AU2014238203B2 - Solid phase peptide synthesis processes and associated systems - Google Patents

Solid phase peptide synthesis processes and associated systems Download PDF

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Publication number
AU2014238203B2
AU2014238203B2 AU2014238203A AU2014238203A AU2014238203B2 AU 2014238203 B2 AU2014238203 B2 AU 2014238203B2 AU 2014238203 A AU2014238203 A AU 2014238203A AU 2014238203 A AU2014238203 A AU 2014238203A AU 2014238203 B2 AU2014238203 B2 AU 2014238203B2
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Australia
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pct
rule
substitute sheet
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conh
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AU2014238203A
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AU2014238203A1 (en
Inventor
Andrea Adamo
Patrick Louis Heider
Klavs F. Jensen
Bradley L. Pentelute
Mark David Simon
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0053—Details of the reactor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
AU2014238203A 2013-03-15 2014-02-24 Solid phase peptide synthesis processes and associated systems Active AU2014238203B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/833,745 2013-03-15
US13/833,745 US9169287B2 (en) 2013-03-15 2013-03-15 Solid phase peptide synthesis processes and associated systems
PCT/US2014/017970 WO2014149387A2 (en) 2013-03-15 2014-02-24 Solid phase peptide synthesis processes and associated systems

Publications (2)

Publication Number Publication Date
AU2014238203A1 AU2014238203A1 (en) 2015-10-15
AU2014238203B2 true AU2014238203B2 (en) 2018-08-23

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014238203A Active AU2014238203B2 (en) 2013-03-15 2014-02-24 Solid phase peptide synthesis processes and associated systems

Country Status (10)

Country Link
US (9) US9169287B2 (enExample)
EP (2) EP2970374B1 (enExample)
JP (4) JP6423849B2 (enExample)
KR (1) KR20150129011A (enExample)
CN (2) CN110885355A (enExample)
AU (1) AU2014238203B2 (enExample)
CA (1) CA2904355A1 (enExample)
DK (1) DK2970374T3 (enExample)
SG (2) SG11201507527WA (enExample)
WO (1) WO2014149387A2 (enExample)

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US9169287B2 (en) 2013-03-15 2015-10-27 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
US9695214B2 (en) 2013-03-15 2017-07-04 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
EP4240110A3 (en) * 2015-06-19 2023-11-08 Protein Technologies, Inc. Chemical reaction vessel and synthesis systems and methods
EP3334750B1 (en) 2015-08-11 2022-10-05 Anie Philip Peptidic tgf-beta antagonists
CN108289925A (zh) * 2015-09-17 2018-07-17 麻省理工学院 固相肽合成方法和相关系统
CN108290923A (zh) 2015-09-17 2018-07-17 麻省理工学院 用于固相肽合成的方法和系统
US10239914B2 (en) 2015-10-23 2019-03-26 Cem Corporation In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures
WO2017070512A1 (en) * 2015-10-23 2017-04-27 Cem Corporation Improvements in solid phase peptide synthesis
EP3365352A4 (en) * 2015-10-23 2019-06-05 CEM Corporation IMPROVEMENTS OF SOLID PHASE PEPTIDE SYNTHESIS
EP3507299B1 (en) * 2016-09-03 2022-07-27 CEM Corporation In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures
USRE49961E1 (en) 2016-10-21 2024-05-07 Cem Corporation Solid phase peptide syntheses
IL293956A (en) 2017-04-12 2022-08-01 Magenta Therapeutics Inc Aryl hydrocarbon receptor antagonist and its uses
JP7412341B2 (ja) 2017-10-31 2024-01-12 エディジーン バイオテクノロジー インコーポレイテッド 造血幹細胞および前駆細胞の増幅のための組成物および方法
EP3703715A1 (en) 2017-10-31 2020-09-09 Magenta Therapeutics, Inc. Compositions and methods for hematopoietic stem and progenitor cell transplant therapy
KR20200096942A (ko) 2017-12-06 2020-08-14 마젠타 테라퓨틱스 인코포레이티드 조혈 줄기 및 자손 세포의 동원을 위한 투여 요법
CN111902411A (zh) 2018-01-03 2020-11-06 美真达治疗公司 用于扩增造血干细胞和祖细胞以及治疗遗传性代谢紊乱的组合物和方法
CN112020508A (zh) 2018-05-04 2020-12-01 法国多肽实验室 具有再循环回路的自动合成反应器系统
EP3807292A4 (en) * 2018-06-14 2022-03-16 CEM Corporation Solvent system for solid phase peptide synthesis
CN111217891B (zh) * 2018-11-27 2023-11-14 深圳翰宇药业股份有限公司 一种特利加压素的合成方法
CN112111001B (zh) * 2019-06-19 2021-10-29 翰宇药业（武汉）有限公司 胸腺肽Tα-1的合成方法
CN110343147B (zh) * 2019-08-22 2021-07-02 凯莱英医药集团（天津）股份有限公司 艾替班特的合成方法
US20220401481A1 (en) 2019-11-01 2022-12-22 Magenta Therapeutics, Inc. Dosing regimens for the mobilization of hematopoietic stem and progenitor cells
CA3167047A1 (en) 2020-02-05 2021-08-12 Martin D. Johnson Three resin reactors in series peptide synthesizer
US11049590B1 (en) 2020-02-12 2021-06-29 Peptilogics, Inc. Artificial intelligence engine architecture for generating candidate drugs
SE2050293A1 (en) * 2020-03-17 2021-09-18 Peptisystems Ab Peptide synthesis and system thereof
US11834480B2 (en) 2020-08-03 2023-12-05 Amide Technologies Protein inhibitors with reduced immunogenicity and resistance to degradation, and methods for their preparation and use
EP4247830A1 (en) * 2020-11-17 2023-09-27 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Extremely fast solid phase synthesis
US20220165359A1 (en) 2020-11-23 2022-05-26 Peptilogics, Inc. Generating anti-infective design spaces for selecting drug candidates
EP4308694A1 (en) 2021-03-16 2024-01-24 Magenta Therapeutics, Inc. Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients
US11512345B1 (en) 2021-05-07 2022-11-29 Peptilogics, Inc. Methods and apparatuses for generating peptides by synthesizing a portion of a design space to identify peptides having non-canonical amino acids
US11587643B2 (en) 2021-05-07 2023-02-21 Peptilogics, Inc. Methods and apparatuses for a unified artificial intelligence platform to synthesize diverse sets of peptides and peptidomimetics
WO2023068987A1 (en) 2021-10-18 2023-04-27 Polypeptide Laboratories Holding (Ppl) Ab Intermittent percolation washing
CN115669843A (zh) * 2022-10-26 2023-02-03 中国农业大学 一种采用高压微射流结合混合肽有效杀灭芽孢的方法
WO2025071365A1 (ko) * 2023-09-27 2025-04-03 에스피투티엑스주식회사 흐름 반응기 및 이를 포함하는 생물학적 고분자 합성 시스템
US12399112B2 (en) 2023-10-23 2025-08-26 Protein Technologies, Inc. On-line monitoring of synthesis reactions
WO2025090409A1 (en) * 2023-10-23 2025-05-01 Protein Technologies, Inc. On-line monitoring of synthesis reactions of peptides

