JP2016525094A5 - - Google Patents
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- Publication number
- JP2016525094A5 JP2016525094A5 JP2016524837A JP2016524837A JP2016525094A5 JP 2016525094 A5 JP2016525094 A5 JP 2016525094A5 JP 2016524837 A JP2016524837 A JP 2016524837A JP 2016524837 A JP2016524837 A JP 2016524837A JP 2016525094 A5 JP2016525094 A5 JP 2016525094A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- ethylene glycol
- process according
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 45
- 150000001875 compounds Chemical class 0.000 claims 27
- 238000000034 method Methods 0.000 claims 11
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims 7
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 claims 7
- 229940043265 methyl isobutyl ketone Drugs 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- 239000012074 organic phase Substances 0.000 claims 5
- 239000008346 aqueous phase Substances 0.000 claims 3
- 238000000622 liquid--liquid extraction Methods 0.000 claims 3
- 238000000638 solvent extraction Methods 0.000 claims 3
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000012071 phase Substances 0.000 claims 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical group [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13176374.0 | 2013-07-12 | ||
| EP13176374 | 2013-07-12 | ||
| PCT/EP2014/064904 WO2015004265A1 (en) | 2013-07-12 | 2014-07-11 | Process for preparing a pyrimidine intermediate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016525094A JP2016525094A (ja) | 2016-08-22 |
| JP2016525094A5 true JP2016525094A5 (enExample) | 2017-08-10 |
| JP6375374B2 JP6375374B2 (ja) | 2018-08-15 |
Family
ID=48790244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016524837A Active JP6375374B2 (ja) | 2013-07-12 | 2014-07-11 | ピリミジン中間体の製造方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9556125B2 (enExample) |
| EP (1) | EP3019479B1 (enExample) |
| JP (1) | JP6375374B2 (enExample) |
| KR (1) | KR102305298B1 (enExample) |
| CN (1) | CN105636940B (enExample) |
| AR (1) | AR096865A1 (enExample) |
| CA (1) | CA2915736C (enExample) |
| DK (1) | DK3019479T3 (enExample) |
| ES (1) | ES2636937T3 (enExample) |
| HR (1) | HRP20171166T1 (enExample) |
| HU (1) | HUE034071T2 (enExample) |
| IL (1) | IL243477B (enExample) |
| MX (1) | MX360768B (enExample) |
| PL (1) | PL3019479T3 (enExample) |
| PT (1) | PT3019479T (enExample) |
| TW (1) | TWI643848B (enExample) |
| WO (1) | WO2015004265A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA201605808B (en) | 2015-08-26 | 2017-08-30 | Cipla Ltd | Process for preparing an endothelin receptor antagonist |
| CN105461638A (zh) * | 2015-12-10 | 2016-04-06 | 合肥久诺医药科技有限公司 | 一种马西替坦晶型及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1345920E (pt) * | 2000-12-18 | 2006-08-31 | Actelion Pharmaceuticals Ltd | Novas sulfonamidas e sua utilizacao como antagonistas dos receptores de endotelina |
| CN103724281A (zh) * | 2013-12-03 | 2014-04-16 | 镇江圣安医药有限公司 | N-[5-（4-溴苯基）-6-[2-[（5-溴-2-嘧啶基）氧基]乙氧基]-4-嘧啶基]-n′-丙基磺酰胺的新型衍生物及其应用 |
| CN103819411A (zh) * | 2014-03-14 | 2014-05-28 | 成都克莱蒙医药科技有限公司 | 一种马西替坦中间体新的制备方法 |
-
2014
- 2014-07-10 AR ARP140102549A patent/AR096865A1/es active IP Right Grant
- 2014-07-11 TW TW103124052A patent/TWI643848B/zh not_active IP Right Cessation
- 2014-07-11 PT PT147372726T patent/PT3019479T/pt unknown
- 2014-07-11 HR HRP20171166TT patent/HRP20171166T1/hr unknown
- 2014-07-11 CA CA2915736A patent/CA2915736C/en active Active
- 2014-07-11 JP JP2016524837A patent/JP6375374B2/ja active Active
- 2014-07-11 DK DK14737272.6T patent/DK3019479T3/en active
- 2014-07-11 WO PCT/EP2014/064904 patent/WO2015004265A1/en not_active Ceased
- 2014-07-11 ES ES14737272.6T patent/ES2636937T3/es active Active
- 2014-07-11 EP EP14737272.6A patent/EP3019479B1/en active Active
- 2014-07-11 CN CN201480039832.2A patent/CN105636940B/zh active Active
- 2014-07-11 PL PL14737272T patent/PL3019479T3/pl unknown
- 2014-07-11 US US14/904,657 patent/US9556125B2/en active Active
- 2014-07-11 HU HUE14737272A patent/HUE034071T2/en unknown
- 2014-07-11 KR KR1020167003201A patent/KR102305298B1/ko not_active Expired - Fee Related
- 2014-07-11 MX MX2016000386A patent/MX360768B/es active IP Right Grant
-
2016
- 2016-01-06 IL IL243477A patent/IL243477B/en active IP Right Grant