JP2016517425A5 - - Google Patents
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- Publication number
- JP2016517425A5 JP2016517425A5 JP2016502376A JP2016502376A JP2016517425A5 JP 2016517425 A5 JP2016517425 A5 JP 2016517425A5 JP 2016502376 A JP2016502376 A JP 2016502376A JP 2016502376 A JP2016502376 A JP 2016502376A JP 2016517425 A5 JP2016517425 A5 JP 2016517425A5
- Authority
- JP
- Japan
- Prior art keywords
- capsule
- targeted
- ileum
- delivery system
- probiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002775 capsule Substances 0.000 claims 44
- 239000006041 probiotic Substances 0.000 claims 39
- 235000018291 probiotics Nutrition 0.000 claims 39
- 210000001072 colon Anatomy 0.000 claims 31
- 210000003405 ileum Anatomy 0.000 claims 31
- 230000000529 probiotic effect Effects 0.000 claims 26
- 239000000203 mixture Substances 0.000 claims 25
- 238000009472 formulation Methods 0.000 claims 21
- 239000002702 enteric coating Substances 0.000 claims 17
- 238000009505 enteric coating Methods 0.000 claims 17
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 7
- 229920001577 copolymer Polymers 0.000 claims 7
- 241000894006 Bacteria Species 0.000 claims 6
- 241000193163 Clostridioides difficile Species 0.000 claims 6
- 238000002360 preparation method Methods 0.000 claims 5
- 241000186000 Bifidobacterium Species 0.000 claims 4
- 241000186660 Lactobacillus Species 0.000 claims 4
- 230000001580 bacterial effect Effects 0.000 claims 4
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 4
- 229940039696 lactobacillus Drugs 0.000 claims 4
- 241000894007 species Species 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 208000010643 digestive system disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 3
- 125000005395 methacrylic acid group Chemical group 0.000 claims 3
- 229940102838 methylmethacrylate Drugs 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 241000606125 Bacteroides Species 0.000 claims 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 2
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims 2
- 230000007928 solubilization Effects 0.000 claims 2
- 238000005063 solubilization Methods 0.000 claims 2
- 208000037384 Clostridium Infections Diseases 0.000 claims 1
- 206010009657 Clostridium difficile colitis Diseases 0.000 claims 1
- 206010054236 Clostridium difficile infection Diseases 0.000 claims 1
- 241000186216 Corynebacterium Species 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 241000255925 Diptera Species 0.000 claims 1
- 208000027244 Dysbiosis Diseases 0.000 claims 1
- 241000605980 Faecalibacterium prausnitzii Species 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229940075534 amino methacrylate copolymer Drugs 0.000 claims 1
- 239000003518 caustics Substances 0.000 claims 1
- 239000006285 cell suspension Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000007140 dysbiosis Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 238000009940 knitting Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361781810P | 2013-03-14 | 2013-03-14 | |
| US61/781,810 | 2013-03-14 | ||
| US201361897378P | 2013-10-30 | 2013-10-30 | |
| US61/897,378 | 2013-10-30 | ||
| PCT/US2014/027228 WO2014152338A1 (en) | 2013-03-14 | 2014-03-14 | Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019000861A Division JP6860596B2 (ja) | 2013-03-14 | 2019-01-07 | プロバイオティクス生物及び／又は治療剤の標的化胃腸管デリバリー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016517425A JP2016517425A (ja) | 2016-06-16 |
| JP2016517425A5 true JP2016517425A5 (enExample) | 2017-04-20 |
| JP6464142B2 JP6464142B2 (ja) | 2019-02-06 |
Family
ID=51581192
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502376A Active JP6464142B2 (ja) | 2013-03-14 | 2014-03-14 | プロバイオティクス生物及び／又は治療剤の標的化胃腸管デリバリー |
| JP2019000861A Active JP6860596B2 (ja) | 2013-03-14 | 2019-01-07 | プロバイオティクス生物及び／又は治療剤の標的化胃腸管デリバリー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019000861A Active JP6860596B2 (ja) | 2013-03-14 | 2019-01-07 | プロバイオティクス生物及び／又は治療剤の標的化胃腸管デリバリー |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US9907755B2 (enExample) |
| EP (1) | EP2968187A4 (enExample) |
| JP (2) | JP6464142B2 (enExample) |
| CN (2) | CN110075130A (enExample) |
| AU (3) | AU2014239883B2 (enExample) |
| BR (1) | BR112015023124A2 (enExample) |
| CA (3) | CA3101218A1 (enExample) |
| RU (1) | RU2015140610A (enExample) |
| WO (1) | WO2014152338A1 (enExample) |
Families Citing this family (150)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| WO2011151941A1 (ja) | 2010-06-04 | 2011-12-08 | 国立大学法人東京大学 | 制御性ｔ細胞の増殖または集積を誘導する作用を有する組成物 |
| BR112013002667B1 (pt) | 2010-08-04 | 2020-02-04 | Thomas Julius Borody | composições para transplante da flora intestinal e métodos para fazê-las e usá-las e dispositivos para administrá-las |
| US12257272B2 (en) | 2015-12-24 | 2025-03-25 | Seed Health, Inc. | Method and system for reducing the likelihood of developing depression in an individual |
| US11998479B2 (en) | 2011-02-04 | 2024-06-04 | Seed Health, Inc. | Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure |
| US11951140B2 (en) * | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
| US12279989B2 (en) | 2011-02-04 | 2025-04-22 | Seed Health, Inc. | Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity |
| EP3610881A1 (en) | 2011-03-09 | 2020-02-19 | Regents Of The University Of Minnesota | Compositions and methods for transplantation of colon microbiota |
| GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| EP3569690B1 (en) | 2011-12-01 | 2024-08-28 | The University of Tokyo | Human-derived bacteria that induce proliferation or accumulation of regulatory t cells |
| CA3008794C (en) | 2012-03-29 | 2021-03-16 | Therabiome, Llc | Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix |
| US9719144B2 (en) | 2012-05-25 | 2017-08-01 | Arizona Board Of Regents | Microbiome markers and therapies for autism spectrum disorders |
| RU2015140610A (ru) | 2013-03-14 | 2017-04-17 | ТЕРАБАЙОМ, ЭлЭлСи | Направленная доставка в желудочно-кишечный тракт пробиотических микроорганизмов и/или терапевтических средств |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| US12246043B2 (en) | 2013-12-20 | 2025-03-11 | Seed Health, Inc. | Topical application to treat acne vulgaris |
| US11998574B2 (en) | 2013-12-20 | 2024-06-04 | Seed Health, Inc. | Method and system for modulating an individual's skin microbiome |
| US11980643B2 (en) | 2013-12-20 | 2024-05-14 | Seed Health, Inc. | Method and system to modify an individual's gut-brain axis to provide neurocognitive protection |
| US12329783B2 (en) | 2013-12-20 | 2025-06-17 | Seed Health, Inc. | Method and system to improve the health of a person's skin microbiome |
| US11969445B2 (en) | 2013-12-20 | 2024-04-30 | Seed Health, Inc. | Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH |
| US12005085B2 (en) | 2013-12-20 | 2024-06-11 | Seed Health, Inc. | Probiotic method and composition for maintaining a healthy vaginal microbiome |
| EP2946773A1 (en) * | 2014-05-19 | 2015-11-25 | Tillotts Pharma AG | Modified release coated capsules |
| DK2946774T3 (da) | 2014-05-19 | 2020-05-25 | Tillotts Pharma Ag | Coatede kapsler med modificeret frigivelse |
| EP3164145A4 (en) | 2014-07-01 | 2018-01-17 | Probi Usa, Inc. | Bi-layer dual release probiotic tablets |
| WO2016065279A1 (en) * | 2014-10-23 | 2016-04-28 | Symbiotic Health Inc. | A capsule for the oral administration of biopharmaceuticals |
| SG10201903823QA (en) * | 2014-10-31 | 2019-05-30 | Whole Biome Inc | Methods and compositions relating to microbial treatment and diagnosis of disorders |
| MA41020A (fr) | 2014-11-25 | 2017-10-03 | Evelo Biosciences Inc | Compositions probiotiques et prébiotiques, et leurs procédés d'utilisation pour la modulation du microbiome |
| EP3193901B1 (en) | 2014-12-23 | 2018-04-04 | 4D Pharma Research Limited | Pirin polypeptide and immune modulation |
| ES2658310T3 (es) * | 2014-12-23 | 2018-03-09 | 4D Pharma Research Limited | Una cepa de bacteroides thetaiotaomicron y su uso en la reducción de la inflamación |
| AU2018205072B2 (en) * | 2014-12-23 | 2020-05-21 | Cj Bioscience, Inc. | Immune modulation |
| EP3294308A4 (en) | 2015-05-14 | 2019-03-06 | University of Puerto Rico | PROCESS FOR RECOVERING THE BIOZOOSE OF NEWBORN |
| CN107949391B (zh) | 2015-05-14 | 2021-11-09 | 克雷斯顿沃控股公司 | 用于粪便菌群移植的组合物以及用于制备和使用它们的方法和用于递送它们的装置 |
| PT3297644T (pt) | 2015-05-22 | 2022-03-30 | Univ Arizona State | Métodos para tratar distúrbios do espetro do autismo e sintomas associados |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| PT3307288T (pt) | 2015-06-15 | 2019-10-17 | 4D Pharma Res Ltd | Composições compreendendo estirpes bacterianas |
| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| MA55434B1 (fr) | 2015-06-15 | 2022-02-28 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| TWI759266B (zh) | 2015-06-15 | 2022-04-01 | 英商4D製藥研究有限公司 | 包含細菌菌株之組合物之用途 |
| CN106822007B (zh) | 2015-09-11 | 2021-12-31 | 西姆莱斯股份公司 | 口服制剂 |
| GB201519088D0 (en) | 2015-10-28 | 2015-12-09 | Metabogen Ab | The use of bacteria formulations |
| MA45287A (fr) | 2015-11-20 | 2018-08-22 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520631D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| ITUB20159138A1 (it) * | 2015-12-22 | 2017-06-22 | Euro Pharma Srl | Formulazioni terapeutiche integrative per la somministrazione separata, sequenziale o simultanea di acido butirrico, G.S.E probiotici e prebiotici. |
| WO2017117142A1 (en) | 2015-12-28 | 2017-07-06 | New York University | Device and method of restoring microbiota of newborns |
| CN115919906A (zh) | 2016-03-04 | 2023-04-07 | 加利福尼亚大学董事会 | 微生物聚生体及其用途 |
| PT3313423T (pt) | 2016-03-04 | 2019-07-10 | 4D Pharma Plc | Composições que compreendem a estirpe blautia bacteriana para tratar a hipersensibilidade visceral |
| GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
| US9855305B2 (en) | 2016-03-29 | 2018-01-02 | Companion Therapeutics Llc | Pharmaceutical composition containing combinations of vitamins, minerals, probiotics, and prebiotics effective in preventing adverse effects associated with the use of proton-pump inhibitors |
| PT3468573T (pt) | 2016-06-14 | 2023-10-16 | Vedanta Biosciences Inc | Tratamento de uma infeção por clostridium difficile |
| US20170360848A1 (en) | 2016-06-15 | 2017-12-21 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for treating autism spectrum disorder and associated symptoms |
| CN109562147B (zh) * | 2016-06-28 | 2023-09-01 | 特里瓦生物制剂有限公司 | 保护微生物组免受口服抗生素 |
