JP2016521696A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016521696A5 JP2016521696A5 JP2016517144A JP2016517144A JP2016521696A5 JP 2016521696 A5 JP2016521696 A5 JP 2016521696A5 JP 2016517144 A JP2016517144 A JP 2016517144A JP 2016517144 A JP2016517144 A JP 2016517144A JP 2016521696 A5 JP2016521696 A5 JP 2016521696A5
- Authority
- JP
- Japan
- Prior art keywords
- ala
- pro
- lys
- seq
- arg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002537 thrombolytic effect Effects 0.000 description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- FYQSMXKJYTZYRP-UHFFFAOYSA-N 6-amino-2-[2-(pyrrolidine-2-carbonylamino)propanoylamino]hexanoic acid Chemical group NCCCCC(C(O)=O)NC(=O)C(C)NC(=O)C1CCCN1 FYQSMXKJYTZYRP-UHFFFAOYSA-N 0.000 description 2
- 108010038807 Oligopeptides Proteins 0.000 description 2
- 102000015636 Oligopeptides Human genes 0.000 description 2
- FYQSMXKJYTZYRP-DCAQKATOSA-N Pro-Ala-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1 FYQSMXKJYTZYRP-DCAQKATOSA-N 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- JOCMUACTOZLBLC-WOYTXXSLSA-N (2s)-6-amino-2-[[(2s)-2-[[(2s)-1-[(2s)-2-[[(2s)-2-aminopropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]hexanoic acid Chemical compound NC(N)=NCCC[C@H](NC(=O)[C@@H](N)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(O)=O JOCMUACTOZLBLC-WOYTXXSLSA-N 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 150000001875 compounds Chemical group 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 108010091735 fibrinogen peptide 6A Proteins 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 229960000103 thrombolytic agent Drugs 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310225330 | 2013-06-05 | ||
| CN201310225330.6 | 2013-06-05 | ||
| PCT/CN2014/079098 WO2014194809A1 (zh) | 2013-06-05 | 2014-06-03 | 具有溶栓、抗栓和自由基清除三重活性的新型化合物、其合成、纳米结构和应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016521696A JP2016521696A (ja) | 2016-07-25 |
| JP2016521696A5 true JP2016521696A5 (enExample) | 2017-02-09 |
| JP6510500B2 JP6510500B2 (ja) | 2019-05-08 |
Family
ID=52007559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016517144A Active JP6510500B2 (ja) | 2013-06-05 | 2014-06-03 | 血栓溶解、抗血栓及びフリーラジカル消去の３つの活性を有する新規の化合物、その合成、ナノ構造と応用 |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US9890193B2 (enExample) |
| EP (1) | EP3006454B1 (enExample) |
| JP (1) | JP6510500B2 (enExample) |
| KR (1) | KR102204781B1 (enExample) |
| CN (1) | CN104231046B (enExample) |
| AU (1) | AU2014277416B2 (enExample) |
| BR (1) | BR112015027164B1 (enExample) |
| CA (1) | CA2914004C (enExample) |
| CY (1) | CY1123976T1 (enExample) |
| DK (1) | DK3006454T3 (enExample) |
| ES (1) | ES2847934T3 (enExample) |
| HR (1) | HRP20210566T1 (enExample) |
| HU (1) | HUE053351T2 (enExample) |
| LT (1) | LT3006454T (enExample) |
| MX (1) | MX362902B (enExample) |
| PH (1) | PH12015502684B1 (enExample) |
| PL (1) | PL3006454T3 (enExample) |
| PT (1) | PT3006454T (enExample) |
| RS (1) | RS61606B1 (enExample) |
| RU (1) | RU2660901C2 (enExample) |
| SI (1) | SI3006454T1 (enExample) |
| SM (1) | SMT202100108T1 (enExample) |
| TW (1) | TWI633889B (enExample) |
| WO (1) | WO2014194809A1 (enExample) |
