JP2015524794A5 - - Google Patents
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- JP2015524794A5 JP2015524794A5 JP2015520979A JP2015520979A JP2015524794A5 JP 2015524794 A5 JP2015524794 A5 JP 2015524794A5 JP 2015520979 A JP2015520979 A JP 2015520979A JP 2015520979 A JP2015520979 A JP 2015520979A JP 2015524794 A5 JP2015524794 A5 JP 2015524794A5
- Authority
- JP
- Japan
- Prior art keywords
- vector
- immunogenic
- mycobacterial
- fusion polypeptide
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000013598 vector Substances 0.000 claims 26
- 230000002163 immunogen Effects 0.000 claims 21
- 239000000427 antigen Substances 0.000 claims 20
- 102000036639 antigens Human genes 0.000 claims 20
- 108091007433 antigens Proteins 0.000 claims 20
- 229920001184 polypeptide Polymers 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 230000004927 fusion Effects 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 13
- 101710166488 6 kDa early secretory antigenic target Proteins 0.000 claims 9
- 101710088334 Diacylglycerol acyltransferase/mycolyltransferase Ag85B Proteins 0.000 claims 9
- 208000015181 infectious disease Diseases 0.000 claims 8
- 239000000047 product Substances 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 239000002245 particle Substances 0.000 claims 5
- 241000894007 species Species 0.000 claims 5
- 206010062207 Mycobacterial infection Diseases 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 4
- 208000027531 mycobacterial infectious disease Diseases 0.000 claims 4
- 230000002458 infectious effect Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 201000008827 tuberculosis Diseases 0.000 claims 3
- 241000283690 Bos taurus Species 0.000 claims 2
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 2
- 101100103958 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Rv1733c gene Proteins 0.000 claims 2
- 241000700618 Vaccinia virus Species 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 241000710929 Alphavirus Species 0.000 claims 1
- 241000178270 Canarypox virus Species 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 101710088335 Diacylglycerol acyltransferase/mycolyltransferase Ag85A Proteins 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 208000000666 Fowlpox Diseases 0.000 claims 1
- 241000700662 Fowlpox virus Species 0.000 claims 1
- 241000714192 Human spumaretrovirus Species 0.000 claims 1
- 241000186660 Lactobacillus Species 0.000 claims 1
- 208000032420 Latent Infection Diseases 0.000 claims 1
- 241000186781 Listeria Species 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 101001057048 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) ESAT-6-like protein EsxB Proteins 0.000 claims 1
- 101100318482 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Rv2005c gene Proteins 0.000 claims 1
- 101100000605 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) acg gene Proteins 0.000 claims 1
- 101100351796 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) pfkB gene Proteins 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 230000005867 T cell response Effects 0.000 claims 1
