UA122478C2 - Водна фармацевтична композиція, яка містить моноклональне антитіло до pd-l1 - Google Patents

Водна фармацевтична композиція, яка містить моноклональне антитіло до pd-l1

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Publication number
UA122478C2
UA122478C2 UAA201604644A UAA201604644A UA122478C2 UA 122478 C2 UA122478 C2 UA 122478C2 UA A201604644 A UAA201604644 A UA A201604644A UA A201604644 A UAA201604644 A UA A201604644A UA 122478 C2 UA122478 C2 UA 122478C2
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Ukraine
Prior art keywords
pdl1 antibody
antibody formulations
formulations
methods
pdl1
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UAA201604644A
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English (en)
Inventor
Їн Ян
Йин Ян
Сридхара Алаватам
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Дженентек, Інк.
Дженентек, Инк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51703416&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA122478(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Дженентек, Інк., Дженентек, Инк. filed Critical Дженентек, Інк.
Publication of UA122478C2 publication Critical patent/UA122478C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Винахід стосується водної фармацевтичної композиції, яка містить моноклональне антитіло до PD-L1 у концентрації 60 мг/мл, ацетат гістидину у концентрації 20 мМ, сахарозу в концентрації 120 мМ, полісорбат 20 у концентрації 0,04% (мас./об.) і має pН 5,8, де зазначене моноклональне антитіло являє собою повнорозмірне антитіло.
UAA201604644A 2013-09-27 2014-09-26 Водна фармацевтична композиція, яка містить моноклональне антитіло до pd-l1 UA122478C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361883953P 2013-09-27 2013-09-27
PCT/US2014/057821 WO2015048520A1 (en) 2013-09-27 2014-09-26 Anti-pdl1 antibody formulations

Publications (1)

Publication Number Publication Date
UA122478C2 true UA122478C2 (uk) 2020-11-25

Family

ID=51703416

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UAA201604644A UA122478C2 (uk) 2013-09-27 2014-09-26 Водна фармацевтична композиція, яка містить моноклональне антитіло до pd-l1

Country Status (33)

Country Link
US (3) US10875922B2 (uk)
EP (3) EP4285928A3 (uk)
JP (3) JP6942465B2 (uk)
KR (1) KR102331663B1 (uk)
CN (1) CN105793288B (uk)
AR (1) AR097791A1 (uk)
AU (3) AU2014324703C1 (uk)
BR (1) BR112016006397B1 (uk)
CA (1) CA2925310C (uk)
CL (1) CL2016000680A1 (uk)
CR (1) CR20160141A (uk)
DK (1) DK3049441T3 (uk)
EA (2) EA201991715A1 (uk)
ES (1) ES2768614T3 (uk)
HK (1) HK1222867A1 (uk)
HR (1) HRP20200102T1 (uk)
HU (1) HUE047194T2 (uk)
IL (3) IL244712B (uk)
LT (1) LT3049441T (uk)
MA (1) MA38960A1 (uk)
MX (3) MX2016003939A (uk)
MY (1) MY175472A (uk)
NZ (1) NZ719036A (uk)
PE (1) PE20160541A1 (uk)
PH (2) PH12016500566A1 (uk)
PL (1) PL3049441T3 (uk)
PT (1) PT3049441T (uk)
RS (1) RS59880B1 (uk)
SG (2) SG11201602283UA (uk)
SI (1) SI3049441T1 (uk)
TW (2) TWI660738B (uk)
UA (1) UA122478C2 (uk)
WO (1) WO2015048520A1 (uk)

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