CN105491883B - 细胞稳定化 - Google Patents

细胞稳定化 Download PDF

Info

Publication number
CN105491883B
CN105491883B CN201480044962.5A CN201480044962A CN105491883B CN 105491883 B CN105491883 B CN 105491883B CN 201480044962 A CN201480044962 A CN 201480044962A CN 105491883 B CN105491883 B CN 105491883B
Authority
CN
China
Prior art keywords
acid
cell
apoptosis
inhibitor
formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201480044962.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN105491883A (zh
Inventor
朱蒂·穆勒-科恩
保罗·迪亚兹
罗尔夫·穆勒
瓦斯科·利贝拉尔
阿尔伯特·佩雷斯-拉达格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomatrica Inc
Original Assignee
Biomatrica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomatrica Inc filed Critical Biomatrica Inc
Publication of CN105491883A publication Critical patent/CN105491883A/zh
Application granted granted Critical
Publication of CN105491883B publication Critical patent/CN105491883B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10Preservation of living parts
    • A01N1/12Chemical aspects of preservation
    • A01N1/122Preservation or perfusion media
    • A01N1/126Physiologically active agents, e.g. antioxidants or nutrients
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CN201480044962.5A 2013-06-13 2014-06-13 细胞稳定化 Expired - Fee Related CN105491883B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361834517P 2013-06-13 2013-06-13
US61/834,517 2013-06-13
PCT/US2014/042396 WO2015002729A2 (en) 2013-06-13 2014-06-13 Cell stabilization

Publications (2)

Publication Number Publication Date
CN105491883A CN105491883A (zh) 2016-04-13
CN105491883B true CN105491883B (zh) 2018-11-02

Family

ID=52144261

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480044962.5A Expired - Fee Related CN105491883B (zh) 2013-06-13 2014-06-13 细胞稳定化

Country Status (6)

Country Link
US (2) US20160135446A1 (https=)
EP (2) EP3007556B1 (https=)
JP (1) JP6604942B2 (https=)
CN (1) CN105491883B (https=)
CA (1) CA2915250A1 (https=)
WO (1) WO2015002729A2 (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010007419A (es) 2008-01-04 2010-11-12 Intellikine Inc Ciertas entidades quimicas, composiciones y metodos.
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
EP2598660B1 (en) 2010-07-26 2017-03-15 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
WO2012018639A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
ES2637113T3 (es) 2011-01-10 2017-10-10 Infinity Pharmaceuticals, Inc. Procedimientos para preparar isoquinolinonas y formas sólidas de isoquinolinonas
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
AU2013337717B2 (en) 2012-11-01 2018-10-25 Infinity Pharmaceuticals, Inc. Treatment of cancers using PI3 kinase isoform modulators
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
CN106687580A (zh) * 2014-06-10 2017-05-17 生物马特里卡公司 在环境温度下稳定血液样品中的代谢活性细胞
ES2786373T3 (es) 2014-06-10 2020-10-09 Biomatrica Inc Estabilización de trombocitos a temperaturas ambiente
ES2818569T3 (es) 2015-09-09 2021-04-13 Drawbridge Health Inc Métodos para la recopilación, estabilización y conservación de muestras
KR20250047404A (ko) 2015-12-08 2025-04-03 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
WO2017130756A1 (ja) * 2016-01-25 2017-08-03 学校法人 慶應義塾 小胞体ストレスを標的とする椎間板変性症に対する治療薬
KR101662975B1 (ko) * 2016-02-15 2016-10-06 서울대학교산학협력단 간암 치료 또는 예방용 조성물
JP7019590B2 (ja) 2016-03-31 2022-02-15 バークレー ライツ,インコーポレイテッド 核酸安定化試薬、キット、及びその使用方法
SG11201811237WA (en) 2016-06-24 2019-01-30 Infinity Pharmaceuticals Inc Combination therapies
EP3656382A1 (en) 2017-01-30 2020-05-27 Université de Liège Perk and ire-1a inhibitors against neurodevelopmental disorders
CN106963769B (zh) * 2017-03-03 2019-10-25 深圳大学 含pi3k抑制剂和perk抑制剂的药物组合物及其应用
GB201804227D0 (en) * 2018-03-16 2018-05-02 Univ Warwick Cryopreserving compositions
CN114615886A (zh) * 2019-08-29 2022-06-10 得克萨斯大学体系董事会 细胞冷冻保存培养基
CN111418579B (zh) * 2020-04-13 2021-05-18 广东华夏健康生命科学有限公司 一种脂肪组织的保存方法、脂肪组织的保存液及其制备方法
JP7741100B2 (ja) 2020-05-04 2025-09-17 アムジェン インコーポレイテッド ミエロイド細胞に発現するトリガー受容体2アゴニストとしての複素環化合物及び使用方法
CN112210594B (zh) * 2020-11-12 2023-09-19 苏州创澜生物科技有限公司 一种逆转录试剂的冻干保护剂
CN112210593B (zh) * 2020-11-12 2023-09-19 苏州创澜生物科技有限公司 一种冻干保护剂、可冻干的pcr试剂及其应用
CN113261557A (zh) * 2021-05-28 2021-08-17 广东先康达生物科技有限公司 一种干细胞冻存液及干细胞冻存方法
CN115363016B (zh) * 2022-08-09 2023-07-18 广州明迅生物科技有限责任公司 细胞储存液及其应用
CN115777693B (zh) * 2023-02-03 2023-04-18 苏州依科赛生物科技股份有限公司 一种细胞冻存液、制备方法、应用方法及用途
WO2025240630A1 (en) * 2024-05-14 2025-11-20 Abbott Laboratories Reagent compositions for isothermal amplification of nucleic acids

