|
US4017500A
(en)
|
1973-07-16 |
1977-04-12 |
Schering Corporation |
Certain 8-amino-1,7-naphthyridines
|
|
DE2908324A1
(de)
|
1979-03-03 |
1980-09-18 |
Hoechst Ag |
Triazolsubstituierte hydratopasaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als pflanzenschutzmittel
|
|
US4792562A
(en)
|
1985-12-04 |
1988-12-20 |
Hoechst-Roussel Pharmaceuticals, Inc. |
N-(pyrrol-1-yl)pyridinamines having memory enhancing activity
|
|
JPH0532662A
(ja)
|
1990-11-09 |
1993-02-09 |
Nissan Chem Ind Ltd |
置換ピラゾール誘導体および農園芸用殺菌剤
|
|
US5214038A
(en)
|
1991-04-15 |
1993-05-25 |
Hoechst-Roussel Pharmaceuticals Inc. |
1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
|
|
DE4120107A1
(de)
|
1991-06-14 |
1992-12-17 |
Schering Ag |
Bicyclisch substituierte vinylimidazole, -triazole und -tetrazole
|
|
TW343965B
(en)
|
1994-03-30 |
1998-11-01 |
Hoffmann La Roche |
Novel mono- and bicyclic DNA gyrase inhibitors
|
|
AU2381397A
(en)
|
1996-04-19 |
1997-11-12 |
Novo Nordisk A/S |
Modulators of molecules with phosphotyrosine recognition units
|
|
EP0887348A1
(en)
|
1997-06-25 |
1998-12-30 |
Boehringer Mannheim Italia S.p.A. |
Bis-Indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them
|
|
JP3712529B2
(ja)
|
1998-04-24 |
2005-11-02 |
大鵬薬品工業株式会社 |
３，３−ジピリジルアクリル酸アミド誘導体又はその薬学的に許容される塩
|
|
AU769864B2
(en)
|
1999-02-12 |
2004-02-05 |
Hoya Corporation |
Eyeglass and its manufacturing method
|
|
AU4692400A
(en)
|
1999-05-03 |
2000-11-17 |
Smithkline Beecham Corporation |
Cxcr-4 receptor antagonists - thrombopoietin mimetics
|
|
JP5278983B2
(ja)
|
1999-11-17 |
2013-09-04 |
塩野義製薬株式会社 |
アミド化合物の新規用途
|
|
GB9929988D0
(en)
|
1999-12-17 |
2000-02-09 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
EP1277738B1
(en)
|
2000-04-27 |
2011-03-30 |
Astellas Pharma Inc. |
Condensed heteroaryl derivatives
|
|
US6608053B2
(en)
|
2000-04-27 |
2003-08-19 |
Yamanouchi Pharmaceutical Co., Ltd. |
Fused heteroaryl derivatives
|
|
CA2414468A1
(en)
|
2000-06-30 |
2002-01-10 |
Sugen, Inc. |
4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
|
|
JP2004512336A
(ja)
*
|
2000-09-15 |
2004-04-22 |
アノーメッド インコーポレイティド |
ケモカインレセプター結合複素環式化合物
|
|
WO2002034748A1
(fr)
|
2000-10-24 |
2002-05-02 |
Sankyo Company, Limited |
Derives d'imidazopyridine
|
|
JP2002255964A
(ja)
|
2000-10-24 |
2002-09-11 |
Sankyo Co Ltd |
イミダゾピリジン誘導体
|
|
US6905669B2
(en)
|
2001-04-24 |
2005-06-14 |
Supergen, Inc. |
Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
|
|
US7429593B2
(en)
|
2001-09-14 |
2008-09-30 |
Shionogi & Co., Ltd. |
Utilities of amide compounds
|
|
ATE425152T1
(de)
*
|
