JP2015533841A5 - - Google Patents
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- JP2015533841A5 JP2015533841A5 JP2015538330A JP2015538330A JP2015533841A5 JP 2015533841 A5 JP2015533841 A5 JP 2015533841A5 JP 2015538330 A JP2015538330 A JP 2015538330A JP 2015538330 A JP2015538330 A JP 2015538330A JP 2015533841 A5 JP2015533841 A5 JP 2015533841A5
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- JP
- Japan
- Prior art keywords
- seq
- mva
- identity
- promoter comprises
- copy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000002773 nucleotide Substances 0.000 claims description 54
- 125000003729 nucleotide group Chemical group 0.000 claims description 54
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 14
- 150000007523 nucleic acids Chemical group 0.000 claims description 14
- 239000000427 antigen Substances 0.000 claims description 11
- 102000036639 antigens Human genes 0.000 claims description 11
- 108091007433 antigens Proteins 0.000 claims description 11
- 206010046865 Vaccinia virus infection Diseases 0.000 claims description 8
- 241000700605 Viruses Species 0.000 claims description 8
- 208000007089 vaccinia Diseases 0.000 claims description 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 241000282412 Homo Species 0.000 claims description 2
- 230000005867 T cell response Effects 0.000 claims description 2
- 230000006698 induction Effects 0.000 claims 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261719429P | 2012-10-28 | 2012-10-28 | |
| US61/719,429 | 2012-10-28 | ||
| PCT/EP2013/003239 WO2014063832A1 (en) | 2012-10-28 | 2013-10-28 | Pr13.5 promoter for robust t-cell and antibody responses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019054129A Division JP6818797B2 (ja) | 2012-10-28 | 2019-03-22 | 強靭なｔ細胞用のｐｒ１３．５プロモータ及び抗体応答 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533841A JP2015533841A (ja) | 2015-11-26 |
| JP2015533841A5 true JP2015533841A5 (https=) | 2016-10-20 |
| JP6505016B2 JP6505016B2 (ja) | 2019-04-24 |
Family
ID=49513897
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015538330A Active JP6505016B2 (ja) | 2012-10-28 | 2013-10-28 | 強靭なｔ細胞用のｐｒ１３．５プロモータ及び抗体応答 |
| JP2019054129A Active JP6818797B2 (ja) | 2012-10-28 | 2019-03-22 | 強靭なｔ細胞用のｐｒ１３．５プロモータ及び抗体応答 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019054129A Active JP6818797B2 (ja) | 2012-10-28 | 2019-03-22 | 強靭なｔ細胞用のｐｒ１３．５プロモータ及び抗体応答 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US9828414B2 (https=) |
| EP (2) | EP2912183B1 (https=) |
| JP (2) | JP6505016B2 (https=) |
| KR (2) | KR20200087880A (https=) |
| CN (1) | CN104755622B (https=) |
| AU (1) | AU2013337018B2 (https=) |
| BR (1) | BR112015009320A2 (https=) |
| CA (1) | CA2887623C (https=) |
| CY (1) | CY1123181T1 (https=) |
| DK (1) | DK2912183T3 (https=) |
| EA (2) | EA032498B1 (https=) |
| ES (1) | ES2800623T3 (https=) |
| HK (1) | HK1212383A1 (https=) |
| HU (1) | HUE049706T2 (https=) |
| IL (1) | IL238130B (https=) |
| IN (1) | IN2015DN03326A (https=) |
| LT (1) | LT2912183T (https=) |
| MX (2) | MX380483B (https=) |
| MY (2) | MY171687A (https=) |
| NZ (1) | NZ706637A (https=) |
| PT (1) | PT2912183T (https=) |
| SG (2) | SG10201704657WA (https=) |
| SI (1) | SI2912183T1 (https=) |
| UA (1) | UA118340C2 (https=) |
| WO (1) | WO2014063832A1 (https=) |
| ZA (1) | ZA201502892B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2912183B1 (en) * | 2012-10-28 | 2020-05-06 | Bavarian Nordic A/S | Pr13.5 promoter for robust t-cell and antibody responses |
| FR3042121A1 (fr) | 2015-10-08 | 2017-04-14 | Jean-Marc Limacher | Composition anti-tumorale |
| ES2921605T3 (es) | 2016-01-29 | 2022-08-30 | Bavarian Nordic As | Vacuna contra el virus de la encefalitis equina basada en el virus de la variolovacuna modificado Ankara (VMA) recombinante |
