CA2904355A1 - Solid phase peptide synthesis processes and associated systems - Google Patents

Solid phase peptide synthesis processes and associated systems Download PDF

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Publication number
CA2904355A1
CA2904355A1 CA2904355A CA2904355A CA2904355A1 CA 2904355 A1 CA2904355 A1 CA 2904355A1 CA 2904355 A CA2904355 A CA 2904355A CA 2904355 A CA2904355 A CA 2904355A CA 2904355 A1 CA2904355 A1 CA 2904355A1
Authority
CA
Canada
Prior art keywords
amino acid
amino acids
peptides
exposing
immobilized peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2904355A
Other languages
English (en)
French (fr)
Inventor
Mark David Simon
Bradley L. Pentelute
Andrea Adamo
Patrick Louis Heider
Klavs F. Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50290261&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2904355(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of CA2904355A1 publication Critical patent/CA2904355A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0053Details of the reactor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
CA2904355A 2013-03-15 2014-02-24 Solid phase peptide synthesis processes and associated systems Abandoned CA2904355A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/833,745 2013-03-15
US13/833,745 US9169287B2 (en) 2013-03-15 2013-03-15 Solid phase peptide synthesis processes and associated systems
PCT/US2014/017970 WO2014149387A2 (en) 2013-03-15 2014-02-24 Solid phase peptide synthesis processes and associated systems

Publications (1)

Publication Number Publication Date
CA2904355A1 true CA2904355A1 (en) 2014-09-25

Family

ID=50290261

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2904355A Abandoned CA2904355A1 (en) 2013-03-15 2014-02-24 Solid phase peptide synthesis processes and associated systems

Country Status (10)

Country Link
US (9) US9169287B2 (enExample)
EP (2) EP2970374B1 (enExample)
JP (4) JP6423849B2 (enExample)
KR (1) KR20150129011A (enExample)
CN (2) CN110885355A (enExample)
AU (1) AU2014238203B2 (enExample)
CA (1) CA2904355A1 (enExample)
DK (1) DK2970374T3 (enExample)
SG (2) SG11201507527WA (enExample)
WO (1) WO2014149387A2 (enExample)

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US9695214B2 (en) 2013-03-15 2017-07-04 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
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CN108290923A (zh) 2015-09-17 2018-07-17 麻省理工学院 用于固相肽合成的方法和系统
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CN111902411A (zh) 2018-01-03 2020-11-06 美真达治疗公司 用于扩增造血干细胞和祖细胞以及治疗遗传性代谢紊乱的组合物和方法
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CN111217891B (zh) * 2018-11-27 2023-11-14 深圳翰宇药业股份有限公司 一种特利加压素的合成方法
CN112111001B (zh) * 2019-06-19 2021-10-29 翰宇药业(武汉)有限公司 胸腺肽Tα-1的合成方法
CN110343147B (zh) * 2019-08-22 2021-07-02 凯莱英医药集团(天津)股份有限公司 艾替班特的合成方法
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US11834480B2 (en) 2020-08-03 2023-12-05 Amide Technologies Protein inhibitors with reduced immunogenicity and resistance to degradation, and methods for their preparation and use
EP4247830A1 (en) * 2020-11-17 2023-09-27 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Extremely fast solid phase synthesis
US20220165359A1 (en) 2020-11-23 2022-05-26 Peptilogics, Inc. Generating anti-infective design spaces for selecting drug candidates
EP4308694A1 (en) 2021-03-16 2024-01-24 Magenta Therapeutics, Inc. Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients
US11512345B1 (en) 2021-05-07 2022-11-29 Peptilogics, Inc. Methods and apparatuses for generating peptides by synthesizing a portion of a design space to identify peptides having non-canonical amino acids
US11587643B2 (en) 2021-05-07 2023-02-21 Peptilogics, Inc. Methods and apparatuses for a unified artificial intelligence platform to synthesize diverse sets of peptides and peptidomimetics
WO2023068987A1 (en) 2021-10-18 2023-04-27 Polypeptide Laboratories Holding (Ppl) Ab Intermittent percolation washing
CN115669843A (zh) * 2022-10-26 2023-02-03 中国农业大学 一种采用高压微射流结合混合肽有效杀灭芽孢的方法
WO2025071365A1 (ko) * 2023-09-27 2025-04-03 에스피투티엑스주식회사 흐름 반응기 및 이를 포함하는 생물학적 고분자 합성 시스템
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US9169287B2 (en) 2013-03-15 2015-10-27 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
US9695214B2 (en) 2013-03-15 2017-07-04 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
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Also Published As

Publication number Publication date
AU2014238203A1 (en) 2015-10-15
EP2970374A2 (en) 2016-01-20
US20210188899A1 (en) 2021-06-24
US9868759B2 (en) 2018-01-16
US10889613B2 (en) 2021-01-12
SG10201801611SA (en) 2018-04-27
US20160102118A1 (en) 2016-04-14
DK2970374T3 (da) 2020-02-10
JP7323275B2 (ja) 2023-08-08
EP3626726A3 (en) 2020-07-29
US11878996B2 (en) 2024-01-23
US20180066012A1 (en) 2018-03-08
WO2014149387A3 (en) 2014-11-27
US20180057525A1 (en) 2018-03-01
CN105164145B (zh) 2019-12-13
CN105164145A (zh) 2015-12-16
JP2019023226A (ja) 2019-02-14
JP2016515114A (ja) 2016-05-26
JP6423849B2 (ja) 2018-11-14
CN110885355A (zh) 2020-03-17
EP2970374B1 (en) 2019-11-06
JP2021119204A (ja) 2021-08-12
EP3626726A2 (en) 2020-03-25
US10988504B2 (en) 2021-04-27
US20140275481A1 (en) 2014-09-18
US20220275021A1 (en) 2022-09-01
KR20150129011A (ko) 2015-11-18
SG11201507527WA (en) 2015-10-29
AU2014238203B2 (en) 2018-08-23
JP2024020587A (ja) 2024-02-14
US9169287B2 (en) 2015-10-27
US20240383944A1 (en) 2024-11-21
US20210188900A1 (en) 2021-06-24
US20240368216A1 (en) 2024-11-07
WO2014149387A8 (en) 2015-10-15
WO2014149387A2 (en) 2014-09-25

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20200225