CN105164145B - 固相肽合成方法及相关系统 - Google Patents

固相肽合成方法及相关系统 Download PDF

Info

Publication number
CN105164145B
CN105164145B CN201480022269.8A CN201480022269A CN105164145B CN 105164145 B CN105164145 B CN 105164145B CN 201480022269 A CN201480022269 A CN 201480022269A CN 105164145 B CN105164145 B CN 105164145B
Authority
CN
China
Prior art keywords
amino acid
peptide
seconds
immobilized
minutes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201480022269.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN105164145A (zh
Inventor
马克·大卫·西蒙
布雷德利·L·彭泰卢特
安德烈亚·阿达莫
帕特里克·路易斯·海德尔
克拉夫斯·F·詹森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50290261&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN105164145(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Priority to CN201911125162.7A priority Critical patent/CN110885355A/zh
Publication of CN105164145A publication Critical patent/CN105164145A/zh
Application granted granted Critical
Publication of CN105164145B publication Critical patent/CN105164145B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0053—Details of the reactor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
CN201480022269.8A 2013-03-15 2014-02-24 固相肽合成方法及相关系统 Active CN105164145B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201911125162.7A CN110885355A (zh) 2013-03-15 2014-02-24 固相肽合成方法及相关系统

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/833,745 2013-03-15
US13/833,745 US9169287B2 (en) 2013-03-15 2013-03-15 Solid phase peptide synthesis processes and associated systems
PCT/US2014/017970 WO2014149387A2 (en) 2013-03-15 2014-02-24 Solid phase peptide synthesis processes and associated systems

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201911125162.7A Division CN110885355A (zh) 2013-03-15 2014-02-24 固相肽合成方法及相关系统

Publications (2)

Publication Number Publication Date
CN105164145A CN105164145A (zh) 2015-12-16
CN105164145B true CN105164145B (zh) 2019-12-13

Family

ID=50290261

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201911125162.7A Pending CN110885355A (zh) 2013-03-15 2014-02-24 固相肽合成方法及相关系统
CN201480022269.8A Active CN105164145B (zh) 2013-03-15 2014-02-24 固相肽合成方法及相关系统

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201911125162.7A Pending CN110885355A (zh) 2013-03-15 2014-02-24 固相肽合成方法及相关系统

Country Status (10)