| US10849936B2 (en) | 2016-07-01 | 2020-12-01 | Regents Of The University Of Minnesota | Compositions and methods for C. difficile treatment |
| TWI802545B (zh) | 2016-07-13 | 2023-05-21 | 英商４Ｄ製藥有限公司 | 包含細菌菌株之組合物 |
| CN109689076A (zh) * | 2016-07-19 | 2019-04-26 | Ao生物医学有限责任公司 | 用于胃肠系统使用和递送至胃肠系统的氨氧化微生物 |
| US20180036352A1 (en) | 2016-08-03 | 2018-02-08 | Crestovo Holdings Llc | Methods for treating ulcerative colitis |
| US20180185421A1 (en) * | 2016-08-29 | 2018-07-05 | Tokyo Metropolitan Government | Composition comprising fecal microbiota |
| CN109219656B (zh) * | 2016-09-06 | 2025-12-09 | 深圳华大生命科学研究院 | 长栖粪杆菌（Faecalibacterium longum）及其应用 |
| WO2018057747A1 (en) * | 2016-09-21 | 2018-03-29 | Finch Therapeutics, Inc. | Pharmaceutical compositions and methods for delivering microbial compositions |
| WO2018071537A1 (en) | 2016-10-11 | 2018-04-19 | Crestovo Holdings Llc | Compositions and methods for treating multiple sclerosis and related disorders |
| US11213549B2 (en) | 2016-10-11 | 2022-01-04 | Finch Therapeutics Holdings Llc | Compositions and method for treating primary sclerosing cholangitis and related disorders |
| US10092601B2 (en) | 2016-10-11 | 2018-10-09 | Crestovo Holdings Llc | Compositions and methods for treating multiple sclerosis and related disorders |
| CN108066296B (zh) * | 2016-11-11 | 2020-11-17 | 南京益恒寿生命科技有限公司 | 一种生物学活性组分结肠靶向组合物及其应用 |
| KR102805966B1 (ko) * | 2016-12-01 | 2025-05-12 | 주식회사 포스코 | 바이오프린팅 기술을 이용한 셀룰로오스 나노섬유 전달체 및 이를 이용한 선택적 방출 방법 |
| GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
| US10596206B1 (en) | 2017-03-14 | 2020-03-24 | Cornell University | Probiotic compositions and methods of use |
| EP3603421A4 (en) * | 2017-03-28 | 2021-02-17 | Ajinomoto Co., Inc. | DIET COMPOSITION TO IMPROVE THE INTRAINTESTINAL ENVIRONMENT |
| WO2018187464A1 (en) | 2017-04-05 | 2018-10-11 | Crestovo Holdings Llc | Compositions and methods for treating diverticulitis and related disorders |
| WO2018187467A1 (en) | 2017-04-05 | 2018-10-11 | Crestovo Holdings Llc | Compositions and methods for treating parkinson's disease (pd) and related disorders |
| RS61872B1 (sr) | 2017-05-22 | 2021-06-30 | 4D Pharma Res Ltd | Kompozicije koje sadrže bakterijske sojeve |
| WO2018215782A1 (en) | 2017-05-24 | 2018-11-29 | 4D Pharma Research Limited | Compositions comprising bacterial strain |
| WO2018218159A1 (en) | 2017-05-26 | 2018-11-29 | Crestovo Holdings Llc | Lyophilized compositions comprising fecal microbe-based therapeutic agents and methods for making and using same |
| RS63393B1 (sr) | 2017-06-14 | 2022-08-31 | 4D Pharma Res Ltd | Kompozicije koje sadrže bakterijske sojeve |
| EP3638271B1 (en) | 2017-06-14 | 2020-10-14 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| JP6840272B2 (ja) | 2017-06-14 | 2021-03-10 | フォーディー ファーマ リサーチ リミテッド４Ｄ Ｐｈａｒｍａ Ｒｅｓｅａｒｃｈ Ｌｉｍｉｔｅｄ | 細菌株を含む組成物 |
| TWI778083B (zh) | 2017-06-16 | 2022-09-21 | 日商表飛鳴製藥股份有限公司 | 脂肪關連疾患及/或炎症的預防或治療劑 |
| EP3641732A1 (en) * | 2017-06-21 | 2020-04-29 | Minerva Neurosciences, Inc. | Gastro-resistant controlled release oral dosage forms |
| CN107307429B (zh) * | 2017-07-04 | 2020-09-22 | 北京英茂药业有限公司 | 益生菌制剂的薄膜包衣预混剂及其制备方法、应用 |
| MA51770A (fr) * | 2017-07-05 | 2020-05-13 | Evelo Biosciences Inc | Compositions et méthodes de traitement du cancer à l'aide de bifidobacterium animalis ssp. lactis |
| US11865145B2 (en) | 2017-08-07 | 2024-01-09 | Finch Therapeutics Holdings Llc | Compositions and methods for maintaining and restoring a healthy gut barrier |
| WO2019046401A1 (en) | 2017-08-29 | 2019-03-07 | Evelo Biosciences, Inc. | TREATMENT OF CANCER USING BLAUTIA STRAIN |
| WO2019046646A1 (en) | 2017-08-30 | 2019-03-07 | Whole Biome Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF MICROBIOMA ASSOCIATED DISORDERS |
| EP3694541A2 (en) * | 2017-10-09 | 2020-08-19 | Enterome S.A. | Microbiota sequence variants of tumor-related antigenic epitopes |
| WO2019099482A1 (en) | 2017-11-14 | 2019-05-23 | Evelo Biosciences, Inc. | Compositions and methods for treating disease using a blautia strain |
| CN111787932A (zh) | 2017-11-15 | 2020-10-16 | 伊夫罗生物科学公司 | 使用免疫调节性乳球菌属细菌菌株治疗免疫病症的组合物和方法 |
| EP3485879A1 (en) * | 2017-11-17 | 2019-05-22 | Maat Pharma | Pharmaceutical oral formulation comrpsing bacteria |
| US10980482B2 (en) | 2017-12-06 | 2021-04-20 | James Phillip Jones | Sampling capsule system and methods |
| CN107998152A (zh) * | 2017-12-14 | 2018-05-08 | 乐普制药科技有限公司 | 一种结肠释放的益生菌片 |
| US11491192B2 (en) * | 2018-01-09 | 2022-11-08 | The Cleveland Clinic Foundation | Treatment and prevention of pathogenic bacterial overgrowth using butyrate-producing bacteria |
| KR102282490B1 (ko) * | 2018-01-12 | 2021-07-28 | 주식회사 엠디헬스케어 | 패칼리박테리움 프라우스니찌 유래 나노소포 및 이의 용도 |
| WO2019152667A1 (en) | 2018-01-31 | 2019-08-08 | Evelo Biosciences, Inc. | Compositions and methods for treating immune disorders using lachnospiraceae bacteria |
| EP3749289A4 (en) * | 2018-02-06 | 2021-11-17 | Robert Niichel | MULTIPARTICLE SUBSTANCE WITH PHARMACEUTICAL OR PROBIOTIC INGREDIENTS |
| CA3090166A1 (en) | 2018-02-06 | 2019-08-15 | Evelo Biosciences, Inc. | Compositions and methods for treating cancer and immune disorders using veillonella bacteria |
| WO2019169143A1 (en) | 2018-02-28 | 2019-09-06 | Evelo Biosciences, Inc. | Compositions and methods for treating cancer using turicibacter sanguinis |
| WO2019169138A1 (en) | 2018-02-28 | 2019-09-06 | Evelo Biosciences, Inc. | Compositions and methods for treating cancer using paraclostridium benzoelyticum |
| WO2019169168A1 (en) | 2018-02-28 | 2019-09-06 | Evelo Biosciences, Inc. | Compositions and methods for treating cancer using agathobaculum |
| WO2019169160A1 (en) | 2018-02-28 | 2019-09-06 | Evelo Biosciences, Inc. | Compositions and methods for treating cancer using ruminococcus gnavus |
| WO2019178057A1 (en) | 2018-03-12 | 2019-09-19 | Evelo Biosciences, Inc. | Methods of treating cancer using burkholderia |
| WO2019178490A1 (en) | 2018-03-15 | 2019-09-19 | Evelo Biosciences, Inc. | Compositions and methods for treating cancer and inflammation using klebsiella oxytoca |
| WO2019178487A2 (en) | 2018-03-15 | 2019-09-19 | Evelo Biosciences, Inc. | Compositions and methods for treating disease using klebsiella quasipneumoniae subsp. similipneumoniae |
| WO2019178494A1 (en) | 2018-03-15 | 2019-09-19 | Evelo Biosciences, Inc. | Compositions and methods for treating cancer and inflammation using tyzzerella nexilis |
| US10780135B2 (en) * | 2018-04-05 | 2020-09-22 | Hooman M. MELAMED | Probiotic formulation and method for weight loss treatment |
| AU2019253714A1 (en) | 2018-04-10 | 2020-11-26 | Siolta Therapeutics, Inc. | Microbial consortia |
| IT201800004764A1 (it) * | 2018-04-20 | 2019-10-20 | Composizione orale per uso come potenziatore di batteri eubiotici già presenti a livello intestinale. | |
| CN112105347A (zh) * | 2018-05-03 | 2020-12-18 | 兆瓦恩卡普有限公司 | 将药物递送至下消化道的剂型 |
| WO2020032885A2 (en) * | 2018-05-04 | 2020-02-13 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Capsule-in-capsule compositions of dabigatran etexilate |
| US20200000732A1 (en) * | 2018-05-30 | 2020-01-02 | DolCas Biotech, LLC | Probiotic compositions and dosage forms, and methods for preparing and using the same |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| US11166990B2 (en) | 2018-07-13 | 2021-11-09 | Finch Therapeutics Holdings Llc | Methods and compositions for treating ulcerative colitis |
| CN113164526A (zh) | 2018-07-19 | 2021-07-23 | 潘德勒姆治疗公司 | 用于微生物植入的方法和组合物 |
| CN108567799A (zh) * | 2018-08-01 | 2018-09-25 | 中国人民解放军总医院 | 一种全粪菌复合胶囊及其制备方法和应用 |
| US12161680B2 (en) | 2018-08-17 | 2024-12-10 | Vedanta Biosciences, Inc. | Methods of decreasing dysbiosis and restoring a microbiome |
| US12144834B2 (en) | 2018-09-13 | 2024-11-19 | Xbiome Inc. | Methods and compositions for treating gastrointestinal and inflammatory disorders |
| US20210393737A1 (en) * | 2018-09-25 | 2021-12-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of mam polypeptides for the treatment of obesity and obesity-related disorders |
| CN113164527A (zh) | 2018-09-27 | 2021-07-23 | 芬奇治疗控股有限责任公司 | 用于治疗癫痫和相关障碍的组合物和方法 |
| CN109999010B (zh) * | 2019-04-23 | 2021-06-15 | 河北地邦动物保健科技有限公司 | 一种益生菌包被微丸及其制备方法 |
| US20220193033A1 (en) * | 2019-04-30 | 2022-06-23 | Dsm Ip Assets B.V. | New delivery system for specific water-soluble vitamins |
| CN110368405A (zh) * | 2019-07-17 | 2019-10-25 | 上海交通大学医学院附属瑞金医院 | 一种肠道菌群的重建方法 |
| PE20221399A1 (es) | 2019-07-19 | 2022-09-15 | Finch Therapeutics Holdings Llc | Metodos y productos para el tratamiento de trastornos gastrointestinales |
| WO2021022110A1 (en) | 2019-08-01 | 2021-02-04 | Evelo Biosciences, Inc. | Inducing immune effects using bacteria of the genus bifidobacterium |
| MX2022001607A (es) | 2019-08-05 | 2022-03-11 | Evelo Biosciences Inc | Composiciones y metodos para tratar la psoriasis y la dermatitis atopica usando prevotella histicola. |
| WO2021030474A1 (en) * | 2019-08-12 | 2021-02-18 | Massachusetts Institute Of Technology | Articles and methods for administration of therapeutic agents |
| JP7741064B2 (ja) | 2019-08-28 | 2025-09-17 | エックスバイオーム インコーポレーテッド | 細菌種を含む組成物及びそれに関連する方法 |
| US20220331378A1 (en) * | 2019-09-13 | 2022-10-20 | Finch Therapeutics Holdings Llc | Compositions and methods for treating autism spectrum disorder |
| CA3153884A1 (en) | 2019-10-07 | 2021-04-15 | Nikole KIMES | Therapeutic pharmaceutical compositions |
| US11918694B2 (en) | 2019-10-21 | 2024-03-05 | Soane Pharma LLC | Orally ingestible delivery system |
| CA3165418A1 (en) * | 2019-12-27 | 2021-07-01 | Evelo Biosciences, Inc. | Solid dosage forms containing bacteria and microbial extracellular vesicles |
| WO2021142279A1 (en) | 2020-01-10 | 2021-07-15 | Evelo Biosciences, Inc. | Compositions and methods of treatment using veillonella parvula |
| KR102163637B1 (ko) * | 2020-04-06 | 2020-10-08 | 김한철 | 건강기능식품의 제조방법 |
| KR102167931B1 (ko) * | 2020-04-06 | 2020-10-20 | 김한철 | 건강기능식품의 제조방법 |
| WO2021221472A1 (ko) * | 2020-04-28 | 2021-11-04 | 주식회사 모든바이오 | 양친매성 진세노사이드를 포함하는 미셀 입자, 이를 포함하는 조성물 및 이의 제조 방법 |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| WO2022061141A1 (en) | 2020-09-21 | 2022-03-24 | Evelo Biosciences, Inc. | Compositions and methods of treating inflammation using prevotella histicola |
| TW202233214A (zh) | 2020-11-06 | 2022-09-01 | 美商艾弗洛生物科技股份有限公司 | 使用小韋榮氏球菌細菌誘導免疫效應 |
| CN112826836A (zh) * | 2021-01-08 | 2021-05-25 | 深圳未知君生物科技有限公司 | 一种粪菌口服制剂及其制备方法 |
| WO2022164422A1 (en) * | 2021-01-26 | 2022-08-04 | Seed Health Inc. | Methods and compositions for precision release of probiotics to improve human health |
| WO2022187064A1 (en) | 2021-03-01 | 2022-09-09 | Evelo Biosciences, Inc. | Compositions and methods of treating inflammation using prevotella histicola |
| WO2022216852A2 (en) * | 2021-04-07 | 2022-10-13 | Siolta Therapeutics, Inc. | Pharmaceutical compositions for treating diseases |
| US12011467B2 (en) | 2021-05-18 | 2024-06-18 | J. Craig Venter Institute, Inc. | Bacterial formulation |
| US20240285699A1 (en) * | 2021-06-24 | 2024-08-29 | Lonza Greenwood Llc | Method to Control Administration of Active Substance to the Digestive Tract |
| EP4429653A4 (en) * | 2021-11-10 | 2025-10-29 | Reverspah Llc | CANCER TREATMENT PROCESSES AND COMPOSITIONS |
| WO2023086873A1 (en) * | 2021-11-10 | 2023-05-19 | Reverspah Llc | Methods and compositions for treating cancer |
| WO2023150376A1 (en) | 2022-02-07 | 2023-08-10 | Evelo Biosciences, Inc. | Compositions and methods of affecting cytokine levels using prevotella histicola |
| KR102464572B1 (ko) * | 2022-03-22 | 2022-11-10 | 대한켐텍 주식회사 | 프로바이오틱스 캡슐제 |
| WO2023183396A1 (en) | 2022-03-22 | 2023-09-28 | Evelo Biosciences, Inc. | Compositions and methods of treating inflammation using prevotella histicola |
| WO2023200837A1 (en) | 2022-04-13 | 2023-10-19 | Evelo Biosciences, Inc. | Compositions and methods of treating inflammation using prevotella histicola |
| CN115671067B (zh) * | 2022-10-25 | 2024-02-06 | 深圳万和制药有限公司 | 黄龙滴丸治疗和预防肠易激综合征的用途 |
| CN116270523B (zh) * | 2023-05-15 | 2023-08-08 | 四川厌氧生物科技有限责任公司 | 一种耐酸的口服双层胶囊及其制备方法 |
| WO2025063915A1 (en) * | 2023-09-21 | 2025-03-27 | Bi̇oprobi̇f Sağlik Gida Arge Sanayi̇ Ve Ti̇caret Li̇mi̇ted Şi̇rketi̇ | Production of probiotic bacteria based biomaterial and bioplastic |
Family Cites Families (133)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1576376A (en) | 1977-03-30 | 1980-10-08 | Benzon As Alfred | Multiple-unit drug dose |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4230687A (en) | 1978-05-30 | 1980-10-28 | Griffith Laboratories U.S.A., Inc. | Encapsulation of active agents as microdispersions in homogeneous natural polymeric matrices |
| ZA825384B (en) | 1981-07-31 | 1983-05-25 | Tillott J B Ltd | Orally administrable pharmaceutical compositions |
| JPS5911177A (ja) | 1982-07-12 | 1984-01-20 | Seikenkai | 新規乳酸桿菌 |
| DK151608C (da) | 1982-08-13 | 1988-06-20 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat med kontrolleret afgivelse |
| US4888176A (en) | 1984-05-21 | 1989-12-19 | Massachusetts Institute Of Technology | Controlled drug delivery high molecular weight polyanhydrides |
| US4839281A (en) | 1985-04-17 | 1989-06-13 | New England Medical Center Hospitals, Inc. | Lactobacillus strains and methods of selection |
| US4789724A (en) | 1986-10-17 | 1988-12-06 | Massachusetts Institute Of Technology | Preparation of anhydride copolymers |
| US6024983A (en) | 1986-10-24 | 2000-02-15 | Southern Research Institute | Composition for delivering bioactive agents for immune response and its preparation |
| US4857311A (en) | 1987-07-31 | 1989-08-15 | Massachusetts Institute Of Technology | Polyanhydrides with improved hydrolytic degradation properties |
| GB8812490D0 (en) | 1988-05-26 | 1988-06-29 | Agricultural & Food Res | Delayed release formulations |
| IT1227154B (it) | 1988-08-05 | 1991-03-19 | A Tosi Farmaceutici S R L Nova | Composizioni farmaceutiche per uso ginecologico a base di lattobacilli |
| AT391323B (de) | 1989-03-10 | 1990-09-25 | Jungbunzlauer Ag | Mikroorganismus der species bacillus coagulans sowie ein verfahren zur herstellung von optisch reiner l(+)-milchsaeure |
| GB8926639D0 (en) | 1989-11-24 | 1990-01-17 | Agricultural & Food Res | Delayed release formulations |
| US5178866A (en) | 1990-03-23 | 1993-01-12 | Alza Corporation | Dosage form for delivering drug to the intestine |
| IT1246382B (it) | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
| WO1991016881A1 (en) | 1990-05-04 | 1991-11-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Colonic drug delivery system |
| IL98087A (en) | 1990-05-04 | 1996-11-14 | Perio Prod Ltd | Preparation for dispensing drugs in the colon |
| GEP19971086B (en) | 1991-02-22 | 1997-12-02 | Tillotts Pharma Ag | Peroral Pharmaceutically Dispensed Form for Selective Introducing of the Medicine into the Intestine |
| US5622649A (en) | 1991-06-27 | 1997-04-22 | Emory University | Multiple emulsions and methods of preparation |
| CZ282760B6 (cs) | 1991-11-22 | 1997-09-17 | Procter And Gamble Pharmaceuticals, Inc. | Risedronátové prostředky se zpožděným uvolňováním |
| KR100217826B1 (ko) | 1992-04-10 | 1999-09-01 | 나까도미 히로다카 | 리포솜조성물 |
| US5330759A (en) * | 1992-08-26 | 1994-07-19 | Sterling Winthrop Inc. | Enteric coated soft capsules and method of preparation thereof |
| ES2123665T3 (es) | 1992-11-30 | 1999-01-16 | Pfizer | Dispositivo para dispensar con membrana soporte de liquido. |
| US5413785A (en) | 1993-01-27 | 1995-05-09 | New England Deaconess Hospital Corp. | Methodology employing lactobacillus GG for reduction of plasma endotoxin levels circulating in-vivo |
| US5686105A (en) | 1993-10-19 | 1997-11-11 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
| US5843479A (en) | 1993-02-26 | 1998-12-01 | The Procter & Gamble Company | Bisacodyl dosage form with multiple enteric polymer coatings for colonic delivery |
