JP2016536012A5 - - Google Patents
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- JP2016536012A5 JP2016536012A5 JP2016549206A JP2016549206A JP2016536012A5 JP 2016536012 A5 JP2016536012 A5 JP 2016536012A5 JP 2016549206 A JP2016549206 A JP 2016549206A JP 2016549206 A JP2016549206 A JP 2016549206A JP 2016536012 A5 JP2016536012 A5 JP 2016536012A5
- Authority
- JP
- Japan
- Prior art keywords
- pkal
- inhibitor
- assay
- subject
- plasma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 20
- 239000003112 inhibitor Substances 0.000 claims 13
- 102000002261 High-Molecular-Weight Kininogen Human genes 0.000 claims 11
- 108010000487 High-Molecular-Weight Kininogen Proteins 0.000 claims 11
- 238000003556 assay Methods 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 239000012190 activator Substances 0.000 claims 5
- 239000000758 substrate Substances 0.000 claims 5
- 102000003827 Plasma Kallikrein Human genes 0.000 claims 4
- 108090000113 Plasma Kallikrein Proteins 0.000 claims 4
- 238000003776 cleavage reaction Methods 0.000 claims 3
- 230000007017 scission Effects 0.000 claims 3
- 238000001262 western blot Methods 0.000 claims 3
- 238000001994 activation Methods 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 108010071241 Factor XIIa Proteins 0.000 claims 1
- 238000010228 ex vivo assay Methods 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000000678 plasma activation Methods 0.000 claims 1
- 238000002203 pretreatment Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361893505P | 2013-10-21 | 2013-10-21 | |
| US61/893,505 | 2013-10-21 | ||
| US201461939837P | 2014-02-14 | 2014-02-14 | |
| US61/939,837 | 2014-02-14 | ||
| PCT/US2014/061247 WO2015061183A1 (en) | 2013-10-21 | 2014-10-17 | Assays for determining plasma kallikrein system biomarkers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020144118A Division JP7135039B2 (ja) | 2013-10-21 | 2020-08-28 | 血漿カリクレイン系バイオマーカーを決定するためのアッセイ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016536012A JP2016536012A (ja) | 2016-11-24 |
| JP2016536012A5 true JP2016536012A5 (cg-RX-API-DMAC7.html) | 2017-11-24 |
| JP6757252B2 JP6757252B2 (ja) | 2020-09-16 |
Family
ID=52993413
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549206A Active JP6757252B2 (ja) | 2013-10-21 | 2014-10-17 | 血漿カリクレイン系バイオマーカーを決定するためのアッセイ |
| JP2020144118A Active JP7135039B2 (ja) | 2013-10-21 | 2020-08-28 | 血漿カリクレイン系バイオマーカーを決定するためのアッセイ |
| JP2022137393A Active JP7668772B2 (ja) | 2013-10-21 | 2022-08-31 | 血漿カリクレイン系バイオマーカーを決定するためのアッセイ |
| JP2024117419A Pending JP2024150637A (ja) | 2013-10-21 | 2024-07-23 | 血漿カリクレイン系バイオマーカーを決定するためのアッセイ |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020144118A Active JP7135039B2 (ja) | 2013-10-21 | 2020-08-28 | 血漿カリクレイン系バイオマーカーを決定するためのアッセイ |
| JP2022137393A Active JP7668772B2 (ja) | 2013-10-21 | 2022-08-31 | 血漿カリクレイン系バイオマーカーを決定するためのアッセイ |
| JP2024117419A Pending JP2024150637A (ja) | 2013-10-21 | 2024-07-23 | 血漿カリクレイン系バイオマーカーを決定するためのアッセイ |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11372002B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3808857B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP6757252B2 (cg-RX-API-DMAC7.html) |
