EA202090759A2 - Коровый белок вируса гепатита в и поверхностный антигенный белок и содержащая их вакцина - Google Patents

Коровый белок вируса гепатита в и поверхностный антигенный белок и содержащая их вакцина

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EA202090759A2
EA202090759A2 EA202090759A EA202090759A EA202090759A2 EA 202090759 A2 EA202090759 A2 EA 202090759A2 EA 202090759 A EA202090759 A EA 202090759A EA 202090759 A EA202090759 A EA 202090759A EA 202090759 A2 EA202090759 A2 EA 202090759A2
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vaccines
virus
protein
hepatitis
hbv
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EA202090759A
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English (en)
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EA202090759A3 (ru
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Дэвид Б. Уэйнер
Цзянь Янь
Ниямекие Обенг-Аджей
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Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания
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Publication of EA202090759A2 publication Critical patent/EA202090759A2/ru
Publication of EA202090759A3 publication Critical patent/EA202090759A3/ru

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Abstract

В настоящей заявке предлагаются последовательности нуклеиновых кислот, кодирующие коровые белки вируса гепатита В (HBV), поверхностные антигенные белки, их фрагменты и комбинации, а также генетические конструкты/векторы и вакцины, которые экспрессируют указанные белковые последовательности. Эти вакцины способны индуцировать иммунный ответ периферически и в печени с помощью набора клеточных и гуморальных агентов. В настоящей заявке предлагаются также способы профилактической и/или терапевтической иммунизации индивидуумов против HBV. Комбинированная вакцина также может быть использована для разработки индивидуальных вакцин для отдельных уровней иммунных ответов на заражение HBV.
EA202090759A 2012-09-19 2013-09-19 Коровый белок вируса гепатита в и поверхностный антигенный белок и содержащая их вакцина EA202090759A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13/622,965 US9238679B2 (en) 2011-02-11 2012-09-19 Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same

Publications (2)

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EA202090759A2 true EA202090759A2 (ru) 2020-07-31
EA202090759A3 EA202090759A3 (ru) 2020-10-30

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EA201590597A EA036030B1 (ru) 2012-09-19 2013-09-19 Иммуногенная вакцина против hbv у человека
EA202090759A EA202090759A3 (ru) 2012-09-19 2013-09-19 Коровый белок вируса гепатита в и поверхностный антигенный белок и содержащая их вакцина

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US (2) US9238679B2 (ru)
EP (1) EP2897640B1 (ru)
JP (3) JP6795303B2 (ru)
KR (3) KR102581951B1 (ru)
CN (2) CN107337719B (ru)
AU (1) AU2013318022B2 (ru)
BR (1) BR112015005987A2 (ru)
CA (2) CA2882839C (ru)
EA (2) EA036030B1 (ru)
HK (2) HK1210702A1 (ru)
MX (2) MX363671B (ru)
NZ (1) NZ705526A (ru)
PH (1) PH12015500308A1 (ru)
SG (2) SG10201702325UA (ru)
UA (1) UA120909C2 (ru)
WO (1) WO2014047286A1 (ru)
ZA (1) ZA201501639B (ru)

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CN117866990A (zh) * 2017-11-16 2024-04-12 华盛顿大学 使用HBV包膜蛋白的HBV PreS1和/或PreS2和/或S-HBsAg区域的治疗乙型肝炎病毒（HBV）的疫苗
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