|
DE10347710B4
(de)
|
2003-10-14 |
2006-03-30 |
Johannes-Gutenberg-Universität Mainz |
Rekombinante Impfstoffe und deren Verwendung
|
|
DE102005046490A1
(de)
|
2005-09-28 |
2007-03-29 |
Johannes-Gutenberg-Universität Mainz |
Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
|
|
PL3892295T3
(pl)
|
2011-05-24 |
2023-07-24 |
BioNTech SE |
Zindywidualizowane szczepionki przeciwnowotworowe
|
|
WO2013143555A1
(en)
|
2012-03-26 |
2013-10-03 |
Biontech Ag |
Rna formulation for immunotherapy
|
|
EP3417874B1
(en)
|
2012-11-28 |
2024-09-11 |
BioNTech SE |
Individualized vaccines for cancer
|
|
EP2983702A2
(en)
*
|
2013-04-07 |
2016-02-17 |
The Broad Institute, Inc. |
Compositions and methods for personalized neoplasia vaccines
|
|
WO2014180490A1
(en)
|
2013-05-10 |
2014-11-13 |
Biontech Ag |
Predicting immunogenicity of t cell epitopes
|
|
WO2015077717A1
(en)
|
2013-11-25 |
2015-05-28 |
The Broad Institute Inc. |
Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
|
|
WO2015085147A1
(en)
*
|
2013-12-05 |
2015-06-11 |
The Broad Institute Inc. |
Polymorphic gene typing and somatic change detection using sequencing data
|
|
US20160310584A1
(en)
*
|
2013-12-06 |
2016-10-27 |
The Broad Institute Inc. |
Formulations for neoplasia vaccines
|
|
KR20230076867A
(ko)
|
2013-12-20 |
2023-05-31 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신생항원 백신과의 병용 요법
|
|
CN113791220A
(zh)
|
2014-09-10 |
2021-12-14 |
豪夫迈·罗氏有限公司 |
免疫原性突变体肽筛选平台
|
|
WO2016045732A1
(en)
|
2014-09-25 |
2016-03-31 |
Biontech Rna Pharmaceuticals Gmbh |
Stable formulations of lipids and liposomes
|
|
EP3234130B1
(en)
*
|
2014-12-19 |
2020-11-25 |
The Broad Institute, Inc. |
Methods for profiling the t-cell- receptor repertoire
|
|
US10975442B2
(en)
|
2014-12-19 |
2021-04-13 |
Massachusetts Institute Of Technology |
Molecular biomarkers for cancer immunotherapy
|
|
US10307491B2
(en)
|
2015-01-30 |
2019-06-04 |
The Regents Of The University Of Michigan |
Liposomal particles comprising biological molecules and uses thereof
|
|
WO2016128060A1
(en)
*
|
2015-02-12 |
2016-08-18 |
Biontech Ag |
Predicting t cell epitopes useful for vaccination
|
|
US11254914B2
(en)
|
2015-03-12 |
2022-02-22 |
Health Research, Inc. |
Enrichment of CD16+ monocytes to improve dendritic cell vaccine quality
|
|
JP2018516847A
(ja)
*
|
2015-03-25 |
2018-06-28 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
生体高分子薬を送達するための組成物及び方法
|
|
EP3075389A1
(en)
*
|
2015-03-31 |
2016-10-05 |
Technische Universität München |
T cell receptors and peptides derived by mutations for the treatment of cancer
|
|
US20190099475A1
(en)
|
2015-04-08 |
2019-04-04 |
Nantomics, Llc |
Cancer neoepitopes
|
|
BR112017022845A2
(pt)
|
2015-04-23 |
2018-07-17 |
Nantomics, Llc |
neoepítopos de câncer
|
|
CN117467603A
(zh)
*
|
2015-04-27 |
2024-01-30 |
癌症研究技术有限公司 |
治疗癌症的方法
|
|
WO2016179006A1
(en)
*
|
2015-05-01 |
2016-11-10 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Methods of isolating t cells and t cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood
|
|
EA201792501A1
(ru)
|
2015-05-13 |
2018-10-31 |
Эйдженус Инк. |
Вакцины для лечения и профилактики рака
|
|
IL294183B2
(en)
*
|
2015-05-20 |
2023-10-01 |
Dana Farber Cancer Inst Inc |
shared neoantigens
|
|
TW202241500A
(zh)
*
|
2015-06-09 |
2022-11-01 |
美商博德研究所有限公司 |
用於贅瘤疫苗之調配物及其製備方法
|
|
MA42543A
(fr)
|
2015-07-30 |
2018-06-06 |
Modernatx Inc |
Arn épitope peptidiques concatémériques
|
|
GB201516047D0
(en)
|
2015-09-10 |
2015-10-28 |
Cancer Rec Tech Ltd |
Method
|
|
WO2017059902A1
(en)
|
2015-10-07 |
2017-04-13 |
Biontech Rna Pharmaceuticals Gmbh |
3' utr sequences for stabilization of rna
|
|
CN108700592B
(zh)
|
2015-10-12 |
2021-08-24 |
南托米克斯有限责任公司 |
新表位的迭代发现及其适应性免疫疗法和方法
|
|
MX2018004544A
(es)
*
|
2015-10-12 |
2018-11-09 |
Nantomics Llc |
Composiciones y métodos para los neoepítopos de cáncer viral.
|
|
CA3003251A1
(en)
|
2015-10-12 |
2017-04-20 |
Nantomics, Llc |
Systems, compositions, and methods for discovery of msi and neoepitopes that predict sensitivity to checkpoint inhibitors
|
|
EP3362929B1
(en)
*
|
2015-10-12 |
2020-08-12 |
Nantomics, LLC |
Viral neoepitopes and uses thereof
|
|
AU2016341309A1
(en)
|
2015-10-22 |
2018-06-07 |
Modernatx, Inc. |
Cancer vaccines
|
|
TWI733719B
(zh)
|
2015-12-07 |
2021-07-21 |
美商河谷控股Ip有限責任公司 |
改善的組合物及用於新表位之病毒遞送的方法及其應用
|
|
ES2970865T3
(es)
|
2015-12-16 |
2024-05-31 |
Gritstone Bio Inc |
Identificación, fabricación y uso de neoantígenos
|
|
IL260030B2
(en)
|
2016-01-08 |
2025-12-01 |
Nykode Therapeutics ASA |
Therapeutic anticancer neoepitope vaccine
|
|
US20170224796A1
(en)
|
2016-02-05 |
2017-08-10 |
Xeme Biopharma Inc. |
Therapeutic Cancer Vaccine Containing Tumor-Associated Neoantigens and Immunostimulants in a Delivery System
|
|
WO2017139725A1
(en)
*
|
2016-02-11 |
2017-08-17 |
Nant Holdings Ip, Llc |
Subcutaneous delivery of adenovirus with dual targeting
|
|
WO2017139694A1
(en)
*
|
2016-02-12 |
2017-08-17 |
Nantomics, Llc |
High-throughput identification of patient-specific neoepitopes as therapeutic targets for cancer immunotherapies
|
|
KR20180117227A
(ko)
|
2016-03-24 |
2018-10-26 |
난트셀, 인크. |
네오에피토프 제시를 위한 시퀀스들 및 시퀀스 배열들
|
|
AU2017254477A1
(en)
*
|
2016-04-18 |
2018-11-01 |
Jennifer G. ABELIN |
Improved HLA epitope prediction
|
|
EP3452082A1
(en)
|
2016-05-04 |
2019-03-13 |
Fred Hutchinson Cancer Research Center |
Cell-based neoantigen vaccines and uses thereof
|
|
SG11201811442UA
(en)
|
2016-06-20 |
2019-01-30 |
Isa Pharmaceuticals B V |
Formulation of a peptide vaccine
|
|
US12257352B2
(en)
|
2016-06-20 |
2025-03-25 |
The Regents Of The University Of Michigan |
Compositions and methods for delivery of biomacromolecule agents
|
|
SG11201900132QA
(en)
*
|
2016-07-20 |
2019-02-27 |
Biontech Rna Pharmaceuticals Gmbh |
Selecting neoepitopes as disease-specific targets for therapy with enhanced efficacy
|
|
US10350280B2
(en)
|
2016-08-31 |
2019-07-16 |
Medgenome Inc. |
Methods to analyze genetic alterations in cancer to identify therapeutic peptide vaccines and kits therefore
|
|
EP3535423B1
(en)
|
2016-11-07 |
2022-01-05 |
The United States of America, as represented by the Secretary, Department of Health and Human Services |
Methods for selecting therapy for a cancer patient
|
|
JP2020500552A
(ja)
*
|
2016-11-23 |
2020-01-16 |
グリットストーン オンコロジー インコーポレイテッド |
新生抗原のウイルスによる送達方法
|
|
WO2018102613A2
(en)
|
2016-12-01 |
2018-06-07 |
Nantomics, Llc |
Tumor antigenicity processing and presentation
|
|
US11549149B2
(en)
|
2017-01-24 |
2023-01-10 |
The Broad Institute, Inc. |
Compositions and methods for detecting a mutant variant of a polynucleotide
|
|
JP7155470B2
(ja)
*
|
2017-03-31 |
2022-10-19 |
エーシーティー ジェノミックス (アイピー) カンパニー リミテッド |
免疫原性がん特異的エピトープのためのランク付けシステム
|
|
WO2018183544A1
(en)
*
|
2017-03-31 |
2018-10-04 |
Dana-Farber Cancer Institute, Inc. |
Method for identification of retained intron tumor neoantigens from patient transcriptome
|
|
CA3060569A1
(en)
*
|
2017-04-19 |
2018-10-25 |
Gritstone Oncology, Inc. |
Neoantigen identification, manufacture, and use
|
|
US11779637B2
(en)
*
|
2017-04-24 |
2023-10-10 |
Nantcell, Inc. |
Targeted neoepitope vectors and methods therefor
|
|
EP3634449A4
(en)
|
2017-05-08 |
2021-03-17 |
Gritstone Oncology, Inc. |
ALPHAVIRUS NEOANTIGEN VECTORS
|
|
EP3622092A4
(en)
|
2017-05-11 |
2021-06-23 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS OF USE OF CD8 + TUMOR-INFILTRATING LYMPHOCYTE SUBTYPES AND GENE SIGNATURES THEREOF
|
|
JP2020522479A
(ja)
|
2017-06-02 |
2020-07-30 |
アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ |
個別化された癌ワクチンを作製する方法
|
|
WO2018224166A1
(en)
|
2017-06-09 |
2018-12-13 |
Biontech Rna Pharmaceuticals Gmbh |
Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy
|
|
AU2018279627B2
(en)
*
|
2017-06-09 |
2023-08-10 |
Seattle Project Corp. |
Neoantigen identification, manufacture, and use
|
|
MA49421A
(fr)
|
2017-06-15 |
2020-04-22 |
Modernatx Inc |
Formulations d'arn
|
|
WO2018234506A2
(en)
*
|
2017-06-21 |
2018-12-27 |
Transgene Sa |
PERSONALIZED VACCINE
|
|
EP3642331B1
(en)
*
|
2017-06-22 |
2023-05-24 |
NEOGAP Therapeutics AB |
T-cell expansion method and uses
|
|
US12049643B2
(en)
|
2017-07-14 |
2024-07-30 |
The Broad Institute, Inc. |
Methods and compositions for modulating cytotoxic lymphocyte activity
|
|
EP3675817A1
(en)
|
2017-08-31 |
2020-07-08 |
Modernatx, Inc. |
Methods of making lipid nanoparticles
|
|
US20200363414A1
(en)
*
|
2017-09-05 |
2020-11-19 |
Gritstone Oncology, Inc. |
Neoantigen Identification for T-Cell Therapy
|
|
US12025615B2
(en)
|
2017-09-15 |
2024-07-02 |
Arizona Board Of Regents On Behalf Of Arizona State University |
Methods of classifying response to immunotherapy for cancer
|
|
EP3688165A4
(en)
*
|
2017-09-25 |
2021-09-29 |
Nant Holdings IP, LLC |
VALIDATION OF THE PRESENTATION OF NEOEPITOPES
|
|
EP4576103A3
(en)
|
2017-10-10 |
2025-08-27 |
Gritstone bio, Inc. |
Neoantigen identification using hotspots
|
|
JP2021502419A
(ja)
*
|
2017-11-07 |
2021-01-28 |
コイミューン インコーポレイテッド |
樹状細胞治療のための方法および使用
|
|
CN111630602A
(zh)
|
2017-11-22 |
2020-09-04 |
磨石肿瘤生物技术公司 |
减少新抗原的接合表位呈递
|
|
US20200368336A1
(en)
*
|
2017-12-01 |
