HRP20171166T1 - Postupak za pripravu intermedijera pirimidina - Google Patents

Postupak za pripravu intermedijera pirimidina Download PDF

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Publication number
HRP20171166T1
HRP20171166T1 HRP20171166TT HRP20171166T HRP20171166T1 HR P20171166 T1 HRP20171166 T1 HR P20171166T1 HR P20171166T T HRP20171166T T HR P20171166TT HR P20171166 T HRP20171166 T HR P20171166T HR P20171166 T1 HRP20171166 T1 HR P20171166T1
Authority
HR
Croatia
Prior art keywords
compound
formula
ethylene glycol
reaction
mixture
Prior art date
Application number
HRP20171166TT
Other languages
English (en)
Croatian (hr)
Inventor
Stefan Abele
Jacques-Alexis Funel
Ivan SCHINDELHOLZ
Original Assignee
Actelion Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd. filed Critical Actelion Pharmaceuticals Ltd.
Publication of HRP20171166T1 publication Critical patent/HRP20171166T1/hr

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Detergent Compositions (AREA)
  • Magnetic Heads (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Manufacturing Cores, Coils, And Magnets (AREA)
HRP20171166TT 2013-07-12 2014-07-11 Postupak za pripravu intermedijera pirimidina HRP20171166T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13176374 2013-07-12
PCT/EP2014/064904 WO2015004265A1 (en) 2013-07-12 2014-07-11 Process for preparing a pyrimidine intermediate
EP14737272.6A EP3019479B1 (en) 2013-07-12 2014-07-11 Process for preparing a pyrimidine intermediate

Publications (1)

Publication Number Publication Date
HRP20171166T1 true HRP20171166T1 (hr) 2017-10-06

Family

ID=48790244

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20171166TT HRP20171166T1 (hr) 2013-07-12 2014-07-11 Postupak za pripravu intermedijera pirimidina

Country Status (17)

Country Link
US (1) US9556125B2 (enExample)
EP (1) EP3019479B1 (enExample)
JP (1) JP6375374B2 (enExample)
KR (1) KR102305298B1 (enExample)
CN (1) CN105636940B (enExample)
AR (1) AR096865A1 (enExample)
CA (1) CA2915736C (enExample)
DK (1) DK3019479T3 (enExample)
ES (1) ES2636937T3 (enExample)
HR (1) HRP20171166T1 (enExample)
HU (1) HUE034071T2 (enExample)
IL (1) IL243477B (enExample)
MX (1) MX360768B (enExample)
PL (1) PL3019479T3 (enExample)
PT (1) PT3019479T (enExample)
TW (1) TWI643848B (enExample)
WO (1) WO2015004265A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA201605808B (en) 2015-08-26 2017-08-30 Cipla Ltd Process for preparing an endothelin receptor antagonist
CN105461638A (zh) * 2015-12-10 2016-04-06 合肥久诺医药科技有限公司 一种马西替坦晶型及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100819668B1 (ko) * 2000-12-18 2008-04-04 액테리온 파마슈티칼 리미티드 신규한 피리미딘-설퍼아마이드
CN103724281A (zh) * 2013-12-03 2014-04-16 镇江圣安医药有限公司 N-[5-(4-溴苯基)-6-[2-[(5-溴-2-嘧啶基)氧基]乙氧基]-4-嘧啶基]-n′-丙基磺酰胺的新型衍生物及其应用
CN103819411A (zh) * 2014-03-14 2014-05-28 成都克莱蒙医药科技有限公司 一种马西替坦中间体新的制备方法

Also Published As

Publication number Publication date
JP6375374B2 (ja) 2018-08-15
CA2915736A1 (en) 2015-01-15
AR096865A1 (es) 2016-02-03
US9556125B2 (en) 2017-01-31
EP3019479A1 (en) 2016-05-18
PT3019479T (pt) 2017-08-11
IL243477B (en) 2018-06-28
MX360768B (es) 2018-11-15
KR20160030972A (ko) 2016-03-21
ES2636937T3 (es) 2017-10-10
CN105636940A (zh) 2016-06-01
WO2015004265A1 (en) 2015-01-15
KR102305298B1 (ko) 2021-09-27
TWI643848B (zh) 2018-12-11
EP3019479B1 (en) 2017-05-10
DK3019479T3 (en) 2017-07-17
HUE034071T2 (en) 2018-01-29
MX2016000386A (es) 2016-04-29
TW201536759A (zh) 2015-10-01
CN105636940B (zh) 2018-02-27
US20160145215A1 (en) 2016-05-26
PL3019479T3 (pl) 2017-10-31
JP2016525094A (ja) 2016-08-22
CA2915736C (en) 2021-07-27

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