JP2016515114A5 - - Google Patents
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- Publication number
- JP2016515114A5 JP2016515114A5 JP2016500356A JP2016500356A JP2016515114A5 JP 2016515114 A5 JP2016515114 A5 JP 2016515114A5 JP 2016500356 A JP2016500356 A JP 2016500356A JP 2016500356 A JP2016500356 A JP 2016500356A JP 2016515114 A5 JP2016515114 A5 JP 2016515114A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- peptide
- immobilized
- immobilized peptide
- protecting group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018197185A JP7323275B2 (ja) | 2013-03-15 | 2018-10-19 | 固相ペプチド合成プロセスおよび関連システム |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/833,745 | 2013-03-15 | ||
| US13/833,745 US9169287B2 (en) | 2013-03-15 | 2013-03-15 | Solid phase peptide synthesis processes and associated systems |
| PCT/US2014/017970 WO2014149387A2 (en) | 2013-03-15 | 2014-02-24 | Solid phase peptide synthesis processes and associated systems |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018197185A Division JP7323275B2 (ja) | 2013-03-15 | 2018-10-19 | 固相ペプチド合成プロセスおよび関連システム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016515114A JP2016515114A (ja) | 2016-05-26 |
| JP2016515114A5 true JP2016515114A5 (enExample) | 2017-03-30 |
| JP6423849B2 JP6423849B2 (ja) | 2018-11-14 |
Family
ID=50290261
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500356A Active JP6423849B2 (ja) | 2013-03-15 | 2014-02-24 | 固相ペプチド合成プロセスおよび関連システム |
| JP2018197185A Active JP7323275B2 (ja) | 2013-03-15 | 2018-10-19 | 固相ペプチド合成プロセスおよび関連システム |
| JP2021083136A Pending JP2021119204A (ja) | 2013-03-15 | 2021-05-17 | 固相ペプチド合成プロセスおよび関連システム |
| JP2023202648A Pending JP2024020587A (ja) | 2013-03-15 | 2023-11-30 | 固相ペプチド合成プロセスおよび関連システム |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018197185A Active JP7323275B2 (ja) | 2013-03-15 | 2018-10-19 | 固相ペプチド合成プロセスおよび関連システム |
| JP2021083136A Pending JP2021119204A (ja) | 2013-03-15 | 2021-05-17 | 固相ペプチド合成プロセスおよび関連システム |
| JP2023202648A Pending JP2024020587A (ja) | 2013-03-15 | 2023-11-30 | 固相ペプチド合成プロセスおよび関連システム |
Country Status (10)
| Country | Link |
|---|---|
| US (9) | US9169287B2 (enExample) |
| EP (2) | EP3626726A3 (enExample) |
| JP (4) | JP6423849B2 (enExample) |
| KR (1) | KR20150129011A (enExample) |
| CN (2) | CN105164145B (enExample) |
| AU (1) | AU2014238203B2 (enExample) |
| CA (1) | CA2904355A1 (enExample) |
| DK (1) | DK2970374T3 (enExample) |
| SG (2) | SG10201801611SA (enExample) |
| WO (1) | WO2014149387A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9695214B2 (en) | 2013-03-15 | 2017-07-04 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
| US9169287B2 (en) | 2013-03-15 | 2015-10-27 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
| EP3311630B1 (en) * | 2015-06-19 | 2023-07-12 | Protein Technologies, Inc. | Chemical reaction vessel and synthesis systems and methods |
| EP3334750B1 (en) | 2015-08-11 | 2022-10-05 | Anie Philip | Peptidic tgf-beta antagonists |
| CN108289925A (zh) * | 2015-09-17 | 2018-07-17 | 麻省理工学院 | 固相肽合成方法和相关系统 |
