JP2016516068A5 - - Google Patents
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- JP2016516068A5 JP2016516068A5 JP2016503207A JP2016503207A JP2016516068A5 JP 2016516068 A5 JP2016516068 A5 JP 2016516068A5 JP 2016503207 A JP2016503207 A JP 2016503207A JP 2016503207 A JP2016503207 A JP 2016503207A JP 2016516068 A5 JP2016516068 A5 JP 2016516068A5
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- JP
- Japan
- Prior art keywords
- substituted
- group
- unsubstituted
- aryl
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C*N(*)C(*)C(N(*)*(C)C)=O Chemical compound C*N(*)C(*)C(N(*)*(C)C)=O 0.000 description 2
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361792679P | 2013-03-15 | 2013-03-15 | |
| US201361792868P | 2013-03-15 | 2013-03-15 | |
| US61/792,679 | 2013-03-15 | ||
| US61/792,868 | 2013-03-15 | ||
| US201361882048P | 2013-09-25 | 2013-09-25 | |
| US201361882056P | 2013-09-25 | 2013-09-25 | |
| US61/882,048 | 2013-09-25 | ||
| US61/882,056 | 2013-09-25 | ||
| US201461934570P | 2014-01-31 | 2014-01-31 | |
| US61/934,570 | 2014-01-31 | ||
| PCT/US2014/029723 WO2014145068A1 (en) | 2013-03-15 | 2014-03-14 | Compositions, formulations and methods for treating ocular diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019147238A Division JP6865254B2 (ja) | 2013-03-15 | 2019-08-09 | 眼疾患を処置するための組成物、製剤、および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016516068A JP2016516068A (ja) | 2016-06-02 |
| JP2016516068A5 true JP2016516068A5 (enExample) | 2017-04-20 |
| JP6572201B2 JP6572201B2 (ja) | 2019-09-04 |
Family
ID=51529957
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503207A Active JP6572201B2 (ja) | 2013-03-15 | 2014-03-14 | 眼疾患を処置するための組成物、製剤、および方法 |
| JP2019147238A Active JP6865254B2 (ja) | 2013-03-15 | 2019-08-09 | 眼疾患を処置するための組成物、製剤、および方法 |
| JP2021064106A Active JP7249374B2 (ja) | 2013-03-15 | 2021-04-05 | 眼疾患を処置するための組成物、製剤、および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019147238A Active JP6865254B2 (ja) | 2013-03-15 | 2019-08-09 | 眼疾患を処置するための組成物、製剤、および方法 |
| JP2021064106A Active JP7249374B2 (ja) | 2013-03-15 | 2021-04-05 | 眼疾患を処置するための組成物、製剤、および方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (10) | US9440963B2 (enExample) |
| EP (3) | EP4101297A1 (enExample) |
| JP (3) | JP6572201B2 (enExample) |
| KR (1) | KR20150129019A (enExample) |
| CN (2) | CN109925312A (enExample) |
| AU (2) | AU2014233363B2 (enExample) |
| BR (1) | BR112015023753A2 (enExample) |
| CA (1) | CA2903871A1 (enExample) |
| ES (2) | ES2928162T3 (enExample) |
| GB (3) | GB2516561B (enExample) |
| HK (2) | HK1206558A1 (enExample) |
| IL (2) | IL240786B (enExample) |
| MX (1) | MX371382B (enExample) |
| MY (1) | MY171945A (enExample) |
| PH (2) | PH12015502153B1 (enExample) |
| SG (1) | SG11201507131WA (enExample) |
| WO (1) | WO2014145068A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101482483B1 (ko) | 2006-04-07 | 2015-01-15 | 에르피오 세러퓨틱스 인코포레이티드 | 인간 단백질 타이로신 포스파타아제 베타(hptp베타)에 결합하는 항체 및 그의 용도 |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| ES2726946T3 (es) | 2009-07-06 | 2019-10-10 | Aerpio Therapeutics Inc | Derivados de benzosulfonamida, composiciones de los mismos y su uso en la prevención de la metástasis de las células cancerosas |
| TR201902233T4 (tr) | 2009-10-30 | 2019-03-21 | Ix Biopharma Ltd | Hızlı çözünen katı dozaj formu. |
| US12186426B2 (en) | 2009-10-30 | 2025-01-07 | Ix Biopharma Ltd. | Solid dosage form |
