JP2016522221A5 - - Google Patents
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- JP2016522221A5 JP2016522221A5 JP2016519695A JP2016519695A JP2016522221A5 JP 2016522221 A5 JP2016522221 A5 JP 2016522221A5 JP 2016519695 A JP2016519695 A JP 2016519695A JP 2016519695 A JP2016519695 A JP 2016519695A JP 2016522221 A5 JP2016522221 A5 JP 2016522221A5
- Authority
- JP
- Japan
- Prior art keywords
- dehydrated
- acid
- cells
- formulation
- apoptosis inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 14
- 238000002360 preparation method Methods 0.000 claims 13
- 238000009472 formulation Methods 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 11
- 229940088872 Apoptosis inhibitor Drugs 0.000 claims 10
- 239000000158 apoptosis inhibitor Substances 0.000 claims 10
- 230000018044 dehydration Effects 0.000 claims 9
- 238000006297 dehydration reaction Methods 0.000 claims 9
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 8
- 229940024606 amino acid Drugs 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 125000000914 phenoxymethylpenicillanyl group Chemical group CC1(S[C@H]2N([C@H]1C(=O)*)C([C@H]2NC(COC2=CC=CC=C2)=O)=O)C 0.000 claims 6
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims 4
- FTEDXVNDVHYDQW-UHFFFAOYSA-N BAPTA Chemical compound OC(=O)CN(CC(O)=O)C1=CC=CC=C1OCCOC1=CC=CC=C1N(CC(O)=O)CC(O)=O FTEDXVNDVHYDQW-UHFFFAOYSA-N 0.000 claims 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 4
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims 4
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical group OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 4
- 229960003237 betaine Drugs 0.000 claims 4
- 239000002738 chelating agent Substances 0.000 claims 4
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 claims 4
- 229960003330 pentetic acid Drugs 0.000 claims 4
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 claims 2
- URDCARMUOSMFFI-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid Chemical compound OCCN(CC(O)=O)CCN(CC(O)=O)CC(O)=O URDCARMUOSMFFI-UHFFFAOYSA-N 0.000 claims 2
- FCKYPQBAHLOOJQ-NXEZZACHSA-N 2-[[(1r,2r)-2-[bis(carboxymethyl)amino]cyclohexyl]-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)[C@@H]1CCCC[C@H]1N(CC(O)=O)CC(O)=O FCKYPQBAHLOOJQ-NXEZZACHSA-N 0.000 claims 2
- BDDLHHRCDSJVKV-UHFFFAOYSA-N 7028-40-2 Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O BDDLHHRCDSJVKV-UHFFFAOYSA-N 0.000 claims 2
- FCKYPQBAHLOOJQ-UHFFFAOYSA-N Cyclohexane-1,2-diaminetetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)C1CCCCC1N(CC(O)=O)CC(O)=O FCKYPQBAHLOOJQ-UHFFFAOYSA-N 0.000 claims 2
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims 2
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 claims 2
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims 2
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 claims 2
- 239000006174 pH buffer Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000002441 reversible effect Effects 0.000 claims 2
- 239000000176 sodium gluconate Substances 0.000 claims 2
- 229940005574 sodium gluconate Drugs 0.000 claims 2
- 235000012207 sodium gluconate Nutrition 0.000 claims 2
- PMMYEEVYMWASQN-IMJSIDKUSA-N trans-4-Hydroxy-L-proline Natural products O[C@@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-IMJSIDKUSA-N 0.000 claims 2