| PT621032E (pt) | 1993-04-23 | 2001-01-31 | Novartis Ag | Dispositivo de distribuicao de libertacao controlada de farmaco |
| US5733568A (en) | 1993-12-03 | 1998-03-31 | Lafor Laboratories Limited | Micro-encapsulated lactobacilli for medical applications |
| US5788687A (en) | 1994-02-01 | 1998-08-04 | Caphco, Inc | Compositions and devices for controlled release of active ingredients |
| JP3867171B2 (ja) | 1994-04-22 | 2007-01-10 | アステラス製薬株式会社 | 結腸特異的薬物放出システム |
| GB9412394D0 (en) | 1994-06-21 | 1994-08-10 | Danbiosyst Uk | Colonic drug delivery composition |
| US5599795A (en) | 1994-08-19 | 1997-02-04 | Mccann; Michael | Method for treatment of idiopathic inflammatory bowel disease (IIBD) |
| FI98343C (fi) | 1995-03-21 | 1997-06-10 | Orion Yhtymae Oy | Peroraalinen formulaatio |
| US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| AU718040B2 (en) | 1995-12-21 | 2000-04-06 | Abbott Laboratories | Use of lactobacillus reuteri to inhibit cryptosporidiosis in mammals |
| AUPN881396A0 (en) | 1996-03-20 | 1996-04-18 | Arnott's Biscuits Limited | Enhancement of microbial colonization of the gastrointestinal tract |
| US6132710A (en) | 1997-03-17 | 2000-10-17 | Probiotix, Inc. | Preventing/treating neonatal NEC by administering lactobacillus salivarius and lactobacillus plantarum or a combination thereof |
| US6811786B1 (en) | 1999-04-01 | 2004-11-02 | Ganeden Biotech, Inc. | Methods for reducing cholesterol using Bacillus coagulans spores, systems and compositions |
| KR100501022B1 (ko) | 1998-07-28 | 2005-07-18 | 다나베 세이야꾸 가부시키가이샤 | 장내 적소 방출형 제제 |
| MXPA01003197A (es) | 1998-09-28 | 2004-04-21 | Warner Lambert Co | Suministro enterico y colonico utilizando capsulas de chpm. |
| DE69914932T2 (de) | 1998-10-20 | 2004-12-09 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Verwendung eines zytokine-produzierenden lactococcus stammes zur behandlung von kolitis |
| JP2003522731A (ja) | 1998-12-11 | 2003-07-29 | ウレックス バイオテック インク． | 泌尿生殖器感染に対する処置および防止のための乳酸菌の経口投与方法 |
| ID29150A (id) | 1999-01-15 | 2001-08-02 | Entpr Ireland Cs | Penggunaan lactobacillus salivarius |
| DK1183014T3 (da) | 1999-06-14 | 2004-02-09 | Cosmo Spa | Smagsmaskerede orale farmaceutiske sammensætninger med kontrolleret frigivelse |
| US6696057B1 (en) | 1999-09-22 | 2004-02-24 | Lacpro Industries, Inc. | Composition and method for treatment of gastrointestinal disorders and hyperlipidemia |
| US6641808B1 (en) | 1999-09-22 | 2003-11-04 | Lacpro Industries, Llc | Composition for treatment of obesity |
| US6849256B1 (en) | 1999-11-08 | 2005-02-01 | Ganeden Biotech Incorporated | Inhibition of pathogens by probiotic bacteria |
| JP2004504264A (ja) | 2000-01-07 | 2004-02-12 | ユニバーシティ オブ シンシナティ | Ｔｈ１又はｔｈ２リンパ球に制御される免疫応答の選択的活性化 |
| FR2808689B1 (fr) | 2000-05-11 | 2004-09-03 | Agronomique Inst Nat Rech | Utilisation de souches acetogenes hydrogenotrophes pour la prevention ou le traitement de troubles digestifs |
| US20040062757A1 (en) | 2001-06-05 | 2004-04-01 | Finegold Sydney M. | Method of testing gastrointestinal diseases associated with species of genus clostridium |
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| GB0017673D0 (en) * | 2000-07-20 | 2000-09-06 | Mw Encap Limited | Delivery device |
| US20030092145A1 (en) | 2000-08-24 | 2003-05-15 | Vic Jira | Viral vaccine composition, process, and methods of use |
| US8263146B2 (en) | 2001-02-19 | 2012-09-11 | Nestec S.A. | Consumable product containing probiotics |
| KR100437497B1 (ko) | 2001-03-07 | 2004-06-25 | 주식회사 프로바이오닉 | 로타바이러스 및 유해 미생물 억제 활성을 가지는 신규내산성 락토바실러스 루테리 프로바이오-16 및 이를함유하는 생균활성제 |
| US7780961B2 (en) | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
| US20030068356A1 (en) | 2001-07-10 | 2003-04-10 | Pather S. Indiran | Sequential drug delivery systems |
| GB0127916D0 (en) | 2001-11-21 | 2002-01-16 | Rowett Res Inst | Method |
| US7101565B2 (en) | 2002-02-05 | 2006-09-05 | Corpak Medsystems, Inc. | Probiotic/prebiotic composition and delivery method |
| US8323692B2 (en) | 2002-02-21 | 2012-12-04 | Valeant International Bermuda | Controlled release dosage forms |
| US20030194429A1 (en) | 2002-04-10 | 2003-10-16 | Miller Frederick H. | Multi-phase, multi-compartment capsular delivery apparatus for therapeutic compositions and methods for using same |
| US7670612B2 (en) | 2002-04-10 | 2010-03-02 | Innercap Technologies, Inc. | Multi-phase, multi-compartment capsular delivery apparatus and methods for using same |
| EP1513545B1 (en) | 2002-06-19 | 2008-03-19 | Actogenix N.V. | Methods and means to promote gut absorption |
| US8168170B2 (en) * | 2002-10-03 | 2012-05-01 | The Procter And Gamble Company | Compositions having an inner core and at least three surrounding layers |
| US7670627B2 (en) | 2002-12-09 | 2010-03-02 | Salvona Ip Llc | pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
| CN2601094Y (zh) | 2003-01-08 | 2004-01-28 | 江西本草天工科技有限责任公司 | 复合胶囊 |
| US20100221321A1 (en) | 2003-02-27 | 2010-09-02 | Innercap Technologies, Inc. | Apparatus And Methods For Delivering A Plurality Of Medicaments For Management Of Co-Morbid Diseases, Illnesses Or Conditions |
| US7718171B2 (en) | 2003-04-07 | 2010-05-18 | Chr. Hansen A/S | Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus |
| US7759105B2 (en) | 2003-08-29 | 2010-07-20 | Cobb & Company, Llp | Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions |
| US8192733B2 (en) | 2003-08-29 | 2012-06-05 | Cobb & Associates | Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions |
| US7731976B2 (en) | 2003-08-29 | 2010-06-08 | Cobb And Company, Llp | Treatment of irritable bowel syndrome using probiotic composition |
| US7749509B2 (en) | 2003-08-29 | 2010-07-06 | Cobb And Company, Llp | Treatment of autism using probiotic composition |
| US7645459B2 (en) | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of bisphosphonates |
| DE102004026706A1 (de) | 2004-05-28 | 2005-12-15 | Merck Patent Gmbh | Orale Darreichungsform enthaltend probiotische Bakterien |
| CN100400036C (zh) | 2004-07-27 | 2008-07-09 | 北京华安佛医药研究中心有限公司 | 胃肠复合型胶囊及其制备方法和应用 |
| DE602005010899D1 (de) | 2004-09-27 | 2008-12-18 | Sigmoid Pharma Ltd | Mikrokapseln mit einem methylxanthin und einem kortikosteroid |
| US20060093592A1 (en) * | 2004-10-04 | 2006-05-04 | Nutracea | Synbiotics |
| US8092793B2 (en) | 2004-12-15 | 2012-01-10 | Qingdao East Sea Pharmaceuticals, Ltd. | Treating inflammatory bowel disease with live bacteria |
| US9149439B2 (en) * | 2005-03-21 | 2015-10-06 | Sandoz Ag | Multi-particulate, modified-release composition |
| US7344867B2 (en) | 2005-04-15 | 2008-03-18 | Eamonn Connolly | Selection and use of lactic acid bacteria for reducing inflammation in mammals |
| HUP0500582A1 (hu) | 2005-06-13 | 2007-08-28 | Csaba Jozsef Dr Jaszberenyi | Szinergetikus élettani hatású élelmiszerek, élelmiszer-adalékok és táplálék-kiegészítõk vagy takarmányadalékok |
| US11744803B2 (en) | 2005-07-29 | 2023-09-05 | Stichting Groningen Centre for Drug Rese | PH-controlled pulsatile delivery system, methods for preparation and use thereof |
| CN101273133A (zh) | 2005-08-30 | 2008-09-24 | 联邦科学工业研究组织 | 生物活性多肽的细菌传送 |
| US9265724B2 (en) * | 2005-11-07 | 2016-02-23 | Ram B. Murty | Oral dosage form of tetrahydrocannabinol and a method of avoiding and/or suppressing hepatic first pass metabolism via targeted chylomicron/lipoprotein delivery |
| AR054730A1 (es) | 2006-02-01 | 2007-07-11 | Allende Miguel Angel Garcia | Nuevas bacterias lacticas utiles como probioticos |
| BRPI0707616A2 (pt) | 2006-02-09 | 2011-05-10 | Alba Therapuetics Corp | formulaÇÕes para um efetor de junÇço oclusiva |
| EP2081557A1 (en) * | 2006-11-17 | 2009-07-29 | DA Volterra | Colonic delivery using zn/pectin beads with a eudragit coating. |
| DE102006062250A1 (de) | 2006-12-22 | 2008-06-26 | Roland Saur-Brosch | Verwendung einer Zusammensetzung aus Mineralstoffen und/oder Vitaminen und gegebenenfalls acetogenen und/oder butyrogenen Bakterien zur oralen oder rektalen Verabreichung für die Behandlung und Vorbeugung von abdominalen Beschwerden |
| US20080233184A1 (en) | 2007-03-19 | 2008-09-25 | Kenneth Looney | Combination enzyme products |
| CN101677958A (zh) * | 2007-03-26 | 2010-03-24 | 帝国制药株式会社 | 用于结肠-特异性递送的口服药物制剂 |
| EP2380564B1 (en) | 2007-04-04 | 2014-10-22 | Sigmoid Pharma Limited | An oral pharmaceutical composition |
| TW200904340A (en) | 2007-05-11 | 2009-02-01 | Mannatech Inc | Processing of natural polysaccharides by selected non-pathogenic microorganisms and methods of making and using the same |
| ES2578261T3 (es) | 2007-05-18 | 2016-07-22 | Nestec S.A. | Lactobacillus johnsonii para prevenir infecciones postoperatorias |
| EP1997499A1 (en) | 2007-05-31 | 2008-12-03 | Puleva Biotech, S.A. | Mammalian milk microorganisms, compositions containing them and their use for the treatment of mastitis |
| US9833510B2 (en) * | 2007-06-12 | 2017-12-05 | Johnson & Johnson Consumer Inc. | Modified release solid or semi-solid dosage forms |
| US20090035370A1 (en) | 2007-08-02 | 2009-02-05 | Drugtech Corporation | Dosage form and method of use |
| EP2022502A1 (en) | 2007-08-10 | 2009-02-11 | Nestec S.A. | Lactobacillus rhamnosus and weight control |
| WO2010027498A2 (en) | 2008-09-03 | 2010-03-11 | New Science Holdings, Llc | Compositions and methods for inducing satiety and treating non-insulin dependent diabetes emillitus, pre-diabetic symptoms, insulin resistance and related disease states and conditions |
| US9757346B2 (en) | 2008-09-03 | 2017-09-12 | Volant Holdings Gmbh | Compositions and methods for treating insulin resistance and non-insulin dependent diabetes mellitus (type II diabetes) |
| US20120247993A1 (en) | 2008-11-14 | 2012-10-04 | Unistraw Patent Holdings Limited | Probiotic Compositions, Methods and Apparatus for Their Administration |
| EP2216034A1 (en) | 2009-02-10 | 2010-08-11 | Nestec S.A. | Lactobacillus helveticus CNCM I-4095 and weight control |
| US9474773B2 (en) | 2009-02-18 | 2016-10-25 | University Of Florida Research Foundation, Inc. | Lactobacillus supplement for alleviating type 1 diabetes |
| FR2942719B1 (fr) | 2009-03-04 | 2011-08-19 | Oreal | Utilisation de microorganismes probiotiques pour limiter les irritations cutanees |
| US8338162B2 (en) | 2009-04-17 | 2012-12-25 | Anaeropharma Science, Inc. | Obligately anaerobic mutant lactic acid bacterium and preparation method therefor, and expression vector functioning in obligately anaerobic lactic acid bacterium |