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872357B1 (en) * 2000-11-22 2005-03-29 Quadrant Drug Delivery Limited Formulation of preservation mixtures containing sensitive biologicals to be stabilized for ambient temperature storage by drying
CN1747971A (zh) * 2002-12-10 2006-03-15 诺瓦提斯公司 抗Nogo A的抗体(“11C7”)及其药物用途
CN101360822A (zh) * 2005-12-01 2009-02-04 生物马特里卡公司 用于生命科学的样品存储和样品管理的综合
CN102947082A (zh) * 2010-04-06 2013-02-27 金沃特公司 生物材料的稳定化的化学脱水

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US918A (en) 1838-09-14 Improvement in the mode of regulating windmills
US7037A (en) 1850-01-22 Grid-ikon slide-valve
JPH0244514B2 (ja) * 1981-09-14 1990-10-04 Nippon Oil Co Ltd Biseibutsuseikintainokoteika*zoshokuho
AU661296B2 (en) * 1991-01-11 1995-07-20 Cobe Laboratories Inc. Method of detecting circulating antibody types using dried or lyophilized cells or cell-like material
US5242792A (en) * 1991-02-25 1993-09-07 The United States Of America As Represented By The Secretary Of The Navy Method for the preservation of red blood cells by lyophilization using glycerol or inositol with disaccharides
US5541290A (en) 1993-06-24 1996-07-30 Harbeson; Scott L. Optically pure calpain inhibitor compounds
CA2235069C (en) * 1995-10-19 2010-12-14 Advanced Reproduction Technologies, Inc. Methods and compositions to improve germ cell and embryo survival and function
US6057117A (en) 1996-04-04 2000-05-02 Chiron Corporation Identification and use of selective inhibitors of glycogen synthase kinase 3
WO1998016528A1 (en) 1996-10-11 1998-04-23 Chiron Corporation Purine inhibitors of glycogen synthase kinase 3 (gsk3)
US6310060B1 (en) 1998-06-24 2001-10-30 Warner-Lambert Company 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
US6821963B2 (en) 1997-07-01 2004-11-23 Warner-Lambert Company 4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
EP1015578A4 (en) * 1997-09-17 2004-12-01 Walker And Eliza Hall Inst Of THERAPEUTIC MOLECULES
WO1999065897A1 (en) 1998-06-19 1999-12-23 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US7001770B1 (en) 1998-10-15 2006-02-21 Canji, Inc. Calpain inhibitors and their applications
CA2349832A1 (en) 1999-01-13 2000-07-20 Warner-Lambert Company Benzenesulfonamide derivatives and their use as mek inhibitors
GB9910580D0 (en) 1999-05-08 1999-07-07 Zeneca Ltd Chemical compounds
IL149778A0 (en) * 1999-11-22 2002-11-10 Universal Preservation Technologies Inc Preservation of sensitive biological material
JP2003516974A (ja) 1999-12-17 2003-05-20 カイロン コーポレイション グリコーゲンシンターゼキナーゼ3のピラジンベースインヒビター
CN100335479C (zh) 1999-12-17 2007-09-05 希龙公司 糖元合成酶激酶3的双环抑制剂
JP3694730B2 (ja) * 2000-03-02 2005-09-14 国立大学法人京都大学 組織の冷却保存液
EP1339702A1 (en) 2000-03-15 2003-09-03 Warner-Lambert Company 5-amide substituted diarylamines as mek inhibitors
WO2001082919A2 (en) 2000-05-04 2001-11-08 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods of and compounds for inhibiting calpains
US6608632B2 (en) 2000-06-12 2003-08-19 Sharp Laboratories Of America, Inc. Methods and systems for improving display resolution in images using sub-pixel sampling and visual error filtering
ES2295191T3 (es) 2000-07-27 2008-04-16 Novartis Vaccines And Diagnostics, Inc. Polipeptidos de gsk3.
US7129242B2 (en) 2000-12-06 2006-10-31 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto
US20040110267A1 (en) * 2000-12-15 2004-06-10 Stratagene Room temperature stable competent cells
CA2441733A1 (en) 2001-03-29 2002-10-10 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
WO2003087335A2 (en) * 2002-04-11 2003-10-23 Medimmune Vaccines, Inc. Preservation of bioactive materials by spray drying
GB0218800D0 (en) 2002-08-13 2002-09-18 Celltech R&D Ltd Chemical compounds
