JP2016533325A - 歯を白くするためのデンタルケア製品 - Google Patents
歯を白くするためのデンタルケア製品 Download PDFInfo
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- JP2016533325A JP2016533325A JP2016516598A JP2016516598A JP2016533325A JP 2016533325 A JP2016533325 A JP 2016533325A JP 2016516598 A JP2016516598 A JP 2016516598A JP 2016516598 A JP2016516598 A JP 2016516598A JP 2016533325 A JP2016533325 A JP 2016533325A
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- dental care
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- care product
- protein
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- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium phosphate dihydrate Substances O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 1
- 229910001649 dickite Inorganic materials 0.000 description 1
- IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 1
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- 239000000178 monomer Substances 0.000 description 1
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- 238000010899 nucleation Methods 0.000 description 1
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- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical class N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 description 1
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- 150000004760 silicates Chemical class 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
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- 239000004299 sodium benzoate Substances 0.000 description 1
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- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
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- 235000011152 sodium sulphate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
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- 238000001356 surgical procedure Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A46B—BRUSHES
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- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
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Abstract
Description
研磨剤、たとえば炭酸塩、リン酸塩、ケイ酸塩、アクリレート、アルミナ;
懸濁剤、たとえばグリセリン、ポリエチレングリコール(PEG)、ソルビトール、キシリトール;
結合剤、たとえばセルロースおよびその誘導体、カラギーナン、パラフィン、キシロース;
界面活性剤、たとえば水添ヒマシ油、ラウリル硫酸ナトリウム;
香料、たとえばカラメル、バニリン、メントール;
保存剤、たとえばエタノール、安息香酸ナトリウム;
着色剤、たとえばソルベントレッド、アシッドブルー3;
活性剤、たとえば好ましくはフッ化アミンなどの第三級アミンの形態のフッ化物またはモノフルオロリン酸ナトリウムなどの有機フッ化物、硝酸および/またはシュウ酸カリウム。
ハイドロキシアパタイト粒子(平均粒径 d50≦300nm(Horiba);結晶化度40-60%、25重量%)の存在/不在下でのオリゴペプチド104(5 mg/ml)の懸濁液を作成した。
1.無色のマニキュア液を用いて、粘土から作られたセラミックプレートを4つの区画に分割する。すべての化学物質を秤量し、管内で合わせる。管をナノ純水で100重量%になるように満たす。ゼラチンを用いるならば、懸濁液を水浴で80℃にて5分間加熱する。その後、懸濁液をボルテックスミキサーによって攪拌する。懸濁液は、セラミックプレートに適用可能な状態になる;適用は、50 μl容量のピペットで2回適用する工程を行う。2回のピペット工程の間に、10分間の中断を入れる。セラミックプレートを約3時間乾燥させる。
上述の試験プロトコルにしたがってm本発明および従来技術のさまざまな組成物を試験した。%は、重量/重量%である。水を加えて100%にする。Curodont Protect(商標)は、1 mg/gのオリゴペプチド104を含む。
31JP JP2008/081424の実施例31の組成物
8% ラクトフェリン、
2% ラクトフェリン加水分解物、
43% グリセロール、
23.5 % ポリエチレングリコール(PEG)、
15% 無水ケイ酸
5% ハイドロキシアパタイト 10 μm
3% メチルセルロースナトリウム
0.3% ラウリル硫酸ナトリウム
1% ハイドロキシアパタイト 1 μm
2% アスコルビン酸
1% アスコルビン酸ナトリウム
0.5 % コラーゲン
0.5 % ゼラチン/コラーゲン分解産物
10% グリセロール
1% エタノール
a)製品の安全性および耐容性の評価、
b)製品の適用頻度の同定および検証、
c)ホワイトニング効果の永続性の評価、
d)反復適用の付加的効果の評価。
家庭での漂白に対して、4未満のΔE;
ホワイトニングストリップスに対して、7日後の約2.4-5.7のΔEまたは14日後の2.9-5.5のΔE;および
強力漂白(歯科医用途のみ)に対して、12までのΔE(Gerlach et al.、2002.;Demarco et al.、2009.;Delfino et al.、2009.)