| JP7053491B2 (ja) * | 2016-05-02 | 2022-04-12 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 治療用ｈｐｖワクチン組み合わせ |
| CN110198733B (zh) | 2016-09-28 | 2024-04-30 | 巴法里安诺迪克有限公司 | 用于增强痘病毒中转基因的稳定性的组合物和方法 |
| WO2018091680A1 (en) | 2016-11-18 | 2018-05-24 | Transgene Sa | Cowpox-based oncolytic vectors |
| CN110168092A (zh) | 2016-12-28 | 2019-08-23 | 特朗斯吉有限公司 | 溶瘤病毒和治疗分子 |
| KR20200015759A (ko) | 2017-06-15 | 2020-02-12 | 얀센 백신스 앤드 프리벤션 비.브이. | Hiv 항원을 인코딩하는 폭스바이러스 벡터, 및 그 사용 방법 |
| WO2019020543A1 (en) | 2017-07-28 | 2019-01-31 | Transgene Sa | ONCOLYTIC VIRUSES EXPRESSING AGENTS TARGETING METABOLIC IMMUNE MODULATORS |
| CN111050790B (zh) | 2017-08-24 | 2024-07-12 | 巴法里安诺迪克有限公司 | 通过静脉内施用重组mva和抗体治疗癌症的组合疗法 |
| KR20200100745A (ko) | 2017-12-19 | 2020-08-26 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | B형 간염 바이러스(hbv)에 대한 면역 반응 유도를 위한 방법 및 조성물 |
| GB201807932D0 (en) * | 2018-05-16 | 2018-06-27 | Redchenko Irina | Compositions and methods for inducing an immune response |
| WO2020011754A1 (en) | 2018-07-09 | 2020-01-16 | Transgene | Chimeric vaccinia viruses |
| CN110904127B (zh) | 2018-09-18 | 2024-09-20 | 瓦赫宁恩研究基金会 | 非洲猪瘟病毒疫苗 |
| JP7555334B2 (ja) | 2018-10-05 | 2024-09-24 | バヴァリアン・ノルディック・アクティーゼルスカブ | 組み換えｍｖａ、及び免疫チェックポイントアンタゴニストまたは免疫チェックポイントアゴニストの静脈内投与によって、がんを治療する併用療法 |
| CA3119503A1 (en) | 2018-11-20 | 2020-05-28 | Bavarian Nordic A/S | Therapy for treating cancer with an intratumoral and/or intravenous administration of a recombinant mva encoding 4-1bbl (cd137l) and/or cd40l |
| US20230190922A1 (en) | 2019-11-20 | 2023-06-22 | Bavarian Nordic A/S | Recombinant MVA Viruses for Intratumoral and/or Intravenous Administration for Treating Cancer |
| EP4164682A1 (en) | 2020-06-10 | 2023-04-19 | Bavarian Nordic A/S | A recombinant modified vaccinia virus ankara (mva) vaccine against coronavirus disease |
| WO2022084333A1 (en) | 2020-10-20 | 2022-04-28 | Janssen Vaccines & Prevention B.V. | Hiv vaccine regimens |
| JP2024535145A (ja) | 2021-09-03 | 2024-09-27 | バヴァリアン・ノルディック・アクティーゼルスカブ | 改変ワクシニアウイルスアンカラ（ｍｖａ）による細胞傷害性導入遺伝子発現を下方調節するためのマイクロｒｎａの利用 |
| EP4452306A1 (en) | 2021-12-23 | 2024-10-30 | Bavarian Nordic A/S | Therapy for modulating immune response with recombinant mva encoding il-12 |
| WO2023118508A1 (en) | 2021-12-23 | 2023-06-29 | Bavarian Nordic A/S | Recombinant mva viruses for intraperitoneal administration for treating cancer |
| AU2023298083A1 (en) | 2022-06-29 | 2025-01-09 | Bavarian Nordic A/S | RECOMBINANT MODIFIED saRNA (VRP) AND VACCINIA VIRUS ANKARA (MVA) PRIME-BOOST REGIMEN |
| US20260049291A1 (en) | 2022-08-18 | 2026-02-19 | Transgene | Chimeric poxviruses |
| EP4648781A1 (en) | 2023-01-12 | 2025-11-19 | Bavarian Nordic A/S | Recombinant modified sarna (vrp) for cancer vaccine |
| FR3160186A1 (fr) | 2024-03-13 | 2025-09-19 | Odimma Therapeutics | Vecteur non-viral pour transcription augmentee |
| WO2025238218A1 (en) | 2024-05-17 | 2025-11-20 | Bavarian Nordic A/S | Viral vectors encoding antigen-displaying protein nanoparticles |
| WO2025238220A1 (en) | 2024-05-17 | 2025-11-20 | Bavarian Nordic A/S | Nucleic acids for vaccination encoding antigen-displaying protein nanoparticles |
| WO2025238219A1 (en) | 2024-05-17 | 2025-11-20 | Bavarian Nordic A/S | Modified vaccinia virus ankara (mva) encoding antigen-displaying protein nanoparticles |
| WO2025238221A1 (en) | 2024-05-17 | 2025-11-20 | Bavarian Nordic A/S | Viral vectors encoding multi-antigen-displaying protein nanoparticles |
| WO2026041811A1 (en) | 2024-08-23 | 2026-02-26 | Transgene | Recombinant poxvirus and method for regulating the expression of toxic conditional gene products of said recombinant poxvirus in a producing cell |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9711957D0 (en) * | 1997-06-09 | 1997-08-06 | Isis Innovation | Methods and reagents for vaccination |
