HRP20192143T1 - Postupak za pripravu 1-(3,5-diklorofenil)-2,2,2-trifluoroetanona i njegovih derivata - Google Patents
Postupak za pripravu 1-(3,5-diklorofenil)-2,2,2-trifluoroetanona i njegovih derivata Download PDFInfo
- Publication number
- HRP20192143T1 HRP20192143T1 HRP20192143TT HRP20192143T HRP20192143T1 HR P20192143 T1 HRP20192143 T1 HR P20192143T1 HR P20192143T T HRP20192143T T HR P20192143TT HR P20192143 T HRP20192143 T HR P20192143T HR P20192143 T1 HRP20192143 T1 HR P20192143T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- formula
- chlorine
- fluorine
- hydrogen
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 6
- 150000001555 benzenes Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 7
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 6
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 6
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 239000000460 chlorine Substances 0.000 claims 6
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 239000011737 fluorine Substances 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000000802 nitrating effect Effects 0.000 claims 2
- YRIZYWQGELRKNT-UHFFFAOYSA-N 1,3,5-trichloro-1,3,5-triazinane-2,4,6-trione Chemical compound ClN1C(=O)N(Cl)C(=O)N(Cl)C1=O YRIZYWQGELRKNT-UHFFFAOYSA-N 0.000 claims 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 239000013067 intermediate product Substances 0.000 claims 1
- 229910017604 nitric acid Inorganic materials 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229950009390 symclosene Drugs 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Claims (4)
1. Postupak priprave spoja formule I
(I),
naznačen time što R1 je vodik, fluor ili klor; koji postupak sadrži
a) reakciju spoja formule II
(II),
pri čemu R1 je vodik, fluor ili klor; sa sredstvom za nitriranje u spoj formule III
(III),
pri čemu R1 je vodik, fluor ili klor;
b) reakciju spoja formule III s trikloroizocijanurnom kiselinom u prisutnosti sumporne kiseline ili isparavajuće sumporne kiseline u spoj formule IV
(IV),
pri čemu R1 je vodik, fluor ili klor; i
c) reakcija spoja formule III s plinovitim klorom na temperaturi od 180°C do 250°C u spoj formule I.
2. Postupak prema patentnom zahtjevu 1, naznačen time što se sredstvo za nitriranje bira od sumporne kiseline, dušične kiseline i njihovih soli.
3. Postupak prema patentnom zahtjevu 1, naznačen time što se postupak provodi bez izoliranja međuprodukta formule III.
4. Spoj formule IV
(IV),
naznačen time što R1 je vodik, fluor ili klor.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14188744 | 2014-10-14 | ||
EP15775221.3A EP3207023B1 (en) | 2014-10-14 | 2015-10-07 | Process for the preparation of 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone and derivatives thereof |
PCT/EP2015/073118 WO2016058881A2 (en) | 2014-10-14 | 2015-10-07 | Process for the preparation of halo-substituted benzenes |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20192143T1 true HRP20192143T1 (hr) | 2020-02-21 |
Family
ID=51690931
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20192143TT HRP20192143T1 (hr) | 2014-10-14 | 2019-11-28 | Postupak za pripravu 1-(3,5-diklorofenil)-2,2,2-trifluoroetanona i njegovih derivata |
Country Status (17)
Country | Link |
---|---|
US (1) | US10040745B2 (hr) |
EP (2) | EP3207023B1 (hr) |
JP (2) | JP6728151B2 (hr) |
KR (3) | KR20230117260A (hr) |
CN (2) | CN109665956A (hr) |
BR (1) | BR112017007506B1 (hr) |
DK (1) | DK3207023T3 (hr) |
ES (1) | ES2755333T3 (hr) |
HR (1) | HRP20192143T1 (hr) |
HU (1) | HUE046755T2 (hr) |
IL (2) | IL251176B (hr) |
MX (2) | MX2017004383A (hr) |
PL (1) | PL3207023T3 (hr) |
RS (1) | RS59795B1 (hr) |
SI (1) | SI3207023T1 (hr) |
TW (2) | TWI687404B (hr) |
WO (1) | WO2016058881A2 (hr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7071036B2 (ja) * | 2019-02-15 | 2022-05-18 | 福建永晶科技股▲ふん▼有限公司 | Friedel-Crafts反応の新しい新方法及び当該方法に用いられる触媒 |
