HUE034071T2 - Process for the preparation of a pyrimidine intermediate - Google Patents

Process for the preparation of a pyrimidine intermediate Download PDF

Info

Publication number
HUE034071T2
HUE034071T2 HUE14737272A HUE14737272A HUE034071T2 HU E034071 T2 HUE034071 T2 HU E034071T2 HU E14737272 A HUE14737272 A HU E14737272A HU E14737272 A HUE14737272 A HU E14737272A HU E034071 T2 HUE034071 T2 HU E034071T2
Authority
HU
Hungary
Prior art keywords
compound
formula
vagy vagy
mixture
ethylene glycol
Prior art date
Application number
HUE14737272A
Other languages
English (en)
Hungarian (hu)
Inventor
Stefan Abele
Jacques Alexis Funel
Ivan Schindelholz
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of HUE034071T2 publication Critical patent/HUE034071T2/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30Halogen atoms or nitro radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Detergent Compositions (AREA)
  • Magnetic Heads (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Manufacturing Cores, Coils, And Magnets (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HUE14737272A 2013-07-12 2014-07-11 Process for the preparation of a pyrimidine intermediate HUE034071T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13176374 2013-07-12

Publications (1)

Publication Number Publication Date
HUE034071T2 true HUE034071T2 (en) 2018-01-29

Family

ID=48790244

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE14737272A HUE034071T2 (en) 2013-07-12 2014-07-11 Process for the preparation of a pyrimidine intermediate

Country Status (17)

Country Link
US (1) US9556125B2 (enExample)
EP (1) EP3019479B1 (enExample)
JP (1) JP6375374B2 (enExample)
KR (1) KR102305298B1 (enExample)
CN (1) CN105636940B (enExample)
AR (1) AR096865A1 (enExample)
CA (1) CA2915736C (enExample)
DK (1) DK3019479T3 (enExample)
ES (1) ES2636937T3 (enExample)
HR (1) HRP20171166T1 (enExample)
HU (1) HUE034071T2 (enExample)
IL (1) IL243477B (enExample)
MX (1) MX360768B (enExample)
PL (1) PL3019479T3 (enExample)
PT (1) PT3019479T (enExample)
TW (1) TWI643848B (enExample)
WO (1) WO2015004265A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA201605808B (en) 2015-08-26 2017-08-30 Cipla Ltd Process for preparing an endothelin receptor antagonist
CN105461638A (zh) * 2015-12-10 2016-04-06 合肥久诺医药科技有限公司 一种马西替坦晶型及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100432070C (zh) * 2000-12-18 2008-11-12 埃科特莱茵药品有限公司 新颖的磺酰胺类化合物及其作为内皮素受体拮抗剂的应用
CN103724281A (zh) * 2013-12-03 2014-04-16 镇江圣安医药有限公司 N-[5-(4-溴苯基)-6-[2-[(5-溴-2-嘧啶基)氧基]乙氧基]-4-嘧啶基]-n′-丙基磺酰胺的新型衍生物及其应用
CN103819411A (zh) * 2014-03-14 2014-05-28 成都克莱蒙医药科技有限公司 一种马西替坦中间体新的制备方法

Also Published As

Publication number Publication date
EP3019479B1 (en) 2017-05-10
KR20160030972A (ko) 2016-03-21
KR102305298B1 (ko) 2021-09-27
US9556125B2 (en) 2017-01-31
JP2016525094A (ja) 2016-08-22
MX2016000386A (es) 2016-04-29
IL243477B (en) 2018-06-28
PL3019479T3 (pl) 2017-10-31
US20160145215A1 (en) 2016-05-26
TWI643848B (zh) 2018-12-11
HRP20171166T1 (hr) 2017-10-06
DK3019479T3 (en) 2017-07-17
CN105636940B (zh) 2018-02-27
WO2015004265A1 (en) 2015-01-15
MX360768B (es) 2018-11-15
CA2915736C (en) 2021-07-27
EP3019479A1 (en) 2016-05-18
AR096865A1 (es) 2016-02-03
ES2636937T3 (es) 2017-10-10
CA2915736A1 (en) 2015-01-15
JP6375374B2 (ja) 2018-08-15
CN105636940A (zh) 2016-06-01
TW201536759A (zh) 2015-10-01
PT3019479T (pt) 2017-08-11

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