CA2528602A1 (en) 2003-06-20 2004-12-29 Celltech R & D Limited Thienopyridone derivatives as kinase inhibitors
GB0314607D0 (en) * 2003-06-23 2003-07-30 Univ Cambridge Tech Preservation method
AU2004203373A1 (en) 2003-07-25 2005-02-10 University Of Chicago Identification of novel factors that block programmed cell death or apoptosis by targeting JNK
US7314755B2 (en) * 2003-10-15 2008-01-01 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Preservation of eukaryotic cells using reversible pore formation
JP2007509123A (ja) 2003-10-24 2007-04-12 セルテック アール アンド ディ リミテッド キナーゼ阻害剤としてのチエノ−ピリジノン誘導体
US20080176209A1 (en) * 2004-04-08 2008-07-24 Biomatrica, Inc. Integration of sample storage and sample management for life science
ES2243131B1 (es) 2004-05-07 2007-02-01 Consejo Sup. Investig. Cientificas Tiamidas derivadas de bifenilo como inhibidores de calpaina.
TWI361066B (en) 2004-07-26 2012-04-01 Chugai Pharmaceutical Co Ltd 5-substituted-2-phenylamino benzamides as mek inhibitors
ES2255848B1 (es) 2004-12-16 2007-07-01 Consejo Superior Investig. Cientificas Derivados de isoquinolina como inhibidores de calpaina.
ES2600460T3 (es) 2005-05-10 2017-02-09 Intermune, Inc. Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés
UA95244C2 (ru) 2005-06-22 2011-07-25 Плексикон, Инк. Соединения и способ модулирования активности киназ, и показания для их применения
JP2009508472A (ja) * 2005-08-11 2009-03-05 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 乾燥細胞形態のための方法および組成物
US7931919B2 (en) * 2005-08-12 2011-04-26 The United States Of America As Represented By The Secretary Of The Army Method of producing glycine-stabilized, lyophilized plasma
SI1934174T1 (sl) 2005-10-07 2011-08-31 Exelixis Inc Inhibitorji MEK in postopki za njihovo uporabo
GB0601962D0 (en) 2006-01-31 2006-03-15 Ucb Sa Therapeutic agents
CA2638734A1 (en) 2006-02-27 2007-09-07 The Board Of Trustees Of The Leland Stanford Junior University Inhibitors of the unfolded protein response and methods for their use
JP5269762B2 (ja) 2006-04-18 2013-08-21 アーディア・バイオサイエンシーズ・インコーポレイテッド Mek阻害剤としてのピリドンスルホンアミドおよびピリドンスルファミド
WO2008007463A1 (fr) * 2006-07-12 2008-01-17 Nippon Zenyaku Kogyo Co., Ltd. Composition de dilution et de stockage de sperme
CN101528231A (zh) 2006-08-16 2009-09-09 埃克塞利希斯股份有限公司 在癌症的治疗中使用pi3k和mek调控剂
JP5611826B2 (ja) 2007-09-04 2014-10-22 ザ スクリプス リサーチ インスティテュート タンパク質キナーゼ阻害剤としての置換されたピリミジニル−アミン
US8178555B2 (en) 2008-06-24 2012-05-15 Takeda Pharmaceutical Company Limited Apoptosis signal-regulating kinase 1 inhibitors
ES2426096T3 (es) 2008-07-01 2013-10-21 Genentech, Inc. Derivados de isoindolona como inhibidores de la quinasa MEK y métodos de utilización
WO2010046949A1 (ja) * 2008-10-22 2010-04-29 Inui Hiroaki 細胞をガラス化保存する方法および細胞のガラス化保存用容器
RU2011120425A (ru) * 2008-10-22 2012-11-27 Де Стат Дер Нидерланден, Верт. Дор Де Министер Ван Ввс Смесь для консервации и ее применение
EP2430195B1 (en) * 2009-05-11 2019-01-23 Biomatrica, INC. Compositions and methods for biological sample storage
EP2435554B1 (en) * 2009-05-26 2017-07-26 Advanced Bionutrition Corporation Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making
TWI598347B (zh) 2009-07-13 2017-09-11 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
NZ604831A (en) 2010-07-02 2014-12-24 Gilead Sciences Inc Apoptosis signal-regulating kinase inhibitors
EP2598660B1 (en) * 2010-07-26 2017-03-15 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
WO2012018639A2 (en) * 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
US20120028933A1 (en) * 2010-07-28 2012-02-02 Baust John M Cell Culture Media Supplement and Method of Molecular Stress Control
US8664244B2 (en) 2010-09-12 2014-03-04 Advenchen Pharmaceuticals, LLC Compounds as c-Met kinase inhibitors
WO2012067240A1 (ja) * 2010-11-19 2012-05-24 セーレン株式会社 細胞のガラス化保存液

