JP2016515545A - Ｈｃｖのｒｎａ−ポリメラーゼｎｓ５ｂのヌクレオシド阻害剤、２−｛［（２ｒ，３ｓ，５ｒ）−５−（４−アミノ−２−オキソ−２ｈ−ピリミジン−１−イル）−３−ヒドロキシ−テトラヒドロ−フラン−２−イルメトキシ］−フェノキシ−ホスホリルアミノ｝−プロピオン酸アルキル、その調製の方法及び使用 - Google Patents

Ｈｃｖのｒｎａ−ポリメラーゼｎｓ５ｂのヌクレオシド阻害剤、２−｛［（２ｒ，３ｓ，５ｒ）−５−（４−アミノ−２−オキソ−２ｈ−ピリミジン−１−イル）−３−ヒドロキシ−テトラヒドロ−フラン−２−イルメトキシ］−フェノキシ−ホスホリルアミノ｝−プロピオン酸アルキル、その調製の方法及び使用 Download PDF

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JP2016515545A
JP2016515545A JP2016504279A JP2016504279A JP2016515545A JP 2016515545 A JP2016515545 A JP 2016515545A JP 2016504279 A JP2016504279 A JP 2016504279A JP 2016504279 A JP2016504279 A JP 2016504279A JP 2016515545 A JP2016515545 A JP 2016515545A
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furan
tetrahydro
phenoxy
oxo
pyrimidin
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アレクサンドル・バシリエビッチ・イワシェンコ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016504279A 2013-03-22 2014-02-19 Ｈｃｖのｒｎａ−ポリメラーゼｎｓ５ｂのヌクレオシド阻害剤、２−｛［（２ｒ，３ｓ，５ｒ）−５−（４−アミノ−２−オキソ−２ｈ−ピリミジン−１−イル）−３−ヒドロキシ−テトラヒドロ−フラン−２−イルメトキシ］−フェノキシ−ホスホリルアミノ｝−プロピオン酸アルキル、その調製の方法及び使用 Pending JP2016515545A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2013112744 2013-03-22
RU2013112744/04A RU2534613C2 (ru) 2013-03-22 2013-03-22 Алкил 2-{ [(2r,3s,5r)-5-(4-амино-2-оксо-2н-пиримидин-1-ил)- -гидрокси-тетрагидро-фуран-2-илметокси]-фенокси-фосфориламино} -пропионаты, нуклеозидные ингибиторы рнк-полимеразы hcv ns5b, способы их получения и применения
PCT/RU2014/000104 WO2014148949A1 (ru) 2013-03-22 2014-02-19 Алкил 2-{[(2r,3s,5r)-5-(4-амино-2-оксо-2н-пиримидин-1-ил)-3-гидрокси-тетрагидро-фуран-2-илметокси]-фенокси-фосфориламино}-пропионаты, нуклеозидные ингибиторы рнк-полимеразы hcv ns5b, способы их получения и применения

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JP2016515545A true JP2016515545A (ja) 2016-05-30
JP2016515545A5 JP2016515545A5 (enExample) 2016-07-07

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JP2016504279A Pending JP2016515545A (ja) 2013-03-22 2014-02-19 Ｈｃｖのｒｎａ−ポリメラーゼｎｓ５ｂのヌクレオシド阻害剤、２−｛［（２ｒ，３ｓ，５ｒ）−５−（４−アミノ−２−オキソ−２ｈ−ピリミジン−１−イル）−３−ヒドロキシ−テトラヒドロ−フラン−２−イルメトキシ］−フェノキシ−ホスホリルアミノ｝−プロピオン酸アルキル、その調製の方法及び使用

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US (1) US20160031927A1 (enExample)
EP (1) EP2977379A1 (enExample)
JP (1) JP2016515545A (enExample)
KR (1) KR20150132879A (enExample)
CN (1) CN105263941A (enExample)
AU (1) AU2014238517A1 (enExample)
CA (1) CA2907455A1 (enExample)
EA (1) EA025878B1 (enExample)
RU (1) RU2534613C2 (enExample)
WO (1) WO2014148949A1 (enExample)

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JP2021511354A (ja) * 2018-01-24 2021-05-06 エスティー ファーム カンパニー リミテッド 新規なヌクレオシドまたはヌクレオチド誘導体およびこれらの用途

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CN106310269B (zh) * 2015-07-03 2021-01-29 中国药科大学 一种具有抗丙型肝炎病毒作用的药物组合物
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KR102145025B1 (ko) * 2020-02-20 2020-08-14 에스티팜 주식회사 신규한 뉴클레오사이드 또는 뉴클레오타이드 유도체 및 이들의 용도
CN111233955B (zh) * 2020-02-28 2022-06-10 南京缘聚医药科技有限公司 一类噻唑酮甲酰胞嘧啶衍生物及其药物用途
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US20160031927A1 (en) 2016-02-04
EA025878B1 (ru) 2017-02-28
RU2013112744A (ru) 2014-09-27
EA201401063A1 (ru) 2015-01-30
EP2977379A1 (en) 2016-01-27
AU2014238517A1 (en) 2015-11-12
KR20150132879A (ko) 2015-11-26
WO2014148949A1 (ru) 2014-09-25
RU2534613C2 (ru) 2014-11-27
CA2907455A1 (en) 2014-09-25
CN105263941A (zh) 2016-01-20

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