ Degli Studi Di Torino | Procedimento per la rivelazione di mutazioni di tipo 1 e 2 del gene calreticulina (calr) e relativo kit |
| EP3468585A2 (en) * | 2016-06-10 | 2019-04-17 | IO Biotech APS | Calr and jak2 vaccine compositions |
| CN106566875A (zh) * | 2016-09-20 | 2017-04-19 | 上海荻硕贝肯医学检验所有限公司 | 用于检测骨髓异常增生综合征mds基因突变的引物、试剂盒及方法 |
| CN107164473B (zh) * | 2017-05-22 | 2020-08-25 | 复旦大学附属华山医院 | 一种检测calr基因1型突变的引物组合物及试剂盒 |
| CN107164474B (zh) * | 2017-05-22 | 2020-09-04 | 复旦大学附属华山医院 | 一种检测calr基因2型突变的引物组合物及试剂盒 |
| CN108949971A (zh) * | 2017-05-23 | 2018-12-07 | 曹国君 | 钙网蛋白基因1型突变检测用封闭pna探针 |
| CN107462706A (zh) * | 2017-08-01 | 2017-12-12 | 广西中医药大学附属瑞康医院（广西中西医结合医院） | 一种肿瘤试剂盒 |
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| CN108434439B (zh) * | 2018-01-23 | 2020-02-07 | 中国人民解放军总医院 | 钙网蛋白的医药用途 |
| US11414698B2 (en) * | 2018-03-22 | 2022-08-16 | Chang Gung Medical Foundation Chang Gung Memorial Hospital At Chiayi | Method of quantifying mutant allele burden of target gene |
| WO2020010250A2 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| RU2679653C1 (ru) * | 2018-08-01 | 2019-02-12 | Общество с ограниченной ответственностью "Формула гена" | Набор реактивов для выявления Ph-негативных миелопролиферативных новообразований и способ диагностики на его основе |
| EP3870572B1 (en) | 2018-10-23 | 2026-05-06 | Myelopro Diagnostics and Research GmbH | Compounds targeting mutant calreticulin |
| JP7706373B2 (ja) * | 2019-02-21 | 2025-07-11 | マレンゴ・セラピューティクス，インコーポレーテッド | カルレティキュリンに結合する多機能性分子およびその使用 |
| AU2020226893B2 (en) | 2019-02-21 | 2025-02-27 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to T cell related cancer cells and uses thereof |
| GB2597851B (en) | 2019-02-21 | 2024-05-29 | Marengo Therapeutics Inc | Antibody molecules that bind to NKP30 and uses thereof |
| CN113508140B (zh) * | 2019-02-28 | 2024-11-19 | 学校法人顺天堂 | 与切断型的突变型Calreticulin结合的抗体以及骨髄增殖性肿瘤的诊断、预防或治疗药 |
| US20220282314A1 (en) * | 2019-08-30 | 2022-09-08 | Toyo Kohan Co., Ltd. | Kit for evaluating a gene mutation related to myeloproliferative neoplasms |
| IL270306A (en) | 2019-10-30 | 2021-05-31 | Yeda Res & Dev | Prevention and treatment of pre-myeloid and myeloid malignancies |
| CN112795647B (zh) * | 2019-11-14 | 2022-08-16 | 北京肿瘤医院(北京大学肿瘤医院) | 一种肿瘤标志物及其应用 |
| CN114980920A (zh) | 2019-11-18 | 2022-08-30 | 詹森生物科技公司 | 基于突变体calr和jak2的疫苗及其用途 |
| AU2020416273A1 (en) | 2020-01-03 | 2022-07-28 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
| US20230139506A1 (en) * | 2020-03-17 | 2023-05-04 | Memorial Sloan Kettering Cancer Center | Heteroclitic cancer vaccines |
| US20240092890A1 (en) * | 2020-08-27 | 2024-03-21 | Juntendo Educational Foundation | Anti-cleaved mutant calr-cd3 bispecific antibody and pharmaceutical composition |
| US20250161441A1 (en) | 2022-02-25 | 2025-05-22 | Juntendo Educational Foundation | Medicine comprising combination of anti-mutant-calr antibody and another drug |
| EP4539875A2 (en) * | 2022-06-17 | 2025-04-23 | Icahn School of Medicine at Mount Sinai | Mutant calr-peptide based vaccine |
| CN117003866B (zh) * | 2023-08-23 | 2025-06-06 | 复旦大学附属华山医院 | 一种抗calr突变蛋白抗体、制备方法及检测试剂盒 |
| WO2025207632A1 (en) * | 2024-03-26 | 2025-10-02 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for the treatment of myeloproliferative neoplasms |
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| US20140271683A1 (en) * | 2010-12-21 | 2014-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Therapeutic and Diagnostic Methods for Manipulating Phagocytosis Through Calreticulin and Low Density Lipoprotein-Related Receptor |
| CN103091499B (zh) * | 2013-01-23 | 2015-07-08 | 三峡大学 | 一种肿瘤标志物钙网蛋白检测试剂盒的制备及应用 |
| AU2014320262B2 (en) | 2013-09-16 | 2019-06-13 | Cemm - Forschungszentrum Fur Molekulare Medizin Gmbh | Mutant calreticulin for the diagnosis of myeloid malignancies |
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