CY1124202T1 - Εμβολια ανασυνδυασμενου zika - Google Patents

Εμβολια ανασυνδυασμενου zika

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Publication number
CY1124202T1
CY1124202T1 CY20211100454T CY211100454T CY1124202T1 CY 1124202 T1 CY1124202 T1 CY 1124202T1 CY 20211100454 T CY20211100454 T CY 20211100454T CY 211100454 T CY211100454 T CY 211100454T CY 1124202 T1 CY1124202 T1 CY 1124202T1
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CY
Cyprus
Prior art keywords
zika virus
recombinant
immunogen
nucleic acid
encoding
Prior art date
Application number
CY20211100454T
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English (en)
Inventor
Erich Tauber
Sabrina SCHRAUF
Matthias Müllner
Katrin Ramsauer
Angelika Irmler
Patrick Csar
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Themis Bioscience Gmbh
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Publication date
Application filed by Themis Bioscience Gmbh filed Critical Themis Bioscience Gmbh
Publication of CY1124202T1 publication Critical patent/CY1124202T1/el

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Abstract

Η παρούσα εφεύρεση αναφέρεται στην παροχή συνθέσεων ανοσογόνων ή εμβολίου που περιλαμβάνουν τουλάχιστον ένα αντιγόνο ανασυνδυα σμένου ιού Zika, όπου το τουλάχιστον ένα αντιγόνο ανασυνδυασμένου ιού Zika κωδικοποιείται από τουλάχιστον μία αλληλουχία νουκλεϊνικού οξέος που κωδικοποιεί τουλάχιστον μία Ε-πρωτεΐνη ενός ιού Zika ή ένα λειτουργικό θραύσμα αυτής. Περαιτέρω παρέχονται μόρια νουκλεϊνικού οξέος και ένας ανασυνδυασμένος χιμαιρικός ιός που κωδικοποιεί και/ή περιλαμβάνει επιλεγμένα αντιγόνα από έναν ιό Zika, που είναι κατάλληλα ως συνθέσεις εμβολίου. Κατά προτίμηση, οι αλληλουχίες που κωδικοποιούν τουλάχιστον ένα αντιγόνο ιού Zika κατάλληλο για την πρόκληση μίας ανοσολογικής αντίδρασης είναι λειτουργικά συνδεδεμένες σε έναν σκελετό φορέα μη προερχόμενο από φλαβοϊό. Περαιτέρω παρέχονται μέθοδοι για τον καθαρισμό των σωματιδίων του ανασυνδυασμένου χιμαιρικού ιού ή της ανοσογόνου σύνθεσης. Τέλος, παρέχεται μία σύνθεση ανοσογόνος/εμβολίου για χρήση σε μία μέθοδο αποτροπής ή αγωγής μίας νόσου ιού Zika.
CY20211100454T 2015-12-23 2021-05-26 Εμβολια ανασυνδυασμενου zika CY1124202T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15202480.8A EP3184119A1 (en) 2015-12-23 2015-12-23 Chromatography based purification strategies for measles scaffold based viruses
EP16162688.2A EP3184118B1 (en) 2015-12-23 2016-03-29 Recombinant zika vaccines
PCT/EP2016/082659 WO2017109222A1 (en) 2015-12-23 2016-12-23 Recombinant zika vaccines

Publications (1)

Publication Number Publication Date
CY1124202T1 true CY1124202T1 (el) 2022-05-27

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US (2) US11110162B2 (el)
EP (5) EP3184119A1 (el)
BR (1) BR112018012962A2 (el)
CY (1) CY1124202T1 (el)
DK (1) DK3393505T3 (el)
ES (1) ES2867954T3 (el)
HR (1) HRP20210591T1 (el)
HU (1) HUE054847T2 (el)
LT (1) LT3393505T (el)
MX (1) MX2018007860A (el)
PL (1) PL3393505T3 (el)
PT (1) PT3393505T (el)
RS (1) RS61939B1 (el)
SG (2) SG10202004516VA (el)
SI (1) SI3393505T1 (el)
WO (2) WO2017109222A1 (el)
ZA (2) ZA201804071B (el)

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