JP2010539915A5 - - Google Patents

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Publication number
JP2010539915A5
JP2010539915A5 JP2010526268A JP2010526268A JP2010539915A5 JP 2010539915 A5 JP2010539915 A5 JP 2010539915A5 JP 2010526268 A JP2010526268 A JP 2010526268A JP 2010526268 A JP2010526268 A JP 2010526268A JP 2010539915 A5 JP2010539915 A5 JP 2010539915A5
Authority
JP
Japan
Prior art keywords
repeat
armadillo repeat
armadillo
protein
collection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010526268A
Other languages
English (en)
Japanese (ja)
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JP2010539915A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2008/062671 external-priority patent/WO2009040338A1/en
Publication of JP2010539915A publication Critical patent/JP2010539915A/ja
Publication of JP2010539915A5 publication Critical patent/JP2010539915A5/ja
Pending legal-status Critical Current

Links

JP2010526268A 2007-09-24 2008-09-23 設計されたアルマジロリピートタンパク質 Pending JP2010539915A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07117059 2007-09-24
PCT/EP2008/062671 WO2009040338A1 (en) 2007-09-24 2008-09-23 Designed armadillo repeat proteins

Publications (2)

Publication Number Publication Date
JP2010539915A JP2010539915A (ja) 2010-12-24
JP2010539915A5 true JP2010539915A5 (enExample) 2011-10-13

Family

ID=38962601

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010526268A Pending JP2010539915A (ja) 2007-09-24 2008-09-23 設計されたアルマジロリピートタンパク質

Country Status (5)