| KR (4) | KR102521947B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN105873951A (cg-RX-API-DMAC7.html) |
| AU (3) | AU2014340450B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112016008970B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2927824C (cg-RX-API-DMAC7.html) |
| DK (1) | DK3060582T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2837858T3 (cg-RX-API-DMAC7.html) |
| IL (3) | IL289514B2 (cg-RX-API-DMAC7.html) |
| PL (1) | PL3060582T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015061183A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3459564T1 (sl) | 2010-01-06 | 2022-06-30 | Takeda Pharmaceutical Company Limited | Proteini, ki vežejo plazemski kalikrein |
| JP2014506257A (ja) * | 2011-01-06 | 2014-03-13 | ダイアックス コーポレーション | 血漿カリクレイン結合タンパク質 |
| EP3456744B1 (en) * | 2013-01-20 | 2023-03-29 | Takeda Pharmaceutical Company Limited | Evaluation and treatment of bradykinin-mediated disorders |
| AU2014340450B2 (en) | 2013-10-21 | 2020-05-21 | Takeda Pharmaceutical Company Limited | Assays for determining plasma kallikrein system biomarkers |
| US10101344B2 (en) | 2013-10-21 | 2018-10-16 | Dyax Corp. | Diagnosis and treatment of autoimmune diseases |
| EA038532B1 (ru) | 2014-01-21 | 2021-09-10 | Такеда Фармасьютикал Компани Лимитед | Способ лечения наследственного ангионевротического отека (hae) |
| IL295414B1 (en) | 2014-03-27 | 2025-10-01 | Takeda Pharmaceuticals Co | Compositions and methods for treating macular edema due to diabetes |
| EP3286226A4 (en) * | 2015-03-30 | 2018-12-05 | Dyax Corp. | Plasma kallikrein inhibitors and uses thereof for preventing hereditary angioedema attack |
| EP3334343B1 (en) * | 2015-08-13 | 2022-10-19 | Takeda Pharmaceutical Company Limited | Evacuated blood collection tubes containing protease inhibitors for the assessment of contact system activation |
| PL3365685T3 (pl) * | 2015-10-19 | 2021-08-02 | Dyax Corp. | Test immunologiczny do wykrywania rozszczepionego wielkocząsteczkowego kininogenu |
| AU2016372159B2 (en) | 2015-12-15 | 2022-03-24 | Takeda Pharmaceutical Company Limited | Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK |
| IL265195B2 (en) * | 2016-09-16 | 2025-02-01 | Dyax Corp | Protein biomarkers for diseases related to the activation system |
| IL315175A (en) * | 2016-09-16 | 2024-10-01 | Takeda Pharmaceuticals Co | RNA biomarkers for hereditary angioedema |
| BR112019005167A2 (pt) * | 2016-09-16 | 2019-07-02 | Dyax Corp. | método e kit para analisar uma amostra |
| EP3521828A1 (en) * | 2018-01-31 | 2019-08-07 | Centogene AG | Method for the diagnosis of hereditary angioedema |
| WO2019165308A1 (en) * | 2018-02-22 | 2019-08-29 | The Regents Of The University Of California | Threshold-stimulated plasma kallikrein activity as a biomarker for diagnosis of bradykinin-mediated angioedema |
| CN111057745B (zh) * | 2019-12-30 | 2022-08-12 | 中国科学院生态环境研究中心 | 一种物质的血液毒性效应的高通量筛选方法 |
| CN113777331A (zh) * | 2020-06-09 | 2021-12-10 | 张曼 | 尿液激肽原-1及其多肽片段在烧伤中的应用 |
| CN114166924B (zh) * | 2021-12-03 | 2024-11-22 | 中国医学科学院北京协和医院 | 尿液蛋白标志物在诊断遗传性血管水肿中的用途 |
| JP2025522757A (ja) * | 2022-06-30 | 2025-07-17 | 武田薬品工業株式会社 | ラナデルマブ治療のためのタンパク質バイオマーカー |
| WO2025153806A1 (en) * | 2024-01-15 | 2025-07-24 | Kalvista Pharmaceuticals Limited | Methods for determining amidolytic activity |
