DK2970374T3 - Fastfase-peptidsyntese - Google Patents

Fastfase-peptidsyntese Download PDF

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Publication number
DK2970374T3
DK2970374T3 DK14711046.4T DK14711046T DK2970374T3 DK 2970374 T3 DK2970374 T3 DK 2970374T3 DK 14711046 T DK14711046 T DK 14711046T DK 2970374 T3 DK2970374 T3 DK 2970374T3
Authority
DK
Denmark
Prior art keywords
solid phase
peptide synthesis
phase peptide
synthesis
solid
Prior art date
Application number
DK14711046.4T
Other languages
English (en)
Inventor
Mark David Simon
Bradley L Pentelute
Andrea Adamo
Klavs F Jensen
Patrick Louis Heider
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50290261&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2970374(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of DK2970374T3 publication Critical patent/DK2970374T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0053—Details of the reactor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
DK14711046.4T 2013-03-15 2014-02-24 Fastfase-peptidsyntese DK2970374T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/833,745 US9169287B2 (en) 2013-03-15 2013-03-15 Solid phase peptide synthesis processes and associated systems
PCT/US2014/017970 WO2014149387A2 (en) 2013-03-15 2014-02-24 Solid phase peptide synthesis processes and associated systems

Publications (1)

Publication Number Publication Date
DK2970374T3 true DK2970374T3 (da) 2020-02-10

Family

ID=50290261

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14711046.4T DK2970374T3 (da) 2013-03-15 2014-02-24 Fastfase-peptidsyntese

Country Status (10)

Country Link
US (7) US9169287B2 (da)
EP (2) EP3626726A3 (da)
JP (4) JP6423849B2 (da)
KR (1) KR20150129011A (da)
CN (2) CN110885355A (da)
AU (1) AU2014238203B2 (da)
CA (1) CA2904355A1 (da)
DK (1) DK2970374T3 (da)
SG (2) SG11201507527WA (da)
WO (1) WO2014149387A2 (da)

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WO2017024407A1 (en) 2015-08-11 2017-02-16 The Royal Institution For The Advancement Of Learning/Mcgill University Peptidic tgf-beta antagonists
EP3960753A1 (en) * 2015-09-17 2022-03-02 Massachusetts Institute Of Technology Solid phase peptide synthesis methods
JP2018530543A (ja) * 2015-09-17 2018-10-18 マサチューセッツ インスティテュート オブ テクノロジー 固相ペプチド合成のための方法およびシステム
CN108368152A (zh) * 2015-10-23 2018-08-03 Cem有限公司 固相肽合成中的改进
US10239914B2 (en) 2015-10-23 2019-03-26 Cem Corporation In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures
US10125163B2 (en) 2015-10-23 2018-11-13 Cem Corporation Solid phase peptide synthesis
JP2019530659A (ja) * 2016-09-03 2019-10-24 シーイーエム・コーポレーション 高温での固相ペプチド合成のためのインサイツ溶媒リサイクル法
USRE49961E1 (en) 2016-10-21 2024-05-07 Cem Corporation Solid phase peptide syntheses
JP7352807B2 (ja) 2017-04-12 2023-09-29 マジェンタ セラピューティクス インコーポレイテッド アリール炭化水素受容体アンタゴニスト及びその使用
JP7412341B2 (ja) 2017-10-31 2024-01-12 エディジーン バイオテクノロジー インコーポレイテッド 造血幹細胞および前駆細胞の増幅のための組成物および方法
AU2018358054A1 (en) 2017-10-31 2020-05-07 Magenta Therapeutics Inc. Compositions and methods for hematopoietic stem and progenitor cell transplant therapy
MX2020005878A (es) 2017-12-06 2020-10-07 Magenta Therapeutics Inc Pautas posológicas para la movilización de células madre y progenitoras hematopoyéticas.
CN111902411A (zh) 2018-01-03 2020-11-06 美真达治疗公司 用于扩增造血干细胞和祖细胞以及治疗遗传性代谢紊乱的组合物和方法
CA3097005C (en) * 2018-05-04 2023-06-13 Polypeptide Laboratoires France Automated synthesis reactor system with a recirculation loop
EP3807292A4 (en) * 2018-06-14 2022-03-16 CEM Corporation SOLVENT SYSTEM FOR SOLID PHASE PEPTIDE SYNTHESIS
CN111217891B (zh) * 2018-11-27 2023-11-14 深圳翰宇药业股份有限公司 一种特利加压素的合成方法
CN112111001B (zh) * 2019-06-19 2021-10-29 翰宇药业（武汉）有限公司 胸腺肽Tα-1的合成方法
CN110343147B (zh) * 2019-08-22 2021-07-02 凯莱英医药集团（天津）股份有限公司 艾替班特的合成方法
EP4051298A1 (en) 2019-11-01 2022-09-07 Magenta Therapeutics, Inc. Dosing regimens for the mobilization of hematopoietic stem and progentor cells
US11049590B1 (en) 2020-02-12 2021-06-29 Peptilogics, Inc. Artificial intelligence engine architecture for generating candidate drugs
SE2050293A1 (en) * 2020-03-17 2021-09-18 Peptisystems Ab Peptide synthesis and system thereof
US11834480B2 (en) 2020-08-03 2023-12-05 Amide Technologies Protein inhibitors with reduced immunogenicity and resistance to degradation, and methods for their preparation and use
US20240287128A1 (en) * 2020-11-17 2024-08-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Extremely fast solid phase synthesis
US20220165359A1 (en) 2020-11-23 2022-05-26 Peptilogics, Inc. Generating anti-infective design spaces for selecting drug candidates
EP4308694A1 (en) 2021-03-16 2024-01-24 Magenta Therapeutics, Inc. Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients
US11512345B1 (en) 2021-05-07 2022-11-29 Peptilogics, Inc. Methods and apparatuses for generating peptides by synthesizing a portion of a design space to identify peptides having non-canonical amino acids
US11587643B2 (en) 2021-05-07 2023-02-21 Peptilogics, Inc. Methods and apparatuses for a unified artificial intelligence platform to synthesize diverse sets of peptides and peptidomimetics
SE546045C2 (en) * 2021-10-18 2024-04-23 Polypeptide Laboratories Holding Ppl Ab Intermittent Percolation Washing
CN115669843A (zh) * 2022-10-26 2023-02-03 中国农业大学 一种采用高压微射流结合混合肽有效杀灭芽孢的方法