- 241000711975 Vesicular stomatitis virus Species 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 239000007894 caplet Substances 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 208000037771 disease arising from reactivation of latent virus Diseases 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 229940039696 lactobacillus Drugs 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000000819 phase cycle Methods 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000007420 reactivation Effects 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305825 | 2012-07-10 | ||
| EP12305825.7 | 2012-07-10 | ||
| EP12306539 | 2012-12-07 | ||
| EP12306539.3 | 2012-12-07 | ||
| EP13305737.2 | 2013-06-03 | ||
| EP13305737 | 2013-06-03 | ||
| PCT/EP2013/064624 WO2014009438A2 (en) | 2012-07-10 | 2013-07-10 | Mycobacterial antigen vaccine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524794A JP2015524794A (ja) | 2015-08-27 |
| JP2015524794A5 true JP2015524794A5 (https=) | 2016-08-25 |
| JP6333814B2 JP6333814B2 (ja) | 2018-05-30 |
Family
ID=48782326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520979A Expired - Fee Related JP6333814B2 (ja) | 2012-07-10 | 2013-07-10 | マイコバクテリア抗原ワクチン |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10357555B2 (https=) |
| EP (1) | EP2872172B1 (https=) |
| JP (1) | JP6333814B2 (https=) |
| KR (1) | KR20150058152A (https=) |
| CN (1) | CN104640564B (https=) |
| BR (1) | BR112015000530A2 (https=) |
| CA (1) | CA2878800A1 (https=) |
| EA (1) | EA029492B1 (https=) |
| IL (1) | IL236650B (https=) |
| MX (1) | MX366206B (https=) |
| MY (1) | MY173004A (https=) |
| SG (1) | SG11201500171YA (https=) |
| TW (1) | TWI638829B (https=) |
| UA (1) | UA119228C2 (https=) |
| WO (1) | WO2014009438A2 (https=) |
| ZA (1) | ZA201500784B (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI638829B (zh) * | 2012-07-10 | 2018-10-21 | 法商傳斯堅公司 | 分枝桿菌抗原疫苗 |
| ES2925950T3 (es) | 2013-06-25 | 2022-10-20 | Int Aids Vaccine Initiative Inc | Composiciones para la tuberculosis y procedimientos de uso de las mismas |
| WO2015104380A1 (en) | 2014-01-09 | 2015-07-16 | Transgene Sa | Fusion of heterooligomeric mycobacterial antigens |
| GB201400819D0 (en) * | 2014-01-17 | 2014-03-05 | Sec Dep For Health The | Mycobacterial antigen composition |
| WO2015126930A2 (en) * | 2014-02-18 | 2015-08-27 | Stc.Unm | Booster drug therapy for mycobacterium infections |
| KR102507483B1 (ko) | 2014-12-01 | 2023-03-07 | 트랜스진 | 안정한 액체 백시니아 바이러스 제제 |
| EP4523756A3 (en) | 2015-02-13 | 2025-05-28 | Transgene | Immunotherapeutic vaccine and antibody combination therapy |
| WO2016131945A1 (en) | 2015-02-20 | 2016-08-25 | Transgene Sa | Combination product with autophagy modulator |
| CN105601747B (zh) * | 2015-10-21 | 2019-05-28 | 中山大学 | 一种结核杆菌融合蛋白及其在诱导外周血单个核细胞产生细胞因子的应用 |
| KR101631054B1 (ko) * | 2015-12-31 | 2016-06-16 | 중앙대학교 산학협력단 | 마이코박테리아 유래 CFP-10 또는 Ag85B에 특이적으로 결합하는 항체 또는 그의 항원 결합 단편 |
| CN105567660B (zh) * | 2016-01-08 | 2018-11-20 | 中国人民解放军第四军医大学 | 一种大肠杆菌重组表达结核分枝杆菌Rv2837c活性蛋白的方法及其应用 |
| CA3023022A1 (en) | 2016-05-04 | 2017-11-09 | Transgene Sa | Combination therapy with cpg tlr9 ligand |
| JP2019521095A (ja) * | 2016-05-21 | 2019-07-25 | インフェクシャス ディズィーズ リサーチ インスティチュート | 二次性結核および非結核性マイコバクテリウム感染症を治療するための組成物および方法 |