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| CA1312564C (en) * | 1985-07-12 | 1993-01-12 | Robert W. Colman | Monoclonal antibodies to human plasma prekallikrein and methods of preparing and using same |
| US5047323A (en) | 1986-01-22 | 1991-09-10 | Temple University Of The Commonwealth System Of Higher Education | Method for detecting human kininogen using monoclonal antibodies thereto |
| US4908431A (en) | 1986-01-22 | 1990-03-13 | Temple University-Of The Commonwealth System Of Higher Education | Monoclonal antibodies to human kininogen and methods of preparing same |
| US4881175A (en) | 1986-09-02 | 1989-11-14 | Genex Corporation | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| KR960009766B1 (ko) | 1986-09-10 | 1996-07-24 | 니혼 소오끼 세이야꾸 가부시기가이샤 | 생리 활성물질 측정법 |
| US4882272A (en) | 1986-10-01 | 1989-11-21 | Temple University - Of The Commonwealth System Of Higher Education | High molecular weight kininogen assay |
| US5025796A (en) | 1988-12-01 | 1991-06-25 | The United States Of America As Represented By The Department Of Health And Human Services | Apparatus and methods for determining in vivo response to thermal stimulation in in an unrestrained subject |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| US5472945A (en) | 1991-08-13 | 1995-12-05 | Temple University- Of The Commonwealth System Of Higher Education | Modulation of blood pressure and inhibition of platelet activation with kininogen fragment |
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| ES2227545T3 (es) | 1994-01-11 | 2005-04-01 | Dyax Corporation | Proteinas y sus analogos del "dominio de kunitz" inhibidores de calicreina. |
| JPH1084995A (ja) | 1996-09-12 | 1998-04-07 | Nippon Zoki Pharmaceut Co Ltd | 血液凝固第ｘｉｉ因子活性化法 |
| US5789261A (en) | 1996-10-30 | 1998-08-04 | Temple University Of The Commonwealth System Of Higher Education | Solid phase immunoassay |
| US6242210B1 (en) | 1997-05-20 | 2001-06-05 | Actinova Limited | Treatment of bacterial infections |
| JP4346798B2 (ja) | 1999-08-19 | 2009-10-21 | 協和メデックス株式会社 | Ｈｃｖコア抗原の検出または定量方法およびそれに用いる検出または定量試薬。 |
| US6994852B1 (en) | 1999-11-12 | 2006-02-07 | Temple University-Of The Commonwealth System Of Higher Education | Inhibition of angiogenesis by antibodies against high molecular weight kininogen domain 5 |
| US7067713B2 (en) * | 2000-01-31 | 2006-06-27 | Pharming Intellectual Property B.V. | C1 Inhibitor produced in the milk of transgenic non-human mammals |
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| WO2009051259A1 (ja) | 2007-10-18 | 2009-04-23 | Miyazaki Prefectural Industrial Support Foundation | 肝疾患診断用バイオマーカー |
| US20110154517A1 (en) * | 2007-10-22 | 2011-06-23 | Georg Dewald | Disorders of vasoregulation and methods of diagnosing them |
| KR20110057086A (ko) | 2008-07-07 | 2011-05-31 | 니폰 조키 세야쿠 가부시키가이샤 | 섬유근 통증의 검사법 |
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| KR101077275B1 (ko) | 2009-05-07 | 2011-10-27 | 한국기초과학지원연구원 | 당단백질의 당쇄화를 이용한 암 진단 방법 |
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
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| SI3459564T1 (sl) | 2010-01-06 | 2022-06-30 | Takeda Pharmaceutical Company Limited | Proteini, ki vežejo plazemski kalikrein |