Country Link
US (1) US9365629B2 (enExample)
EP (1) EP2198022B1 (enExample)
JP (1) JP2010539915A (enExample)
CA (1) CA2700391A1 (enExample)
WO (1) WO2009040338A1 (enExample)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9433684B2 (en) 2008-08-19 2016-09-06 Nektar Therapeutics Conjugates of small-interfering nucleic acids
TWI510246B (zh) 2010-04-30 2015-12-01 Molecular Partners Ag 抑制vegf-a受體交互作用的經修飾結合性蛋白質
US9284361B2 (en) 2010-11-26 2016-03-15 Molecular Partners Ag Designed repeat proteins binding to serum albumin
SG191955A1 (en) 2011-02-15 2013-08-30 Immunogen Inc Cytotoxic benzodiazepine derivatives
JP6209159B2 (ja) 2011-06-21 2017-10-04 イミュノジェン・インコーポレーテッド ペプチドリンカーを有する新規メイタンシノイド誘導体およびその結合体
WO2014031566A1 (en) 2012-08-22 2014-02-27 Immunogen, Inc. Cytotoxic benzodiazepine derivatives
EP2738180A1 (en) 2012-11-30 2014-06-04 Molecular Partners AG Binding proteins comprising at least two binding domains against HER2.
JP6423804B2 (ja) 2013-02-28 2018-11-14 イミュノジェン・インコーポレーテッド 細胞結合剤及び細胞毒性剤を含む複合体
WO2014134483A2 (en) 2013-02-28 2014-09-04 Immunogen, Inc. Conjugates comprising cell-binding agents and cytotoxic agents
WO2014194030A2 (en) 2013-05-31 2014-12-04 Immunogen, Inc. Conjugates comprising cell-binding agents and cytotoxic agents
WO2014191574A1 (en) 2013-05-31 2014-12-04 Molecular Partners Ag Designed ankyrin repeat proteins binding to hepatocyte growth factor
CN105873952A (zh) 2013-10-31 2016-08-17 弗莱德哈钦森癌症研究中心 经修饰的造血干细胞/祖细胞和非t效应细胞及其用途
PL3083671T3 (pl) 2013-12-20 2021-03-22 Fred Hutchinson Cancer Center Znakowane chimeryczne cząsteczki efektorowe i ich receptory
US10665324B2 (en) 2014-07-07 2020-05-26 Yeda Research And Development Co. Ltd. Method of computational protein design
MX2017002758A (es) 2014-09-03 2017-10-20 Immunogen Inc Derivados de benzodiazepina citotoxicos.
JP2017527562A (ja) 2014-09-03 2017-09-21 イミュノジェン・インコーポレーテッド 細胞毒性ベンゾジアゼピン誘導体
HK1246317A1 (zh) 2015-03-05 2018-09-07 Fred Hutchinson Cancer Center 免疫调节融合蛋白及其用途
SG11201707606RA (en) 2015-04-02 2017-10-30 Molecular Partners Ag Designed ankyrin repeat domains with binding specificity for serum albumin
EP3288569A4 (en) 2015-04-29 2018-12-19 Fred Hutchinson Cancer Research Center Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof
WO2016176652A2 (en) 2015-04-29 2016-11-03 Fred Hutchinson Cancer Research Center Modified stem cells and uses thereof
WO2017106728A2 (en) * 2015-12-16 2017-06-22 University Of Washington Repeat protein architectures
CR20180503A (es) 2016-04-14 2018-12-21 Hutchinson Fred Cancer Res Composiciones y métodos para programar células terapéuticas utilizando nanoportadores de ácidos nucleicos dirigidos
KR102270315B1 (ko) 2016-09-22 2021-06-29 몰리큘라 파트너스 아게 재조합 결합 단백질 및 그의 용도
CA3052779A1 (en) 2017-02-17 2018-08-23 Fred Hutchinson Cancer Research Center Combination therapies for treatment of bcma-related cancers and autoimmune disorders
SG10202109376YA (en) 2017-02-28 2021-10-28 Immunogen Inc Maytansinoid derivatives with self-immolative peptide linkers and conjugates thereof
WO2018165046A1 (en) 2017-03-07 2018-09-13 Igc Bio, Inc. A computational pipeline for antibody modeling and design
JP2020511136A (ja) 2017-03-17 2020-04-16 フレッド ハッチンソン キャンサー リサーチ センター 免疫調節性融合タンパク質およびその使用
WO2018195243A1 (en) 2017-04-20 2018-10-25 Immunogen, Inc. Cytotoxic benzodiazepine derivatives and conjugates thereof
WO2019133652A1 (en) 2017-12-28 2019-07-04 Immunogen, Inc. Benzodiazepine derivatives
US12398402B2 (en) 2018-09-12 2025-08-26 Fred Hutchinson Cancer Center Reducing CD33 expression to selectively protect therapeutic cells
CA3133802A1 (en) 2019-03-21 2020-09-24 Immunogen, Inc. Methods of preparing cell-binding agent-drug conjugates
CN113661172A (zh) 2019-03-29 2021-11-16 伊缪诺金公司 用于抑制异常细胞生长或治疗增生性疾病的细胞毒性双苯并二氮杂䓬衍生物及其与细胞结合剂的缀合物
CN119119176A (zh) 2019-04-26 2024-12-13 伊缪诺金公司 喜树碱衍生物
AU2020286715A1 (en) 2019-06-04 2021-12-23 Molecular Partners Ag Recombinant 4-1 BB binding proteins and their use
CN114269366A (zh) 2019-06-04 2022-04-01 分子伴侣公司 重组fap结合蛋白及其用途
