JP2016515576A5 - - Google Patents

Info

Publication number

JP2016515576A5

JP2016515576A5 JP2016505482A JP2016505482A JP2016515576A5 JP 2016515576 A5 JP2016515576 A5 JP 2016515576A5 JP 2016505482 A JP2016505482 A JP 2016505482A JP 2016505482 A JP2016505482 A JP 2016505482A JP 2016515576 A5 JP2016515576 A5 JP 2016515576A5

Authority

JP

Japan

Prior art keywords

less

dry powder

microns

tiotropium

dry

Prior art date

2014-03-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000843 powder Substances 0.000 claims 41
• 239000002245 particle Substances 0.000 claims 25
• 229940110309 tiotropium Drugs 0.000 claims 21
• LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 claims 21
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 16
• 239000003814 drug Substances 0.000 claims 14
• 229940124597 therapeutic agent Drugs 0.000 claims 14
• 229940112141 dry powder inhaler Drugs 0.000 claims 12
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 8
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 8
• 229960001469 fluticasone furoate Drugs 0.000 claims 8
• XTULMSXFIHGYFS-VLSRWLAYSA-N fluticasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(F)[C@@]4(C)C=CC(=O)C=C4[C@@H](F)C[C@H]3[C@@H]2C[C@H]1C)C(=O)SCF)C(=O)C1=CC=CO1 XTULMSXFIHGYFS-VLSRWLAYSA-N 0.000 claims 8
• 239000008194 pharmaceutical composition Substances 0.000 claims 8
• 239000011780 sodium chloride Substances 0.000 claims 8
• BLUGYPPOFIHFJS-UUFHNPECSA-N (2s)-n-[(2s)-1-[[(3r,4s,5s)-3-methoxy-1-[(2s)-2-[(1r,2r)-1-methoxy-2-methyl-3-oxo-3-[[(1s)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 BLUGYPPOFIHFJS-UUFHNPECSA-N 0.000 claims 6
• 208000007934 ACTH-independent macronodular adrenal hyperplasia Diseases 0.000 claims 6
• 239000002775 capsule Substances 0.000 claims 6
• LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 claims 4
• LUKZNWIVRBCLON-GXOBDPJESA-N Ciclesonide Chemical compound C1([C@H]2O[C@@]3([C@H](O2)C[C@@H]2[C@@]3(C[C@H](O)[C@@H]3[C@@]4(C)C=CC(=O)C=C4CC[C@H]32)C)C(=O)COC(=O)C(C)C)CCCCC1 LUKZNWIVRBCLON-GXOBDPJESA-N 0.000 claims 4
• 201000003883 Cystic fibrosis Diseases 0.000 claims 4
• 229960003728 ciclesonide Drugs 0.000 claims 4
• 239000010419 fine particle Substances 0.000 claims 4
• 229960002744 mometasone furoate Drugs 0.000 claims 4
• WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 claims 4
• 208000023504 respiratory system disease Diseases 0.000 claims 4
• 229960000257 tiotropium bromide Drugs 0.000 claims 4
• 239000003246 corticosteroid Substances 0.000 claims 3
• 229960001334 corticosteroids Drugs 0.000 claims 3
• 239000011859 microparticle Substances 0.000 claims 3
• SMNDYUVBFMFKNZ-UHFFFAOYSA-N 2-furoic acid Chemical compound OC(=O)C1=CC=CO1 SMNDYUVBFMFKNZ-UHFFFAOYSA-N 0.000 claims 2
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
• 208000006673 asthma Diseases 0.000 claims 2
• 201000009267 bronchiectasis Diseases 0.000 claims 2
• 229960002714 fluticasone Drugs 0.000 claims 2
• MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 2
• CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
• 230000009798 acute exacerbation Effects 0.000 claims 1
• 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
• 229940125389 long-acting beta agonist Drugs 0.000 claims 1
• 229940125390 short-acting beta agonist Drugs 0.000 claims 1