- 229920003169 water-soluble polymer Polymers 0.000 claims 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 150000002016 disaccharides Chemical class 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 230000003100 immobilizing effect Effects 0.000 claims 1
- 229960002429 proline Drugs 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361834517P | 2013-06-13 | 2013-06-13 | |
| US61/834,517 | 2013-06-13 | ||
| PCT/US2014/042396 WO2015002729A2 (en) | 2013-06-13 | 2014-06-13 | Cell stabilization |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016522221A JP2016522221A (ja) | 2016-07-28 |
| JP2016522221A5 true JP2016522221A5 (https=) | 2017-07-20 |
| JP6604942B2 JP6604942B2 (ja) | 2019-11-13 |
Family
ID=52144261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016519695A Expired - Fee Related JP6604942B2 (ja) | 2013-06-13 | 2014-06-13 | 細胞安定化 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20160135446A1 (https=) |
| EP (2) | EP3007556B1 (https=) |
| JP (1) | JP6604942B2 (https=) |
| CN (1) | CN105491883B (https=) |
| CA (1) | CA2915250A1 (https=) |
| WO (1) | WO2015002729A2 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010007419A (es) | 2008-01-04 | 2010-11-12 | Intellikine Inc | Ciertas entidades quimicas, composiciones y metodos. |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| EP2598660B1 (en) | 2010-07-26 | 2017-03-15 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| WO2012018639A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| ES2637113T3 (es) | 2011-01-10 | 2017-10-10 | Infinity Pharmaceuticals, Inc. | Procedimientos para preparar isoquinolinonas y formas sólidas de isoquinolinonas |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| AU2013337717B2 (en) | 2012-11-01 | 2018-10-25 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using PI3 kinase isoform modulators |
| US9725703B2 (en) | 2012-12-20 | 2017-08-08 | Biomatrica, Inc. | Formulations and methods for stabilizing PCR reagents |
| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| CN106687580A (zh) * | 2014-06-10 | 2017-05-17 | 生物马特里卡公司 | 在环境温度下稳定血液样品中的代谢活性细胞 |
| ES2786373T3 (es) | 2014-06-10 | 2020-10-09 | Biomatrica Inc | Estabilización de trombocitos a temperaturas ambiente |
| ES2818569T3 (es) | 2015-09-09 | 2021-04-13 | Drawbridge Health Inc | Métodos para la recopilación, estabilización y conservación de muestras |
| KR20250047404A (ko) | 2015-12-08 | 2025-04-03 | 바이오매트리카 인코포레이티드 | 적혈구 침강 속도의 감소 |
| WO2017130756A1 (ja) * | 2016-01-25 | 2017-08-03 | 学校法人 慶應義塾 | 小胞体ストレスを標的とする椎間板変性症に対する治療薬 |
| KR101662975B1 (ko) * | 2016-02-15 | 2016-10-06 | 서울대학교산학협력단 | 간암 치료 또는 예방용 조성물 |
| JP7019590B2 (ja) | 2016-03-31 | 2022-02-15 | バークレー ライツ，インコーポレイテッド | 核酸安定化試薬、キット、及びその使用方法 |
| SG11201811237WA (en) | 2016-06-24 | 2019-01-30 | Infinity Pharmaceuticals Inc | Combination therapies |
| EP3656382A1 (en) | 2017-01-30 | 2020-05-27 | Université de Liège | Perk and ire-1a inhibitors against neurodevelopmental disorders |
| CN106963769B (zh) * | 2017-03-03 | 2019-10-25 | 深圳大学 | 含pi3k抑制剂和perk抑制剂的药物组合物及其应用 |
| GB201804227D0 (en) * | 2018-03-16 | 2018-05-02 | Univ Warwick | Cryopreserving compositions |
