JP2016534059A5 - - Google Patents
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- JP2016534059A5 JP2016534059A5 JP2016525063A JP2016525063A JP2016534059A5 JP 2016534059 A5 JP2016534059 A5 JP 2016534059A5 JP 2016525063 A JP2016525063 A JP 2016525063A JP 2016525063 A JP2016525063 A JP 2016525063A JP 2016534059 A5 JP2016534059 A5 JP 2016534059A5
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- KFLQYBLSEZRKTN-MOPGFXCFSA-N CC(N(CC[C@H]1NC(C=C)=O)C[C@@H]1Nc1nc(ccc(-c(c(Cl)c(cc2OC)OC)c2Cl)c2)c2cn1)=O Chemical compound CC(N(CC[C@H]1NC(C=C)=O)C[C@@H]1Nc1nc(ccc(-c(c(Cl)c(cc2OC)OC)c2Cl)c2)c2cn1)=O KFLQYBLSEZRKTN-MOPGFXCFSA-N 0.000 description 1
- 0 CCN(C1O)c2cc(N[C@](CCCC3)[C@]3NC(C#C)=O)ncc2C=C1c(c(Cl)c(*)cc1OC)c1Cl Chemical compound CCN(C1O)c2cc(N[C@](CCCC3)[C@]3NC(C#C)=O)ncc2C=C1c(c(Cl)c(*)cc1OC)c1Cl 0.000 description 1
- ZAOOOJFIXJSQSK-QWHCGFSZSA-N CCN(c(nc(N[C@H](CCC1)[C@H]1NC(C=C)=O)nc1)c1N=C1c(c(Cl)c(cc2OC)OC)c2Cl)C1=O Chemical compound CCN(c(nc(N[C@H](CCC1)[C@H]1NC(C=C)=O)nc1)c1N=C1c(c(Cl)c(cc2OC)OC)c2Cl)C1=O ZAOOOJFIXJSQSK-QWHCGFSZSA-N 0.000 description 1
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- JHMGYDVAEUYQHL-UHFFFAOYSA-N COc(cc(c(Cl)c1-c(cc2)cc3c2nc(NC2CCCCC2)nc3)OC)c1Cl Chemical compound COc(cc(c(Cl)c1-c(cc2)cc3c2nc(NC2CCCCC2)nc3)OC)c1Cl JHMGYDVAEUYQHL-UHFFFAOYSA-N 0.000 description 1
- WEYGASMDUSXWOC-MSOLQXFVSA-N COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@@H](CCCC2)[C@@H]2NC(C=C)=O)nc3)OC)c1Cl Chemical compound COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@@H](CCCC2)[C@@H]2NC(C=C)=O)nc3)OC)c1Cl WEYGASMDUSXWOC-MSOLQXFVSA-N 0.000 description 1
- NCKDVUYBTAQHDX-COYJEINXSA-N COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@@H](CCCC2)[C@H]2NC(/C=C\COc(c(Cl)c2-c4ccc5nc(N[C@@H](CNCC6)[C@@H]6NC(C=C)=O)ncc5c4)cc(OC)c2Cl)=O)nc3)OC)c1Cl Chemical compound COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@@H](CCCC2)[C@H]2NC(/C=C\COc(c(Cl)c2-c4ccc5nc(N[C@@H](CNCC6)[C@@H]6NC(C=C)=O)ncc5c4)cc(OC)c2Cl)=O)nc3)OC)c1Cl NCKDVUYBTAQHDX-COYJEINXSA-N 0.000 description 1
- BVDNESAVRVJTNC-CCLHPLFOSA-N COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@@H]([C@H](C2)NC(C#C)=O)c4c2cccc4)nc3)OC)c1Cl Chemical compound COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@@H]([C@H](C2)NC(C#C)=O)c4c2cccc4)nc3)OC)c1Cl BVDNESAVRVJTNC-CCLHPLFOSA-N 0.000 description 1
- WEYGASMDUSXWOC-QZTJIDSGSA-N COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@H](CCCC2)[C@@H]2NC(C=C)=O)nc3)OC)c1Cl Chemical compound COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@H](CCCC2)[C@@H]2NC(C=C)=O)nc3)OC)c1Cl WEYGASMDUSXWOC-QZTJIDSGSA-N 0.000 description 1
- WEYGASMDUSXWOC-ZWKOTPCHSA-N COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@H](CCCC2)[C@H]2NC(C=C)=O)nc3)OC)c1Cl Chemical compound COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@H](CCCC2)[C@H]2NC(C=C)=O)nc3)OC)c1Cl WEYGASMDUSXWOC-ZWKOTPCHSA-N 0.000 description 1
