DK2970374T3 - Fastfase-peptidsyntese - Google Patents
Fastfase-peptidsyntese Download PDFInfo
- Publication number
- DK2970374T3 DK2970374T3 DK14711046.4T DK14711046T DK2970374T3 DK 2970374 T3 DK2970374 T3 DK 2970374T3 DK 14711046 T DK14711046 T DK 14711046T DK 2970374 T3 DK2970374 T3 DK 2970374T3
- Authority
- DK
- Denmark
- Prior art keywords
- solid phase
- peptide synthesis
- phase peptide
- synthesis
- solid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/833,745 US9169287B2 (en) | 2013-03-15 | 2013-03-15 | Solid phase peptide synthesis processes and associated systems |
PCT/US2014/017970 WO2014149387A2 (en) | 2013-03-15 | 2014-02-24 | Solid phase peptide synthesis processes and associated systems |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2970374T3 true DK2970374T3 (da) | 2020-02-10 |
Family
ID=50290261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14711046.4T DK2970374T3 (da) | 2013-03-15 | 2014-02-24 | Fastfase-peptidsyntese |
Country Status (10)
Country | Link |
---|---|
US (7) | US9169287B2 (da) |
EP (2) | EP2970374B1 (da) |
JP (4) | JP6423849B2 (da) |
KR (1) | KR20150129011A (da) |
CN (2) | CN105164145B (da) |
AU (1) | AU2014238203B2 (da) |
CA (1) | CA2904355A1 (da) |
DK (1) | DK2970374T3 (da) |
SG (2) | SG11201507527WA (da) |
WO (1) | WO2014149387A2 (da) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9695214B2 (en) | 2013-03-15 | 2017-07-04 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
US9169287B2 (en) | 2013-03-15 | 2015-10-27 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
WO2016205546A1 (en) * | 2015-06-19 | 2016-12-22 | Protein Technologies, Inc. | Chemical reaction vessel and synthesis systems and methods |
EP3334750B1 (en) | 2015-08-11 | 2022-10-05 | Anie Philip | Peptidic tgf-beta antagonists |
JP7054922B2 (ja) * | 2015-09-17 | 2022-04-15 | マサチューセッツ インスティテュート オブ テクノロジー | 固相ペプチド合成方法および関連するシステム |
EP3350197A4 (en) * | 2015-09-17 | 2019-04-24 | Massachusetts Institute of Technology | METHODS AND SYSTEMS FOR SYNTHESIZING SOLID-STATE PEPTIDE |
US10239914B2 (en) | 2015-10-23 | 2019-03-26 | Cem Corporation | In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures |
US10125163B2 (en) | 2015-10-23 | 2018-11-13 | Cem Corporation | Solid phase peptide synthesis |
CN108368152A (zh) * | 2015-10-23 | 2018-08-03 | Cem有限公司 | 固相肽合成中的改进 |
CN109715647A (zh) * | 2016-09-03 | 2019-05-03 | Cem有限公司 | 用于高温固相肽合成的原位溶剂回收方法 |
USRE49961E1 (en) | 2016-10-21 | 2024-05-07 | Cem Corporation | Solid phase peptide syntheses |
BR112019021282A2 (pt) | 2017-04-12 | 2020-05-19 | Magenta Therapeutics Inc | antagonistas de receptor aril hidrocarboneto e usos dos mesmos |
WO2019089833A1 (en) | 2017-10-31 | 2019-05-09 | Magenta Therapeutics Inc. | Compositions and methods for hematopoietic stem and progenitor cell transplant therapy |
AU2018358241A1 (en) | 2017-10-31 | 2020-05-07 | Edigene Biotechnology, Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells |
JP2021505172A (ja) | 2017-12-06 | 2021-02-18 | マジェンタ セラピューティクス インコーポレイテッドMagenta Therapeutics, Inc. | 造血幹細胞及び前駆細胞を動員させるための投薬レジメン |
CN111902411A (zh) | 2018-01-03 | 2020-11-06 | 美真达治疗公司 | 用于扩增造血干细胞和祖细胞以及治疗遗传性代谢紊乱的组合物和方法 |
WO2019211531A1 (fr) * | 2018-05-04 | 2019-11-07 | Polypeptide Laboratoires France | Systeme automatise de reacteur de synthese avec une boucle de recirculation |
EP3807292A4 (en) * | 2018-06-14 | 2022-03-16 | CEM Corporation | SOLVENT SYSTEM FOR SOLID PHASE PEPTIDE SYNTHESIS |