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872357B1 (en) * 2000-11-22 2005-03-29 Quadrant Drug Delivery Limited Formulation of preservation mixtures containing sensitive biologicals to be stabilized for ambient temperature storage by drying
CN1747971A (zh) * 2002-12-10 2006-03-15 诺瓦提斯公司 抗Nogo A的抗体(“11C7”)及其药物用途
CN101360822A (zh) * 2005-12-01 2009-02-04 生物马特里卡公司 用于生命科学的样品存储和样品管理的综合
CN102947082A (zh) * 2010-04-06 2013-02-27 金沃特公司 生物材料的稳定化的化学脱水

Also Published As

Publication number Publication date
WO2015002729A2 (en) 2015-01-08
US20160135446A1 (en) 2016-05-19
JP6604942B2 (ja) 2019-11-13
EP3632208A1 (en) 2020-04-08
EP3007556A2 (en) 2016-04-20
WO2015002729A3 (en) 2015-05-07
EP3007556B1 (en) 2020-05-20
EP3007556A4 (en) 2017-03-08
CN105491883A (zh) 2016-04-13
US20180184644A1 (en) 2018-07-05
JP2016522221A (ja) 2016-07-28
CA2915250A1 (en) 2015-01-08

Similar Documents

Publication Publication Date Title
CN105491883B (zh) 细胞稳定化
Driskill et al. Control of stem cell renewal and fate by YAP and TAZ
Ivey et al. Platelet-derived growth factor receptor-α is essential for cardiac fibroblast survival
Bailey et al. Synthetically scalable poly (ampholyte) which dramatically enhances cellular cryopreservation
Shaw LKB1 and AMP‐activated protein kinase control of mTOR signalling and growth
Yang et al. Molecular mechanism of size control in development and human diseases
CN111655258B (zh) 用于冷冻保存的组合物和其使用方法
TW201821610A (zh) 哺乳動物細胞凍結保存液
Fong et al. Mouse preimplantation embryo responses to culture medium osmolarity include increased expression of CCM2 and p38 MAPK activation
Choi et al. Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells
Armesto et al. Molecular characterization and transcriptional regulation of the renin–angiotensin system genes in Senegalese sole (Solea senegalensis Kaup, 1858): Differential gene regulation by salinity
Melo-Narvaez et al. Cold storage of human precision-cut lung slices in TiProtec preserves cellular composition and transcriptional responses and enables on-demand mechanistic studies
Drescher et al. How does hypothermia protect cardiomyocytes during cardioplegic ischemia?
Greenway et al. Discordant responses of mitogen-activated protein kinases to anoxia and freezing exposures in hatchling turtles
WO2020235206A1 (ja) 上皮細胞培養用培養容器及びその使用
Chen et al. Polyethylene glycol and caspase inhibitor emricasan alleviate cold injury in primary rat hepatocytes
Peter et al. Short-term in situ effects of prolactin and insulin on ion transport in liver and intestine of freshwater climbing perch (Anabas testudineus Bloch)
Morita et al. Microplate-Based Cryopreservation of Adherent-Cultured Human Cell Lines Using Amino Acids and Proteins
WO2020096995A1 (en) Compositions and methods for reducing cryopreservation toxicity
Al-Otaibi Novel cryo-protective agents to improve the quality of cryopreserved mammalian cells
Ashrafi Cryopreservation outcomes in cardiac cells: Correlating membrane integrity with functional performance
Rubeo Innovative strategies for cardioprotection in critical conditions: heart transplantation, sepsis, aging and cancer
Darmasaputra et al. Functional consequences of somatic polyploidy in development and disease
de Lima The role of mitochondria in the cell-to-cell interactions that regulate fitness during early mouse embryonic development
Park N-MYC Downstream Regulated Gene 1 (NDRG1): A Molecular Switch for Cellular Adaptation to Hypoxia

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20181102

Termination date: 20210613