| WO2012009447A2 (en) | 2010-07-13 | 2012-01-19 | University Of Rochester | THE cAMP/PKA/HDAC5 PATHWAY AND USES THEREOF |
| EP2645932B1 (en) | 2010-12-02 | 2016-03-02 | Becton, Dickinson and Company | Blood collection devices containing blood stabilization agent |
| JP2014506257A (ja) * | 2011-01-06 | 2014-03-13 | ダイアックス コーポレーション | 血漿カリクレイン結合タンパク質 |
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| EP3456744B1 (en) | 2013-01-20 | 2023-03-29 | Takeda Pharmaceutical Company Limited | Evaluation and treatment of bradykinin-mediated disorders |
| KR20150141940A (ko) | 2013-02-01 | 2015-12-21 | 벡톤 디킨슨 앤드 컴퍼니 | 접촉 경로를 저해하는 첨가제를 함유한 채혈 기구 |
| AU2014340450B2 (en) | 2013-10-21 | 2020-05-21 | Takeda Pharmaceutical Company Limited | Assays for determining plasma kallikrein system biomarkers |
| US10101344B2 (en) | 2013-10-21 | 2018-10-16 | Dyax Corp. | Diagnosis and treatment of autoimmune diseases |
| EA038532B1 (ru) | 2014-01-21 | 2021-09-10 | Такеда Фармасьютикал Компани Лимитед | Способ лечения наследственного ангионевротического отека (hae) |
| PL3365685T3 (pl) | 2015-10-19 | 2021-08-02 | Dyax Corp. | Test immunologiczny do wykrywania rozszczepionego wielkocząsteczkowego kininogenu |
| AU2016372159B2 (en) | 2015-12-15 | 2022-03-24 | Takeda Pharmaceutical Company Limited | Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK |
| WO2021154992A1 (en) | 2020-01-28 | 2021-08-05 | Orgenesis Inc. | Process and system for acellular therapy |
-
2014
- 2014-10-17 AU AU2014340450A patent/AU2014340450B2/en active Active
- 2014-10-17 KR KR1020227027698A patent/KR102521947B1/ko active Active
- 2014-10-17 EP EP20197583.6A patent/EP3808857B1/en active Active
- 2014-10-17 EP EP14856778.7A patent/EP3060582B1/en active Active
- 2014-10-17 KR KR1020257014548A patent/KR20250066486A/ko active Pending
- 2014-10-17 ES ES14856778T patent/ES2837858T3/es active Active
- 2014-10-17 CA CA2927824A patent/CA2927824C/en active Active
- 2014-10-17 KR KR1020237012295A patent/KR20230054745A/ko not_active Ceased
- 2014-10-17 PL PL14856778T patent/PL3060582T3/pl unknown
- 2014-10-17 IL IL289514A patent/IL289514B2/en unknown
- 2014-10-17 JP JP2016549206A patent/JP6757252B2/ja active Active
- 2014-10-17 US US15/030,811 patent/US11372002B2/en active Active
- 2014-10-17 CN CN201480070281.6A patent/CN105873951A/zh active Pending
- 2014-10-17 BR BR112016008970-7A patent/BR112016008970B1/pt active IP Right Grant
- 2014-10-17 KR KR1020167013432A patent/KR102432826B1/ko active Active
- 2014-10-17 DK DK14856778.7T patent/DK3060582T3/da active
- 2014-10-17 WO PCT/US2014/061247 patent/WO2015061183A1/en not_active Ceased
-
2016
- 2016-04-19 IL IL245205A patent/IL245205B/en active IP Right Grant
-
2020
- 2020-04-19 IL IL274055A patent/IL274055B/en unknown
- 2020-08-10 AU AU2020217316A patent/AU2020217316B2/en active Active
- 2020-08-28 JP JP2020144118A patent/JP7135039B2/ja active Active
-
2021
- 2021-12-20 US US17/555,636 patent/US12442824B2/en active Active
-
2022
- 2022-08-31 JP JP2022137393A patent/JP7668772B2/ja active Active
-
2024
- 2024-05-21 AU AU2024203355A patent/AU2024203355A1/en active Pending
- 2024-07-23 JP JP2024117419A patent/JP2024150637A/ja active Pending
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