| US20120276149A1 (en) | 2009-10-15 | 2012-11-01 | Dan Littman | Methods for modulating bacterial infection |
| US8999721B2 (en) | 2009-10-23 | 2015-04-07 | Therabrake, Inc. | Method and system to provide personalized pharmaceutical compositions and dosages |
| US8367418B2 (en) | 2009-10-23 | 2013-02-05 | Therasyn Sensors, Inc. | Method and system to provide personalized pharmaceutical compositions and dosages |
| HRP20160834T1 (hr) * | 2010-02-23 | 2016-09-23 | Da Volterra | Formulacije za oralnu dopremu adsorbensa u crijevo |
| US20130273154A1 (en) | 2011-03-02 | 2013-10-17 | Joseph M. Fayad | Oral formulations Mimetic of Roux-en-Y gastric bypass actions on the ileal brake; Compositions, Methods of Treatment, Diagnostics and Systems for treatment of metabolic syndrome manifestations including insulin resistance, fatty liver disease, hpperlipidemia, and type 2 diabetes |
| US9707207B2 (en) * | 2010-05-26 | 2017-07-18 | The United States Of America As Represented By The Department Of Veterans Affairs | Method for diagnosing, preventing, and treating neurological diseases |
| WO2011151941A1 (ja) | 2010-06-04 | 2011-12-08 | 国立大学法人東京大学 | 制御性ｔ細胞の増殖または集積を誘導する作用を有する組成物 |
| AU2011268146A1 (en) | 2010-06-17 | 2013-01-10 | Actogenix Nv | Compositions and methods for treating inflammatory conditions |
| EP2397145A1 (en) | 2010-06-18 | 2011-12-21 | Nestec S.A. | L. johnsonii La1, B. longum NCC2705 and immune disorders |
| WO2012077038A1 (en) * | 2010-12-06 | 2012-06-14 | Degama Berrier Ltd. | Composition and method for improving stability and extending shelf life of probiotic bacteria and food products thereof |
| RU2442572C1 (ru) | 2010-12-23 | 2012-02-20 | Ольга Львовна Титова | Энтеросолюбильная оболочка и композиция для ее получения |
| CN110152000A (zh) | 2011-03-02 | 2019-08-23 | J·深塔格 | 用于单独治疗肝脂肪变性或治疗伴有丙型肝炎病毒感染的肝脂肪变性的组合物 |
| GB2490671B (en) | 2011-05-09 | 2017-12-20 | Mw Encap Ltd | Dosage Unit for Administration of Antibiotics to the Small and Large Intestine |
| CA2848762C (en) | 2011-09-14 | 2021-07-27 | Queen's University At Kingston | Method for treatment of disorders of the gastrointestinal system |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| EP3569690B1 (en) | 2011-12-01 | 2024-08-28 | The University of Tokyo | Human-derived bacteria that induce proliferation or accumulation of regulatory t cells |
| CA3008794C (en) | 2012-03-29 | 2021-03-16 | Therabiome, Llc | Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix |
| US8906668B2 (en) | 2012-11-23 | 2014-12-09 | Seres Health, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
| AU2014205553A1 (en) | 2013-01-08 | 2015-07-09 | Volant Holdings Gmbh | Activation of the endogenous ileal brake hormone pathway for organ regeneration and related compositions, methods of treatment, diagnostics, and regulatory systems |
| KR102222273B1 (ko) | 2013-02-04 | 2021-03-08 | 세레스 테라퓨틱스, 인코포레이티드 | 조성물 및 방법 |
| WO2014121304A1 (en) | 2013-02-04 | 2014-08-07 | Seres Health, Inc. | Compositions and methods |
| HK1220495A1 (zh) | 2013-03-14 | 2017-05-05 | Seres Therapeutics, Inc. | 从材料和组合物中检测和富集病原体的方法 |
| RU2015140610A (ru) | 2013-03-14 | 2017-04-17 | ТЕРАБАЙОМ, ЭлЭлСи | Направленная доставка в желудочно-кишечный тракт пробиотических микроорганизмов и/или терапевтических средств |
| WO2014145958A2 (en) | 2013-03-15 | 2014-09-18 | Seres Health, Inc. | Network-based microbial compositions and methods |
| EP3074027B1 (en) | 2013-11-25 | 2024-12-18 | Seres Therapeutics, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
| EP3082431A4 (en) | 2013-12-16 | 2017-11-15 | Seres Therapeutics, Inc. | Bacterial compositions and methods of use thereof for treatment of immune system disorders |
-
2014
- 2014-03-14 RU RU2015140610A patent/RU2015140610A/ru not_active Application Discontinuation
- 2014-03-14 CA CA3101218A patent/CA3101218A1/en not_active Abandoned
- 2014-03-14 EP EP14767949.2A patent/EP2968187A4/en active Pending
- 2014-03-14 CA CA2904389A patent/CA2904389C/en active Active
- 2014-03-14 WO PCT/US2014/027228 patent/WO2014152338A1/en not_active Ceased
- 2014-03-14 JP JP2016502376A patent/JP6464142B2/ja active Active
- 2014-03-14 AU AU2014239883A patent/AU2014239883B2/en active Active
- 2014-03-14 CN CN201811473452.6A patent/CN110075130A/zh active Pending
- 2014-03-14 US US14/771,830 patent/US9907755B2/en active Active
- 2014-03-14 CA CA3013541A patent/CA3013541C/en active Active
- 2014-03-14 BR BR112015023124A patent/BR112015023124A2/pt not_active Application Discontinuation
- 2014-03-14 CN CN201480014872.1A patent/CN105120847B/zh active Active
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2018
- 2018-01-18 US US15/874,543 patent/US10369111B2/en active Active
- 2018-12-21 AU AU2018282453A patent/AU2018282453B2/en active Active
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2019
- 2019-01-07 JP JP2019000861A patent/JP6860596B2/ja active Active
- 2019-06-19 US US16/446,053 patent/US11590083B2/en active Active
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2020
- 2020-11-12 AU AU2020267253A patent/AU2020267253A1/en not_active Abandoned
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2023
- 2023-02-28 US US18/115,008 patent/US20230277468A1/en not_active Abandoned
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