BR112016006397A2 - formulações de anticorpo de anti-pdl1 - Google Patents

formulações de anticorpo de anti-pdl1

Info

Publication number
BR112016006397A2
BR112016006397A2 BR112016006397A BR112016006397A BR112016006397A2 BR 112016006397 A2 BR112016006397 A2 BR 112016006397A2 BR 112016006397 A BR112016006397 A BR 112016006397A BR 112016006397 A BR112016006397 A BR 112016006397A BR 112016006397 A2 BR112016006397 A2 BR 112016006397A2
Authority
BR
Brazil
Prior art keywords
pdl1 antibody
antibody formulations
formulations
methods
pdl1
Prior art date
Application number
BR112016006397A
Other languages
English (en)
Other versions
BR112016006397B1 (pt
Inventor
Alavattam Sreedhara
Yang Ying
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51703416&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112016006397(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BR112016006397A2 publication Critical patent/BR112016006397A2/pt
Publication of BR112016006397B1 publication Critical patent/BR112016006397B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

a invenção provê formulações farmacêuticas aquosas estáveis compreendendo um anticorpo de anti-pdl1. a invenção também provê métodos para formação de tais formulações e métodos de uso de tais formulações.
BR112016006397-0A 2013-09-27 2014-09-26 Formulações de anticorpo de anti-pdl1, seu uso, artigo de fabricação e composição BR112016006397B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361883953P 2013-09-27 2013-09-27
US61/883,953 2013-09-27
PCT/US2014/057821 WO2015048520A1 (en) 2013-09-27 2014-09-26 Anti-pdl1 antibody formulations

Publications (2)

Publication Number Publication Date
BR112016006397A2 true BR112016006397A2 (pt) 2017-09-26
BR112016006397B1 BR112016006397B1 (pt) 2024-01-16

Family

ID=51703416

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016006397-0A BR112016006397B1 (pt) 2013-09-27 2014-09-26 Formulações de anticorpo de anti-pdl1, seu uso, artigo de fabricação e composição

Country Status (33)

Country Link
US (3) US10875922B2 (pt)
EP (3) EP4285928A3 (pt)
JP (3) JP6942465B2 (pt)
KR (1) KR102331663B1 (pt)
CN (1) CN105793288B (pt)
AR (1) AR097791A1 (pt)
AU (3) AU2014324703C1 (pt)
BR (1) BR112016006397B1 (pt)
CA (1) CA2925310C (pt)
CL (1) CL2016000680A1 (pt)
CR (1) CR20160141A (pt)
DK (1) DK3049441T3 (pt)
EA (2) EA033817B1 (pt)
ES (1) ES2768614T3 (pt)
HK (1) HK1222867A1 (pt)
HR (1) HRP20200102T1 (pt)
HU (1) HUE047194T2 (pt)
IL (3) IL244712B (pt)
LT (1) LT3049441T (pt)
MA (1) MA38960A1 (pt)
MX (3) MX2016003939A (pt)
MY (1) MY175472A (pt)
NZ (1) NZ719036A (pt)
PE (1) PE20160541A1 (pt)
PH (2) PH12016500566A1 (pt)
PL (1) PL3049441T3 (pt)
PT (1) PT3049441T (pt)
RS (1) RS59880B1 (pt)
SG (2) SG10201708542RA (pt)
SI (1) SI3049441T1 (pt)
TW (2) TWI714022B (pt)
UA (1) UA122478C2 (pt)
WO (1) WO2015048520A1 (pt)

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