JP2016536005A5 - - Google Patents
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- JP2016536005A5 JP2016536005A5 JP2016543983A JP2016543983A JP2016536005A5 JP 2016536005 A5 JP2016536005 A5 JP 2016536005A5 JP 2016543983 A JP2016543983 A JP 2016543983A JP 2016543983 A JP2016543983 A JP 2016543983A JP 2016536005 A5 JP2016536005 A5 JP 2016536005A5
- Authority
- JP
- Japan
- Prior art keywords
- cell population
- test cell
- mitochondrial
- contacting
- outer membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 27
- 230000002438 mitochondrial effect Effects 0.000 claims description 15
- 230000008823 permeabilization Effects 0.000 claims description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 11
- 101150082208 DIABLO gene Proteins 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 230000035945 sensitivity Effects 0.000 claims description 3
- RZCJYMOBWVJQGV-UHFFFAOYSA-N 2-naphthyloxyacetic acid Chemical compound C1=CC=CC2=CC(OCC(=O)O)=CC=C21 RZCJYMOBWVJQGV-UHFFFAOYSA-N 0.000 claims description 2
- 102000018832 Cytochromes Human genes 0.000 claims description 2
- 108010052832 Cytochromes Proteins 0.000 claims description 2
- 102100033189 Diablo IAP-binding mitochondrial protein Human genes 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 230000003834 intracellular effect Effects 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims description 2
- FNEZBBILNYNQGC-UHFFFAOYSA-N methyl 2-(3,6-diamino-9h-xanthen-9-yl)benzoate Chemical compound COC(=O)C1=CC=CC=C1C1C2=CC=C(N)C=C2OC2=CC(N)=CC=C21 FNEZBBILNYNQGC-UHFFFAOYSA-N 0.000 claims description 2
- 231100001143 noxa Toxicity 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 238000010212 intracellular staining Methods 0.000 claims 1
- 238000012758 nuclear staining Methods 0.000 claims 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 14
- 238000004020 luminiscence type Methods 0.000 description 1
- 210000001700 mitochondrial membrane Anatomy 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361879869P | 2013-09-19 | 2013-09-19 | |
| US61/879,869 | 2013-09-19 | ||
| PCT/US2014/056284 WO2015042249A1 (en) | 2013-09-19 | 2014-09-18 | Methods of bh3 profiling |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019188457A Division JP2020012850A (ja) | 2013-09-19 | 2019-10-15 | Ｂｈ３プロファイリングの方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016536005A JP2016536005A (ja) | 2016-11-24 |
| JP2016536005A5 true JP2016536005A5 (cg-RX-API-DMAC7.html) | 2017-11-02 |
| JP6663852B2 JP6663852B2 (ja) | 2020-03-13 |
Family
ID=52689380
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016543983A Active JP6663852B2 (ja) | 2013-09-19 | 2014-09-18 | Ｂｈ３プロファイリングの方法 |
| JP2019188457A Withdrawn JP2020012850A (ja) | 2013-09-19 | 2019-10-15 | Ｂｈ３プロファイリングの方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019188457A Withdrawn JP2020012850A (ja) | 2013-09-19 | 2019-10-15 | Ｂｈ３プロファイリングの方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10739333B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3047276B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6663852B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014323526B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2922503C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015042249A1 (cg-RX-API-DMAC7.html) |
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| CN103180318B (zh) | 2010-05-14 | 2017-05-10 | 达那-法伯癌症研究所 | 雄性避孕组合物以及使用方法 |
| MX384074B (es) | 2010-05-14 | 2025-03-12 | Dana Farber Cancer Inst Inc | Composiciones y métodos para tratar neoplasias, enfermedades inflamatorias y otros trastornos. |
| CA2885230C (en) | 2012-09-19 | 2021-08-03 | Anthony Letai | Dynamic bh3 profiling |
| CA2918910A1 (en) | 2013-07-25 | 2015-01-29 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
| EP3047276B1 (en) | 2013-09-19 | 2023-06-14 | Dana-Farber Cancer Institute, Inc. | Methods of bh3 profiling |
| US11446309B2 (en) | 2013-11-08 | 2022-09-20 | Dana-Farber Cancer Institute, Inc. | Combination therapy for cancer using bromodomain and extra-terminal (BET) protein inhibitors |
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| MX376748B (es) | 2014-10-27 | 2025-03-07 | Tensha Therapeutics Inc | Inhibidores del bromodominio. |
| WO2016115105A1 (en) | 2015-01-12 | 2016-07-21 | Eutropics Pharmaceuticals, Inc. | Context dependent diagnostics test for guiding cancer treatment |
| BR112017022666A8 (pt) | 2015-04-20 | 2022-10-18 | Tolero Pharmaceuticals Inc | Preparando resposta à alvocidib por perfilamento mitocondrial |
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| TR201911032T4 (tr) | 2015-05-18 | 2019-08-21 | Tolero Pharmaceuticals Inc | Artırılmış biyoyararlanıma sahip alvocıdıb ön ilaçları. |
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| JP7083497B2 (ja) | 2015-08-03 | 2022-06-13 | スミトモ ファーマ オンコロジー， インコーポレイテッド | がんの処置のための併用療法 |
| HK1256417A1 (zh) | 2015-09-11 | 2019-09-20 | 达纳-法伯癌症研究所股份有限公司 | 氰基噻吩並三唑並二氮雜環庚三烯及其用途 |
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| SG11201803210YA (en) | 2015-11-25 | 2018-05-30 | Dana Farber Cancer Inst Inc | Bivalent bromodomain inhibitors and uses thereof |
| US11279694B2 (en) | 2016-11-18 | 2022-03-22 | Sumitomo Dainippon Pharma Oncology, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| CN110234659A (zh) | 2016-12-19 | 2019-09-13 | 特雷罗药物股份有限公司 | 用于敏感性分析的分析肽和方法 |
| US11497756B2 (en) | 2017-09-12 | 2022-11-15 | Sumitomo Pharma Oncology, Inc. | Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib |
| KR20210099066A (ko) | 2018-12-04 | 2021-08-11 | 스미토모 다이니폰 파마 온콜로지, 인크. | 암의 치료를 위한 작용제로서 사용하기 위한 cdk9 억제제 및 그의 다형체 |
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-
2014
- 2014-09-18 EP EP14845952.2A patent/EP3047276B1/en active Active
- 2014-09-18 US US15/022,987 patent/US10739333B2/en active Active
- 2014-09-18 CA CA2922503A patent/CA2922503C/en active Active
- 2014-09-18 JP JP2016543983A patent/JP6663852B2/ja active Active
- 2014-09-18 WO PCT/US2014/056284 patent/WO2015042249A1/en not_active Ceased
- 2014-09-18 AU AU2014323526A patent/AU2014323526B2/en active Active
-
2019
- 2019-10-15 JP JP2019188457A patent/JP2020012850A/ja not_active Withdrawn
-
2020
- 2020-07-02 US US16/919,173 patent/US11867687B2/en active Active
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