2002-03-13 |
2009-03-15 |
Janssen Pharmaceutica Nv |
Aminocarbonylderivate als histone-deacetylase- inhibitoren
|
|
JP2003313126A
(ja)
|
2002-04-23 |
2003-11-06 |
Sankyo Co Ltd |
イミダゾピリジン誘導体を有効成分とする医薬
|
|
JP2004002826A
(ja)
|
2002-04-24 |
2004-01-08 |
Sankyo Co Ltd |
高分子イミダゾピリジン誘導体
|
|
JP4235726B2
(ja)
|
2002-11-19 |
2009-03-11 |
国立大学法人 奈良先端科学技術大学院大学 |
大きな二光子吸収特性を示すアセチレン結合により連結されたビス（イミダゾリルポルフィリン金属錯体）を構成単位とするポルフィリン連鎖体及びその製造方法
|
|
AU2003900608A0
(en)
|
2003-02-11 |
2003-02-27 |
Fujisawa Pharmaceutical Co., Ltd. |
Hdac inhibitor
|
|
CA2557541C
(en)
|
2004-02-26 |
2014-12-16 |
Aska Pharmaceutical Co., Ltd. |
Pyrimidine derivatives
|
|
AU2005250116B2
(en)
|
2004-06-01 |
2011-01-20 |
F. Hoffmann-La Roche Ag |
3-amino-1-arylpropyl indoles as monoamine reuptake inhibitor
|
|
JP2008515821A
(ja)
|
2004-10-06 |
2008-05-15 |
レセプトイコン・アンパルトセルスカブ |
薬物誘発性細胞毒性の予防のための化合物の使用
|
|
GB0423653D0
(en)
|
2004-10-25 |
2004-11-24 |
Piramed Ltd |
Pharmaceutical compounds
|
|
JP2008530136A
(ja)
*
|
2005-02-14 |
2008-08-07 |
ミイカナ セラピューティクス インコーポレイテッド |
ヒストンデアセチラーゼの阻害剤として有用な縮合複素環化合物
|
|
AU2006226861B2
(en)
|
2005-03-22 |
2012-08-16 |
Dana-Farber Cancer Institute, Inc. |
Treatment of protein degradation disorders
|
|
WO2006127587A1
(en)
|
2005-05-20 |
2006-11-30 |
Vertex Pharmaceuticals Incorporated |
Pyrrolopyridines useful as inhibitors of protein kinase
|
|
TW200716545A
(en)
|
2005-06-10 |
2007-05-01 |
Sigma Tau Ind Farmaceuti |
Indole derivatives having anti-tumor activity
|
|
WO2007050348A2
(en)
|
2005-10-21 |
2007-05-03 |
Merck & Co., Inc. |
Potassium channel inhibitors
|
|
JP2009523812A
(ja)
|
2006-01-19 |
2009-06-25 |
オーエスアイ・ファーマスーティカルズ・インコーポレーテッド |
融合へテロ二環式キナーゼ阻害剤
|
|
WO2007085540A1
(en)
|
2006-01-27 |
2007-08-02 |
Glaxo Group Limited |
1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives
|
|
EP2046799B1
(en)
|
2006-04-26 |
2017-07-19 |
Genentech, Inc. |
Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them
|
|
BRPI0710866A2
(pt)
|
2006-04-26 |
2012-08-14 |
Hoffmann La Roche |
compostos farmacÊuticos
|
|
JPWO2008007780A1
(ja)
|
2006-07-13 |
2009-12-10 |
協和発酵キリン株式会社 |
ペンタジエナミド誘導体
|
|
AU2007296743B2
(en)
|
2006-09-11 |
2012-02-16 |
Curis, Inc. |
Tyrosine kinase inhibitors containing a zinc binding moiety
|
|
CN101573333B
(zh)
*
|
2006-10-28 |
2013-06-12 |
梅特希尔基因公司 |
组蛋白脱乙酰酶抑制剂
|
|
CA2670223A1
(en)
|
2006-11-22 |
2008-05-29 |
Karus Therapeutics Limited |
Depsipeptides and their therapeutic use
|
|
MX2009008253A
(es)
|
2007-01-31 |
2009-10-12 |
Vertex Pharma |
Derivados de 2-aminopiridina utiles como inhibidores de cinasa.