| ZA (1) | ZA201507237B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106608905B (zh) * | 2015-10-22 | 2020-10-16 | 彭莉 | 四氢异喹啉-3-甲酰-k(grpak)rgdv,其合成,活性及应用 |
| CN106608902A (zh) * | 2015-10-22 | 2017-05-03 | 彭莉 | 二羟基二甲基四氢异喹啉-3-甲酰-Lys(Lys),其合成,活性及应用 |
| JP6663774B2 (ja) | 2016-03-30 | 2020-03-13 | 東京エレクトロン株式会社 | 基板搬送方法及び基板処理システム |
| ES3017234T3 (en) * | 2019-09-25 | 2025-05-12 | Lumosa Therapeutics Co Ltd | Pharmaceutical composition comprising thrombolytic peptide-tetrahydroisoquinoline conjugate |
| KR20230041966A (ko) * | 2020-05-15 | 2023-03-27 | 신헬릭스 | 펩티드 스캐폴드, 이를 제조하기 위한 방법, 및 가용성 지지체로서의 이의 용도 |
| AU2022244890A1 (en) | 2021-03-22 | 2023-09-28 | Lumosa Therapeutics Co., Ltd. | Dc009 for treating acute ischemic stroke |
| CN115403653B (zh) * | 2022-05-19 | 2024-08-06 | 首都医科大学 | D(+)-β-(3,4-二羟基苯基)-乳酰-Pro-Ala-Lys,其合成及应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5222632B2 (enExample) * | 1972-08-22 | 1977-06-18 | ||
| JP2004523530A (ja) | 2001-01-23 | 2004-08-05 | イーライ・リリー・アンド・カンパニー | メラノコルチン受容体アゴニストとしてのピペラジンおよびピペリジン誘導体 |
| JP2005527492A (ja) | 2002-01-23 | 2005-09-15 | イーライ・リリー・アンド・カンパニー | メラノコルチン受容体アゴニスト |
| AU2003297773A1 (en) * | 2002-12-23 | 2004-07-29 | Janssen Pharmaceutica N.V. | Heteroaryl peptidomimetics as thrombin receptor antagonists |
| CN101190941B (zh) * | 2006-11-30 | 2010-12-01 | 首都医科大学 | 具有溶血栓活性的多肽、其制备方法及应用 |
| CN101190895B (zh) | 2006-11-30 | 2010-05-26 | 首都医科大学 | N-[(3s)-1,2,3,4-四氢异喹啉-3-甲酰基]氨基酸、其制备方法及应用 |
| CN101200493B (zh) | 2006-12-11 | 2011-11-09 | 首都医科大学 | （3s）-n-（l-氨基酰）-1，2，3，4-四氢异喹啉-3-羧酸、其制备方法及应用 |
| CN101497651B (zh) | 2008-01-30 | 2012-06-27 | 首都医科大学 | 具有溶血栓活性的化合物、其制备方法、其应用 |
| CN102241740B (zh) * | 2008-01-30 | 2014-02-19 | 首都医科大学 | 具有溶血栓活性的化合物、其制备方法、其应用 |
| CN101899084B (zh) | 2009-05-26 | 2012-09-05 | 首都医科大学 | (3s)-1,2,3,4-四氢异喹啉-3-羧酸三肽缀合物及其制备方法和应用 |
| CN102120727B (zh) | 2010-01-07 | 2013-08-28 | 首都医科大学 | N-[(3s)-n-氨基酰-1,2,3,4-四氢异喹啉-3-甲酰基]氨基酸及其合成方法和应用 |
| CN102127097A (zh) | 2010-01-15 | 2011-07-20 | 首都医科大学 | N-（3s-1,2,3,4-四氢异喹啉-3-甲酰基）氨基酸铜络合物及其制备方法和应用 |
| CN102477068B (zh) | 2010-11-30 | 2013-07-24 | 首都医科大学 | 用于制备溶血栓药物的氨基酸衍生物及其制备方法和应用 |
| HRP20170784T8 (hr) * | 2011-10-14 | 2018-05-18 | Bristol-Myers Squibb Company | Supstituirani spojevi tetrahidroizohinolina kao inhbitori xia faktora |
| CN103145797B (zh) | 2011-12-07 | 2015-05-20 | 首都医科大学 | [(3s)-1,2,3,4-四氢异喹啉-3-甲酰基]-Lys修饰的RGD四肽,其合成和在医学中的应用 |
| CN103450338B (zh) | 2012-05-29 | 2016-08-24 | 首都医科大学 | 杂环羧酸修饰的胸腺五肽，其制备，抗肿瘤作用和应用 |
| CN103450330B (zh) * | 2012-06-01 | 2016-05-25 | 首都医科大学 | 二羟基四氢异喹啉-3-甲酰氨基酸、其合成、抗血栓作用和应用 |
| CN105884905A (zh) * | 2012-09-05 | 2016-08-24 | 上海晟顺生物科技有限公司 | 同时具溶血栓、清除自由基和血栓靶向功能的新颖化合物及其制备方法和用途 |
| CN102887941A (zh) * | 2012-09-05 | 2013-01-23 | 永光制药有限公司 | Pak/咪唑啉/rgd三元缀合物及其制备方法和用途 |
-
2014
- 2014-06-03 CN CN201410242169.8A patent/CN104231046B/zh active Active
- 2014-06-03 JP JP2016517144A patent/JP6510500B2/ja active Active
- 2014-06-03 MX MX2015015924A patent/MX362902B/es active IP Right Grant
- 2014-06-03 AU AU2014277416A patent/AU2014277416B2/en active Active
- 2014-06-03 HU HUE14807973A patent/HUE053351T2/hu unknown
- 2014-06-03 PT PT148079734T patent/PT3006454T/pt unknown
- 2014-06-03 RS RS20210349A patent/RS61606B1/sr unknown
- 2014-06-03 DK DK14807973.4T patent/DK3006454T3/da active
- 2014-06-03 KR KR1020157035673A patent/KR102204781B1/ko active Active
- 2014-06-03 LT LTEP14807973.4T patent/LT3006454T/lt unknown
- 2014-06-03 HR HRP20210566TT patent/HRP20210566T1/hr unknown
- 2014-06-03 EP EP14807973.4A patent/EP3006454B1/en active Active
- 2014-06-03 PL PL14807973T patent/PL3006454T3/pl unknown
- 2014-06-03 WO PCT/CN2014/079098 patent/WO2014194809A1/zh not_active Ceased
- 2014-06-03 CA CA2914004A patent/CA2914004C/en active Active
- 2014-06-03 RU RU2015147247A patent/RU2660901C2/ru active
- 2014-06-03 SI SI201431789T patent/SI3006454T1/sl unknown
- 2014-06-03 BR BR112015027164-2A patent/BR112015027164B1/pt active IP Right Grant
- 2014-06-03 SM SM20210108T patent/SMT202100108T1/it unknown
- 2014-06-03 ES ES14807973T patent/ES2847934T3/es active Active
- 2014-06-04 TW TW103119375A patent/TWI633889B/zh active
-
2015
- 2015-09-30 ZA ZA201507237A patent/ZA201507237B/en unknown
- 2015-12-01 PH PH12015502684A patent/PH12015502684B1/en unknown
- 2015-12-02 US US14/956,723 patent/US9890193B2/en active Active
-
2018
- 2018-01-03 US US15/861,300 patent/US10351594B2/en active Active
-
2019
- 2019-07-09 US US16/506,674 patent/US20200055895A1/en not_active Abandoned
-
2021
- 2021-03-22 CY CY20211100244T patent/CY1123976T1/el unknown
- 2021-04-08 US US17/225,775 patent/US20210355163A1/en not_active Abandoned
-
2023
- 2023-03-09 US US18/181,494 patent/US20230312644A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016521696A5 (enExample) | ||
| CY1118442T1 (el) | Μεθοδοι αγωγης δια της χρησεως εκλεκτικων αναστολεων bcl-2 | |
| ECSP099601A (es) | Inhibidores de proteasa de serina | |
| UY33665A (es) | Derivado peptídico | |
| JP2016525888A5 (enExample) | ||
| JP2011527560A5 (enExample) | ||
| JP2010534684A5 (enExample) | ||
| JP2011168603A5 (enExample) | ||
| WO2014205317A3 (en) | Cyclic peptides as protein targeting agents | |
| ES2691091T3 (es) | Vacuna conjugada de péptido antigénico de WT1 | |
| JP2013539454A5 (enExample) | ||
| EA201490804A1 (ru) | Препараты этанерцепта, стабилизированные хлоридом натрия | |
| AR077629A1 (es) | Mimetico de smac | |
| MX356517B (es) | Polipéptidos de fusión de serpina y métodos de uso de los mismos. | |
| EA201390806A1 (ru) | Конструкция пептидного каркаса | |
| JP2019505521A5 (enExample) | ||
| MX386616B (es) | Compuestos de carfilzomib pegilados. | |
| EA201170703A1 (ru) | Производные адамантилбензамида | |
| WO2011157447A3 (en) | Modified parvovirus having enhanced anti-tumour efficacy | |
| JP2012529293A5 (enExample) | ||
| MX381224B (es) | Potentes moduladores de gamma-secretasa. | |
| Mitsuhashi et al. | The complete genome sequence of the Alphaentomopoxvirus Anomala cuprea entomopoxvirus, including its terminal hairpin loop sequences, suggests a potentially unique mode of apoptosis inhibition and mode of DNA replication | |
| RU2018101431A (ru) | Ингибиторы индоламин-2,3-диоксигеназы | |
| CU24609B1 (es) | Proteína de fusión que comprende una proteína de subunidad de ferritina monomérica unida a una proteína de dominio alfa 3 de mic | |
| DOP2012000078A (es) | Derivados de espirolactama y usos de los mismos |