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US9695214B2 (en) 2013-03-15 2017-07-04 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
JP2018530543A (ja) 2015-09-17 2018-10-18 マサチューセッツ インスティテュート オブ テクノロジー 固相ペプチド合成のための方法およびシステム
EP3960753A1 (en) 2015-09-17 2022-03-02 Massachusetts Institute Of Technology Solid phase peptide synthesis methods

Also Published As

Publication number Publication date
US10988504B2 (en) 2021-04-27
US20140275481A1 (en) 2014-09-18
WO2014149387A8 (en) 2015-10-15
CN105164145B (zh) 2019-12-13
JP2019023226A (ja) 2019-02-14
US20220275021A1 (en) 2022-09-01
JP7323275B2 (ja) 2023-08-08
KR20150129011A (ko) 2015-11-18
US20180066012A1 (en) 2018-03-08
CN110885355A (zh) 2020-03-17
US20160102118A1 (en) 2016-04-14
EP2970374B1 (en) 2019-11-06
JP2021119204A (ja) 2021-08-12
AU2014238203B2 (en) 2018-08-23
US20180057525A1 (en) 2018-03-01
AU2014238203A1 (en) 2015-10-15
US20210188899A1 (en) 2021-06-24
US9868759B2 (en) 2018-01-16
US20210188900A1 (en) 2021-06-24
CN105164145A (zh) 2015-12-16
US9169287B2 (en) 2015-10-27
JP6423849B2 (ja) 2018-11-14
JP2024020587A (ja) 2024-02-14
US11878996B2 (en) 2024-01-23
WO2014149387A2 (en) 2014-09-25
EP3626726A2 (en) 2020-03-25
SG10201801611SA (en) 2018-04-27
JP2016515114A (ja) 2016-05-26
EP2970374A2 (en) 2016-01-20
US10889613B2 (en) 2021-01-12
CA2904355A1 (en) 2014-09-25
EP3626726A3 (en) 2020-07-29
SG11201507527WA (en) 2015-10-29
WO2014149387A3 (en) 2014-11-27

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