- GKQWMHRQOVMSIE-SJORKVTESA-N COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@H](CCOC2)[C@H]2NC(C=C)=O)nc3)OC)c1Cl Chemical compound COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@H](CCOC2)[C@H]2NC(C=C)=O)nc3)OC)c1Cl GKQWMHRQOVMSIE-SJORKVTESA-N 0.000 description 1
- JPCIRONPDKKKBK-DLBZAZTESA-N COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@H](CNCC2)[C@H]2NC(C=C)=O)nc3)OC)c1Cl Chemical compound COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@H](CNCC2)[C@H]2NC(C=C)=O)nc3)OC)c1Cl JPCIRONPDKKKBK-DLBZAZTESA-N 0.000 description 1
- MGZKYOAQVGSSGC-DLBZAZTESA-N COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@H](COCC2)[C@H]2NC(C=C)=O)nc3)OC)c1Cl Chemical compound COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@H](COCC2)[C@H]2NC(C=C)=O)nc3)OC)c1Cl MGZKYOAQVGSSGC-DLBZAZTESA-N 0.000 description 1
- FRVZTFULMVCLRE-HYVNUMGLSA-N COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@H](C[C@@H](C2)O)[C@H]2NC(C=C)=O)nc3)OC)c1Cl Chemical compound COc(cc(c(Cl)c1-c(cc2)cc3c2nc(N[C@H](C[C@@H](C2)O)[C@H]2NC(C=C)=O)nc3)OC)c1Cl FRVZTFULMVCLRE-HYVNUMGLSA-N 0.000 description 1
- AWQOOPSJCUIVQO-JKSUJKDBSA-N COc(cc(c(Cl)c1-c(cc2Cl)cc3c2nc(N[C@H](COCC2)[C@H]2NC(C=C)=O)nc3)OC)c1Cl Chemical compound COc(cc(c(Cl)c1-c(cc2Cl)cc3c2nc(N[C@H](COCC2)[C@H]2NC(C=C)=O)nc3)OC)c1Cl AWQOOPSJCUIVQO-JKSUJKDBSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361895472P | 2013-10-25 | 2013-10-25 | |
| US61/895,472 | 2013-10-25 | ||
| US201461927782P | 2014-01-15 | 2014-01-15 | |
| US61/927,782 | 2014-01-15 | ||
| PCT/US2014/061974 WO2015061572A1 (en) | 2013-10-25 | 2014-10-23 | Inhibitors of the fibroblast growth factor receptor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018186710A Division JP2019019131A (ja) | 2013-10-25 | 2018-10-01 | 繊維芽細胞成長因子受容体の阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016534059A JP2016534059A (ja) | 2016-11-04 |
| JP2016534059A5 true JP2016534059A5 (enExample) | 2017-11-30 |
| JP6458023B2 JP6458023B2 (ja) | 2019-01-23 |
Family
ID=51947473
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016525063A Active JP6458023B2 (ja) | 2013-10-25 | 2014-10-23 | 繊維芽細胞成長因子受容体の阻害剤 |
| JP2018186710A Pending JP2019019131A (ja) | 2013-10-25 | 2018-10-01 | 繊維芽細胞成長因子受容体の阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018186710A Pending JP2019019131A (ja) | 2013-10-25 | 2018-10-01 | 繊維芽細胞成長因子受容体の阻害剤 |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US9434700B2 (enExample) |
| EP (2) | EP3060560A1 (enExample) |
| JP (2) | JP6458023B2 (enExample) |
| KR (1) | KR102405452B1 (enExample) |
| CN (2) | CN105658642B (enExample) |
| AU (1) | AU2014339972B9 (enExample) |
| BR (1) | BR112016008849B8 (enExample) |
| CA (1) | CA2928042C (enExample) |
| CY (1) | CY1125393T1 (enExample) |
| DK (1) | DK3395814T3 (enExample) |
| ES (1) | ES2924111T3 (enExample) |
| HR (1) | HRP20220840T1 (enExample) |
| HU (1) | HUE059037T2 (enExample) |
| IL (1) | IL244738B (enExample) |
| LT (1) | LT3395814T (enExample) |
| MX (1) | MX2016005297A (enExample) |
| PH (1) | PH12016500739B1 (enExample) |
| PL (1) | PL3395814T3 (enExample) |
| PT (1) | PT3395814T (enExample) |
| RS (1) | RS63405B1 (enExample) |
