JP2016533335A5 - - Google Patents
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- JP2016533335A5 JP2016533335A5 JP2016517363A JP2016517363A JP2016533335A5 JP 2016533335 A5 JP2016533335 A5 JP 2016533335A5 JP 2016517363 A JP2016517363 A JP 2016517363A JP 2016517363 A JP2016517363 A JP 2016517363A JP 2016533335 A5 JP2016533335 A5 JP 2016533335A5
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- Prior art keywords
- formulation
- monoclonal antibody
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- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 29
- 238000009472 formulation Methods 0.000 claims 27
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 238000002360 preparation method Methods 0.000 claims 10
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 6
- 229930006000 Sucrose Natural products 0.000 claims 6
- 229920000136 polysorbate Polymers 0.000 claims 6
- 229950008882 polysorbate Drugs 0.000 claims 6
- 239000005720 sucrose Substances 0.000 claims 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 4
- 229910001092 metal group alloy Inorganic materials 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 2
- 230000004071 biological effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000011521 glass Substances 0.000 claims 2
- 229910000856 hastalloy Inorganic materials 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 235000017281 sodium acetate Nutrition 0.000 claims 2
- 239000001632 sodium acetate Substances 0.000 claims 2
- 239000010935 stainless steel Substances 0.000 claims 2
- 229910001220 stainless steel Inorganic materials 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 1
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 1
- 229940068977 polysorbate 20 Drugs 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021107154A JP2021169458A (ja) | 2013-09-27 | 2021-06-29 | 抗ｐｄｌ１抗体製剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361883953P | 2013-09-27 | 2013-09-27 | |
| US61/883,953 | 2013-09-27 | ||
| PCT/US2014/057821 WO2015048520A1 (en) | 2013-09-27 | 2014-09-26 | Anti-pdl1 antibody formulations |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019104978A Division JP2019194195A (ja) | 2013-09-27 | 2019-06-05 | 抗ｐｄｌ１抗体製剤 |
| JP2021107154A Division JP2021169458A (ja) | 2013-09-27 | 2021-06-29 | 抗ｐｄｌ１抗体製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016533335A JP2016533335A (ja) | 2016-10-27 |
| JP2016533335A5 true JP2016533335A5 (OSRAM) | 2017-11-09 |
| JP6942465B2 JP6942465B2 (ja) | 2021-09-29 |
Family
ID=51703416
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016517363A Active JP6942465B2 (ja) | 2013-09-27 | 2014-09-26 | 抗ｐｄｌ１抗体製剤 |
| JP2019104978A Withdrawn JP2019194195A (ja) | 2013-09-27 | 2019-06-05 | 抗ｐｄｌ１抗体製剤 |
| JP2021107154A Withdrawn JP2021169458A (ja) | 2013-09-27 | 2021-06-29 | 抗ｐｄｌ１抗体製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019104978A Withdrawn JP2019194195A (ja) | 2013-09-27 | 2019-06-05 | 抗ｐｄｌ１抗体製剤 |
| JP2021107154A Withdrawn JP2021169458A (ja) | 2013-09-27 | 2021-06-29 | 抗ｐｄｌ１抗体製剤 |
Country Status (32)
| Country | Link |
|---|---|
| US (4) | US10875922B2 (OSRAM) |
| EP (3) | EP3049441B1 (OSRAM) |
| JP (3) | JP6942465B2 (OSRAM) |
| KR (1) | KR102331663B1 (OSRAM) |
| CN (1) | CN105793288B (OSRAM) |
| AR (2) | AR097791A1 (OSRAM) |
| AU (3) | AU2014324703C1 (OSRAM) |
| BR (1) | BR112016006397B1 (OSRAM) |
| CA (1) | CA2925310C (OSRAM) |
| CL (1) | CL2016000680A1 (OSRAM) |
| CR (1) | CR20160141A (OSRAM) |
| DK (1) | DK3049441T3 (OSRAM) |
| EA (2) | EA033817B1 (OSRAM) |
| ES (1) | ES2768614T3 (OSRAM) |
| HR (1) | HRP20200102T1 (OSRAM) |
| HU (1) | HUE047194T2 (OSRAM) |
| IL (3) | IL244712B (OSRAM) |
| LT (1) | LT3049441T (OSRAM) |
| MA (1) | MA38960A1 (OSRAM) |
| MX (3) | MX375378B (OSRAM) |
| MY (1) | MY175472A (OSRAM) |
| NZ (1) | NZ719036A (OSRAM) |
| PE (1) | PE20160541A1 (OSRAM) |
| PH (2) | PH12016500566A1 (OSRAM) |
| PL (1) | PL3049441T3 (OSRAM) |
| PT (1) | PT3049441T (OSRAM) |
| RS (1) | RS59880B1 (OSRAM) |
| SG (2) | SG10201708542RA (OSRAM) |
| SI (1) | SI3049441T1 (OSRAM) |
| TW (2) | TWI660738B (OSRAM) |
| UA (1) | UA122478C2 (OSRAM) |
| WO (1) | WO2015048520A1 (OSRAM) |
Families Citing this family (126)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2010077634A1 (en) | 2008-12-09 | 2010-07-08 | Genentech, Inc. | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| WO2012154861A2 (en) | 2011-05-09 | 2012-11-15 | Mayo Foundation For Medical Education And Research | Cancer treatments |
| EP2903610B1 (en) | 2012-10-01 | 2021-11-03 | Mayo Foundation For Medical Education And Research | Cancer treatments |
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| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
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| CA2950926A1 (en) | 2014-06-13 | 2015-12-17 | Mayo Foundation For Medical Education And Research | Albumin-bound paclitaxel nanoparticle/rituximab complexes for treatment of cd20-expressing lymphomas |
