EA201270517A1 - Микобактериальные вакцины - Google Patents

Микобактериальные вакцины

Info

Publication number
EA201270517A1
EA201270517A1 EA201270517A EA201270517A EA201270517A1 EA 201270517 A1 EA201270517 A1 EA 201270517A1 EA 201270517 A EA201270517 A EA 201270517A EA 201270517 A EA201270517 A EA 201270517A EA 201270517 A1 EA201270517 A1 EA 201270517A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fusion protein
domain
proposed
микобактериальные
вакцины
Prior art date
Application number
EA201270517A
Other languages
English (en)
Russian (ru)
Inventor
Александра Джейн Спенсер
Мэттью Гай Коттингейм
Эдриан Вивиан Синтон Хилл
Фергел Хилл
Original Assignee
Исис Инновейшн Лимитед
Имаксио Са
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Исис Инновейшн Лимитед, Имаксио Са filed Critical Исис Инновейшн Лимитед
Publication of EA201270517A1 publication Critical patent/EA201270517A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1289—Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EA201270517A 2009-10-16 2010-10-15 Микобактериальные вакцины EA201270517A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0918154.6A GB0918154D0 (en) 2009-10-16 2009-10-16 Mycobacterial vaccines
PCT/GB2010/051741 WO2011045612A1 (en) 2009-10-16 2010-10-15 Mycobacterial vaccines

Publications (1)

Publication Number Publication Date
EA201270517A1 true EA201270517A1 (ru) 2012-12-28

Family

ID=41462453

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270517A EA201270517A1 (ru) 2009-10-16 2010-10-15 Микобактериальные вакцины

Country Status (14)

Country Link
US (1) US9181311B2 (https=)
EP (1) EP2488549B1 (https=)
JP (1) JP2013507907A (https=)
KR (1) KR20120083899A (https=)
CN (1) CN102666575B (https=)
AU (1) AU2010308120B2 (https=)
BR (1) BR112012008790A2 (https=)
CA (1) CA2776001A1 (https=)
EA (1) EA201270517A1 (https=)
GB (1) GB0918154D0 (https=)
NZ (1) NZ599259A (https=)
PH (1) PH12012500849A1 (https=)
WO (1) WO2011045612A1 (https=)
ZA (1) ZA201202363B (https=)

Families Citing this family (29)