Country Link
US (9) US9169287B2 (enExample)
EP (2) EP2970374B1 (enExample)
JP (4) JP6423849B2 (enExample)
KR (1) KR20150129011A (enExample)
CN (2) CN110885355A (enExample)
AU (1) AU2014238203B2 (enExample)
CA (1) CA2904355A1 (enExample)
DK (1) DK2970374T3 (enExample)
SG (2) SG11201507527WA (enExample)
WO (1) WO2014149387A2 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9169287B2 (en) 2013-03-15 2015-10-27 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
US9695214B2 (en) 2013-03-15 2017-07-04 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
EP4240110A3 (en) * 2015-06-19 2023-11-08 Protein Technologies, Inc. Chemical reaction vessel and synthesis systems and methods
EP3334750B1 (en) 2015-08-11 2022-10-05 Anie Philip Peptidic tgf-beta antagonists
CN108289925A (zh) * 2015-09-17 2018-07-17 麻省理工学院 固相肽合成方法和相关系统
CN108290923A (zh) 2015-09-17 2018-07-17 麻省理工学院 用于固相肽合成的方法和系统
US10239914B2 (en) 2015-10-23 2019-03-26 Cem Corporation In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures
WO2017070512A1 (en) * 2015-10-23 2017-04-27 Cem Corporation Improvements in solid phase peptide synthesis
EP3365352A4 (en) * 2015-10-23 2019-06-05 CEM Corporation IMPROVEMENTS OF SOLID PHASE PEPTIDE SYNTHESIS
EP3507299B1 (en) * 2016-09-03 2022-07-27 CEM Corporation In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures
USRE49961E1 (en) 2016-10-21 2024-05-07 Cem Corporation Solid phase peptide syntheses
IL293956A (en) 2017-04-12 2022-08-01 Magenta Therapeutics Inc Aryl hydrocarbon receptor antagonist and its uses
JP7412341B2 (ja) 2017-10-31 2024-01-12 エディジーン バイオテクノロジー インコーポレイテッド 造血幹細胞および前駆細胞の増幅のための組成物および方法
EP3703715A1 (en) 2017-10-31 2020-09-09 Magenta Therapeutics, Inc. Compositions and methods for hematopoietic stem and progenitor cell transplant therapy
KR20200096942A (ko) 2017-12-06 2020-08-14 마젠타 테라퓨틱스 인코포레이티드 조혈 줄기 및 자손 세포의 동원을 위한 투여 요법
CN111902411A (zh) 2018-01-03 2020-11-06 美真达治疗公司 用于扩增造血干细胞和祖细胞以及治疗遗传性代谢紊乱的组合物和方法
CN112020508A (zh) 2018-05-04 2020-12-01 法国多肽实验室 具有再循环回路的自动合成反应器系统
EP3807292A4 (en) * 2018-06-14 2022-03-16 CEM Corporation Solvent system for solid phase peptide synthesis
CN111217891B (zh) * 2018-11-27 2023-11-14 深圳翰宇药业股份有限公司 一种特利加压素的合成方法
CN112111001B (zh) * 2019-06-19 2021-10-29 翰宇药业（武汉）有限公司 胸腺肽Tα-1的合成方法
CN110343147B (zh) * 2019-08-22 2021-07-02 凯莱英医药集团（天津）股份有限公司 艾替班特的合成方法
US20220401481A1 (en) 2019-11-01 2022-12-22 Magenta Therapeutics, Inc. Dosing regimens for the mobilization of hematopoietic stem and progenitor cells
CA3167047A1 (en) 2020-02-05 2021-08-12 Martin D. Johnson Three resin reactors in series peptide synthesizer
US11049590B1 (en) 2020-02-12 2021-06-29 Peptilogics, Inc. Artificial intelligence engine architecture for generating candidate drugs
SE2050293A1 (en) * 2020-03-17 2021-09-18 Peptisystems Ab Peptide synthesis and system thereof
US11834480B2 (en) 2020-08-03 2023-12-05 Amide Technologies Protein inhibitors with reduced immunogenicity and resistance to degradation, and methods for their preparation and use
EP4247830A1 (en) * 2020-11-17 2023-09-27 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Extremely fast solid phase synthesis
US20220165359A1 (en) 2020-11-23 2022-05-26 Peptilogics, Inc. Generating anti-infective design spaces for selecting drug candidates
EP4308694A1 (en) 2021-03-16 2024-01-24 Magenta Therapeutics, Inc. Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients
US11512345B1 (en) 2021-05-07 2022-11-29 Peptilogics, Inc. Methods and apparatuses for generating peptides by synthesizing a portion of a design space to identify peptides having non-canonical amino acids
US11587643B2 (en) 2021-05-07 2023-02-21 Peptilogics, Inc. Methods and apparatuses for a unified artificial intelligence platform to synthesize diverse sets of peptides and peptidomimetics
WO2023068987A1 (en) 2021-10-18 2023-04-27 Polypeptide Laboratories Holding (Ppl) Ab Intermittent percolation washing
CN115669843A (zh) * 2022-10-26 2023-02-03 中国农业大学 一种采用高压微射流结合混合肽有效杀灭芽孢的方法
WO2025071365A1 (ko) * 2023-09-27 2025-04-03 에스피투티엑스주식회사 흐름 반응기 및 이를 포함하는 생물학적 고분자 합성 시스템
US12399112B2 (en) 2023-10-23 2025-08-26 Protein Technologies, Inc. On-line monitoring of synthesis reactions
WO2025090409A1 (en) * 2023-10-23 2025-05-01 Protein Technologies, Inc. On-line monitoring of synthesis reactions of peptides