|
|
CN101663276A
(zh)
|
2007-01-31 |
2010-03-03 |
沃泰克斯药物股份有限公司 |
用作激酶抑制剂的2-氨基吡啶衍生物
|
|
JP5746860B2
(ja)
|
2007-04-09 |
2015-07-08 |
メチルジーン インコーポレイテッド |
ヒストンデアセチラーゼ阻害剤
|
|
WO2008139987A1
(ja)
|
2007-04-26 |
2008-11-20 |
Japan Science And Technology Agency |
Ｇタンパク質共役型レセプタ－作動剤
|
|
WO2008137270A1
(en)
|
2007-05-04 |
2008-11-13 |
H. Lundbeck A/S |
Methods of diagnosing and monitoring of npy y5 based disorders
|
|
WO2008150827A1
(en)
|
2007-05-29 |
2008-12-11 |
Smithkline Beecham Corporation |
Naphthyridine, derivatives as p13 kinase inhibitors
|
|
GB0710528D0
(en)
|
2007-06-01 |
2007-07-11 |
Glaxo Group Ltd |
Novel compounds
|
|
WO2009063240A1
(en)
|
2007-11-16 |
2009-05-22 |
Arrow Therapeutics Limited |
2,4-diaminopyrimidine derivatives useful as inhibitors of aurora kinase
|
|
US20110288070A1
(en)
*
|
2008-05-05 |
2011-11-24 |
ROGERS Kathryn |
Methods for treating cognitive disorders using inhibitors of histone deacetylase
|
|
EP2324022A1
(de)
|
2008-08-05 |
2011-05-25 |
Boehringer Ingelheim International GmbH |
Substituierte naphthyridine und ihre verwendung als arzneimittel
|
|
AU2009299894A1
(en)
|
2008-10-03 |
2010-04-08 |
Merck Serono S.A. |
4 -morpholino-pyrido [3, 2 -d] pyrimidines active on Pi3k
|
|
GB2465405A
(en)
|
2008-11-10 |
2010-05-19 |
Univ Basel |
Triazine, pyrimidine and pyridine analogues and their use in therapy
|
|
JP5597649B2
(ja)
*
|
2009-01-28 |
2014-10-01 |
カルス セラピューティクス リミテッド |
スクリプタイドアイソスター（ｓｃｒｉｐｔａｉｄｉｓｏｓｔｅｒｅｓ）およびその治療における使用
|
|
CA2768466C
(en)
*
|
2009-07-22 |
2018-08-14 |
The Board Of Trustees Of The University Of Illinois |
Hdac inhibitors and therapeutic methods using the same
|
|
IN2012DN01325A
(cg-RX-API-DMAC7.html)
|
2009-08-20 |
2015-06-05 |
Karus Therapeutics Ltd |
|
|
GB201007347D0
(en)
|
2010-04-30 |
2010-06-16 |
Karus Therapeutics Ltd |
Compounds
|
|
EP2624832B1
(en)
|
2010-10-08 |
2017-09-27 |
Vib Vzw |
Hdac inhibitors to treat charcot-marie-tooth disease
|
|
JP5775171B2
(ja)
|
2010-12-16 |
2015-09-09 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
三環系ｐｉ３ｋ阻害剤化合物及びその使用方法
|
|
EP2670733B1
(en)
|
2011-02-01 |
2019-04-10 |
The Board of Trustees of the University of Illionis |
N-hydroxybenzamide derivatives as hdac inhibitors and therapeutic methods using the same
|
|
EP2508510A1
(en)
|
2011-04-06 |
2012-10-10 |
Ikerchem, S.L. |
Hydroxyphenyl pyrrole compounds containing an hydroxamic acid as hdac inhibitors and medicinal applications thereof
|
|
US9512083B2
(en)
|
2011-07-20 |
2016-12-06 |
The General Hospital Corporation |
Histone deacetylase 6 selective inhibitors for the treatment of bone disease
|
|
AU2012319188B2
(en)
|
2011-10-03 |
2016-11-24 |
Sloan-Kettering Institute For Cancer Research |
Novel molecules that selectively inhibit histone deacetylase 6 relative to histone deacetylase 1
|
|
BR112014007963A2
(pt)
|
2011-10-04 |
2013-04-11 |
Inst For Hepatitis And Virus Res |