| ES2782999T3 (es) | 2009-11-06 | 2020-09-16 | Aerpio Therapeutics Inc | Composiciones y métodos para tratar la colitis |
| US20180092883A1 (en) * | 2010-10-07 | 2018-04-05 | Aerpio Therapeutics, Inc. | Phosphatase inhibitors for treating ocular diseases |
| CA2819475C (en) | 2010-12-08 | 2019-02-12 | Convatec Technologies Inc. | Integrated system for assessing wound exudates |
| US9526816B2 (en) | 2010-12-08 | 2016-12-27 | Convatec Technologies Inc. | Wound exudate monitor accessory |
| AU2012323849B2 (en) | 2011-10-13 | 2017-04-20 | EyePoint, Inc. | Treatment of ocular disease |
| CA2850830A1 (en) | 2011-10-13 | 2013-04-18 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome and cancer |
| CA2886573C (en) * | 2012-10-11 | 2019-04-02 | Stephen Lim Chin Beng | Solid dosage form |
| GB2516561B (en) * | 2013-03-15 | 2016-03-09 | Aerpio Therapeutics Inc | Compositions, formulations and methods for treating ocular diseases |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| CN106232120B (zh) | 2014-02-19 | 2021-01-08 | 爱尔皮奥治疗有限公司 | 制备n-苄基-3-羟基-4-取代的-吡啶-2-(1h)-酮的方法 |
| EP3116503A4 (en) * | 2014-03-14 | 2017-08-23 | Aerpio Therapeutics, Inc. | Hptp-beta inhibitors |
| US9539245B2 (en) | 2014-08-07 | 2017-01-10 | Aerpio Therapeutics, Inc. | Combination of immunotherapies with activators of Tie-2 |
| MY194736A (en) | 2015-09-23 | 2022-12-15 | Aerpio Therapeutics Inc | Methods of treating intraocular pressure with activators of tie-2 |
| WO2017075814A1 (zh) * | 2015-11-06 | 2017-05-11 | 华为技术有限公司 | 一种语音漫游方法,移动性管理网元及接入网网元 |
| US10253094B2 (en) | 2016-07-20 | 2019-04-09 | Aerpio Therapeutics, Inc. | Antibodies that target human protein tyrosine phosphatase-beta (HPTP-beta) and methods of use thereof to treat ocular conditions |
| CN109996440A (zh) * | 2016-10-21 | 2019-07-09 | 曼宁研究有限公司 | Ve-ptp敲除 |
| US10894824B2 (en) | 2018-09-24 | 2021-01-19 | Aerpio Pharmaceuticals, Inc. | Multispecific antibodies that target HPTP-β (VE-PTP) and VEGF |
| WO2020214851A1 (en) * | 2019-04-18 | 2020-10-22 | Aerpio Pharmaceuticals, Inc. | Methods of treating hypertension with activators of tie-2 |
| WO2020223209A1 (en) | 2019-04-29 | 2020-11-05 | Aerpio Pharmaceuticals, Inc. | Tie-2 activators targeting the schlemm's canal |
| MA54325A (fr) | 2019-06-05 | 2022-05-11 | Regeneron Pharma | Dispositifs et procédés pour l'administration précise de doses |
| US11413242B2 (en) | 2019-06-24 | 2022-08-16 | EyePoint Pharmaceuticals, Inc. | Formulations of Tie-2 activators and methods of use thereof |
| CA3156225A1 (en) | 2019-10-29 | 2021-05-06 | EyePoint Pharmaceuticals, Inc. | Small molecule activators of tie-2 |
| JP2023530457A (ja) * | 2020-06-16 | 2023-07-18 | リプカ,エイミー | 小分子ve-ptp阻害剤 |
| CN116940355A (zh) * | 2020-12-18 | 2023-10-24 | 视点制药公司 | 用于制造tie-2的小分子激活剂的方法 |
| USD1120314S1 (en) | 2022-11-30 | 2026-03-24 | Regeneron Pharmaceuticals, Inc. | Dose delivery device |
| WO2025128706A1 (en) * | 2023-12-11 | 2025-06-19 | Massachusetts Eye And Ear Infirmary | Methods of using tie-2 activators |
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| US5078486A (en) | 1989-10-13 | 1992-01-07 | Evans David W | Self-calibrating vision test apparatus |
| US5688781A (en) * | 1994-08-19 | 1997-11-18 | Bristol-Myers Squibb Company | Method for treating vascular leak syndrome |