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4192796A (en) * 1979-03-26 1980-03-11 American Cyanamid Company Polymers stabilized with organo-phosphorus compounds
WO1982003077A1 (en) * 1981-03-10 1982-09-16 Inc Bioresearch High performance peptide synthesis
EP1923396A2 (en) * 2006-10-24 2008-05-21 CEM Corporation Microwave-Assisted Peptide Synthesis
CN101665528A (zh) * 2009-09-17 2010-03-10 中国药科大学 微波促进固相合成苦瓜mc-jj2多肽类似物及其应用
CN102924568A (zh) * 2012-11-20 2013-02-13 天津铭恒科技发展有限公司 一种合成多肽及其制备方法和用途

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093550A (en) 1975-06-04 1978-06-06 Riedel-De Haen Aktiengesellschaft Column for high pressure liquid chromatography
US4192798A (en) 1978-11-20 1980-03-11 Bioresearch, Inc. Rapid, large scale, automatable high pressure peptide synthesis
US4598049A (en) 1983-08-31 1986-07-01 Systec Inc. General purpose gene synthesizer
US4746490A (en) * 1983-09-22 1988-05-24 Saneii Hossain H Solid phase peptide synthesizer
EP0156875A4 (en) * 1983-09-22 1986-02-13 Hossain H Saneii PEPTIDE SYNTHETIZING DEVICE IN SOLID PHASE.
US4668476A (en) 1984-03-23 1987-05-26 Applied Biosystems, Inc. Automated polypeptide synthesis apparatus
US5061635A (en) 1987-07-13 1991-10-29 City Of Hope Protein or peptide sequencing method
US4861866A (en) 1987-01-21 1989-08-29 Eldex Laboratories, Inc. Continuous flow peptide synthesizer
US5807525A (en) 1995-08-17 1998-09-15 Hybridon, Inc. Apparatus and process for multi stage solid phase synthesis of long chained organic molecules
IL128829A (en) 1996-09-09 2005-08-31 Zealand Pharma As Solid phase sythesis of peptides with pre-sequences
WO1998034633A1 (en) 1997-02-11 1998-08-13 Mallinckrodt Chemical, Inc. Reactor and method for solid phase peptide synthesis
ES2329955T3 (es) 1997-04-28 2009-12-02 Novartis Vaccines And Diagnostics, Inc. Aparato para la sintesis de oligomeros, especialmente peptoides, con reciclado de reactivos.
AUPP616498A0 (en) 1998-09-25 1998-10-15 University Of Queensland, The Synthesis of cyclic peptides
AU2003280206A1 (en) 2002-06-10 2004-02-02 Geneprot, Inc. Carboxy protection strategies for acidic c-terminal amino acids in chemical ligation of oligopeptides
US7393920B2 (en) 2003-06-23 2008-07-01 Cem Corporation Microwave-assisted peptide synthesis
WO2006071470A2 (en) 2004-12-03 2006-07-06 California Institute Of Technology Microfluidic devices with chemical reaction circuits
KR101014799B1 (ko) 2008-06-05 2011-02-15 애니젠 주식회사 펩타이드 합성 제조 장치
US8535947B2 (en) 2010-09-30 2013-09-17 Protein Technologies, Inc. On-line monitoring of deprotection reaction in peptide automated synthesizer comprising UV detector
TWI510781B (zh) 2010-10-29 2015-12-01 Scinopharm Taiwan Ltd 即時監測固相胜肽合成反應之質譜系統
US20150217254A1 (en) 2012-09-10 2015-08-06 Mohammad Boroomand Automated peptide synthesizer
WO2014042591A1 (en) 2012-09-11 2014-03-20 Heptagon Micro Optics Pte. Ltd. Manufacture of truncated lenses, of pairs of truncated lenses and of corresponding devices
US9169287B2 (en) 2013-03-15 2015-10-27 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
US9695214B2 (en) 2013-03-15 2017-07-04 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
CN108289925A (zh) 2015-09-17 2018-07-17 麻省理工学院 固相肽合成方法和相关系统
CN108290923A (zh) 2015-09-17 2018-07-17 麻省理工学院 用于固相肽合成的方法和系统