aminotiazoles substituídos como inibidores de cãncer, incluindo carcinoma hepatocelular, e como inibidores da replicação do vírus da hepatite
|
|
KR20130047623A
(ko)
*
|
2011-10-28 |
2013-05-08 |
주식회사종근당 |
신규한 선택적인 히스톤탈아세틸화 효소 억제제로서의 하이드록사메이트 유도체 및 이를 포함하는 약제학적 조성물
|
|
AU2012354094C1
(en)
|
2011-12-15 |
2015-10-15 |
Novartis Ag |
Use of inhibitors of the activity or function of PI3K
|
|
KR101415742B1
(ko)
|
2011-12-21 |
2014-07-04 |
영남대학교 산학협력단 |
6―아미노피리딘―3―올 유도체 또는 이의 약제학적 허용가능한 염 및 이를 유효성분으로 함유하는 혈관신생으로 인한 질환의 예방 또는 치료용 약학조성물
|
|
GB201204125D0
(en)
|
2012-03-08 |
2012-04-25 |
Karus Therapeutics Ltd |
Compounds
|
|
US9695108B2
(en)
|
2012-08-23 |
2017-07-04 |
Georgetown University |
Compounds and methods of use thereof for treating tumors
|
|
NZ707366A
(en)
|
2012-11-07 |
2018-11-30 |
Karus Therapeutics Ltd |
Novel histone deacetylase inhibitors and their use in therapy
|
|
KR20150079745A
(ko)
|
2012-11-08 |
2015-07-08 |
리젠 파마슈티컬스 소시에떼 아노님 |
Pde4 억제제 및 pi3 델타 또는 이중 pi3 델타-감마 키나아제 억제제를 함유하는 약제학적 조성물
|
|
US9169214B2
(en)
|
2012-12-21 |
2015-10-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
|
|
EP2971181B1
(en)
*
|
2013-03-13 |
2019-02-20 |
The University of North Carolina At Chapel Hill |
Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis
|
|
WO2014139145A1
(en)
|
2013-03-15 |
2014-09-18 |
Hutchison Medipharma Limited |
Novel pyrimidine and pyridine compounds and usage thereof
|
|
WO2014153280A1
(en)
|
2013-03-22 |
2014-09-25 |
Merck Sharp & Dohme Corp. |
2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
|
|
NZ714283A
(en)
|
2013-05-10 |
2020-04-24 |
Karus Therapeutics Ltd |
Novel histone deacetylase inhibitors
|
|
JP6584391B2
(ja)
|
2013-10-10 |
2019-10-02 |
アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． |
非ホジキンリンパ腫を治療するための、ｈｄａｃ阻害剤単独またはｐｉ３ｋ阻害剤との組み合わせ
|
|
GB201402431D0
(en)
|
2014-02-12 |
2014-03-26 |
Karus Therapeutics Ltd |
Compounds
|
|
EP3187497A4
(en)
|
2014-08-26 |
2018-02-07 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound
|
|
GB201419228D0
(en)
|
2014-10-29 |
2014-12-10 |
Karus Therapeutics Ltd |
Compounds
|
|
GB201419264D0
(en)
|
2014-10-29 |
2014-12-10 |
Karus Therapeutics Ltd |
Compounds
|
|
GB201514756D0
(en)
|
2015-08-19 |
2015-09-30 |
Karus Therapeutics Ltd |
Compound and method of use
|
|
GB201609786D0
(en)
|
2016-06-03 |
2016-07-20 |
Karus Therapeutics Ltd |
Compounds and method of use
|
|
WO2017222952A1
(en)
|
2016-06-23 |
2017-12-28 |
Merck Sharp & Dohme Corp. |
3- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors
|
|
US11066396B2
(en)
|
2016-06-23 |
2021-07-20 |
Merck Sharp & Dohme Corp. |
3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors
|
|
WO2017222950A1
(en)
|
2016-06-23 |
2017-12-28 |
Merck Sharp & Dohme Corp. |
3-heterocyclyl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors
|
|
GB201803361D0
(en)
|
2018-03-01 |
2018-04-18 |
Karus Therapeutics Ltd |
Histone deacetylase inhibitors
|