Dabanoglu et al.、2009、Am J Dent 22:23-29
Dahl et al.、2003、Crit Rev Oral Biol Med 14(4):292-304
Delfino et al.、2009、J Appl. Oral Sci 17(4):284-8
Demarco et al.、2009. Braz Oral Res. 23 Suppl 1:64-70
Gerlach et al.、2002. Am J Dent. 15 Spec No:7A-12A
Jiang et al、2008、J Dent 36(11):907-914
Jin et al.、2013、Eur I Oral Sci 121:382-388
Lim et al.、2009、Biomed Mater 4(2):025017
Mohd et al.、2007、Biomed Mater Eng 17(2):69-75
Niwa et al. J Mater Sci Mater Med 2001;12:277-281
Raoufi、S. and D. Birkhed(2010). Int Dent J60(6):419-423
Roveri、Battistelli et al.、2009、J Nanomaterial、special issue、Article ID 746383
EP 1 762 215 A1、EP 2 327 428 A2
US 20050037948 A1、US 20080075675 A1、US 2008199431 A1、US 20100247589 A1、US 20100297203 A1、US 2010/0247457 A1
US 6,548,630
WO 2004/007532 A1、WO 2006/073889 A2、WO 2007/000979 A1、WO 2006/047315 A2、WO 2007/137606 A1、WO 2008/113030 A2、WO 2009/026729 A1、WO 2010/041636 A1、WO 2010/103887 A1、WO 2013/068020 A1、WO2010/019651 A1
JP2008/081424、JPH115722
JPH115722、JP2008/081424、JP 2007/0176862、JP 2001/131041、CN101385856。
Claims (15)
- 0.01-50 μmの大きさを有する鉱物粒子0.4-40重量%およびヒドロゲルであるタンパク質マトリックスを形成する能力があるタンパク質0.001-5重量%を含むデンタルケア製品であって、フルオロフォアを含むデンタルケア製品。
- 該タンパク質が、自己組織化ペプチドであり、該粒子が、好ましくは1-25 μm、より好ましくは4-20 μmの大きさを有する、請求項1に記載のデンタルケア製品。
- 該フルオロフォアが、タンパク質のアミノ酸残基、好ましくはTrpであり、好ましくはタンパク質の残基の5%以上がTrpである、前記請求項のいずれかに記載のデンタルケア製品。
- タンパク質が、ヒドロゲルを形成する、前記請求項のいずれかに記載のデンタルケア製品。
- 該タンパク質が、コラーゲン、アメロゲニン、血清アルブミン、リゾチーム、自己組織化ペプチドおよび超分子集合体から選ばれる、前記請求項のいずれかに記載のデンタルケア製品。
- 該タンパク質が、配列番号:1または配列番号:2に対して少なくとも60%の配列同一性を有する自己組織化ペプチドであるか、または好ましくは配列番号:1または配列番号:2を含む自己組織化ペプチドである前記請求項のいずれかに記載のデンタルケア製品。
- 該鉱物粒子が、リン酸カルシウム粒子、炭酸カルシウム粒子、カオリンまたは参加チタン粒子、好ましくはリン酸カルシウム粒子である、前記請求項のいずれかに記載のデンタルケア製品。
- 該鉱物粒子が、ハイドロキシアパタイトを含む、前記請求項のいずれかに記載のデンタルケア製品。
- デンタルケア製品が、練り歯磨き、予防ペースト、歯磨き粉、歯研磨剤、歯用ゲル、チューインガム、キャンディー、トローチ剤、うがい薬、ホワイトニングストリップ、コーティングされたデンタルフロス、コーティングされた歯ブラシ、ペイント・オン・ゲル、ワニス、ベニヤ、およびゲルまたはペーストを含むチューブ、シリンジまたはデンタルトレーから選ばれる、前記請求項のいずれかに記載のデンタルケア製品。
- 練り歯磨きまたはゲルであり、デンタルフロスまたは歯ブラシ上に任意にコーティングされる、0.5-40重量%の該鉱物粒子および0.02-1重量%、好ましくは0.05wt%の該マトリックスタンパク質を含む、前記請求項のいずれかに記載のデンタルケア製品。
- 30-70 %の該鉱物粒子が、の200-600 nm大きさを有する、前記請求項のいずれかに記載のデンタルケア製品。
- 製品が、Curodont(商標)Protectおよび追加されたハイドロキシアパタイト粒子を含む、前記請求項のいずれかに記載のデンタルケア製品。
- 歯のホワイトニングのための、前記請求項のいずれかに記載のデンタルケア製品の美容的使用。
- 過敏な歯の治療および/または虫歯の予防または治療における使用のための、請求項1〜12のいずれかに記載のデンタルケア製品。
- 請求項1〜12のいずれかに記載のデンタルケア製品を歯に塗布することを含む、歯の美容的ホワイトニング方法であって、組成物が、1、2、3、4、5、6、7日間またはそれ以上、好ましくは毎日、1日1、2または3回塗布されるのが好ましい方法。
Applications Claiming Priority (5)
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EP13185928.2A EP2853256A1 (en) | 2013-09-25 | 2013-09-25 | Dental care product for tooth whitening |
EP13185928.2 | 2013-09-25 | ||
EP14180365 | 2014-08-08 | ||
EP14180365.0 | 2014-08-08 | ||
PCT/EP2014/070487 WO2015044268A1 (en) | 2013-09-25 | 2014-09-25 | Dental care product for tooth whitening |
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JP6649251B2 JP6649251B2 (ja) | 2020-02-19 |
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EP (1) | EP3049054B1 (ja) |
JP (1) | JP6649251B2 (ja) |
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HK (1) | HK1218870A1 (ja) |
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EP3248591A1 (en) | 2016-05-24 | 2017-11-29 | Credentis AG | Method and product for caries treatment |
EP3248590A1 (en) | 2016-05-24 | 2017-11-29 | Credentis AG | Personal dental care product for caries treatment |
DK3500287T3 (da) * | 2016-08-16 | 2022-07-25 | Credentis Ag | Præparat omfattende selvsamlende peptider til brug ved behandling af parodontitis og/eller peri-implantitis |
CN107440986A (zh) * | 2017-08-11 | 2017-12-08 | 烟台市华昕生物医药科技有限公司 | 一种牙膏 |
CN108888770A (zh) * | 2018-07-30 | 2018-11-27 | 郑州兰茜生物工程有限公司 | 一种健齿固齿抗菌消炎的口腔保健剂及其制备方法 |
CN111000747B (zh) * | 2018-12-31 | 2021-06-15 | 美釉(西安)生物技术有限公司 | 一种防牙釉质脱矿的矿化材料及其应用 |
EP3914223A1 (en) * | 2019-01-22 | 2021-12-01 | Universidad De Los Andes | Dental floss for preventing or treating dental caries and periodontal disease |
IT201900008910A1 (it) * | 2019-06-13 | 2020-12-13 | L I Co Rice S R L | Complesso tra un idrolizzato di lattoferrina e una silice, processo di produzione dello stesso, e relativi usi. |
EP3763348A1 (en) * | 2019-07-10 | 2021-01-13 | Credentis AG | Self-assembling peptides in the prevention and treatment of cavitated carious lesions |
EP3831360A1 (en) * | 2019-12-04 | 2021-06-09 | Credentis AG | Personal dental care product for preventing demineralisation |
EP4084819A1 (en) | 2020-01-03 | 2022-11-09 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Tnap locally administered for promoting periodontal health |
US11154470B1 (en) * | 2020-07-31 | 2021-10-26 | vVardis AG | Anti-inflammatory and senolytic dental care product with tooth whitening characteristics |
EP3984517A1 (en) * | 2020-10-19 | 2022-04-20 | Credentis AG | Accelerating tooth remineralisation and bone regeneration with self-assembling peptides and amorphous calcium phosphate |
EP4385458A1 (en) | 2022-12-14 | 2024-06-19 | vVardis AG | Oral film with multiple regions for therapy of periodontal and dental diseases or disorders |
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ES2669548T3 (es) | 2018-05-28 |
CA2915962A1 (en) | 2015-04-02 |
JP6649251B2 (ja) | 2020-02-19 |
RU2673820C2 (ru) | 2018-11-30 |
CN105555255B (zh) | 2019-07-12 |
US10314776B2 (en) | 2019-06-11 |
HK1218870A1 (zh) | 2017-03-17 |
CN105555255A (zh) | 2016-05-04 |
EP3049054B1 (en) | 2018-04-04 |
BR112016000077B1 (pt) | 2020-12-22 |
WO2015044268A1 (en) | 2015-04-02 |
RU2016115635A3 (ja) | 2018-05-21 |
EP3049054A1 (en) | 2016-08-03 |
PL3049054T3 (pl) | 2018-08-31 |
RU2016115635A (ru) | 2017-10-30 |
BR112016000077B8 (pt) | 2022-01-18 |
AU2014327234A1 (en) | 2016-02-25 |
AU2014327234B2 (en) | 2019-02-21 |
US20160199283A1 (en) | 2016-07-14 |
SG11201600874YA (en) | 2016-04-28 |
CA2915962C (en) | 2021-09-21 |
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