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4192796A (en) * 1979-03-26 1980-03-11 American Cyanamid Company Polymers stabilized with organo-phosphorus compounds
WO1982003077A1 (en) * 1981-03-10 1982-09-16 Inc Bioresearch High performance peptide synthesis
EP1923396A2 (en) * 2006-10-24 2008-05-21 CEM Corporation Microwave-Assisted Peptide Synthesis
CN101665528A (zh) * 2009-09-17 2010-03-10 中国药科大学 微波促进固相合成苦瓜mc-jj2多肽类似物及其应用
CN102924568A (zh) * 2012-11-20 2013-02-13 天津铭恒科技发展有限公司 一种合成多肽及其制备方法和用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
微波辐射在多肽合成中的研究进展;岑涛等;《化学世界》;20090725(第7期);439-442 *

Also Published As

Publication number Publication date
AU2014238203A1 (en) 2015-10-15
EP2970374A2 (en) 2016-01-20
US20210188899A1 (en) 2021-06-24
US9868759B2 (en) 2018-01-16
US10889613B2 (en) 2021-01-12
SG10201801611SA (en) 2018-04-27
US20160102118A1 (en) 2016-04-14
DK2970374T3 (da) 2020-02-10
JP7323275B2 (ja) 2023-08-08
EP3626726A3 (en) 2020-07-29
US11878996B2 (en) 2024-01-23
CA2904355A1 (en) 2014-09-25
US20180066012A1 (en) 2018-03-08
WO2014149387A3 (en) 2014-11-27
US20180057525A1 (en) 2018-03-01
CN105164145A (zh) 2015-12-16
JP2019023226A (ja) 2019-02-14
JP2016515114A (ja) 2016-05-26
JP6423849B2 (ja) 2018-11-14
CN110885355A (zh) 2020-03-17
EP2970374B1 (en) 2019-11-06
JP2021119204A (ja) 2021-08-12
EP3626726A2 (en) 2020-03-25
US10988504B2 (en) 2021-04-27
US20140275481A1 (en) 2014-09-18
US20220275021A1 (en) 2022-09-01
KR20150129011A (ko) 2015-11-18
SG11201507527WA (en) 2015-10-29
AU2014238203B2 (en) 2018-08-23
JP2024020587A (ja) 2024-02-14
US9169287B2 (en) 2015-10-27
US20240383944A1 (en) 2024-11-21
US20210188900A1 (en) 2021-06-24
US20240368216A1 (en) 2024-11-07
WO2014149387A8 (en) 2015-10-15
WO2014149387A2 (en) 2014-09-25

Similar Documents

Publication Publication Date Title
CN105164145B (zh) 固相肽合成方法及相关系统
US9695214B2 (en) Solid phase peptide synthesis processes and associated systems
JP5199126B2 (ja) グルカゴン様ペプチドの合成
Cistrone et al. Native chemical ligation of peptides and proteins
Jensen Solid-phase peptide synthesis: an introduction
RS51281B (sr) Sinteza insulinotropičnog peptida
JP2024113180A (ja) ペプチド合成およびそのシステム
JP2004511424A (ja) テンプレートを固定したβヘアピンループ類似物の合成
Gesellchen et al. Synthesis of peptides and proteins by chemical and biotechnological means
Wang et al. 2-(2-nitrophenyl) propyl: A rapidly released photolabile COOH-protecting group for solid-phase peptide synthesis
Murray et al. Solid-phase peptide synthesis using microwave irradiation
JP2025531129A (ja) ペプチド合成方法
US20120165505A1 (en) Beta Helical Peptide Structures Stable in Aqueous and Non-Aqueous Media
US20240083938A1 (en) Peptide Synthesis Processes
CN120842360A (zh) 基于固相片段连接法合成司美格鲁肽的方法
Jensen Peptide Synthesis
CN118754966A (zh) 一种瑞他鲁肽的制备方法
Gesellchen et al. Biotechnological Means
Pflaum et al. Solid phase peptide synthesis of the fragment BPC 157 of human gastric juice protein BPC and its analogues

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant