CN110885355A - 固相肽合成方法及相关系统 - Google Patents

固相肽合成方法及相关系统 Download PDF

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Publication number
CN110885355A
CN110885355A CN201911125162.7A CN201911125162A CN110885355A CN 110885355 A CN110885355 A CN 110885355A CN 201911125162 A CN201911125162 A CN 201911125162A CN 110885355 A CN110885355 A CN 110885355A
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China
Prior art keywords
amino acid
peptide
immobilized
peptides
seconds
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CN201911125162.7A
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English (en)
Chinese (zh)
Inventor
马克·大卫·西蒙
布雷德利·L·彭泰卢特
安德烈亚·阿达莫
帕特里克·路易斯·海德尔
克拉夫斯·F·詹森
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of CN110885355A publication Critical patent/CN110885355A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0053—Details of the reactor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
CN201911125162.7A 2013-03-15 2014-02-24 固相肽合成方法及相关系统 Pending CN110885355A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/833,745 US9169287B2 (en) 2013-03-15 2013-03-15 Solid phase peptide synthesis processes and associated systems
US13/833,745 2013-03-15
CN201480022269.8A CN105164145B (zh) 2013-03-15 2014-02-24 固相肽合成方法及相关系统

Related Parent Applications (1)

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CN201480022269.8A Division CN105164145B (zh) 2013-03-15 2014-02-24 固相肽合成方法及相关系统

Publications (1)

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CN110885355A true CN110885355A (zh) 2020-03-17

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CN201911125162.7A Pending CN110885355A (zh) 2013-03-15 2014-02-24 固相肽合成方法及相关系统
CN201480022269.8A Active CN105164145B (zh) 2013-03-15 2014-02-24 固相肽合成方法及相关系统

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US (9) US9169287B2 (enExample)
EP (2) EP3626726A3 (enExample)
JP (4) JP6423849B2 (enExample)
KR (1) KR20150129011A (enExample)
CN (2) CN110885355A (enExample)
AU (1) AU2014238203B2 (enExample)
CA (1) CA2904355A1 (enExample)
DK (1) DK2970374T3 (enExample)
SG (2) SG10201801611SA (enExample)
WO (1) WO2014149387A2 (enExample)

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US9695214B2 (en) 2013-03-15 2017-07-04 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
CN107736079A (zh) * 2015-06-19 2018-02-23 蛋白质科技公司 化学反应容器及合成系统和方法
EP3334750B1 (en) 2015-08-11 2022-10-05 Anie Philip Peptidic tgf-beta antagonists
CN108290923A (zh) * 2015-09-17 2018-07-17 麻省理工学院 用于固相肽合成的方法和系统
EP3349775B1 (en) * 2015-09-17 2021-12-01 Massachusetts Institute of Technology Solid phase peptide synthesis methods and associated systems
US10239914B2 (en) 2015-10-23 2019-03-26 Cem Corporation In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures
US10125163B2 (en) 2015-10-23 2018-11-13 Cem Corporation Solid phase peptide synthesis
CN108368152A (zh) * 2015-10-23 2018-08-03 Cem有限公司 固相肽合成中的改进
WO2018044356A1 (en) * 2016-09-03 2018-03-08 Cem Corporation In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures
USRE49961E1 (en) 2016-10-21 2024-05-07 Cem Corporation Solid phase peptide syntheses
IL293956A (en) 2017-04-12 2022-08-01 Magenta Therapeutics Inc Aryl hydrocarbon receptor antagonist and its uses
US20190343885A1 (en) 2017-10-31 2019-11-14 Magenta Therapeutics Inc. Compositions and methods for hematopoietic stem and progenitor cell transplant therapy
CA3079405A1 (en) 2017-10-31 2019-05-09 Magenta Therapeutics Inc. Compositions and methods for the expansion of hematopoietic stem and progenitor cells
SG11202004913TA (en) 2017-12-06 2020-06-29 Magenta Therapeutics Inc Dosing regimens for the mobilization of hematopoietic stem and progenitor cells
US20200338132A1 (en) 2018-01-03 2020-10-29 Magenta Therapeutics Inc. Compositions and methods for the expansion of hematopoietic stem and progenitor cells and treatment of inherited metabolic disorders
CN112020508A (zh) 2018-05-04 2020-12-01 法国多肽实验室 具有再循环回路的自动合成反应器系统
US11014959B2 (en) * 2018-06-14 2021-05-25 Cem Corporation Solvent system for solid phase peptide synthesis
CN111217891B (zh) * 2018-11-27 2023-11-14 深圳翰宇药业股份有限公司 一种特利加压素的合成方法
CN112111001B (zh) * 2019-06-19 2021-10-29 翰宇药业（武汉）有限公司 胸腺肽Tα-1的合成方法
CN110343147B (zh) * 2019-08-22 2021-07-02 凯莱英医药集团（天津）股份有限公司 艾替班特的合成方法
WO2021087406A1 (en) 2019-11-01 2021-05-06 Magenta Therapeutics, Inc. Dosing regimens for the mobilization of hematopoietic stem and progentor cells
EP4100417A2 (en) 2020-02-05 2022-12-14 Eli Lilly and Company Resin reactors in series peptide synthesizer
US11049590B1 (en) 2020-02-12 2021-06-29 Peptilogics, Inc. Artificial intelligence engine architecture for generating candidate drugs
SE2050293A1 (en) * 2020-03-17 2021-09-18 Peptisystems Ab Peptide synthesis and system thereof
US11834480B2 (en) 2020-08-03 2023-12-05 Amide Technologies Protein inhibitors with reduced immunogenicity and resistance to degradation, and methods for their preparation and use
EP4247830A1 (en) * 2020-11-17 2023-09-27 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Extremely fast solid phase synthesis
US11403316B2 (en) 2020-11-23 2022-08-02 Peptilogics, Inc. Generating enhanced graphical user interfaces for presentation of anti-infective design spaces for selecting drug candidates
WO2022197776A1 (en) 2021-03-16 2022-09-22 Magenta Therapeutics, Inc. Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients
US11587643B2 (en) 2021-05-07 2023-02-21 Peptilogics, Inc. Methods and apparatuses for a unified artificial intelligence platform to synthesize diverse sets of peptides and peptidomimetics
US11512345B1 (en) 2021-05-07 2022-11-29 Peptilogics, Inc. Methods and apparatuses for generating peptides by synthesizing a portion of a design space to identify peptides having non-canonical amino acids
WO2023068987A1 (en) 2021-10-18 2023-04-27 Polypeptide Laboratories Holding (Ppl) Ab Intermittent percolation washing
CN115669843A (zh) * 2022-10-26 2023-02-03 中国农业大学 一种采用高压微射流结合混合肽有效杀灭芽孢的方法
WO2025071365A1 (ko) * 2023-09-27 2025-04-03 에스피투티엑스주식회사 흐름 반응기 및 이를 포함하는 생물학적 고분자 합성 시스템
CN120882482A (zh) 2023-10-23 2025-10-31 蛋白质技术股份有限公司 肽合成反应的在线监视
WO2025090409A1 (en) * 2023-10-23 2025-05-01 Protein Technologies, Inc. On-line monitoring of synthesis reactions of peptides

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WO1998034633A1 (en) * 1997-02-11 1998-08-13 Mallinckrodt Chemical, Inc. Reactor and method for solid phase peptide synthesis
EP1923396A2 (en) * 2006-10-24 2008-05-21 CEM Corporation Microwave-Assisted Peptide Synthesis

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US9695214B2 (en) 2013-03-15 2017-07-04 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
CN108290923A (zh) 2015-09-17 2018-07-17 麻省理工学院 用于固相肽合成的方法和系统
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Also Published As

Publication number Publication date
JP2024020587A (ja) 2024-02-14
EP2970374B1 (en) 2019-11-06
JP2021119204A (ja) 2021-08-12
SG10201801611SA (en) 2018-04-27
US20240383944A1 (en) 2024-11-21
JP2016515114A (ja) 2016-05-26
US20240368216A1 (en) 2024-11-07
JP7323275B2 (ja) 2023-08-08
EP2970374A2 (en) 2016-01-20
CA2904355A1 (en) 2014-09-25
WO2014149387A2 (en) 2014-09-25
DK2970374T3 (da) 2020-02-10
US20210188899A1 (en) 2021-06-24
US20160102118A1 (en) 2016-04-14
US20180066012A1 (en) 2018-03-08
JP2019023226A (ja) 2019-02-14
AU2014238203B2 (en) 2018-08-23
CN105164145B (zh) 2019-12-13
US20210188900A1 (en) 2021-06-24
US10889613B2 (en) 2021-01-12
US10988504B2 (en) 2021-04-27
US20140275481A1 (en) 2014-09-18
KR20150129011A (ko) 2015-11-18
SG11201507527WA (en) 2015-10-29
US9169287B2 (en) 2015-10-27
JP6423849B2 (ja) 2018-11-14
CN105164145A (zh) 2015-12-16
US20180057525A1 (en) 2018-03-01
US9868759B2 (en) 2018-01-16
US20220275021A1 (en) 2022-09-01
US11878996B2 (en) 2024-01-23
WO2014149387A8 (en) 2015-10-15
AU2014238203A1 (en) 2015-10-15
EP3626726A2 (en) 2020-03-25
WO2014149387A3 (en) 2014-11-27
EP3626726A3 (en) 2020-07-29

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