| AU2017285424B2 (en) * | 2016-06-16 | 2022-08-18 | International Aids Vaccine Initiative, Inc. | Tuberculosis compositions and methods of treating or preventing tuberculosis |
| CN109843321A (zh) * | 2016-06-22 | 2019-06-04 | 国际艾滋病疫苗行动组织公司 | 作为结核病疫苗的重组巨细胞病毒载体 |
| BR112019004913B1 (pt) * | 2016-09-16 | 2022-07-12 | Infectious Disease Research Institute | Vacinas que compreendem polipeptídeos de mycobacterium leprae para a prevenção, tratamento e diagnóstico de lepra |
| WO2018069316A2 (en) | 2016-10-10 | 2018-04-19 | Transgene Sa | Immunotherapeutic product and mdsc modulator combination therapy |
| CN106546737A (zh) * | 2016-10-24 | 2017-03-29 | 广州迪澳医疗科技有限公司 | 一种体外检测活动性结核的方法 |
| WO2018151930A1 (en) * | 2017-02-17 | 2018-08-23 | The Methodist Hospital | Compositions and methods of determining a level of infection in a subject |
| CN107236023B (zh) * | 2017-05-12 | 2021-05-07 | 苏州创澜生物科技有限公司 | 一种用于检测结核感染的抗原组合物及其应用 |
| WO2019079155A1 (en) | 2017-10-17 | 2019-04-25 | International Aids Vaccine Initiative, Inc. | CASSETTES OF ANTIGENS OF TUBERCULOSIS |
| CA3098015A1 (en) | 2018-04-26 | 2019-10-31 | Children's National Medical Center | Mycobacterial antigen compositions and methods of use |
| CN109536431A (zh) * | 2018-12-04 | 2019-03-29 | 江苏省农业科学院 | 复合生化复苏因子组合物及其应用 |
| KR102135328B1 (ko) * | 2018-12-19 | 2020-07-17 | 대한민국 | 결핵 2가 항원을 발현하는 약독화된 재조합 백시니아 바이러스 및 이를 포함하는 결핵 예방용 조성물 |
| KR102157770B1 (ko) * | 2019-01-11 | 2020-09-18 | 주식회사 파이지노믹스 | 가축의 결핵 진단을 위한 항원 펩타이드 조성물 및 이의 용도 |
| CN109970183B (zh) * | 2019-03-31 | 2021-01-15 | 浙江大学 | 一种复苏促进因子在印染废水处理中的应用及处理方法 |
| EP3983011A1 (en) * | 2019-06-14 | 2022-04-20 | Statens Serum Institut | Fusion proteins for tuberculosis vaccines |
| CN110590958B (zh) * | 2019-09-11 | 2021-04-13 | 中国人民解放军总医院第八医学中心 | 一种串联多肽及其在抗结核分枝杆菌的免疫保护中的应用 |
| CN110590957B (zh) * | 2019-09-11 | 2021-06-01 | 中国人民解放军总医院第八医学中心 | 一种融合蛋白及其在抗结核分枝杆菌的免疫保护中的应用 |
| RU2724896C1 (ru) * | 2019-11-14 | 2020-06-26 | федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации | Полиантигенная вакцина для профилактики и вспомогательного лечения туберкулеза |
| EP3842065A1 (en) * | 2019-12-23 | 2021-06-30 | Transgene | Process for designing a recombinant poxvirus for a therapeutic vaccine |
| CN111443208B (zh) * | 2020-03-23 | 2024-01-19 | 中国医学科学院北京协和医院 | 鉴别活动性结核病和潜伏性结核病的组合物 |
| MX2023001187A (es) * | 2020-07-31 | 2023-04-04 | Combined Therapeutics Inc | Composiciones y métodos para una vacunación mejorada. |
| KR20220059111A (ko) * | 2020-11-02 | 2022-05-10 | 한양대학교 에리카산학협력단 | 결핵균의 Rv2626c 단백질에서 유래한 패혈증 치료용 펩타이드 |
| US20250319173A1 (en) * | 2021-03-12 | 2025-10-16 | Institut Pasteur | Lentiviral vectors targeting antigens to mhc-ii pathway and inducing protective cd8+ and cd4+ t-cell immunity in a host |
| CN116262794B (zh) * | 2021-12-13 | 2024-09-13 | 江苏瑞科生物技术股份有限公司 | 重组结核分枝杆菌抗原、其制备方法和应用 |
| KR102878370B1 (ko) * | 2022-06-17 | 2025-10-31 | 주식회사 미코라파 | 면역활성 부위 융합 단백질을 포함하는 결핵 백신 조성물 |
| EP4561617A1 (en) * | 2022-07-29 | 2025-06-04 | University of Cape Town | Vaccine constructs comprising tuberculosis antigens |
| WO2024027910A1 (en) * | 2022-08-03 | 2024-02-08 | BioNTech SE | Rna for preventing or treating tuberculosis |