CN111217891B (zh) * | 2018-11-27 | 2023-11-14 | 深圳翰宇药业股份有限公司 | 一种特利加压素的合成方法 |
CN112111001B (zh) * | 2019-06-19 | 2021-10-29 | 翰宇药业(武汉)有限公司 | 胸腺肽Tα-1的合成方法 |
CN110343147B (zh) * | 2019-08-22 | 2021-07-02 | 凯莱英医药集团(天津)股份有限公司 | 艾替班特的合成方法 |
EP4051298A1 (en) | 2019-11-01 | 2022-09-07 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progentor cells |
US11049590B1 (en) | 2020-02-12 | 2021-06-29 | Peptilogics, Inc. | Artificial intelligence engine architecture for generating candidate drugs |
SE2050293A1 (en) * | 2020-03-17 | 2021-09-18 | Peptisystems Ab | Peptide synthesis and system thereof |
US11834480B2 (en) | 2020-08-03 | 2023-12-05 | Amide Technologies | Protein inhibitors with reduced immunogenicity and resistance to degradation, and methods for their preparation and use |
WO2022107134A1 (en) * | 2020-11-17 | 2022-05-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Extremely fast solid phase synthesis |
US11403316B2 (en) | 2020-11-23 | 2022-08-02 | Peptilogics, Inc. | Generating enhanced graphical user interfaces for presentation of anti-infective design spaces for selecting drug candidates |
EP4308694A1 (en) | 2021-03-16 | 2024-01-24 | Magenta Therapeutics, Inc. | Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients |
US11512345B1 (en) | 2021-05-07 | 2022-11-29 | Peptilogics, Inc. | Methods and apparatuses for generating peptides by synthesizing a portion of a design space to identify peptides having non-canonical amino acids |
US11587643B2 (en) | 2021-05-07 | 2023-02-21 | Peptilogics, Inc. | Methods and apparatuses for a unified artificial intelligence platform to synthesize diverse sets of peptides and peptidomimetics |
KR20240095247A (ko) * | 2021-10-18 | 2024-06-25 | 폴리펩티드 레브러토리즈 홀딩 (피피엘) 에이비 | 간헐적 삼출 세척 |
CN115669843A (zh) * | 2022-10-26 | 2023-02-03 | 中国农业大学 | 一种采用高压微射流结合混合肽有效杀灭芽孢的方法 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4093550A (en) | 1975-06-04 | 1978-06-06 | Riedel-De Haen Aktiengesellschaft | Column for high pressure liquid chromatography |
US4192798A (en) | 1978-11-20 | 1980-03-11 | Bioresearch, Inc. | Rapid, large scale, automatable high pressure peptide synthesis |
US4192796A (en) * | 1979-03-26 | 1980-03-11 | American Cyanamid Company | Polymers stabilized with organo-phosphorus compounds |
ZA821537B (en) | 1981-03-10 | 1984-01-25 | Bioresearch Inc | High performance peptide synthesis |
US4598049A (en) | 1983-08-31 | 1986-07-01 | Systec Inc. | General purpose gene synthesizer |
WO1985001224A1 (en) * | 1983-09-22 | 1985-03-28 | Saneii Hossain H | Solid phase peptide synthesizer |
US4746490A (en) * | 1983-09-22 | 1988-05-24 | Saneii Hossain H | Solid phase peptide synthesizer |
US4668476A (en) | 1984-03-23 | 1987-05-26 | Applied Biosystems, Inc. | Automated polypeptide synthesis apparatus |
US5061635A (en) | 1987-07-13 | 1991-10-29 | City Of Hope | Protein or peptide sequencing method |
US4861866A (en) | 1987-01-21 | 1989-08-29 | Eldex Laboratories, Inc. | Continuous flow peptide synthesizer |
US5807525A (en) | 1995-08-17 | 1998-09-15 | Hybridon, Inc. | Apparatus and process for multi stage solid phase synthesis of long chained organic molecules |
WO1998011125A1 (en) | 1996-09-09 | 1998-03-19 | Zealand Pharmaceuticals A/S | Improved solid-phase peptide synthesis and agent for use in such synthesis |
KR100463630B1 (ko) | 1997-02-11 | 2005-05-25 | 말린크로트, 인코포레이티드 | 고상 펩티드 합성용 반응기 및 방법_ |
JP4727769B2 (ja) * | 1997-04-28 | 2011-07-20 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 試薬再循環を用いてオリゴマー、特に、ペプトイドを合成するための装置 |