| CN114615886A (zh) * | 2019-08-29 | 2022-06-10 | 得克萨斯大学体系董事会 | 细胞冷冻保存培养基 |
| CN111418579B (zh) * | 2020-04-13 | 2021-05-18 | 广东华夏健康生命科学有限公司 | 一种脂肪组织的保存方法、脂肪组织的保存液及其制备方法 |
| JP7741100B2 (ja) | 2020-05-04 | 2025-09-17 | アムジェン インコーポレイテッド | ミエロイド細胞に発現するトリガー受容体２アゴニストとしての複素環化合物及び使用方法 |
| CN112210594B (zh) * | 2020-11-12 | 2023-09-19 | 苏州创澜生物科技有限公司 | 一种逆转录试剂的冻干保护剂 |
| CN112210593B (zh) * | 2020-11-12 | 2023-09-19 | 苏州创澜生物科技有限公司 | 一种冻干保护剂、可冻干的pcr试剂及其应用 |
| CN113261557A (zh) * | 2021-05-28 | 2021-08-17 | 广东先康达生物科技有限公司 | 一种干细胞冻存液及干细胞冻存方法 |
| CN115363016B (zh) * | 2022-08-09 | 2023-07-18 | 广州明迅生物科技有限责任公司 | 细胞储存液及其应用 |
| CN115777693B (zh) * | 2023-02-03 | 2023-04-18 | 苏州依科赛生物科技股份有限公司 | 一种细胞冻存液、制备方法、应用方法及用途 |
| WO2025240630A1 (en) * | 2024-05-14 | 2025-11-20 | Abbott Laboratories | Reagent compositions for isothermal amplification of nucleic acids |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US918A (en) | 1838-09-14 | Improvement in the mode of regulating windmills | ||
| US7037A (en) | 1850-01-22 | Grid-ikon slide-valve | ||
| JPH0244514B2 (ja) * | 1981-09-14 | 1990-10-04 | Nippon Oil Co Ltd | Biseibutsuseikintainokoteika*zoshokuho |
| AU661296B2 (en) * | 1991-01-11 | 1995-07-20 | Cobe Laboratories Inc. | Method of detecting circulating antibody types using dried or lyophilized cells or cell-like material |
| US5242792A (en) * | 1991-02-25 | 1993-09-07 | The United States Of America As Represented By The Secretary Of The Navy | Method for the preservation of red blood cells by lyophilization using glycerol or inositol with disaccharides |
| US5541290A (en) | 1993-06-24 | 1996-07-30 | Harbeson; Scott L. | Optically pure calpain inhibitor compounds |
| CA2235069C (en) * | 1995-10-19 | 2010-12-14 | Advanced Reproduction Technologies, Inc. | Methods and compositions to improve germ cell and embryo survival and function |
| US6057117A (en) | 1996-04-04 | 2000-05-02 | Chiron Corporation | Identification and use of selective inhibitors of glycogen synthase kinase 3 |
| WO1998016528A1 (en) | 1996-10-11 | 1998-04-23 | Chiron Corporation | Purine inhibitors of glycogen synthase kinase 3 (gsk3) |
| US6310060B1 (en) | 1998-06-24 | 2001-10-30 | Warner-Lambert Company | 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors |
| US6821963B2 (en) | 1997-07-01 | 2004-11-23 | Warner-Lambert Company | 4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors |
| EP1015578A4 (en) * | 1997-09-17 | 2004-12-01 | Walker And Eliza Hall Inst Of | THERAPEUTIC MOLECULES |
| WO1999065897A1 (en) | 1998-06-19 | 1999-12-23 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| US7001770B1 (en) | 1998-10-15 | 2006-02-21 | Canji, Inc. | Calpain inhibitors and their applications |
| CA2349832A1 (en) | 1999-01-13 | 2000-07-20 | Warner-Lambert Company | Benzenesulfonamide derivatives and their use as mek inhibitors |
| GB9910580D0 (en) | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
| IL149778A0 (en) * | 1999-11-22 | 2002-11-10 | Universal Preservation Technologies Inc | Preservation of sensitive biological material |
| JP2003516974A (ja) | 1999-12-17 | 2003-05-20 | カイロン コーポレイション | グリコーゲンシンターゼキナーゼ３のピラジンベースインヒビター |
| CN100335479C (zh) | 1999-12-17 | 2007-09-05 | 希龙公司 | 糖元合成酶激酶3的双环抑制剂 |
