WO2009051259A1 - 肝疾患診断用バイオマーカー - Google Patents

肝疾患診断用バイオマーカー Download PDF

Info

Publication number
WO2009051259A1
WO2009051259A1 PCT/JP2008/068985 JP2008068985W WO2009051259A1 WO 2009051259 A1 WO2009051259 A1 WO 2009051259A1 JP 2008068985 W JP2008068985 W JP 2008068985W WO 2009051259 A1 WO2009051259 A1 WO 2009051259A1
Authority
WO
WIPO (PCT)
Prior art keywords
liver disease
sequence
marker
diagnosis
alcoholic fatty
Prior art date
Application number
PCT/JP2008/068985
Other languages
English (en)
French (fr)
Inventor
Hirohito Tsubouchi
Hirofumi Uto
Takeshi Okanoue
Yo-Ichi Ishida
Yuko Sato
Masayuki Sudo
Original Assignee
Miyazaki Prefectural Industrial Support Foundation
Kagoshima University
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miyazaki Prefectural Industrial Support Foundation, Kagoshima University, Chugai Seiyaku Kabushiki Kaisha filed Critical Miyazaki Prefectural Industrial Support Foundation
Priority to US12/738,684 priority Critical patent/US8263347B2/en
Priority to JP2009538198A priority patent/JP5424331B2/ja
Priority to EP08840152A priority patent/EP2216651A4/en
Publication of WO2009051259A1 publication Critical patent/WO2009051259A1/ja

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

　簡便に判定可能な肝疾患診断用マーカー、その抗体、診断薬、診断方法、及び血液または血清の検出方法を提供する。 　プロテオーム解析により、健常者の血清に比べ非アルコール性脂肪肝患者の血清に有意に差があると認められるキニノーゲン全長及び3つの部分ペプチド（配列Ａ；440～456番目、配列Ｂ；439～456番目、配列Ｃ；438～456番目）を見出し、非アルコール性脂肪肝の診断薬や検診に簡便に利用できる検出方法を確立した。キニノーゲン系マーカーとC4系のマーカー（全長、部分ペプチド）を併用することにより、非アルコール性脂肪肝疾患に加えて、更に慢性肝炎及び無症候性ウイルスキャリアを識別することが出来る。
PCT/JP2008/068985 2007-10-18 2008-10-20 肝疾患診断用バイオマーカー WO2009051259A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/738,684 US8263347B2 (en) 2007-10-18 2008-10-20 Biomarker for diagnosis of liver disease
JP2009538198A JP5424331B2 (ja) 2007-10-18 2008-10-20 肝疾患診断用バイオマーカー
EP08840152A EP2216651A4 (en) 2007-10-18 2008-10-20 BIOMARKER FOR THE DIAGNOSIS OF A HEPATIC DISEASE

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-270799 2007-10-18
JP2007270799 2007-10-18
JP2008145337 2008-06-03
JP2008-145337 2008-06-03

Publications (1)

Publication Number Publication Date
WO2009051259A1 true WO2009051259A1 (ja) 2009-04-23

Family

ID=40567518

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/068985 WO2009051259A1 (ja) 2007-10-18 2008-10-20 肝疾患診断用バイオマーカー

Country Status (4)

Country Link
US (1) US8263347B2 (ja)
EP (1) EP2216651A4 (ja)
JP (1) JP5424331B2 (ja)
WO (1) WO2009051259A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010071789A (ja) * 2008-09-18 2010-04-02 Chiba Univ 多発性硬化症またはｎｍｏの検査マーカーの測定方法
WO2012061466A2 (en) * 2010-11-02 2012-05-10 The General Hospital Corporation Methods for treating steatotic disease
WO2014046045A1 (ja) * 2012-09-18 2014-03-27 国立大学法人鹿児島大学 血中hcv検出方法及び抗hcv治療の効果判定方法
US10118955B2 (en) 2008-11-07 2018-11-06 The General Hospital Corporation C-terminal fragments of glucagon-like peptide-1 (GLP-1)
US10137171B2 (en) 2011-07-06 2018-11-27 The General Hospital Corporation Methods of treatment using a pentapeptide derived from the C-Terminus of Glucagon-Like Peptide 1 (GLP-1)
JP2019505185A (ja) * 2015-12-15 2019-02-28 ダイアックス コーポレーション 完全長の高分子量キニノーゲン（ｈｍｗｋ）と切断されたｈｍｗｋとを区別するためのペプチド定量アッセイ