AUPP616498A0 (en) | 1998-09-25 | 1998-10-15 | University Of Queensland, The | Synthesis of cyclic peptides |
US7566697B2 (en) | 2002-06-10 | 2009-07-28 | Amylin Pharmaceuticals, Inc. | Carboxy protection strategies for acidic C-terminal amino acids in chemical ligation of oligopeptides |
US7393920B2 (en) * | 2003-06-23 | 2008-07-01 | Cem Corporation | Microwave-assisted peptide synthesis |
US7902488B2 (en) * | 2003-06-23 | 2011-03-08 | Cem Corporation | Microwave-assisted peptide synthesis |
EP1838431A4 (en) | 2004-12-03 | 2012-08-22 | California Inst Of Techn | MICROFLUIDIC DEVICES WITH CIRCUITRY OF CHEMICAL REACTIONS |
KR101014799B1 (ko) | 2008-06-05 | 2011-02-15 | 애니젠 주식회사 | 펩타이드 합성 제조 장치 |
CN101665528A (zh) * | 2009-09-17 | 2010-03-10 | 中国药科大学 | 微波促进固相合成苦瓜mc-jj2多肽类似物及其应用 |
US8535947B2 (en) | 2010-09-30 | 2013-09-17 | Protein Technologies, Inc. | On-line monitoring of deprotection reaction in peptide automated synthesizer comprising UV detector |
TWI510781B (zh) | 2010-10-29 | 2015-12-01 | Scinopharm Taiwan Ltd | 即時監測固相胜肽合成反應之質譜系統 |
US20150217254A1 (en) | 2012-09-10 | 2015-08-06 | Mohammad Boroomand | Automated peptide synthesizer |
CN104822517B (zh) | 2012-09-11 | 2017-10-03 | 新加坡恒立私人有限公司 | 截断型镜片、截断型镜片对及相应装置的制造 |
CN102924568A (zh) * | 2012-11-20 | 2013-02-13 | 天津铭恒科技发展有限公司 | 一种合成多肽及其制备方法和用途 |
US9695214B2 (en) | 2013-03-15 | 2017-07-04 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
US9169287B2 (en) | 2013-03-15 | 2015-10-27 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
JP7054922B2 (ja) | 2015-09-17 | 2022-04-15 | マサチューセッツ インスティテュート オブ テクノロジー | 固相ペプチド合成方法および関連するシステム |
EP3350197A4 (en) | 2015-09-17 | 2019-04-24 | Massachusetts Institute of Technology | METHODS AND SYSTEMS FOR SYNTHESIZING SOLID-STATE PEPTIDE |
-
2013
- 2013-03-15 US US13/833,745 patent/US9169287B2/en active Active
-
2014
- 2014-02-24 WO PCT/US2014/017970 patent/WO2014149387A2/en active Application Filing
- 2014-02-24 SG SG11201507527WA patent/SG11201507527WA/en unknown
- 2014-02-24 CN CN201480022269.8A patent/CN105164145B/zh active Active
- 2014-02-24 CN CN201911125162.7A patent/CN110885355A/zh active Pending
- 2014-02-24 DK DK14711046.4T patent/DK2970374T3/da active
- 2014-02-24 SG SG10201801611SA patent/SG10201801611SA/en unknown
- 2014-02-24 AU AU2014238203A patent/AU2014238203B2/en active Active
- 2014-02-24 KR KR1020157029308A patent/KR20150129011A/ko not_active Application Discontinuation
- 2014-02-24 JP JP2016500356A patent/JP6423849B2/ja active Active
- 2014-02-24 EP EP14711046.4A patent/EP2970374B1/en active Active
- 2014-02-24 EP EP19202972.6A patent/EP3626726A3/en active Pending
- 2014-02-24 CA CA2904355A patent/CA2904355A1/en not_active Abandoned
-
2015
- 2015-09-14 US US14/853,683 patent/US9868759B2/en active Active
-
2017
- 2017-05-22 US US15/602,056 patent/US10889613B2/en active Active
- 2017-09-05 US US15/695,795 patent/US10988504B2/en active Active
-
2018
- 2018-10-19 JP JP2018197185A patent/JP7323275B2/ja active Active
-
2020
- 2020-12-18 US US17/127,961 patent/US20210188900A1/en not_active Abandoned
- 2020-12-18 US US17/127,951 patent/US11878996B2/en active Active
-
2021
- 2021-05-17 JP JP2021083136A patent/JP2021119204A/ja active Pending
- 2021-12-21 US US17/558,525 patent/US20220275021A1/en not_active Abandoned
-
2023
- 2023-11-30 JP JP2023202648A patent/JP2024020587A/ja active Pending
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