| RU (1) | RU2704112C2 (enExample) |
| SI (1) | SI3395814T1 (enExample) |
| SM (1) | SMT202200292T1 (enExample) |
| TW (1) | TWI675828B (enExample) |
| UY (1) | UY35798A (enExample) |
| WO (1) | WO2015061572A1 (enExample) |
| ZA (1) | ZA201601971B (enExample) |
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| PE20190736A1 (es) | 2012-06-13 | 2019-05-23 | Incyte Holdings Corp | Compuestos triciclicos sustituidos como inhibidores del receptor del factor de crecimiento de fibroblastos (fgfr) |
| US8802697B2 (en) * | 2012-07-11 | 2014-08-12 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| ES2892423T3 (es) | 2013-03-15 | 2022-02-04 | Celgene Car Llc | Compuestos de heteroarilo y usos de los mismos |
| WO2014160521A1 (en) | 2013-03-15 | 2014-10-02 | Blueprint Medicines Corporation | Piperazine derivatives and their use as kit modulators |
| TWI647220B (zh) | 2013-03-15 | 2019-01-11 | 美商西建卡爾有限責任公司 | 雜芳基化合物及其用途 |
| AU2014228746B2 (en) | 2013-03-15 | 2018-08-30 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
| KR102269032B1 (ko) | 2013-04-19 | 2021-06-24 | 인사이트 홀딩스 코포레이션 | Fgfr 저해제로서 이환식 헤테로사이클 |
| ES2683127T3 (es) | 2013-10-17 | 2018-09-25 | Blueprint Medicines Corporation | Composiciones útiles para tratar trastornos relacionados con la KIT |
| CN110354128A (zh) | 2013-10-18 | 2019-10-22 | 卫材R&D管理有限公司 | 嘧啶fgfr4抑制剂 |
| MX367723B (es) | 2013-10-25 | 2019-09-03 | Novartis Ag | Compuestos de anillos fusionados bicíclicos derivados de piridilo como inhibidores de fgfr4. |
| AU2014339972B9 (en) | 2013-10-25 | 2019-05-30 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
| AU2015296322B2 (en) | 2014-07-26 | 2019-09-19 | Sunshine Lake Pharma Co., Ltd. | 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as CDK inhibitors and uses thereof |
| EP3200786B1 (en) | 2014-10-03 | 2019-08-28 | Novartis AG | Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| ES2895769T3 (es) | 2015-02-20 | 2022-02-22 | Incyte Corp | Heterociclos bicíclicos como inhibidores de FGFR |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| US9802917B2 (en) | 2015-03-25 | 2017-10-31 | Novartis Ag | Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide |
| CA2982562C (en) | 2015-04-14 | 2023-06-13 | Eisai R&D Management Co., Ltd. | Crystalline fgfr4 inhibitor compound and uses thereof |
| DK3322706T3 (da) | 2015-07-16 | 2021-02-01 | Array Biopharma Inc | Substituerede pyrazolo[1,5-a]pyridin-forbindelser som ret-kinaseinhibitorer |
| MX2018001032A (es) | 2015-07-24 | 2018-11-09 | Blueprint Medicines Corp | Compuestos utiles para el tratamiento de trastornos relacionados con kit y pdgfr. |
| CN108137607B (zh) | 2015-08-26 | 2021-04-06 | 缆图药品公司 | 适用于治疗与ntrk相关的病症的化合物和组合物 |
| JP2018534296A (ja) | 2015-10-26 | 2018-11-22 | ロクソ オンコロジー， インコーポレイテッドＬｏｘｏ Ｏｎｃｏｌｏｇｙ， Ｉｎｃ． | Ｔｒｋ阻害薬耐性がんにおける点変異およびそれに関連する方法 |
| EA038890B1 (ru) | 2015-11-02 | 2021-11-03 | Блюпринт Медсинс Корпорейшн | Ингибиторы ret |
| CA3005741A1 (en) | 2015-11-19 | 2017-05-26 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to ntrk |