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GB201006405D0 (en) * 2010-04-16 2010-06-02 Isis Innovation Poxvirus expression system
EP2812704A4 (en) * 2012-02-07 2016-03-23 Intuitive Biosciences Inc MYCOBACTERIUM STUBERCULOSIS-SPECIFIC PEPTIDES FOR DETECTING INFECTION OR IMMUNIZATION OF NON-MUSCLE PRIMATES
TWI638829B (zh) * 2012-07-10 2018-10-21 法商傳斯堅公司 分枝桿菌抗原疫苗
EP2931896B1 (en) 2012-12-11 2019-01-16 Osivax SAS Modified coiled coil type proteins having improved properties
CN105143251B (zh) 2013-03-18 2021-05-11 奥西瓦科斯公司 流感核蛋白疫苗
CN103290053A (zh) * 2013-05-17 2013-09-11 中国人民解放军第四军医大学 唾液腺导管细胞特异性启动子的腺病毒载体及其构建方法
ES2925950T3 (es) * 2013-06-25 2022-10-20 Int Aids Vaccine Initiative Inc Composiciones para la tuberculosis y procedimientos de uso de las mismas
US10226522B2 (en) 2013-08-30 2019-03-12 Globeimmune, Inc. Compositions and methods for the treatment or prevention of tuberculosis
CN106029870A (zh) * 2014-01-16 2016-10-12 凯利斯塔公司 用于增强的氨基酸产生的微生物及相关方法
CN104805063A (zh) * 2014-01-24 2015-07-29 中国人民解放军第三〇九医院 结核分枝杆菌潜伏感染相关蛋白及其制备和应用
US10406218B2 (en) 2014-04-09 2019-09-10 La Jolla Institute For Allergy And Immunology Specific and unique T cell responses and molecular signatures for the treatment and diagnosis of Mycobacterium tuberculosis
CN107076744B (zh) * 2014-08-29 2021-01-19 国家科研中心 用于诊断潜伏性感染的结核分枝杆菌的组合物
US10342863B2 (en) 2015-03-24 2019-07-09 Fred Hutchinson Cancer Research Center Engineered and multimerized human immunodeficiency virus envelope glycoproteins and uses thereof
CN106237317A (zh) * 2015-06-15 2016-12-21 复旦大学 由结核分枝杆菌抗原组成的结核疫苗
GB201513176D0 (en) 2015-07-27 2015-09-09 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
AU2017285424B2 (en) 2016-06-16 2022-08-18 International Aids Vaccine Initiative, Inc. Tuberculosis compositions and methods of treating or preventing tuberculosis
CN108239660B (zh) * 2016-12-26 2021-08-10 上海生物制品研究所有限责任公司 一种重组结核病疫苗，其制备方法及应用
EP3634449A4 (en) 2017-05-08 2021-03-17 Gritstone Oncology, Inc. ALPHAVIRUS NEOANTIGEN VECTORS
US11591375B2 (en) * 2018-01-22 2023-02-28 Oregon State University Immunogenic compositions comprising Mycobacterium bovis surface proteins and uses thereof
MX2021014525A (es) 2019-05-30 2022-03-17 Gritstone Bio Inc Adenovirus modificados.
CN110240637A (zh) * 2019-06-04 2019-09-17 华中农业大学 牛分枝杆菌免疫相关的分子伴侣蛋白GroEL2及其编码基因与应用
KR102193304B1 (ko) * 2019-10-24 2020-12-22 충남대학교산학협력단 Rv2299c-ESAT6-HspX-RipA 융합단백질의 BCG 백신 booster용 조성물
CN110724182B (zh) * 2019-11-15 2022-04-08 上海交通大学 提高菌阴结核感染检测敏感性的标志物组合及应用
WO2021119545A1 (en) * 2019-12-11 2021-06-17 Gritstone Bio, Inc. Durable vaccination
CN116438308A (zh) 2020-08-06 2023-07-14 磨石生物公司 多表位疫苗盒
CN112979825A (zh) * 2021-02-04 2021-06-18 兰州大学 结核分枝杆菌融合蛋白lt29构建及其表达纯化方法和应用
CN113999865B (zh) * 2021-10-09 2023-06-16 安徽理工大学 结核分枝杆菌融合蛋白ar2及其构建与表达纯化方法和应用
CN115920003B (zh) * 2022-08-31 2024-11-29 中国医学科学院病原生物学研究所 脂蛋白LprG及其基因作为抗结核分枝杆菌药物靶点的应用
CN116041543B (zh) * 2022-12-07 2023-12-26 中国疾病预防控制中心传染病预防控制所 结核分枝杆菌多抗原融合蛋白及其编码基因和应用

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CA2049964A1 (en) * 1990-01-26 1991-07-27 Biogen, Inc. C4 binding protein fusion proteins
WO2005014654A2 (en) 2003-08-12 2005-02-17 Avidis Sa Product comprising a c4bp core protein and a monomeric antigen, and its use
CN1284854C (zh) * 2003-03-06 2006-11-15 钟森 用于预防结核病和免疫治疗的嵌合型dna疫苗
EP1957528B1 (en) * 2005-11-30 2012-11-07 University of Copenhagen A nucleotide vaccine
EP1795540A1 (en) * 2005-11-30 2007-06-13 Imaxio Multimeric complexes of antigens and an adjuvant
GB0706912D0 (en) 2007-04-10 2007-05-16 Isis Innovation Novel viral vaccines
CN101428143B (zh) * 2008-12-09 2011-05-11 武汉大学 携带结核基因的减毒细菌载体结核疫苗及制备方法和应用

Also Published As

Publication number Publication date
NZ599259A (en) 2014-03-28
US9181311B2 (en) 2015-11-10
JP2013507907A (ja) 2013-03-07
PH12012500849A1 (en) 2014-03-24
CA2776001A1 (en) 2011-04-21
EP2488549A1 (en) 2012-08-22
US20120282290A1 (en) 2012-11-08
CN102666575B (zh) 2015-07-15
GB0918154D0 (en) 2009-12-02
BR112012008790A2 (pt) 2019-09-24
AU2010308120B2 (en) 2015-01-22
WO2011045612A1 (en) 2011-04-21
EP2488549B1 (en) 2015-07-29
ZA201202363B (en) 2013-01-30
AU2010308120A1 (en) 2012-05-03
KR20120083899A (ko) 2012-07-26
CN102666575A (zh) 2012-09-12

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