CA3138805A1 (en) 2019-06-04 2020-12-10 Johannes Schilling Designed ankyrin repeat domain with improved stability
SG11202111943UA (en) 2019-07-02 2021-11-29 Hutchinson Fred Cancer Res Recombinant ad35 vectors and related gene therapy improvements
US20230041822A1 (en) 2019-12-11 2023-02-09 Molecular Partners Ag Recombinant peptide-mhc complex binding proteins and their generation and use
CA3161326A1 (en) 2019-12-11 2021-06-17 Molecular Partners Ag Designed ankyrin repeat domains with altered surface residues
US20230142283A1 (en) * 2020-03-05 2023-05-11 University Of Washington Rigid helical junctions for modular repeat protein sculpting and methods of use
TW202208404A (zh) 2020-05-06 2022-03-01 瑞士商分子組合公司 新穎錨蛋白重複結合蛋白質及其用途
BR112022023049A2 (pt) 2020-05-14 2022-12-20 Molecular Partners Ag Proteínas multiespecíficas
JP2023528207A (ja) 2020-05-14 2023-07-04 モレキュラー パートナーズ アクチェンゲゼルシャフト 組換えcd40結合タンパク質及びそれらの使用
US20240108746A1 (en) 2020-12-16 2024-04-04 Molecular Partners Ag Novel slow-release prodrugs
WO2022129428A1 (en) 2020-12-16 2022-06-23 Molecular Partners Ag Recombinant cd3 binding proteins and their use
CA3211248A1 (en) 2021-03-09 2022-09-15 Nina RESCHKE Novel darpin based cd33 engagers
EP4305063A1 (en) 2021-03-09 2024-01-17 Molecular Partners AG Protease cleavable prodrugs
WO2022190016A1 (en) 2021-03-09 2022-09-15 Molecular Partners Ag Novel darpin based multi-specific t-cell engagers
CA3211368A1 (en) 2021-03-09 2022-09-15 Molecular Partners Ag Novel darpin based cd123 engagers
WO2023110983A1 (en) 2021-12-14 2023-06-22 Molecular Partners Ag Designed repeat domains with dual binding specificity and their use
US20250368704A1 (en) * 2022-01-07 2025-12-04 Universität Zürich Stabilizing n-cap sequences for armadillo repeat proteins
WO2023215725A1 (en) 2022-05-02 2023-11-09 Fred Hutchinson Cancer Center Compositions and methods for cellular immunotherapy
CA3262553A1 (en) 2022-08-01 2024-02-08 Molecular Partners Ag REHEARSAL AREAS DESIGNED WITH MODIFIED CHARGES AND THEIR USE
WO2024179981A1 (en) 2023-02-27 2024-09-06 Molecular Partners Ag Darpins for use in reducing renal accumulation of drugs
WO2024251695A1 (en) 2023-06-06 2024-12-12 Molecular Partners Ag Recombinant cd47 binding proteins and their use
WO2024251628A1 (en) 2023-06-06 2024-12-12 Molecular Partners Ag Recombinant cd16a binding proteins and their use
WO2024251742A1 (en) 2023-06-06 2024-12-12 Molecular Partners Ag Recombinant cd2 binding proteins and their use
WO2025068607A1 (en) * 2023-09-29 2025-04-03 Universität Zürich Modular armadillo repeat proteins
WO2025101820A1 (en) 2023-11-08 2025-05-15 Fred Hutchinson Cancer Center Compositions and methods for cellular immunotherapy
WO2025146491A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent
WO2025146487A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Multispecific binding proteins
WO2025146490A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Recombinant cd117 binding proteins and their use
WO2025163082A1 (en) 2024-01-31 2025-08-07 Molecular Partners Ag Dll3-specific binding constructs and their use in radiotherapy
WO2025163144A1 (en) 2024-01-31 2025-08-07 Molecular Partners Ag Recombinant mesothelin binding proteins and their use
WO2025181039A1 (en) 2024-03-01 2025-09-04 Molecular Partners Ag Therapeutic combinations comprising a multi-specific t cell engager
WO2025245169A1 (en) 2024-05-21 2025-11-27 Fred Hutchinson Cancer Center Immunotherapy cells equipped with a collagen-targeting payload

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7417130B2 (en) * 2000-09-08 2008-08-26 University Of Zurich Collection of repeat proteins comprising repeat modules
US20060115813A1 (en) * 2001-06-08 2006-06-01 Incyte Corporation Intracellular signaling molecules
US7049482B1 (en) * 2004-11-30 2006-05-23 Korea Kumho Petrochemical Co., Ltd. Nucleic acid molecule encoding an armadillo repeat protein, aria and a method utilizing aria to generate salt tolerant plants

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