| ATE273384T1 (de) | 1995-04-06 | 2004-08-15 | Regeneron Pharma | Tie-2 liganden, herstellungsverfahren und verwendung |
| US20030040463A1 (en) | 1996-04-05 | 2003-02-27 | Wiegand Stanley J. | TIE-2 ligands, methods of making and uses thereof |
| US6455031B1 (en) * | 1997-06-18 | 2002-09-24 | David G Davies | Methods and compositions for controlling biofilm development |
| US5980929A (en) | 1998-03-13 | 1999-11-09 | Johns Hopkins University, School Of Medicine | Use of a protein tyrosine kinase pathway inhibitor in the treatment of retinal ischmemia or ocular inflammation |
| US5919813C1 (en) | 1998-03-13 | 2002-01-29 | Univ Johns Hopkins Med | Use of a protein tyrosine kinase pathway inhibitor in the treatment of diabetic retinopathy |
| US6455035B1 (en) * | 1999-03-26 | 2002-09-24 | Regeneron Pharmaceuticals, Inc. | Angiopoietins and methods of use thereof |
| CA2368670C (en) | 1999-03-26 | 2012-06-05 | Chitra Suri | Modulation of vascular permeability by means of tie2 receptor activators |
| US6924264B1 (en) * | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
| HUP0302779A3 (en) | 2000-06-23 | 2005-12-28 | Schering Ag | Combinations and compositions which interfere with vegf/vegf and angiopoietin/tie receptor function and their use (ii) |
| CN1487935A (zh) * | 2000-12-11 | 2004-04-07 | ����ҩƷ��ҵ��ʽ���� | 改良型水溶性药物组合物 |
| SE518981C2 (sv) | 2000-12-14 | 2002-12-17 | Shl Medical Ab | Autoinjektor |
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| US20030158199A1 (en) * | 2002-01-25 | 2003-08-21 | Kylix, B.V. | Novel compounds for inhibition of Tie-2 |
| AU2003231098A1 (en) | 2002-04-25 | 2003-11-10 | University Of Connecticut Health Center | Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality |
| US7226755B1 (en) | 2002-09-25 | 2007-06-05 | The Procter & Gamble Company | HPTPbeta as a target in treatment of angiogenesis mediated disorders |
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| AU2003279911A1 (en) * | 2002-10-09 | 2004-05-04 | Kosan Biosciences, Inc. | Therapeutic formulations |
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| WO2004060373A1 (ja) * | 2002-12-27 | 2004-07-22 | Santen Pharmaceutical Co., Ltd. | 滲出型加齢黄斑変性治療剤 |
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| US20050059639A1 (en) | 2003-09-11 | 2005-03-17 | Wei Edward T. | Ophthalmic compositions and method for treating eye discomfort and pain |
| US7771742B2 (en) | 2004-04-30 | 2010-08-10 | Allergan, Inc. | Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods |
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| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| US7893040B2 (en) | 2005-07-22 | 2011-02-22 | Oculis Ehf | Cyclodextrin nanotechnology for ophthalmic drug delivery |
| PL1968594T3 (pl) | 2005-11-29 | 2011-03-31 | Glaxosmithkline Llc | Leczenie zaburzeń neowaskularyzacyjnych oka, takich jak zwyrodnienie plamki żółtej, rozszerzenie naczyń siatkówki w zespole Hippla i Lindaua, zapalenie błony naczyniowej oka i obrzęk plamki |
| EP2518083A3 (en) | 2005-12-15 | 2012-12-05 | Medimmune Limited | Combination of angiopoietin-2 antagonist and of VEGF-A, KDR and/or FLTL antagonist for treating cancer |
| EP1982718A4 (en) * | 2006-02-09 | 2010-05-12 | Daiichi Sankyo Co Ltd | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OF CANCER |
| KR101482483B1 (ko) * | 2006-04-07 | 2015-01-15 | 에르피오 세러퓨틱스 인코포레이티드 | 인간 단백질 타이로신 포스파타아제 베타(hptp베타)에 결합하는 항체 및 그의 용도 |