| US10683325B2 (en) * | 2015-09-17 | 2020-06-16 | Massachusetts Institute Of Technology | Methods and systems for solid phase peptide synthesis |
| US10239914B2 (en) | 2015-10-23 | 2019-03-26 | Cem Corporation | In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures |
| EP3365352A4 (en) * | 2015-10-23 | 2019-06-05 | CEM Corporation | IMPROVEMENTS OF SOLID PHASE PEPTIDE SYNTHESIS |
| US10125163B2 (en) | 2015-10-23 | 2018-11-13 | Cem Corporation | Solid phase peptide synthesis |
| CN109715647A (zh) * | 2016-09-03 | 2019-05-03 | Cem有限公司 | 用于高温固相肽合成的原位溶剂回收方法 |
| USRE49961E1 (en) | 2016-10-21 | 2024-05-07 | Cem Corporation | Solid phase peptide syntheses |
| JP7352807B2 (ja) | 2017-04-12 | 2023-09-29 | マジェンタ セラピューティクス インコーポレイテッド | アリール炭化水素受容体アンタゴニスト及びその使用 |
| AU2018358054A1 (en) | 2017-10-31 | 2020-05-07 | Magenta Therapeutics Inc. | Compositions and methods for hematopoietic stem and progenitor cell transplant therapy |
| EP3704232A1 (en) | 2017-10-31 | 2020-09-09 | Magenta Therapeutics, Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells |
| BR112020011186A2 (pt) | 2017-12-06 | 2020-11-17 | Magenta Therapeutics, Inc. | regimes de dosagem para a mobilização de células-tronco e progenitoras hematopoiéticas |
| US20200338132A1 (en) | 2018-01-03 | 2020-10-29 | Magenta Therapeutics Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells and treatment of inherited metabolic disorders |
| WO2019211531A1 (fr) * | 2018-05-04 | 2019-11-07 | Polypeptide Laboratoires France | Systeme automatise de reacteur de synthese avec une boucle de recirculation |
| EP3807292A4 (en) * | 2018-06-14 | 2022-03-16 | CEM Corporation | Solvent system for solid phase peptide synthesis |
| CN111217891B (zh) * | 2018-11-27 | 2023-11-14 | 深圳翰宇药业股份有限公司 | 一种特利加压素的合成方法 |
| CN112111001B (zh) * | 2019-06-19 | 2021-10-29 | 翰宇药业（武汉）有限公司 | 胸腺肽Tα-1的合成方法 |
| CN110343147B (zh) * | 2019-08-22 | 2021-07-02 | 凯莱英医药集团（天津）股份有限公司 | 艾替班特的合成方法 |
| WO2021087406A1 (en) | 2019-11-01 | 2021-05-06 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progentor cells |
| EP4100417A2 (en) | 2020-02-05 | 2022-12-14 | Eli Lilly and Company | Resin reactors in series peptide synthesizer |
| US11049590B1 (en) | 2020-02-12 | 2021-06-29 | Peptilogics, Inc. | Artificial intelligence engine architecture for generating candidate drugs |
| SE2050293A1 (en) * | 2020-03-17 | 2021-09-18 | Peptisystems Ab | Peptide synthesis and system thereof |
| US11834480B2 (en) | 2020-08-03 | 2023-12-05 | Amide Technologies | Protein inhibitors with reduced immunogenicity and resistance to degradation, and methods for their preparation and use |
| WO2022107134A1 (en) * | 2020-11-17 | 2022-05-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Extremely fast solid phase synthesis |
| US11403316B2 (en) | 2020-11-23 | 2022-08-02 | Peptilogics, Inc. | Generating enhanced graphical user interfaces for presentation of anti-infective design spaces for selecting drug candidates |
| WO2022197776A1 (en) | 2021-03-16 | 2022-09-22 | Magenta Therapeutics, Inc. | Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients |
| US11587643B2 (en) | 2021-05-07 | 2023-02-21 | Peptilogics, Inc. | Methods and apparatuses for a unified artificial intelligence platform to synthesize diverse sets of peptides and peptidomimetics |
| US11512345B1 (en) | 2021-05-07 | 2022-11-29 | Peptilogics, Inc. | Methods and apparatuses for generating peptides by synthesizing a portion of a design space to identify peptides having non-canonical amino acids |
| US20250026783A1 (en) * | 2021-10-18 | 2025-01-23 | Polypeptide Laboratories Holding (Ppl) Ab | Intermittent Percolation Washing |
| CN115669843A (zh) * | 2022-10-26 | 2023-02-03 | 中国农业大学 | 一种采用高压微射流结合混合肽有效杀灭芽孢的方法 |
| WO2025071365A1 (ko) * | 2023-09-27 | 2025-04-03 | 에스피투티엑스주식회사 | 흐름 반응기 및 이를 포함하는 생물학적 고분자 합성 시스템 |
| WO2025090409A1 (en) * | 2023-10-23 | 2025-05-01 | Protein Technologies, Inc. | On-line monitoring of synthesis reactions of peptides |
| US12399112B2 (en) | 2023-10-23 | 2025-08-26 | Protein Technologies, Inc. | On-line monitoring of synthesis reactions |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4093550A (en) | 1975-06-04 | 1978-06-06 | Riedel-De Haen Aktiengesellschaft | Column for high pressure liquid chromatography |
| US4192798A (en) | 1978-11-20 | 1980-03-11 | Bioresearch, Inc. | Rapid, large scale, automatable high pressure peptide synthesis |
| US4192796A (en) * | 1979-03-26 | 1980-03-11 | American Cyanamid Company | Polymers stabilized with organo-phosphorus compounds |
| ZA821537B (en) | 1981-03-10 | 1984-01-25 | Bioresearch Inc | High performance peptide synthesis |
| US4598049A (en) | 1983-08-31 | 1986-07-01 | Systec Inc. | General purpose gene synthesizer |
| WO1985001224A1 (en) * | 1983-09-22 | 1985-03-28 | Saneii Hossain H | Solid phase peptide synthesizer |
| US4746490A (en) * | 1983-09-22 | 1988-05-24 | Saneii Hossain H | Solid phase peptide synthesizer |
| US4668476A (en) * | 1984-03-23 | 1987-05-26 | Applied Biosystems, Inc. | Automated polypeptide synthesis apparatus |
| US5061635A (en) | 1987-07-13 | 1991-10-29 | City Of Hope | Protein or peptide sequencing method |
| US4861866A (en) | 1987-01-21 | 1989-08-29 | Eldex Laboratories, Inc. | Continuous flow peptide synthesizer |
| US5807525A (en) | 1995-08-17 | 1998-09-15 | Hybridon, Inc. | Apparatus and process for multi stage solid phase synthesis of long chained organic molecules |
| DK0929567T3 (da) | 1996-09-09 | 2005-06-27 | Zealand Pharma As | Forbedret fastfase-peptidsyntese og middel til anvendelse af en sådan syntese |
| CA2250784C (en) * | 1997-02-11 | 2004-04-20 | Mallinckrodt Chemical, Inc. | Reactor and method for solid phase peptide synthesis |
| US6033631A (en) | 1997-04-28 | 2000-03-07 | Chiron Corporation | Synthesizer with reagent recycling |
| AUPP616498A0 (en) | 1998-09-25 | 1998-10-15 | University Of Queensland, The | Synthesis of cyclic peptides |
| DE60303314T2 (de) | 2002-06-10 | 2006-08-17 | Geneprot, Inc., Meyrin | Verfahren zum carboxygruppenschutz der säuren c-terminalen aminosäuren bei chemischer verknüpfung von oligopeptiden |
| US7393920B2 (en) * | 2003-06-23 | 2008-07-01 | Cem Corporation | Microwave-assisted peptide synthesis |
| US7902488B2 (en) * | 2003-06-23 | 2011-03-08 | Cem Corporation | Microwave-assisted peptide synthesis |