2020-11-26 |
Shanghai Jenomed Biotech Co., Ltd. |
Method for preparing personalized cancer vaccine
|
|
WO2019122050A1
(en)
|
2017-12-22 |
2019-06-27 |
Isa Pharmaceuticals B.V. |
Methods of immunization
|
|
CN108491689B
(zh)
*
|
2018-02-01 |
2019-07-09 |
杭州纽安津生物科技有限公司 |
基于转录组的肿瘤新抗原鉴定方法
|
|
MA52363A
(fr)
|
2018-04-26 |
2021-03-03 |
Agenus Inc |
Compositions peptidiques de liaison à une protéine de choc thermique (hsp) et leurs méthodes d'utilisation
|
|
WO2019227106A1
(en)
|
2018-05-25 |
2019-11-28 |
The Wistar Institute |
Tumor-specific neoantigens and methods of using the same
|
|
WO2019241315A1
(en)
|
2018-06-12 |
2019-12-19 |
Obsidian Therapeutics, Inc. |
Pde5 derived regulatory constructs and methods of use in immunotherapy
|
|
AU2019293244B2
(en)
*
|
2018-06-27 |
2026-04-02 |
Modernatx, Inc. |
Personalized cancer vaccine epitope selection
|
|
WO2020020444A1
(en)
*
|
2018-07-24 |
2020-01-30 |
Biontech Rna Pharmaceuticals Gmbh |
Individualized vaccines for cancer
|
|
CA3106564A1
(en)
|
2018-07-26 |
2020-01-30 |
Frame Pharmaceuticals B.V. |
Cancer vaccines for breast cancer
|
|
US20220349010A1
(en)
|
2018-07-26 |
2022-11-03 |
Frame Pharmaceuticals B.V. |
Method of preparing subject-specific immunogenic compositions based on a neo open-reading-frame peptide database
|
|
JP7642530B2
(ja)
*
|
2018-09-04 |
2025-03-10 |
トレオス バイオ リミテッド |
ペプチドワクチン
|
|
JP7598315B2
(ja)
*
|
2018-09-05 |
2024-12-11 |
エンエーセー オンコイミュニティ アクスイェ セルスカプ |
併用療法用dnaワクチンを標的とするネオアンチゲン
|
|
WO2020061457A1
(en)
|
2018-09-20 |
2020-03-26 |
Modernatx, Inc. |
Preparation of lipid nanoparticles and methods of administration thereof
|
|
MX2021003654A
(es)
|
2018-09-27 |
2021-05-28 |
Nykode Therapeutics AS |
Metodo para seleccionar neoepitopes.
|
|
CN109337873A
(zh)
*
|
2018-09-30 |
2019-02-15 |
北京鼎成肽源生物技术有限公司 |
一种lrff细胞
|
|
MA54192A
(fr)
*
|
2018-11-07 |
2021-09-15 |
Modernatx Inc |
Vaccins à arn contre le cancer
|
|
US20220062394A1
(en)
|
2018-12-17 |
2022-03-03 |
The Broad Institute, Inc. |
Methods for identifying neoantigens
|
|
GB201821207D0
(en)
|
2018-12-24 |
2019-02-06 |
Tcer Ab |
Immunotherapy therapy
|
|
EP3930755A4
(en)
*
|
2019-03-01 |
2023-03-22 |
Flow Pharma Inc. |
DESIGN, MANUFACTURE AND USE OF PERSONALIZED CANCER VACCINES
|
|
WO2020185411A1
(en)
*
|
2019-03-08 |
2020-09-17 |
Nantomics, Llc |
System and method for variant calling
|
|
CN110059625B
(zh)
*
|
2019-04-18 |
2023-04-07 |
重庆大学 |
一种基于mixup的人脸训练与识别方法
|
|
EP3963335B1
(en)
*
|
2019-05-03 |
2024-08-21 |
Epivax Therapeutics, Inc. |
Neoantigens in cancer
|
|
MX2021014525A
(es)
|
2019-05-30 |
2022-03-17 |
Gritstone Bio Inc |
Adenovirus modificados.