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WO1982003077A1 (en) * 1981-03-10 1982-09-16 Inc Bioresearch High performance peptide synthesis
EP1923396A2 (en) * 2006-10-24 2008-05-21 CEM Corporation Microwave-Assisted Peptide Synthesis

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US9169287B2 (en) 2013-03-15 2015-10-27 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
US9695214B2 (en) 2013-03-15 2017-07-04 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
CN108289925A (zh) 2015-09-17 2018-07-17 麻省理工学院 固相肽合成方法和相关系统
CN108290923A (zh) 2015-09-17 2018-07-17 麻省理工学院 用于固相肽合成的方法和系统

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Also Published As

Publication number Publication date
AU2014238203A1 (en) 2015-10-15
EP2970374A2 (en) 2016-01-20
US20210188899A1 (en) 2021-06-24
US9868759B2 (en) 2018-01-16
US10889613B2 (en) 2021-01-12
SG10201801611SA (en) 2018-04-27
US20160102118A1 (en) 2016-04-14
DK2970374T3 (da) 2020-02-10
JP7323275B2 (ja) 2023-08-08
EP3626726A3 (en) 2020-07-29
US11878996B2 (en) 2024-01-23
CA2904355A1 (en) 2014-09-25
US20180066012A1 (en) 2018-03-08
WO2014149387A3 (en) 2014-11-27
US20180057525A1 (en) 2018-03-01
CN105164145B (zh) 2019-12-13
CN105164145A (zh) 2015-12-16
JP2019023226A (ja) 2019-02-14
JP2016515114A (ja) 2016-05-26
JP6423849B2 (ja) 2018-11-14
CN110885355A (zh) 2020-03-17
EP2970374B1 (en) 2019-11-06
JP2021119204A (ja) 2021-08-12
EP3626726A2 (en) 2020-03-25
US10988504B2 (en) 2021-04-27
US20140275481A1 (en) 2014-09-18
US20220275021A1 (en) 2022-09-01
KR20150129011A (ko) 2015-11-18
SG11201507527WA (en) 2015-10-29
JP2024020587A (ja) 2024-02-14
US9169287B2 (en) 2015-10-27
US20240383944A1 (en) 2024-11-21
US20210188900A1 (en) 2021-06-24
US20240368216A1 (en) 2024-11-07
WO2014149387A8 (en) 2015-10-15
WO2014149387A2 (en) 2014-09-25

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