| JP2008522795A (ja) | 2004-12-03 | 2008-07-03 | カリフォルニア インスティチュート オブ テクノロジー | 化学反応回路を有するマイクロ流体装置 |
| KR101014799B1 (ko) | 2008-06-05 | 2011-02-15 | 애니젠 주식회사 | 펩타이드 합성 제조 장치 |
| CN101665528A (zh) * | 2009-09-17 | 2010-03-10 | 中国药科大学 | 微波促进固相合成苦瓜mc-jj2多肽类似物及其应用 |
| US8535947B2 (en) | 2010-09-30 | 2013-09-17 | Protein Technologies, Inc. | On-line monitoring of deprotection reaction in peptide automated synthesizer comprising UV detector |
| TWI510781B (zh) | 2010-10-29 | 2015-12-01 | Scinopharm Taiwan Ltd | 即時監測固相胜肽合成反應之質譜系統 |
| US20150217254A1 (en) | 2012-09-10 | 2015-08-06 | Mohammad Boroomand | Automated peptide synthesizer |
| SG10201701641RA (en) | 2012-09-11 | 2017-04-27 | Heptagon Micro Optics Pte Ltd | Manufacture of truncated lenses, of pairs of truncated lenses and of corresponding devices |
| CN102924568A (zh) * | 2012-11-20 | 2013-02-13 | 天津铭恒科技发展有限公司 | 一种合成多肽及其制备方法和用途 |
| US9169287B2 (en) | 2013-03-15 | 2015-10-27 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
| US9695214B2 (en) | 2013-03-15 | 2017-07-04 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
| CN108289925A (zh) | 2015-09-17 | 2018-07-17 | 麻省理工学院 | 固相肽合成方法和相关系统 |
| US10683325B2 (en) | 2015-09-17 | 2020-06-16 | Massachusetts Institute Of Technology | Methods and systems for solid phase peptide synthesis |
-
2013
- 2013-03-15 US US13/833,745 patent/US9169287B2/en active Active
-
2014
- 2014-02-24 EP EP19202972.6A patent/EP3626726A3/en active Pending
- 2014-02-24 WO PCT/US2014/017970 patent/WO2014149387A2/en not_active Ceased
- 2014-02-24 EP EP14711046.4A patent/EP2970374B1/en active Active
- 2014-02-24 CA CA2904355A patent/CA2904355A1/en not_active Abandoned
- 2014-02-24 CN CN201480022269.8A patent/CN105164145B/zh active Active
- 2014-02-24 DK DK14711046.4T patent/DK2970374T3/da active
- 2014-02-24 SG SG10201801611SA patent/SG10201801611SA/en unknown
- 2014-02-24 KR KR1020157029308A patent/KR20150129011A/ko not_active Withdrawn
- 2014-02-24 AU AU2014238203A patent/AU2014238203B2/en active Active
- 2014-02-24 JP JP2016500356A patent/JP6423849B2/ja active Active
- 2014-02-24 CN CN201911125162.7A patent/CN110885355A/zh active Pending
- 2014-02-24 SG SG11201507527WA patent/SG11201507527WA/en unknown
-
2015
- 2015-09-14 US US14/853,683 patent/US9868759B2/en active Active
-
2017
- 2017-05-22 US US15/602,056 patent/US10889613B2/en active Active
- 2017-09-05 US US15/695,795 patent/US10988504B2/en active Active
-
2018
- 2018-10-19 JP JP2018197185A patent/JP7323275B2/ja active Active
-
2020
- 2020-12-18 US US17/127,951 patent/US11878996B2/en active Active
- 2020-12-18 US US17/127,961 patent/US20210188900A1/en not_active Abandoned
-
2021
- 2021-05-17 JP JP2021083136A patent/JP2021119204A/ja active Pending
- 2021-12-21 US US17/558,525 patent/US20220275021A1/en not_active Abandoned
-
2023
- 2023-11-29 US US18/523,727 patent/US20240368216A1/en active Pending
- 2023-11-30 JP JP2023202648A patent/JP2024020587A/ja active Pending
- 2023-12-01 US US18/526,685 patent/US20240383944A1/en active Pending
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