| JP3694730B2 (ja) * | 2000-03-02 | 2005-09-14 | 国立大学法人京都大学 | 組織の冷却保存液 |
| EP1339702A1 (en) | 2000-03-15 | 2003-09-03 | Warner-Lambert Company | 5-amide substituted diarylamines as mek inhibitors |
| WO2001082919A2 (en) | 2000-05-04 | 2001-11-08 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods of and compounds for inhibiting calpains |
| US6608632B2 (en) | 2000-06-12 | 2003-08-19 | Sharp Laboratories Of America, Inc. | Methods and systems for improving display resolution in images using sub-pixel sampling and visual error filtering |
| ES2295191T3 (es) | 2000-07-27 | 2008-04-16 | Novartis Vaccines And Diagnostics, Inc. | Polipeptidos de gsk3. |
| US6872357B1 (en) * | 2000-11-22 | 2005-03-29 | Quadrant Drug Delivery Limited | Formulation of preservation mixtures containing sensitive biologicals to be stabilized for ambient temperature storage by drying |
| US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
| US20040110267A1 (en) * | 2000-12-15 | 2004-06-10 | Stratagene | Room temperature stable competent cells |
| CA2441733A1 (en) | 2001-03-29 | 2002-10-10 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| WO2003087335A2 (en) * | 2002-04-11 | 2003-10-23 | Medimmune Vaccines, Inc. | Preservation of bioactive materials by spray drying |
| GB0218800D0 (en) | 2002-08-13 | 2002-09-18 | Celltech R&D Ltd | Chemical compounds |
| GB0228832D0 (en) * | 2002-12-10 | 2003-01-15 | Novartis Ag | Organic compound |
| CA2528602A1 (en) | 2003-06-20 | 2004-12-29 | Celltech R & D Limited | Thienopyridone derivatives as kinase inhibitors |
| GB0314607D0 (en) * | 2003-06-23 | 2003-07-30 | Univ Cambridge Tech | Preservation method |
| AU2004203373A1 (en) | 2003-07-25 | 2005-02-10 | University Of Chicago | Identification of novel factors that block programmed cell death or apoptosis by targeting JNK |
| US7314755B2 (en) * | 2003-10-15 | 2008-01-01 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Preservation of eukaryotic cells using reversible pore formation |
| JP2007509123A (ja) | 2003-10-24 | 2007-04-12 | セルテック アール アンド ディ リミテッド | キナーゼ阻害剤としてのチエノ−ピリジノン誘導体 |
| US20080176209A1 (en) * | 2004-04-08 | 2008-07-24 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| US20060099567A1 (en) * | 2004-04-08 | 2006-05-11 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| ES2243131B1 (es) | 2004-05-07 | 2007-02-01 | Consejo Sup. Investig. Cientificas | Tiamidas derivadas de bifenilo como inhibidores de calpaina. |
| TWI361066B (en) | 2004-07-26 | 2012-04-01 | Chugai Pharmaceutical Co Ltd | 5-substituted-2-phenylamino benzamides as mek inhibitors |
| ES2255848B1 (es) | 2004-12-16 | 2007-07-01 | Consejo Superior Investig. Cientificas | Derivados de isoquinolina como inhibidores de calpaina. |
| ES2600460T3 (es) | 2005-05-10 | 2017-02-09 | Intermune, Inc. | Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés |
| UA95244C2 (ru) | 2005-06-22 | 2011-07-25 | Плексикон, Инк. | Соединения и способ модулирования активности киназ, и показания для их применения |
| JP2009508472A (ja) * | 2005-08-11 | 2009-03-05 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 乾燥細胞形態のための方法および組成物 |
| US7931919B2 (en) * | 2005-08-12 | 2011-04-26 | The United States Of America As Represented By The Secretary Of The Army | Method of producing glycine-stabilized, lyophilized plasma |