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102062780A (zh) * 2010-11-23 2011-05-18 北京正旦国际科技有限责任公司 一种多肽免疫试剂盒及其检测方法
CN102539767B (zh) * 2011-09-29 2014-03-12 北京正旦国际科技有限责任公司 检测多肽标志物抗原的elisa试剂盒
CN102507939B (zh) * 2011-10-21 2014-03-12 北京正旦国际科技有限责任公司 一种肝硬化elisa检测试剂盒
CN102507941B (zh) * 2011-10-25 2014-04-30 北京正旦国际科技有限责任公司 一种肝硬化免疫质谱检测试剂盒
CN102507936B (zh) * 2011-11-09 2013-10-23 北京正旦国际科技有限责任公司 一种肝癌标志物多抗免疫质谱试剂盒
CN102520175B (zh) * 2011-11-14 2014-04-16 北京正旦国际科技有限责任公司 一种肝癌多肽标志物抗原竞争性酶联免疫检测试剂盒
CA2897336C (en) * 2013-01-20 2023-10-17 Dyax Corp. Evaluation and treatment of pkal-mediated disorders
WO2015106129A1 (en) * 2014-01-10 2015-07-16 Beth Israel Deaconess Medical Center, Inc. Diagnosis of chronic liver diseases
CN104316695B (zh) * 2014-08-22 2016-08-24 北京蛋白质组研究中心 用于检测肝癌与肝硬化相关多肽-蛋白组合式标志物的双抗体夹心试剂盒
US10295550B2 (en) 2014-11-17 2019-05-21 The Rockefeller University Compositions and methods for use in diagnosis of alzheimer's disease
GB201614455D0 (en) * 2016-08-24 2016-10-05 Univ Oxford Innovation Ltd Biomarkers

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04110660A (ja) 1990-08-30 1992-04-13 Green Cross Corp:The 肝疾患診断用試薬
JP2006300689A (ja) 2005-04-20 2006-11-02 Mcbi:Kk 肝疾患病態判定用マーカー及び該マーカーを用いる肝疾患病態判定方法
JP2006308533A (ja) 2005-05-02 2006-11-09 Mcbi:Kk 新規肝がんバイオマーカーおよび該バイオマーカーを用いた肝がんの検出方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10082512B2 (en) 2005-05-05 2018-09-25 Drexel University Diagnosis of liver pathology through assessment of protein glycosylation
WO2007022248A2 (en) 2005-08-16 2007-02-22 Sloan Kettering Institute For Cancer Research Methods of detection of cancer using peptide profiles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04110660A (ja) 1990-08-30 1992-04-13 Green Cross Corp:The 肝疾患診断用試薬
JP2006300689A (ja) 2005-04-20 2006-11-02 Mcbi:Kk 肝疾患病態判定用マーカー及び該マーカーを用いる肝疾患病態判定方法
JP2006308533A (ja) 2005-05-02 2006-11-09 Mcbi:Kk 新規肝がんバイオマーカーおよび該バイオマーカーを用いた肝がんの検出方法

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BOUHNIK J. ET AL.: "Biochemical and physiological studies on two T-kininogen species using monoclonal antibodies.", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1122, no. 1, 13 July 1992 (1992-07-13), pages 70 - 76, XP027464027 *
C CORDOVA ET AL.: "Hageman factor, high molecular weight kininogen, and prekallikrein in chronic liver disease", J CLIN PATHOL, vol. 39, 1986, pages 1003 - 1005
DUMESTRE-PERARD ET AL., CLIN EXP IMMUNOL, vol. 127, 2002, pages 131 - 136
FUJII M.: "Kakushu Kan Shikkan ni Okeru Kessho Kallikrein-kinin-kei no Hendo to sono Rinshoteki Igi -Tokuni Alcohol-sei Kan Shogai o Chushin to shite", JAPANESE JOURNAL OF GASTROENTEROLOGICAL SURGERY, vol. 82, no. 3, 5 March 1985 (1985-03-05), pages 450 - 458, XP008134338 *
IKEDA Y. ET AL.: "Chumoku sareru Jin Kanren Tanpaku-45 C4", KIDNEY AND DIALYSIS, vol. 61, no. 6, 25 December 2006 (2006-12-25), pages 750 - 752, XP008141113 *
MAEJIMA Y. ET AL.: "Kan Shikkan Kanja ni Okeru Kessei Hotaika Oyobi C3, C4 Tanpaku Ryo ni tsuite no Kento", JOURNAL OF TOKYO WOMEN'S MEDICAL UNIVERSITY, vol. 51, no. 4, 1981, pages 441 - 446, XP008141114 *
ROBERT W. COLMAN ET AL.: "Contact System: A Vascular Biology Modulator With Anticoagulant, Profibrinolytic, Antiadhesive, and Proinflammatory Attributes", BLOOD, vol. 90, no. 10, 1997, pages 3819 - 3833
SATO Y. ET AL.: "'Kessei Proteome Kaiseki de Dotei shita Kininogen Danpen wa Hi-Alcohol-sei Shibokan Shikkan de Zoka suru', Dai 44 Kai", THE JAPAN SOCIETY OF HEPATOLOGY SOKAI KOEN YOSHI, vol. 49, no. SUPPLE, 30 April 2008 (2008-04-30), pages A163, XP008141116 *
See also references of EP2216651A4

