WO2015151116A3 - Process for producing 2-fluoro-6-(trifluoromethyl)pyridine compounds - Google Patents

Process for producing 2-fluoro-6-(trifluoromethyl)pyridine compounds Download PDF

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Publication number
WO2015151116A3
WO2015151116A3 PCT/IN2015/000146 IN2015000146W WO2015151116A3 WO 2015151116 A3 WO2015151116 A3 WO 2015151116A3 IN 2015000146 W IN2015000146 W IN 2015000146W WO 2015151116 A3 WO2015151116 A3 WO 2015151116A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluoro
pyridine compounds
trifluoromethyl
formula
producing
Prior art date
Application number
PCT/IN2015/000146
Other languages
French (fr)
Other versions
WO2015151116A2 (en
Inventor
Ram Singh
Satish Kumar
Mahendra Kumar
Shailendra Kumar Singh
Ashutosh Agarwal
Original Assignee
Jubilant Life Sciences Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jubilant Life Sciences Limited filed Critical Jubilant Life Sciences Limited
Publication of WO2015151116A2 publication Critical patent/WO2015151116A2/en
Publication of WO2015151116A3 publication Critical patent/WO2015151116A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

The present invention relates to an industrially feasible and economically viable process for the preparation of 2-fluoro-6-(trifluoromethyl)pyridine compounds of Formula (I). The process comprises fluorination of one or more pyridine compounds of Formula (II) with a fluorinating agent and isolating 2-fluoro-6-(trifluoromethylpyridine compound of Formula (I) obtained, which are useful as intermediates in the synthesis of many agrochemical and pharmaceutical products.
PCT/IN2015/000146 2014-03-31 2015-03-27 Process for producing 2-fluoro-6-(trifluoromethyl)pyridine compounds WO2015151116A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN915/DEL/2014 2014-03-31
IN915DE2014 2014-03-31

Publications (2)

Publication Number Publication Date
WO2015151116A2 WO2015151116A2 (en) 2015-10-08
WO2015151116A3 true WO2015151116A3 (en) 2016-01-14

Family

ID=54241400

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2015/000146 WO2015151116A2 (en) 2014-03-31 2015-03-27 Process for producing 2-fluoro-6-(trifluoromethyl)pyridine compounds

Country Status (1)

Country Link
WO (1) WO2015151116A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10227303B2 (en) 2015-05-05 2019-03-12 Srf Limited Process for the preparation of halosubstituted trifluoromethylpyridines
CN106316933B (en) * 2016-08-20 2018-06-19 大连九信精细化工有限公司 A kind of continuous preparation method of the fluoro- 6- trifluoromethyl pyridines of 2-
CN106748981A (en) * 2016-11-29 2017-05-31 大连九信精细化工有限公司 A kind of residual recoverying and utilizing method of fluoromethyl pyridine reactor
CN109988101B (en) * 2017-12-29 2022-06-07 沈阳化工研究院有限公司 Synthesis method of 2-fluoro-6-trifluoromethylpyridine
WO2020164217A1 (en) * 2019-02-15 2020-08-20 Fujian Yongjing Technology Co., Ltd New process for manufacture of fluoroaryl compounds and derivatives
WO2020164218A1 (en) * 2019-02-15 2020-08-20 Fujian Yongjing Technology Co., Ltd New process for friedel-crafts reaction, and catalyst therefore
JP7353011B2 (en) * 2019-02-15 2023-09-29 フジアン ヨンジン テクノロジー カンパニー リミテッド New production method for fluorinated benzene, fluorinated benzophenone, and their derivatives
US20230322661A1 (en) * 2020-08-21 2023-10-12 Ses Holdings Pte. Ltd. Synthesis of N,N-Branched Sulfamoyl Fluoride Compounds Using Bismuth Trifluoride
CN115485258A (en) * 2021-03-04 2022-12-16 浙江中欣氟材股份有限公司 Method for preparing 2, 2-di (3, 4-dimethylphenyl) hexafluoropropane

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3682936A (en) * 1970-10-02 1972-08-08 Dow Chemical Co Certain 6-(trifluoromethyl)-pyridinols
US4590279A (en) * 1982-11-26 1986-05-20 The Dow Chemical Company Preparation of (trifluoromethyl)pyridines under liquid phase conditions
WO2000014068A1 (en) * 1998-09-03 2000-03-16 Syngenta Limited Chemical process for preparing 2-hydroxy-6-trifluoromethylpyridine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3682936A (en) * 1970-10-02 1972-08-08 Dow Chemical Co Certain 6-(trifluoromethyl)-pyridinols
US4590279A (en) * 1982-11-26 1986-05-20 The Dow Chemical Company Preparation of (trifluoromethyl)pyridines under liquid phase conditions
WO2000014068A1 (en) * 1998-09-03 2000-03-16 Syngenta Limited Chemical process for preparing 2-hydroxy-6-trifluoromethylpyridine

Also Published As

Publication number Publication date
WO2015151116A2 (en) 2015-10-08

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