| WO2015195476A1 (en) | 2014-06-16 | 2015-12-23 | Mayo Foundation For Medical Education And Research | Treating myelomas |
| KR20170060042A (ko) | 2014-09-13 | 2017-05-31 | 노파르티스 아게 | Alk 억제제의 조합 요법 |
| US9446148B2 (en) | 2014-10-06 | 2016-09-20 | Mayo Foundation For Medical Education And Research | Carrier-antibody compositions and methods of making and using the same |
| MX389663B (es) | 2014-10-14 | 2025-03-20 | Novartis Ag | Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas. |
| MX2017011644A (es) | 2015-03-13 | 2017-12-04 | Cytomx Therapeutics Inc | Anticuerpos anti-pdl1, anticuerpos anti-pdl1 activables y metodos de uso de los mismos. |
| CA3025145A1 (en) | 2015-05-22 | 2016-12-01 | Translational Drug Development Llc | Benzamide and active compound compositions and methods of use |
| US10947598B2 (en) | 2015-09-29 | 2021-03-16 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for determining the metabolic status of lymphomas |
| AU2016332725A1 (en) | 2015-09-29 | 2018-03-22 | Celgene Corporation | PD-1 binding proteins and methods of use thereof |
| TW201713360A (en) | 2015-10-06 | 2017-04-16 | Mayo Foundation | Methods of treating cancer using compositions of antibodies and carrier proteins |
| CA3004804A1 (en) | 2015-11-17 | 2017-05-26 | Jiangsu Hengrui Medicine Co., Ltd. | Pd-l1 antibody, antigen-binding fragment thereof and medical application thereof |
| PL3386541T3 (pl) * | 2015-12-07 | 2021-04-06 | Merck Patent Gmbh | Wodna formulacja farmaceutyczna zawierającą przeciwciało anty-pd-1 awelumab |
| SI3394103T1 (sl) | 2015-12-22 | 2023-10-30 | Regeneron Pharmaceuticals, Inc. | Kombinacija protiteles proti-PD-1 in bispecifičnih protiteles proti-CD20/proti-CD3 za zdravljenje raka |
| ES2837155T3 (es) | 2016-01-04 | 2021-06-29 | Inst Nat Sante Rech Med | Uso de PD-1 y Tim-3 como medida de células CD8+ para predecir y tratar el carcinoma de células renales |
| US11571469B2 (en) | 2016-01-07 | 2023-02-07 | Mayo Foundation For Medical Education And Research | Methods of treating cancer with interferon wherein the cancer cells are HLA negative or have reduced HLA expression |
| KR20180097615A (ko) | 2016-01-08 | 2018-08-31 | 에프. 호프만-라 로슈 아게 | Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법 |
| EP3413874A4 (en) | 2016-02-12 | 2020-01-22 | Mayo Foundation for Medical Education and Research | TREATMENTS FOR BLOOD CANCER |
| CN109153719B (zh) * | 2016-03-15 | 2022-12-30 | 中外制药株式会社 | 使用pd-1轴结合拮抗剂和抗gpc3抗体治疗癌症的方法 |
| AU2017238119A1 (en) | 2016-03-21 | 2018-10-11 | Mayo Foundation For Medical Education And Research | Methods for reducing toxicity of a chemotherapeutic drug |
| EP3432928A4 (en) | 2016-03-21 | 2019-11-20 | Mayo Foundation for Medical Education and Research | PROCESS FOR IMPROVING THE THERAPEUTIC INDEX FOR CHEMOTHERAPEUTIC |
| US10618969B2 (en) | 2016-04-06 | 2020-04-14 | Mayo Foundation For Medical Education And Research | Carrier-binding agent compositions and methods of making and using the same |
| TW202408578A (zh) | 2016-05-13 | 2024-03-01 | 美商再生元醫藥公司 | 藉由投予pd-1抑制劑治療皮膚癌之方法 |
| CN109414500B (zh) * | 2016-06-13 | 2022-02-25 | 奥美药业有限公司 | 治疗和诊断用pd-l1特异性单克隆抗体 |
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| CN106967172B (zh) | 2016-08-23 | 2019-01-08 | 康方药业有限公司 | 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途 |
| CN106977602B (zh) | 2016-08-23 | 2018-09-25 | 中山康方生物医药有限公司 | 一种抗pd1单克隆抗体、其药物组合物及其用途 |
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| WO2018048815A1 (en) | 2016-09-06 | 2018-03-15 | Nantibodyfc, Llc | Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins |
| RU2019110071A (ru) * | 2016-09-06 | 2020-10-08 | Мэйо Фаундейшн Фор Медикал Эдьюкейшн Энд Рисерч | Способы лечения злокачественных новообразований, экспрессирующих pd-l1 |
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| US10751414B2 (en) | 2016-09-19 | 2020-08-25 | Celgene Corporation | Methods of treating psoriasis using PD-1 binding antibodies |
| JP2019534859A (ja) | 2016-09-19 | 2019-12-05 | セルジーン コーポレイション | Ｐｄ−１結合タンパク質を使用して白斑を治療する方法 |
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| WO2018172508A1 (en) | 2017-03-24 | 2018-09-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating melanoma |
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| US20230183379A1 (en) | 2018-11-20 | 2023-06-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Bispecific antibody targeting transferrin receptor 1 and soluble antigen |
| JP2022513693A (ja) * | 2018-11-29 | 2022-02-09 | ハーバー・バイオメド・セラピューティクス・リミテッド | 抗ｐｄ－ｌ１抗体製剤 |
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| CN120468425A (zh) | 2019-01-30 | 2025-08-12 | 国家医疗保健研究所 | 用于鉴定患有癌症的受试者是否将获得对免疫检查点抑制剂的应答的方法和组合物 |
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