| IL318534A (en) * | 2022-08-03 | 2025-03-01 | BioNTech SE | RNA for preventing or treating tuberculosis |
| CN116162141B (zh) * | 2022-11-30 | 2024-04-12 | 中国疾病预防控制中心传染病预防控制所 | 一种结核分枝杆菌抗原epcra013及其应用 |
| CN116041543B (zh) * | 2022-12-07 | 2023-12-26 | 中国疾病预防控制中心传染病预防控制所 | 结核分枝杆菌多抗原融合蛋白及其编码基因和应用 |
| CN116063418B (zh) * | 2022-12-08 | 2024-04-12 | 中国疾病预防控制中心传染病预防控制所 | 结核分枝杆菌抗原组合物epdpa015及其制备方法与应用 |
| WO2025092548A1 (zh) * | 2023-11-03 | 2025-05-08 | 烟台派诺生物技术有限公司 | 一种用于预防结核分枝杆菌感染的纳米颗粒疫苗及其制备方法 |
| CN118108815B (zh) * | 2024-04-23 | 2024-07-23 | 成都康华生物制品股份有限公司 | 结核分枝杆菌多免疫原抗原、编码其的mRNA、应用 |
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| JP5421250B2 (ja) | 2007-07-03 | 2014-02-19 | トランスジーン ソシエテ アノニム | トリ不死化細胞株 |
| GB0722105D0 (en) * | 2007-11-10 | 2007-12-19 | Sec Dep For Environment Food A | Antigens |
| US7670609B2 (en) | 2007-11-27 | 2010-03-02 | Aeras Global Tb Vaccine Foundation | Recombinant BCG tuberculosis vaccine designed to elicit immune responses to Mycobacterium tuberculosis in all physiological stages of infection and disease |
| US8361482B2 (en) * | 2007-11-27 | 2013-01-29 | Aeras Global Tb Vaccine Foundation | Recombinant BCG tuberculosis vaccine designed to elicit immune responses to mycobacterium tuberculosis in all physiological stages of infection and disease |
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| GB201008512D0 (en) * | 2010-05-21 | 2010-07-07 | Health Prot Agency | Mycobacterial antigen composition |
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| US20150211012A1 (en) * | 2012-08-31 | 2015-07-30 | Laboratorios Del Dr. Esteve S.A. | Mycobacterium comprising expression vector with two auxotrophic selection markers and its use as vaccine |
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| GB201400819D0 (en) * | 2014-01-17 | 2014-03-05 | Sec Dep For Health The | Mycobacterial antigen composition |
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-
2013
- 2013-07-10 TW TW102124693A patent/TWI638829B/zh not_active IP Right Cessation
- 2013-07-10 CA CA2878800A patent/CA2878800A1/en not_active Abandoned
- 2013-07-10 EP EP13735275.3A patent/EP2872172B1/en not_active Not-in-force
- 2013-07-10 BR BR112015000530A patent/BR112015000530A2/pt not_active Application Discontinuation
- 2013-07-10 KR KR1020157003607A patent/KR20150058152A/ko not_active Abandoned
- 2013-07-10 EA EA201590184A patent/EA029492B1/ru not_active IP Right Cessation
- 2013-07-10 CN CN201380046981.7A patent/CN104640564B/zh not_active Expired - Fee Related
- 2013-07-10 SG SG11201500171YA patent/SG11201500171YA/en unknown
- 2013-07-10 MY MYPI2015000055A patent/MY173004A/en unknown
- 2013-07-10 WO PCT/EP2013/064624 patent/WO2014009438A2/en not_active Ceased
- 2013-07-10 JP JP2015520979A patent/JP6333814B2/ja not_active Expired - Fee Related
- 2013-07-10 US US14/413,565 patent/US10357555B2/en not_active Expired - Fee Related
- 2013-07-10 MX MX2015000449A patent/MX366206B/es active IP Right Grant
- 2013-10-07 UA UAA201501068A patent/UA119228C2/uk unknown
-
2015
- 2015-01-11 IL IL236650A patent/IL236650B/en not_active IP Right Cessation
- 2015-02-03 ZA ZA2015/00784A patent/ZA201500784B/en unknown
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