| SI1934174T1 (sl) | 2005-10-07 | 2011-08-31 | Exelixis Inc | Inhibitorji MEK in postopki za njihovo uporabo |
| GB0601962D0 (en) | 2006-01-31 | 2006-03-15 | Ucb Sa | Therapeutic agents |
| CA2638734A1 (en) | 2006-02-27 | 2007-09-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibitors of the unfolded protein response and methods for their use |
| JP5269762B2 (ja) | 2006-04-18 | 2013-08-21 | アーディア・バイオサイエンシーズ・インコーポレイテッド | Ｍｅｋ阻害剤としてのピリドンスルホンアミドおよびピリドンスルファミド |
| WO2008007463A1 (fr) * | 2006-07-12 | 2008-01-17 | Nippon Zenyaku Kogyo Co., Ltd. | Composition de dilution et de stockage de sperme |
| CN101528231A (zh) | 2006-08-16 | 2009-09-09 | 埃克塞利希斯股份有限公司 | 在癌症的治疗中使用pi3k和mek调控剂 |
| JP5611826B2 (ja) | 2007-09-04 | 2014-10-22 | ザ スクリプス リサーチ インスティテュート | タンパク質キナーゼ阻害剤としての置換されたピリミジニル−アミン |
| US8178555B2 (en) | 2008-06-24 | 2012-05-15 | Takeda Pharmaceutical Company Limited | Apoptosis signal-regulating kinase 1 inhibitors |
| ES2426096T3 (es) | 2008-07-01 | 2013-10-21 | Genentech, Inc. | Derivados de isoindolona como inhibidores de la quinasa MEK y métodos de utilización |
| WO2010046949A1 (ja) * | 2008-10-22 | 2010-04-29 | Inui Hiroaki | 細胞をガラス化保存する方法および細胞のガラス化保存用容器 |
| RU2011120425A (ru) * | 2008-10-22 | 2012-11-27 | Де Стат Дер Нидерланден, Верт. Дор Де Министер Ван Ввс | Смесь для консервации и ее применение |
| EP2430195B1 (en) * | 2009-05-11 | 2019-01-23 | Biomatrica, INC. | Compositions and methods for biological sample storage |
| EP2435554B1 (en) * | 2009-05-26 | 2017-07-26 | Advanced Bionutrition Corporation | Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making |
| TWI598347B (zh) | 2009-07-13 | 2017-09-11 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| WO2011127217A1 (en) * | 2010-04-06 | 2011-10-13 | Genvault Corporation | Stabilized chemical dehydration of biological material |
| NZ604831A (en) | 2010-07-02 | 2014-12-24 | Gilead Sciences Inc | Apoptosis signal-regulating kinase inhibitors |
| EP2598660B1 (en) * | 2010-07-26 | 2017-03-15 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| WO2012018639A2 (en) * | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| US20120028933A1 (en) * | 2010-07-28 | 2012-02-02 | Baust John M | Cell Culture Media Supplement and Method of Molecular Stress Control |
| US8664244B2 (en) | 2010-09-12 | 2014-03-04 | Advenchen Pharmaceuticals, LLC | Compounds as c-Met kinase inhibitors |
| WO2012067240A1 (ja) * | 2010-11-19 | 2012-05-24 | セーレン株式会社 | 細胞のガラス化保存液 |
-
2014
- 2014-06-13 WO PCT/US2014/042396 patent/WO2015002729A2/en not_active Ceased
- 2014-06-13 US US14/895,475 patent/US20160135446A1/en not_active Abandoned
- 2014-06-13 EP EP14819510.0A patent/EP3007556B1/en active Active
- 2014-06-13 JP JP2016519695A patent/JP6604942B2/ja not_active Expired - Fee Related
- 2014-06-13 EP EP19209890.3A patent/EP3632208A1/en not_active Withdrawn
- 2014-06-13 CA CA2915250A patent/CA2915250A1/en not_active Abandoned
- 2014-06-13 CN CN201480044962.5A patent/CN105491883B/zh not_active Expired - Fee Related
-
2017
- 2017-12-21 US US15/850,805 patent/US20180184644A1/en active Pending
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