JP2013507907A5 - - Google Patents

Info

Publication number

JP2013507907A5

JP2013507907A5 JP2012533696A JP2012533696A JP2013507907A5 JP 2013507907 A5 JP2013507907 A5 JP 2013507907A5 JP 2012533696 A JP2012533696 A JP 2012533696A JP 2012533696 A JP2012533696 A JP 2012533696A JP 2013507907 A5 JP2013507907 A5 JP 2013507907A5

Authority

JP

Japan

Prior art keywords

fusion protein

domain

vector

polynucleotide sequence

acid sequence

Prior art date

2010-10-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 108020001507 fusion proteins Proteins 0.000 claims 23
• 102000037865 fusion proteins Human genes 0.000 claims 23
• 239000013598 vector Substances 0.000 claims 17
• 108091033319 polynucleotide Proteins 0.000 claims 16
• 102000040430 polynucleotide Human genes 0.000 claims 16
• 239000002157 polynucleotide Substances 0.000 claims 16
• 239000012634 fragment Substances 0.000 claims 10
• 125000003275 alpha amino acid group Chemical group 0.000 claims 9
• 230000002163 immunogen Effects 0.000 claims 7
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 4
• 239000000427 antigen Substances 0.000 claims 4
• 102000036639 antigens Human genes 0.000 claims 4
• 108091007433 antigens Proteins 0.000 claims 4
• 150000007523 nucleic acids Chemical group 0.000 claims 4
• 239000002773 nucleotide Substances 0.000 claims 3
• 125000003729 nucleotide group Chemical group 0.000 claims 3
• 230000002265 prevention Effects 0.000 claims 3
• 101710159767 C4b-binding protein alpha chain Proteins 0.000 claims 2
• 102100037084 C4b-binding protein alpha chain Human genes 0.000 claims 2
• 108020004414 DNA Proteins 0.000 claims 2
• 206010062207 Mycobacterial infection Diseases 0.000 claims 2
• 101100377720 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) fbpA gene Proteins 0.000 claims 2
• 101100377732 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) fbpB gene Proteins 0.000 claims 2
• 101100489774 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) fbpC gene Proteins 0.000 claims 2
• 230000000890 antigenic effect Effects 0.000 claims 2
• 230000000295 complement effect Effects 0.000 claims 2
• 102000034356 gene-regulatory proteins Human genes 0.000 claims 2
• 108091006104 gene-regulatory proteins Proteins 0.000 claims 2
• 230000028993 immune response Effects 0.000 claims 2
• 230000001939 inductive effect Effects 0.000 claims 2
• 208000027531 mycobacterial infectious disease Diseases 0.000 claims 2
• 238000006384 oligomerization reaction Methods 0.000 claims 2
• 230000003449 preventive effect Effects 0.000 claims 2
• 230000037452 priming Effects 0.000 claims 2
• 230000004936 stimulating effect Effects 0.000 claims 2
• 230000001225 therapeutic effect Effects 0.000 claims 2
• 201000008827 tuberculosis Diseases 0.000 claims 2
• 229960005486 vaccine Drugs 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241001217856 Chimpanzee adenovirus Species 0.000 claims 1
• 241000598171 Human adenovirus sp. Species 0.000 claims 1
• 241001183012 Modified Vaccinia Ankara virus Species 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 239000013612 plasmid Substances 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1
• 241000990167 unclassified Simian adenoviruses Species 0.000 claims 1
• 241000701161 unidentified adenovirus Species 0.000 claims 1
• 239000013603 viral vector Substances 0.000 claims 1