|
|
WO2020252145A1
(en)
*
|
2019-06-11 |
2020-12-17 |
Iogenetics, Llc |
Neoantigen immunotherapies
|
|
KR20220056847A
(ko)
*
|
2019-06-21 |
2022-05-06 |
커날 바이오로직스, 인크. |
조작된 종양선택적 단백질 발현
|
|
CN110514845B
(zh)
*
|
2019-08-22 |
2022-09-27 |
深圳新合睿恩生物医疗科技有限公司 |
一种肿瘤新生抗原免疫原性检测方法及检测平台
|
|
CN116688107A
(zh)
*
|
2019-09-06 |
2023-09-05 |
北京微九九科技有限公司 |
一种肿瘤疫苗的制备方法及使用该方法制备的肿瘤疫苗
|
|
WO2021067550A1
(en)
|
2019-10-02 |
2021-04-08 |
Arizona Board Of Regents On Behalf Of Arizona State University |
Methods and compositions for identifying neoantigens for use in treating and preventing cancer
|
|
WO2021092436A1
(en)
*
|
2019-11-08 |
2021-05-14 |
The Regents Of The University Of California |
Identification of splicing-derived antigens for treating cancer
|
|
JP7496111B2
(ja)
*
|
2019-12-24 |
2024-06-06 |
国立大学法人東京工業大学 |
サブキャリア変調方式テラヘルツレーダー
|
|
US11011253B1
(en)
*
|
2020-07-09 |
2021-05-18 |
Brian Hie |
Escape profiling for therapeutic and vaccine development
|
|
CN116438308A
(zh)
|
2020-08-06 |
2023-07-14 |
磨石生物公司 |
多表位疫苗盒
|
|
US11058751B1
(en)
|
2020-11-20 |
2021-07-13 |
Think Therapeutics, Inc. |
Compositions for optimized RAS peptide vaccines
|
|
CN116710115A
(zh)
|
2020-11-20 |
2023-09-05 |
思维疗法股份有限公司 |
用于优化的肽疫苗的组合物和方法
|
|
US11421015B2
(en)
|
2020-12-07 |
2022-08-23 |
Think Therapeutics, Inc. |
Method of compact peptide vaccines using residue optimization
|
|
WO2022125511A1
(en)
*
|
2020-12-07 |
2022-06-16 |
Iogenetics, Llc |
Administration of anti-tumor vaccines
|
|
US20240229143A1
(en)
*
|
2020-12-07 |
2024-07-11 |
Iogenetics, Llc |
Formulation of peptide immunotherapies
|
|
GB202104715D0
(en)
|
2021-04-01 |
2021-05-19 |
Achilles Therapeutics Uk Ltd |
Identification of clonal neoantigens and uses thereof
|
|
US11464842B1
(en)
|
2021-04-28 |
2022-10-11 |
Think Therapeutics, Inc. |
Compositions and method for optimized peptide vaccines using residue optimization
|
|
CN113069537A
(zh)
*
|
2021-04-29 |
2021-07-06 |
江苏欣生元生物科技有限公司 |
一种基于ras变异新生抗原表位的融合蛋白纳米疫苗及其制备方法
|
|
JP2024517793A
(ja)
|
2021-04-30 |
2024-04-23 |
ティゲン・ファーマ・ソシエテ・アノニム |
単一容器リンパ球拡大
|
|
CN112972666B
(zh)
*
|
2021-05-12 |
2021-08-31 |
山东兴瑞生物科技有限公司 |
个性化基因修饰肿瘤dc疫苗的制备方法
|
|
US12537072B1
(en)
|
2021-05-27 |
2026-01-27 |
Amazon Technologies, Inc. |
Immunogenic response prediction based on major histocompatibility complex (MHC) data
|
|
US20220383996A1
(en)
*
|
2021-05-27 |
2022-12-01 |
Amazon Technologies, Inc. |
Assigning peptides to peptide groups for vaccine development
|
|
US20230132140A1
(en)
*
|
2021-09-15 |
2023-04-27 |
Celloram Inc. |
Method of treating cancer
|
|
TW202340474A
(zh)
|
2022-01-11 |
2023-10-16 |
大陸商深圳市珈鈺生物科技有限公司 |
樹突細胞腫瘤疫苗和其用途
|
|
EP4522728A1
(en)
*
|
2022-05-11 |
2025-03-19 |
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud - Centro De Investigação Da Fundação Champalimaud |
Method of preparing and expanding a population of immune cells for cancer therapy, potency assay for tumor recognition, biological vaccine preparation and epitope target for antibodies
|
|
WO2024077256A1
(en)
|
2022-10-07 |
2024-04-11 |
The General Hospital Corporation |
Methods and compositions for high-throughput discovery ofpeptide-mhc targeting binding proteins
|
|
WO2024097864A1
(en)
|
2022-11-02 |
2024-05-10 |
Tigen Pharma Sa |
Expansion of lymphocytes
|
|
US12531162B1
(en)
*
|
2023-05-31 |
2026-01-20 |
Northeastern University |
Multi-dimensional phenotypic space for genotype to phenotype mapping and intelligent design of cancer drug therapies using a deep learning net
|
|
WO2024261339A1
(en)
|
2023-06-23 |
2024-12-26 |
Tigen Pharma Sa |
Lymphocyte-stimulatory matrix (lsm) and uses thereof for expansion of lymphocyte populations
|
|
US12562256B2
(en)
*
|
2023-11-07 |
2026-02-24 |
New York University |
Systems, methods and computer-accessible medium for identifying target pairs for CAR-T therapy
|
|
WO2025202937A1
(en)
|
2024-03-26 |
2025-10-02 |
BioNTech SE |
Cancer vaccines
|
|
CN120600110B
(zh)
*
|
2025-08-06 |
2025-12-09 |
上海交通大学医学院附属仁济医院 |
基于人工智能的多变病原t细胞表位精准筛选方法
|