CN105263941A - 2-{[(2r,3s,5r)-5-(4-氨基-2-氧代-2h-嘧啶-1-基)-3-羟基-四氢-呋喃-2-基甲氧基]-苯氧基-磷酰基氨基}-丙酸烷基酯类、hcv rna-聚合酶ns5b的核苷抑制剂、其制备方法及用途 - Google Patents

2-{[(2r,3s,5r)-5-(4-氨基-2-氧代-2h-嘧啶-1-基)-3-羟基-四氢-呋喃-2-基甲氧基]-苯氧基-磷酰基氨基}-丙酸烷基酯类、hcv rna-聚合酶ns5b的核苷抑制剂、其制备方法及用途 Download PDF

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Publication number
CN105263941A
CN105263941A CN201480024794.3A CN201480024794A CN105263941A CN 105263941 A CN105263941 A CN 105263941A CN 201480024794 A CN201480024794 A CN 201480024794A CN 105263941 A CN105263941 A CN 105263941A
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furan
tetrahydro
oxo
pyrimidin
phenoxy
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亚历山大·瓦西里耶维奇·伊瓦切恩科
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Asavi Co ltd
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201480024794.3A 2013-03-22 2014-02-19 2-{[(2r,3s,5r)-5-(4-氨基-2-氧代-2h-嘧啶-1-基)-3-羟基-四氢-呋喃-2-基甲氧基]-苯氧基-磷酰基氨基}-丙酸烷基酯类、hcv rna-聚合酶ns5b的核苷抑制剂、其制备方法及用途 Pending CN105263941A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2013112744 2013-03-22
RU2013112744/04A RU2534613C2 (ru) 2013-03-22 2013-03-22 Алкил 2-{ [(2r,3s,5r)-5-(4-амино-2-оксо-2н-пиримидин-1-ил)- -гидрокси-тетрагидро-фуран-2-илметокси]-фенокси-фосфориламино} -пропионаты, нуклеозидные ингибиторы рнк-полимеразы hcv ns5b, способы их получения и применения
PCT/RU2014/000104 WO2014148949A1 (ru) 2013-03-22 2014-02-19 Алкил 2-{[(2r,3s,5r)-5-(4-амино-2-оксо-2н-пиримидин-1-ил)-3-гидрокси-тетрагидро-фуран-2-илметокси]-фенокси-фосфориламино}-пропионаты, нуклеозидные ингибиторы рнк-полимеразы hcv ns5b, способы их получения и применения

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CN105263941A true CN105263941A (zh) 2016-01-20

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CN201480024794.3A Pending CN105263941A (zh) 2013-03-22 2014-02-19 2-{[(2r,3s,5r)-5-(4-氨基-2-氧代-2h-嘧啶-1-基)-3-羟基-四氢-呋喃-2-基甲氧基]-苯氧基-磷酰基氨基}-丙酸烷基酯类、hcv rna-聚合酶ns5b的核苷抑制剂、其制备方法及用途

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US (1) US20160031927A1 (enExample)
EP (1) EP2977379A1 (enExample)
JP (1) JP2016515545A (enExample)
KR (1) KR20150132879A (enExample)
CN (1) CN105263941A (enExample)
AU (1) AU2014238517A1 (enExample)
CA (1) CA2907455A1 (enExample)
EA (1) EA025878B1 (enExample)
RU (1) RU2534613C2 (enExample)
WO (1) WO2014148949A1 (enExample)

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CN108732280A (zh) * 2017-04-18 2018-11-02 广东东阳光药业有限公司 一种分离检测盐酸达卡他韦及其光学异构体的方法
CN109843900A (zh) * 2016-08-19 2019-06-04 桑多斯股份公司 治疗丙型肝炎的索非布韦衍生物
CN111233955A (zh) * 2020-02-28 2020-06-05 南京缘聚医药科技有限公司 一类噻唑酮甲酰胞嘧啶衍生物及其药物用途
CN111902419A (zh) * 2018-01-24 2020-11-06 St制药株式会社 新的核苷或核苷酸衍生物及其用途
CN116751241A (zh) * 2022-08-12 2023-09-15 杭州爱科瑞思生物医药有限公司 2’-去氧-2’,2’-二氟胞苷ProTide的制备及其应用

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WO2016078160A1 (zh) * 2014-11-17 2016-05-26 常州方圆制药有限公司 胞苷衍生物及其应用
CN104546783A (zh) * 2014-12-12 2015-04-29 安徽一灵药业有限公司 一种索非布韦薄膜包衣片制剂及其制备方法
CN106132972B (zh) * 2015-02-06 2018-08-31 银杏树药业(苏州)有限公司 用于治疗hcv感染的氨基磷酸酯
CN106310269B (zh) * 2015-07-03 2021-01-29 中国药科大学 一种具有抗丙型肝炎病毒作用的药物组合物
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CN110045108B (zh) * 2019-05-28 2021-10-29 江南大学 一种基于辣椒碱指标的地沟油酶联免疫检测试剂盒及其检测方法
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Cited By (7)

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CN109843900A (zh) * 2016-08-19 2019-06-04 桑多斯股份公司 治疗丙型肝炎的索非布韦衍生物
CN108732280A (zh) * 2017-04-18 2018-11-02 广东东阳光药业有限公司 一种分离检测盐酸达卡他韦及其光学异构体的方法
CN111902419A (zh) * 2018-01-24 2020-11-06 St制药株式会社 新的核苷或核苷酸衍生物及其用途
CN111902419B (zh) * 2018-01-24 2023-11-24 St制药株式会社 新的核苷或核苷酸衍生物及其用途
CN111233955A (zh) * 2020-02-28 2020-06-05 南京缘聚医药科技有限公司 一类噻唑酮甲酰胞嘧啶衍生物及其药物用途
CN111233955B (zh) * 2020-02-28 2022-06-10 南京缘聚医药科技有限公司 一类噻唑酮甲酰胞嘧啶衍生物及其药物用途
CN116751241A (zh) * 2022-08-12 2023-09-15 杭州爱科瑞思生物医药有限公司 2’-去氧-2’,2’-二氟胞苷ProTide的制备及其应用

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US20160031927A1 (en) 2016-02-04
EA025878B1 (ru) 2017-02-28
RU2013112744A (ru) 2014-09-27
EA201401063A1 (ru) 2015-01-30
JP2016515545A (ja) 2016-05-30
EP2977379A1 (en) 2016-01-27
AU2014238517A1 (en) 2015-11-12
KR20150132879A (ko) 2015-11-26
WO2014148949A1 (ru) 2014-09-25
RU2534613C2 (ru) 2014-11-27
CA2907455A1 (en) 2014-09-25

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Application publication date: 20160120