| US7589212B2 (en) | 2006-06-27 | 2009-09-15 | Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| US20130023542A1 (en) | 2006-06-27 | 2013-01-24 | Aerpio Therapeutics Inc. | Human protein tyrosine phosphatase inhibitors and methods of use |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| US7795444B2 (en) | 2006-06-27 | 2010-09-14 | Warner Chilcott Company | Human protein tyrosine phosphatase inhibitors and methods of use |
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| WO2008027013A2 (en) * | 2006-08-29 | 2008-03-06 | National Cancer Centre | Combination of mtor antagonist and angiogenesis inhibitor for the treatment of cancer |
| US8957022B2 (en) * | 2006-10-27 | 2015-02-17 | Sunnybrook Health Sciences Centre | Multimeric tie 2 agonists and uses thereof in stimulating angiogenesis |
| ES2365931T3 (es) | 2006-12-13 | 2011-10-13 | Shl Group Ab | Inyector automático. |
| EP2131898B1 (en) | 2007-03-23 | 2017-08-30 | SHL Group AB | Auto injector |
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| US11078262B2 (en) | 2007-04-30 | 2021-08-03 | Allergan, Inc. | High viscosity macromolecular compositions for treating ocular conditions |
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| WO2009037141A1 (en) | 2007-09-18 | 2009-03-26 | Shl Group Ab | Automatic injection device with needle insertion |
| CN101980716B (zh) * | 2008-03-31 | 2012-11-21 | 株式会社资生堂 | 血管成熟化、正常化或稳定化剂以及皱纹防止和/或改善剂 |
| EP2303365B1 (en) | 2008-05-20 | 2017-07-26 | SHL Group AB | Medicament delivery device with a damper |
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| KR20110027659A (ko) * | 2008-06-18 | 2011-03-16 | 가부시키가이샤 시세이도 | 림프관의 안정화제 |
| WO2010010689A1 (ja) * | 2008-07-22 | 2010-01-28 | 株式会社メニコン | コンタクトレンズ用液剤 |
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| ES2726946T3 (es) | 2009-07-06 | 2019-10-10 | Aerpio Therapeutics Inc | Derivados de benzosulfonamida, composiciones de los mismos y su uso en la prevención de la metástasis de las células cancerosas |
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| ES2782999T3 (es) | 2009-11-06 | 2020-09-16 | Aerpio Therapeutics Inc | Composiciones y métodos para tratar la colitis |
| JP2011201811A (ja) * | 2010-03-25 | 2011-10-13 | Shiseido Co Ltd | Tie2活性化剤、血管の成熟化、正常化又は安定化剤、リンパ管安定化剤並びにしわ防止・改善剤及びむくみ改善・予防剤 |
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| CA2797247C (en) * | 2010-04-28 | 2019-10-22 | Sunnybrook Health Sciences Centre | Methods and uses of tie2 binding and/or activating agents |
| US20180092883A1 (en) | 2010-10-07 | 2018-04-05 | Aerpio Therapeutics, Inc. | Phosphatase inhibitors for treating ocular diseases |
| NZ610230A (en) | 2010-10-07 | 2015-07-31 | Aerpio Therapeutics Inc | Compositions and methods for treating ocular edema, neovascularization and related diseases |
| CN103249422A (zh) * | 2010-12-02 | 2013-08-14 | 丸善制药株式会社 | Tie2活化剂、血管内皮生长因子抑制剂、血管生成抑制剂、血管成熟剂、血管正常化剂及血管稳定剂、以及药物组合物 |
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| AU2012323849B2 (en) | 2011-10-13 | 2017-04-20 | EyePoint, Inc. | Treatment of ocular disease |
| CA2850830A1 (en) | 2011-10-13 | 2013-04-18 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome and cancer |
| GB2516561B (en) * | 2013-03-15 | 2016-03-09 | Aerpio Therapeutics Inc | Compositions, formulations and methods for treating ocular diseases |