| AR107912A1 (es) | 2016-03-17 | 2018-06-28 | Blueprint Medicines Corp | Inhibidores de ret |
| RS65988B1 (sr) | 2016-04-04 | 2024-10-31 | Loxo Oncology Inc | Postupak lečenja pedijatrijskih karcinoma |
| MX386416B (es) | 2016-04-04 | 2025-03-18 | Loxo Oncology Inc | Formulaciones liquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida. |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| EP3442977B1 (en) | 2016-04-15 | 2023-06-28 | Blueprint Medicines Corporation | Inhibitors of activin receptor-like kinase |
| JP7372740B2 (ja) | 2016-05-10 | 2023-11-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 細胞生存性及び／又は細胞増殖を低減するための薬物の組み合わせ |
| HUE063877T2 (hu) | 2016-05-18 | 2024-02-28 | Loxo Oncology Inc | (S)-N-(5-((R)-2-(2,5-dlfluorofenil)pirolidin-1-il)plrazolo[1,5-A]pirimidin-3-il) -3-hidroxipirolidin-1-karboxamid elõállítása |
| WO2018017983A1 (en) | 2016-07-22 | 2018-01-25 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to ret |
| WO2018022761A1 (en) | 2016-07-27 | 2018-02-01 | Blueprint Medicines Corporation | Substituted cyclopentane-amides for treating disorders related to ret |
| US10744139B2 (en) * | 2016-09-01 | 2020-08-18 | Nanjing Transthera Biosciences Co. Ltd. | Inhibitors of fibroblast growth factor receptor and use thereof |
| CN110022900A (zh) * | 2016-09-08 | 2019-07-16 | 蓝图药品公司 | 成纤维细胞生长因子受体4抑制剂与细胞周期蛋白依赖性激酶抑制剂的组合 |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| CN106986809B (zh) * | 2016-12-02 | 2020-03-24 | 广东省微生物研究所（广东省微生物分析检测中心） | 一种5-溴-6-氯-3-吲哚辛酯的合成方法 |
| TWI725266B (zh) * | 2016-12-19 | 2021-04-21 | 大陸商上海和譽生物醫藥科技有限公司 | Fgfr4抑制劑、其製備方法與藥學上的應用 |
| CN108264511B (zh) * | 2017-01-03 | 2021-04-13 | 浙江海正药业股份有限公司 | 杂环类衍生物及其制备方法和其在医药上的用途 |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| CA3049136C (en) | 2017-01-18 | 2022-06-14 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors |
| CN108503593B (zh) * | 2017-02-28 | 2021-04-27 | 暨南大学 | 2-氨基嘧啶类化合物及其应用 |
| AU2018229148B2 (en) * | 2017-03-03 | 2022-08-04 | Auckland Uniservices Limited | FGFR kinase inhibitors and pharmaceutical uses |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| WO2018183712A1 (en) | 2017-03-31 | 2018-10-04 | Blueprint Medicines Corporation | Pyrrolo[1,2-b]pyridazine compounds and compositions useful for treating disorders related to kit and pdgfr |
| CN108689878B (zh) * | 2017-04-10 | 2023-05-09 | 浙江九洲药业股份有限公司 | 光学活性二氨基衍生物的制备方法 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| SG11202001979PA (en) | 2017-09-05 | 2020-04-29 | Bioardis Llc | Aromatic derivative, preparation method for same, and medical applications thereof |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI812649B (zh) | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| CN111566102B (zh) | 2017-10-18 | 2023-09-08 | 缆图药品公司 | 作为激活素受体样激酶抑制剂的取代的吡咯并吡啶 |
| JP7076565B2 (ja) * | 2017-11-01 | 2022-05-27 | グアンドン ジョンシェン ファーマシューティカル カンパニー リミテッド | Ｆｇｆｒ４阻害剤として用いられる化合物の塩形態、結晶形及びその製造方法 |
| CN109745325B (zh) * | 2017-11-08 | 2022-02-15 | 上海翰森生物医药科技有限公司 | Fgfr4抑制剂、其制备方法和用途 |
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