| GB9922361D0 (en) * | 1999-09-21 | 1999-11-24 | Isis Innovation | Generating an immune response to an antigen |
| UA76731C2 (uk) | 2000-11-23 | 2006-09-15 | Баваріан Нордік А/С | Штам mva-bn модифікованого вірусу коров'ячої віспи ankara, фармацевтична композиція, вакцина, застосування mva-bn для приготування лікарського препарату та для приготування вакцини, спосіб введення гомологічної і/або гетерологічної послідовності нуклеїнової кислоти в клітини-мішені in vitro, спосіб одержання пептиду або білка, спосіб одержання mva-bn, клітина, набір для основної/бустерної імунізації |
| US7527960B2 (en) * | 2004-06-25 | 2009-05-05 | Merial Limited | Avipox recombinants expressing foot and mouth disease virus genes |
| JP2008301792A (ja) * | 2007-06-11 | 2008-12-18 | National Univ Corp Shizuoka Univ | 改変ポリヘドリンプロモーター、バクミド変異体及び目的タンパク質の製造方法 |
| NZ592082A (en) | 2008-11-27 | 2013-03-28 | Bavarian Nordic As | Promoters for recombinant viral expression |
| US8394385B2 (en) * | 2009-03-13 | 2013-03-12 | Bavarian Nordic A/S | Optimized early-late promoter combined with repeated vaccination favors cytotoxic T cell response against recombinant antigen in MVA vaccines |
| EP2912183B1 (en) * | 2012-10-28 | 2020-05-06 | Bavarian Nordic A/S | Pr13.5 promoter for robust t-cell and antibody responses |
-
2013
- 2013-10-28 EP EP13783852.0A patent/EP2912183B1/en active Active
- 2013-10-28 DK DK13783852.0T patent/DK2912183T3/da active
- 2013-10-28 MX MX2015005264A patent/MX380483B/es unknown
- 2013-10-28 SG SG10201704657WA patent/SG10201704657WA/en unknown
- 2013-10-28 NZ NZ706637A patent/NZ706637A/en unknown
- 2013-10-28 US US14/437,939 patent/US9828414B2/en active Active
- 2013-10-28 ES ES13783852T patent/ES2800623T3/es active Active
- 2013-10-28 EA EA201590831A patent/EA032498B1/ru not_active IP Right Cessation
- 2013-10-28 WO PCT/EP2013/003239 patent/WO2014063832A1/en not_active Ceased
- 2013-10-28 LT LTEP13783852.0T patent/LT2912183T/lt unknown
- 2013-10-28 SI SI201331731T patent/SI2912183T1/sl unknown
- 2013-10-28 CA CA2887623A patent/CA2887623C/en active Active
- 2013-10-28 AU AU2013337018A patent/AU2013337018B2/en active Active
- 2013-10-28 IN IN3326DEN2015 patent/IN2015DN03326A/en unknown
- 2013-10-28 JP JP2015538330A patent/JP6505016B2/ja active Active
- 2013-10-28 MY MYPI2015701223A patent/MY171687A/en unknown
- 2013-10-28 SG SG11201503200PA patent/SG11201503200PA/en unknown
- 2013-10-28 CN CN201380054013.0A patent/CN104755622B/zh active Active
- 2013-10-28 MY MYPI2018001787A patent/MY194609A/en unknown
- 2013-10-28 HU HUE13783852A patent/HUE049706T2/hu unknown
- 2013-10-28 BR BR112015009320A patent/BR112015009320A2/pt not_active Application Discontinuation
- 2013-10-28 HK HK16100267.8A patent/HK1212383A1/xx unknown
- 2013-10-28 EA EA201990114A patent/EA201990114A1/ru unknown
- 2013-10-28 PT PT137838520T patent/PT2912183T/pt unknown
- 2013-10-28 EP EP20172647.8A patent/EP3778904A1/en active Pending
- 2013-10-28 KR KR1020207020263A patent/KR20200087880A/ko not_active Ceased
- 2013-10-28 KR KR1020157009206A patent/KR102135818B1/ko active Active
- 2013-10-28 UA UAA201505223A patent/UA118340C2/uk unknown
-
2015
- 2015-04-02 IL IL238130A patent/IL238130B/en active IP Right Grant
- 2015-04-24 MX MX2021001638A patent/MX2021001638A/es unknown
- 2015-04-28 ZA ZA2015/02892A patent/ZA201502892B/en unknown
-
2017
- 2017-11-22 US US15/821,035 patent/US11028130B2/en active Active
-
2019
- 2019-03-22 JP JP2019054129A patent/JP6818797B2/ja active Active
-
2020
- 2020-07-08 CY CY20201100630T patent/CY1123181T1/el unknown
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