CN112110806B (zh) * | 2020-09-10 | 2022-11-15 | 浙江永太科技股份有限公司 | 一种1-(3,5-二氯-4-氟-苯基)-2,2,2-三氟乙酮的制备方法及中间体 |
WO2022061914A1 (zh) * | 2020-09-28 | 2022-03-31 | 台州臻挚生物科技有限公司 | 一种3,5-二卤三氟苯乙酮及其衍生物的制备方法 |
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JPS60246327A (ja) | 1984-05-22 | 1985-12-06 | Asahi Glass Co Ltd | 芳香族塩素化合物の製造方法 |
JPH03275646A (ja) * | 1990-03-27 | 1991-12-06 | Asahi Glass Co Ltd | フッ素化安息香酸類の製造方法 |
JPH08259507A (ja) * | 1995-03-24 | 1996-10-08 | Nissan Chem Ind Ltd | アセトフェノン誘導体のニトロ化方法 |
JPH08268975A (ja) * | 1995-03-30 | 1996-10-15 | Nissan Chem Ind Ltd | ニトロハロゲノアセトフェノン誘導体の製造法 |
KR100240198B1 (ko) * | 1997-08-09 | 2000-01-15 | 김충섭 | 트리플루오프메틸기가 치환된 알케닐기를 갖는 신규의 프로페노 익 에스테르 및 아미드 유도체 |
CN100400529C (zh) * | 2003-10-08 | 2008-07-09 | 中国科学院化学研究所 | 含氟芳香族有机四酸二酐及制备方法和用途 |
CA2621228C (en) | 2005-09-02 | 2014-05-27 | Nissan Chemical Industries, Ltd. | Isoxazoline-substituted benzamide compound and pesticide |
CN101426769A (zh) * | 2006-04-20 | 2009-05-06 | 杜邦公司 | 五元杂环无脊椎害虫防治剂 |
CN101177379A (zh) | 2006-11-10 | 2008-05-14 | 浙江富盛控股集团有限公司 | 一种2,4,6-三氯氟苯的制备方法 |
CN101377862A (zh) | 2007-08-31 | 2009-03-04 | 张帝 | 一种密码防窥的技术方法 |
JP5472638B2 (ja) * | 2008-03-18 | 2014-04-16 | 日産化学工業株式会社 | 1−(置換フェニル)−1−置換シリルエーテル、アルコールまたはケトンの製造方法および中間体 |
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WO2011071057A1 (ja) * | 2009-12-09 | 2011-06-16 | 塩野義製薬株式会社 | 含硫黄複素環誘導体を含有するアルツハイマー症の治療用または予防用医薬組成物 |
JP2012082186A (ja) * | 2010-09-15 | 2012-04-26 | Bayer Cropscience Ag | 殺虫性アリールピロリジン類 |
JP2014500865A (ja) * | 2010-11-03 | 2014-01-16 | ビーエーエスエフ ソシエタス・ヨーロピア | 置換イソオキサゾリン化合物及びそれらの前駆体4−クロロベンズアルデヒドオキシム、4−ブロモベンズアルデヒドオキシム又は4−ヨードベンズアルデヒドオキシムを製造するための方法 |
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RU2705577C2 (ru) | 2011-12-30 | 2019-11-08 | Ханми Фарм. Ко., Лтд. | ПРОИЗВОДНЫЕ ТИЕНО[3,2-d]ПИРИМИДИНА, ОБЛАДАЮЩИЕ ИНГИБИРУЮЩЕЙ АКТИВНОСТЬЮ В ОТНОШЕНИИ ПРОТЕИНКИНАЗ |
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-
2015
- 2015-10-07 SI SI201531012T patent/SI3207023T1/sl unknown
- 2015-10-07 PL PL15775221T patent/PL3207023T3/pl unknown
- 2015-10-07 MX MX2017004383A patent/MX2017004383A/es unknown
- 2015-10-07 HU HUE15775221A patent/HUE046755T2/hu unknown
- 2015-10-07 DK DK15775221T patent/DK3207023T3/da active
- 2015-10-07 KR KR1020237025980A patent/KR20230117260A/ko not_active Application Discontinuation
- 2015-10-07 JP JP2017519682A patent/JP6728151B2/ja active Active
- 2015-10-07 KR KR1020177009561A patent/KR102436959B1/ko active IP Right Grant
- 2015-10-07 ES ES15775221T patent/ES2755333T3/es active Active
- 2015-10-07 RS RS20191533A patent/RS59795B1/sr unknown
- 2015-10-07 CN CN201910041997.8A patent/CN109665956A/zh active Pending
- 2015-10-07 EP EP15775221.3A patent/EP3207023B1/en active Active
- 2015-10-07 WO PCT/EP2015/073118 patent/WO2016058881A2/en active Application Filing
- 2015-10-07 US US15/515,271 patent/US10040745B2/en active Active
- 2015-10-07 CN CN201580055749.9A patent/CN106795093B/zh active Active
- 2015-10-07 KR KR1020227012489A patent/KR20220051422A/ko active Application Filing
- 2015-10-07 EP EP19190828.4A patent/EP3597627A1/en active Pending
- 2015-10-07 BR BR112017007506-7A patent/BR112017007506B1/pt active IP Right Grant
- 2015-10-13 TW TW108116398A patent/TWI687404B/zh active
- 2015-10-13 TW TW104133497A patent/TWI670256B/zh active
-
2017
- 2017-03-15 IL IL251176A patent/IL251176B/en active IP Right Grant
- 2017-04-04 MX MX2021002896A patent/MX2021002896A/es unknown
-
2019
- 2019-11-28 HR HRP20192143TT patent/HRP20192143T1/hr unknown
-
2020
- 2020-02-04 IL IL272451A patent/IL272451A/en active IP Right Grant
- 2020-07-01 JP JP2020114073A patent/JP6987930B2/ja active Active
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