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010071789A (ja) * 2008-09-18 2010-04-02 Chiba Univ 多発性硬化症またはｎｍｏの検査マーカーの測定方法
US10118955B2 (en) 2008-11-07 2018-11-06 The General Hospital Corporation C-terminal fragments of glucagon-like peptide-1 (GLP-1)
WO2012061466A2 (en) * 2010-11-02 2012-05-10 The General Hospital Corporation Methods for treating steatotic disease
WO2012061466A3 (en) * 2010-11-02 2012-07-19 The General Hospital Corporation Methods for treating steatotic disease
US9040481B2 (en) 2010-11-02 2015-05-26 The General Hospital Corporation Methods for treating steatotic disease
US10137171B2 (en) 2011-07-06 2018-11-27 The General Hospital Corporation Methods of treatment using a pentapeptide derived from the C-Terminus of Glucagon-Like Peptide 1 (GLP-1)
WO2014046045A1 (ja) * 2012-09-18 2014-03-27 国立大学法人鹿児島大学 血中hcv検出方法及び抗hcv治療の効果判定方法
JP2014059219A (ja) * 2012-09-18 2014-04-03 Kagoshima Univ 血中ｈｃｖ検出方法及び抗ｈｃｖ治療の効果判定方法
JP2019505185A (ja) * 2015-12-15 2019-02-28 ダイアックス コーポレーション 完全長の高分子量キニノーゲン（ｈｍｗｋ）と切断されたｈｍｗｋとを区別するためのペプチド定量アッセイ
JP7092669B2 (ja) 2015-12-15 2022-06-28 武田薬品工業株式会社 完全長の高分子量キニノーゲン（ｈｍｗｋ）と切断されたｈｍｗｋとを区別するためのペプチド定量アッセイ
US11668718B2 (en) 2015-12-15 2023-06-06 Takeda Pharmaceutical Company Limited Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK
JP7425117B2 (ja) 2015-12-15 2024-01-30 武田薬品工業株式会社 完全長の高分子量キニノーゲン（ｈｍｗｋ）と切断されたｈｍｗｋとを区別するためのペプチド定量アッセイ

Also Published As

Publication number Publication date
US20110129859A1 (en) 2011-06-02
JP5424331B2 (ja) 2014-02-26
EP2216651A4 (en) 2010-12-01
US8263347B2 (en) 2012-09-11
JPWO2009051259A1 (ja) 2011-03-03
EP2216651A1 (en) 2010-08-11

Similar Documents

Publication Publication Date Title
WO2009051259A1 (ja) 肝疾患診断用バイオマーカー
WO2010027903A8 (en) Lung cancer diagnosis
TW200740840A (en) Diagnostic test kits
WO2002035232A3 (en) Method for detecting ovarian cancer based on human kallikrein 6 (hk6)
WO2007117444A3 (en) Protein detection by aptamers
WO2006127861A3 (en) Diagnosis of diseases and conditions by analysis of histopathologically processed biological samples using liquid tissue preparations
WO2005121788A3 (en) Method for the early detection of renal disease and injury
WO2010011357A3 (en) Detection of prostate cancer using psa glycosylation patterns
WO2011015602A3 (en) Lung cancer biomarkers
GB0718967D0 (en) Peptide imaging agents
WO2003070894A3 (en) A non-invasive diagnostic test utilizing histone modification markers
WO2012012802A3 (en) Neoepitope detection of disease using protein arrays
WO2007079284A3 (en) Lung cancer diagnostic assay
CA2808611A1 (en) Detecting circulating cartilage oligomeric matrix protein in liver cirrhosis
WO2010132447A3 (en) Methods for detecting pre-diabetes and diabetes using differential protein glycosylation
WO2012103324A3 (en) Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto
Imai et al. Diagnostic usefulness of APRI and FIB-4 for the prediction of liver fibrosis after liver transplantation in patients infected with hepatitis C virus
PL376121A1 (pl) Zestaw diagnostyczny do badania surowic zwierząt na obecność przeciwciał RHD oraz zestaw diagnostyczny do wykrywania wirusa RHD
CN101539574B (zh) Survivin抗体的应用及以其制备的食管癌免疫层析检测试纸条
WO2008067806A3 (de) Diagnose und risikostratifizierung von herzinsuffizienz mittels neurophysin
WO2009014342A3 (en) Markers and kit for diagnosis of alzheimer's disease
WO2009132655A3 (en) Design and use of sortilin specific molecular imaging ligands
WO2009016734A1 (ja) 軽度認知機能障害の検定方法
JP2006300689A (ja) 肝疾患病態判定用マーカー及び該マーカーを用いる肝疾患病態判定方法
ATE509270T1 (de) Aus blutplättchen gewonnene mikropartikel als neue diagnosemarker für eine herz-kreislauf- erkrankung

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08840152

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009538198

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008840152

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 12738684

Country of ref document: US