| US20150050277A1 (en) * | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| US20160151410A1 (en) | 2013-07-02 | 2016-06-02 | The Trustees Of Columbia University In The City Of New York | Clearance of bioactive lipids from membrane structures by cyclodextrins |
| CN106232120B (zh) | 2014-02-19 | 2021-01-08 | 爱尔皮奥治疗有限公司 | 制备n-苄基-3-羟基-4-取代的-吡啶-2-(1h)-酮的方法 |
| EP3116503A4 (en) | 2014-03-14 | 2017-08-23 | Aerpio Therapeutics, Inc. | Hptp-beta inhibitors |
| US9719135B2 (en) * | 2014-07-03 | 2017-08-01 | Mannin Research Inc. | Conditional angiopoietin-1/angiopoietin-2 double knock-out mice with defective ocular drainage system |
-
2014
- 2014-03-14 GB GB1411935.8A patent/GB2516561B/en active Active
- 2014-03-14 WO PCT/US2014/029723 patent/WO2014145068A1/en not_active Ceased
- 2014-03-14 EP EP22171032.0A patent/EP4101297A1/en active Pending
- 2014-03-14 BR BR112015023753A patent/BR112015023753A2/pt not_active Application Discontinuation
- 2014-03-14 GB GB1709419.4A patent/GB2549865B/en active Active
- 2014-03-14 EP EP19174479.6A patent/EP3607821B1/en active Active
- 2014-03-14 HK HK15107185.3A patent/HK1206558A1/xx unknown
- 2014-03-14 US US13/999,670 patent/US9440963B2/en active Active
- 2014-03-14 JP JP2016503207A patent/JP6572201B2/ja active Active
- 2014-03-14 SG SG11201507131WA patent/SG11201507131WA/en unknown
- 2014-03-14 ES ES19174479T patent/ES2928162T3/es active Active
- 2014-03-14 KR KR1020157029411A patent/KR20150129019A/ko not_active Ceased
- 2014-03-14 HK HK16108038.9A patent/HK1219836A1/zh unknown
- 2014-03-14 CN CN201910221542.4A patent/CN109925312A/zh active Pending
- 2014-03-14 ES ES14762974T patent/ES2766326T3/es active Active
- 2014-03-14 EP EP14762974.5A patent/EP2967066B1/en active Active
- 2014-03-14 MX MX2015011131A patent/MX371382B/es active IP Right Grant
- 2014-03-14 GB GB1520656.8A patent/GB2540638B/en active Active
- 2014-03-14 CA CA2903871A patent/CA2903871A1/en not_active Abandoned
- 2014-03-14 AU AU2014233363A patent/AU2014233363B2/en active Active
- 2014-03-14 CN CN201480028572.9A patent/CN105307498B/zh active Active
- 2014-03-14 MY MYPI2015002288A patent/MY171945A/en unknown
-
2015
- 2015-08-24 IL IL240786A patent/IL240786B/en active IP Right Grant
- 2015-09-15 PH PH12015502153A patent/PH12015502153B1/en unknown
-
2016
- 2016-04-14 US US15/099,161 patent/US20160220541A1/en not_active Abandoned
- 2016-04-14 US US15/098,955 patent/US20160220540A1/en not_active Abandoned
-
2017
- 2017-02-27 US US15/443,622 patent/US20180022741A1/en not_active Abandoned
- 2017-09-28 AU AU2017235953A patent/AU2017235953B2/en not_active Expired - Fee Related
-
2018
- 2018-04-20 US US15/958,355 patent/US20180237430A1/en not_active Abandoned
- 2018-04-20 US US15/958,346 patent/US20180237429A1/en not_active Abandoned
- 2018-04-20 US US15/958,358 patent/US20180237431A1/en not_active Abandoned
- 2018-05-02 US US15/969,109 patent/US20180251457A1/en not_active Abandoned
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2019
- 2019-07-11 IL IL267997A patent/IL267997A/en unknown
- 2019-08-09 JP JP2019147238A patent/JP6865254B2/ja active Active
- 2019-09-04 PH PH12019502018A patent/PH12019502018A1/en unknown
-
2020
- 2020-05-29 US US16/888,247 patent/US20200361926A1/en not_active Abandoned
-
2021
- 2021-04-05 JP JP2021064106A patent/JP7249374B2/ja active Active
-
2022
- 2022-03-03 US US17/685,802 patent/US12152023B2/en active Active
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