EA202090759A2 - Коровый белок вируса гепатита в и поверхностный антигенный белок и содержащая их вакцина - Google Patents
Коровый белок вируса гепатита в и поверхностный антигенный белок и содержащая их вакцинаInfo
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- EA202090759A2 EA202090759A2 EA202090759A EA202090759A EA202090759A2 EA 202090759 A2 EA202090759 A2 EA 202090759A2 EA 202090759 A EA202090759 A EA 202090759A EA 202090759 A EA202090759 A EA 202090759A EA 202090759 A2 EA202090759 A2 EA 202090759A2
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- vaccines
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- protein
- hepatitis
- hbv
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- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
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Abstract
В настоящей заявке предлагаются последовательности нуклеиновых кислот, кодирующие коровые белки вируса гепатита В (HBV), поверхностные антигенные белки, их фрагменты и комбинации, а также генетические конструкты/векторы и вакцины, которые экспрессируют указанные белковые последовательности. Эти вакцины способны индуцировать иммунный ответ периферически и в печени с помощью набора клеточных и гуморальных агентов. В настоящей заявке предлагаются также способы профилактической и/или терапевтической иммунизации индивидуумов против HBV. Комбинированная вакцина также может быть использована для разработки индивидуальных вакцин для отдельных уровней иммунных ответов на заражение HBV.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/622,965 US9238679B2 (en) | 2011-02-11 | 2012-09-19 | Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same |
Publications (2)
Publication Number | Publication Date |
---|---|
EA202090759A2 true EA202090759A2 (ru) | 2020-07-31 |
EA202090759A3 EA202090759A3 (ru) | 2020-10-30 |
Family
ID=48945721
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201590597A EA036030B1 (ru) | 2012-09-19 | 2013-09-19 | Иммуногенная вакцина против hbv у человека |
EA202090759A EA202090759A3 (ru) | 2012-09-19 | 2013-09-19 | Коровый белок вируса гепатита в и поверхностный антигенный белок и содержащая их вакцина |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201590597A EA036030B1 (ru) | 2012-09-19 | 2013-09-19 | Иммуногенная вакцина против hbv у человека |
Country Status (17)
Country | Link |
---|---|
US (2) | US9238679B2 (ru) |
EP (1) | EP2897640B1 (ru) |
JP (3) | JP6795303B2 (ru) |
KR (3) | KR20230141895A (ru) |
CN (2) | CN104640565B (ru) |
AU (1) | AU2013318022B2 (ru) |
BR (1) | BR112015005987A2 (ru) |
CA (2) | CA2882839C (ru) |
EA (2) | EA036030B1 (ru) |
HK (2) | HK1210702A1 (ru) |
MX (2) | MX363671B (ru) |
NZ (1) | NZ705526A (ru) |
PH (1) | PH12015500308B1 (ru) |
SG (2) | SG10201702325UA (ru) |
UA (1) | UA120909C2 (ru) |
WO (1) | WO2014047286A1 (ru) |
ZA (1) | ZA201501639B (ru) |
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PT2672992T (pt) | 2011-02-11 | 2020-07-27 | Univ Pennsylvania | Molécula de ácidos nucleicos codificando proteína nuclear do vírus da hepatite b e vacina compreendendo a mesma |
CN109414496B (zh) | 2016-04-06 | 2024-01-26 | 华盛顿大学 | 用于乙型肝炎病毒(hbv)的使用hbv核心抗原的治疗性疫苗 |
KR20190096329A (ko) * | 2016-07-05 | 2019-08-19 | 유니버시티 오브 매사추세츠 | 녹내장에서 신경보호 요법으로서 sfasl의 aav2-매개된 유전자 전달 |
CN106421774B (zh) * | 2016-09-08 | 2019-05-28 | 中国科学院生物物理研究所 | PreS1用于制备乙肝疫苗以及治疗慢性乙型肝炎的用途 |
KR20190092371A (ko) * | 2016-09-21 | 2019-08-07 | 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 | 섬유아세포 활성화 단백질을 표적화하는 최적화된 합성 컨센서스 면역원성 조성물 |
US11471527B2 (en) | 2017-06-05 | 2022-10-18 | Beacle Inc. | Virus-like particles including HBs-L antigen protein for causing immune response against HBV |
CN111542340B (zh) * | 2017-11-16 | 2023-12-19 | 华盛顿大学 | 治疗性乙型肝炎病毒(hbv)疫苗 |
US20220047695A1 (en) * | 2018-12-21 | 2022-02-17 | The Wistar Institute Of Anatomy And Biology | Compositions comprising self-assembling vaccines and methods of using the same |
KR102175170B1 (ko) * | 2019-02-19 | 2020-11-05 | 대한민국 | HBV enhancer 억제인자 ACK1을 포함하는 B형 간염 치료용 조성물 |
CA3143680A1 (en) * | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 or anti-pd-l1 antibody |
US11497808B2 (en) | 2019-09-30 | 2022-11-15 | Gilead Sciences, Inc. | HBV vaccines and methods treating HBV |
CN111494616A (zh) * | 2020-04-27 | 2020-08-07 | 重庆医科大学附属永川医院 | 一种新冠病毒免疫增强型基因疫苗及其制备方法 |
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