JP2010539915A - 設計されたアルマジロリピートタンパク質 - Google Patents

設計されたアルマジロリピートタンパク質 Download PDF

Info

Publication number
JP2010539915A
JP2010539915A JP2010526268A JP2010526268A JP2010539915A JP 2010539915 A JP2010539915 A JP 2010539915A JP 2010526268 A JP2010526268 A JP 2010526268A JP 2010526268 A JP2010526268 A JP 2010526268A JP 2010539915 A JP2010539915 A JP 2010539915A
Authority
JP
Japan
Prior art keywords
repeat
protein
armadillo
module
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010526268A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010539915A5 (enExample
Inventor
パルメジャーニ,ファビオ
ペラリン,リッカルド
ラルセン,アナス・ペーター
ヴァラダムセッティ,ゴーサム
シュトゥンプ,ミハエル・トビアス
プリュックトゥーン,アンドレアス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zurich Universitaet Institut fuer Medizinische Virologie
Original Assignee
Zurich Universitaet Institut fuer Medizinische Virologie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zurich Universitaet Institut fuer Medizinische Virologie filed Critical Zurich Universitaet Institut fuer Medizinische Virologie
Publication of JP2010539915A publication Critical patent/JP2010539915A/ja
Publication of JP2010539915A5 publication Critical patent/JP2010539915A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1044Preparation or screening of libraries displayed on scaffold proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
JP2010526268A 2007-09-24 2008-09-23 設計されたアルマジロリピートタンパク質 Pending JP2010539915A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07117059 2007-09-24
PCT/EP2008/062671 WO2009040338A1 (en) 2007-09-24 2008-09-23 Designed armadillo repeat proteins

Publications (2)

Publication Number Publication Date
JP2010539915A true JP2010539915A (ja) 2010-12-24
JP2010539915A5 JP2010539915A5 (enExample) 2011-10-13

Family

ID=38962601

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010526268A Pending JP2010539915A (ja) 2007-09-24 2008-09-23 設計されたアルマジロリピートタンパク質

Country Status (5)

Country Link
US (1) US9365629B2 (enExample)
EP (1) EP2198022B1 (enExample)
JP (1) JP2010539915A (enExample)
CA (1) CA2700391A1 (enExample)
WO (1) WO2009040338A1 (enExample)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9089610B2 (en) 2008-08-19 2015-07-28 Nektar Therapeutics Complexes of small-interfering nucleic acids
AR081361A1 (es) 2010-04-30 2012-08-29 Molecular Partners Ag Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a
CN113278077A (zh) 2010-11-26 2021-08-20 分子组合公司 设计的与血清白蛋白结合的重复蛋白
KR20140010076A (ko) 2011-02-15 2014-01-23 이뮤노젠 아이엔씨 세포독성 벤조다이아제핀 유도체
MX350954B (es) 2011-06-21 2017-09-26 Immunogen Inc Derivados de maitansinoides novedosos con enlazador de peptido y conjugados de estos.
HK1211208A1 (zh) 2012-08-22 2016-05-20 Immunogen, Inc. 細胞毒性苯並二氮呯衍生物
EP2738180A1 (en) 2012-11-30 2014-06-04 Molecular Partners AG Binding proteins comprising at least two binding domains against HER2.
HK1219422A1 (zh) 2013-02-28 2017-04-07 Immunogen, Inc. 包含细胞结合剂及细胞毒素剂的轭合物
EP2961435B1 (en) 2013-02-28 2019-05-01 ImmunoGen, Inc. Conjugates comprising cell-binding agents and cytotoxic agents
CN105209483B (zh) 2013-05-31 2021-07-27 分子组合公司 与肝细胞生长因子结合的设计锚蛋白重复蛋白
WO2014194030A2 (en) 2013-05-31 2014-12-04 Immunogen, Inc. Conjugates comprising cell-binding agents and cytotoxic agents
AU2014342020C1 (en) 2013-10-31 2019-09-05 Fred Hutchinson Cancer Research Center Modified hematopoietic stem/progenitor and non-T effector cells, and uses thereof
AU2014368892B2 (en) 2013-12-20 2019-06-13 Fred Hutchinson Cancer Center Tagged chimeric effector molecules and receptors thereof
CN106605228B (zh) 2014-07-07 2019-08-16 耶达研究及发展有限公司 计算蛋白质设计的方法
TW201613930A (en) 2014-09-03 2016-04-16 Immunogen Inc Cytotoxic benzodiazepine derivatives
PT3189056T (pt) 2014-09-03 2020-09-04 Immunogen Inc Derivados citotóxicos de benzodiazepina
CN107531805A (zh) 2015-03-05 2018-01-02 弗雷德哈钦森癌症研究中心 免疫调节融合蛋白及其用途
BR112017020986A2 (pt) 2015-04-02 2018-08-14 Molecular Partners Ag. proteínas de ligação recombinantes e seu uso
JP6985934B2 (ja) 2015-04-29 2021-12-22 フレッド ハッチンソン キャンサー リサーチ センター 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用
WO2016176652A2 (en) 2015-04-29 2016-11-03 Fred Hutchinson Cancer Research Center Modified stem cells and uses thereof
WO2017106728A2 (en) * 2015-12-16 2017-06-22 University Of Washington Repeat protein architectures
CN109121413A (zh) 2016-04-14 2019-01-01 弗莱德哈钦森癌症研究中心 使用靶向核酸纳米载体编程治疗性细胞的组合物和方法
ES2953516T3 (es) 2016-09-22 2023-11-14 Molecular Partners Ag Proteínas de unión recombinantes y su uso
JP2020507605A (ja) 2017-02-17 2020-03-12 フレッド ハッチンソン キャンサー リサーチ センター Bcma関連癌および自己免疫疾患の治療のための併用療法
CN116785450A (zh) 2017-02-28 2023-09-22 伊缪诺金公司 具有自分解肽接头的类美登素衍生物和其缀合物
US11127483B2 (en) 2017-03-07 2021-09-21 Igc Bio, Inc. Computational pipeline for antibody modeling and design
MX2019010812A (es) 2017-03-17 2019-12-11 Hutchinson Fred Cancer Res Proteinas de fusion inmunomoduladoras y sus usos.
TW201839001A (zh) 2017-04-20 2018-11-01 美商伊繆諾金公司 細胞毒性苯并二氮平衍生物及其綴合物
EP3732178A1 (en) 2017-12-28 2020-11-04 ImmunoGen, Inc. Benzodiazepine derivatives
US12398402B2 (en) 2018-09-12 2025-08-26 Fred Hutchinson Cancer Center Reducing CD33 expression to selectively protect therapeutic cells
AU2020240310A1 (en) 2019-03-21 2021-10-07 Immunogen, Inc. Methods of preparing cell-binding agent-drug conjugates
EP3947395A1 (en) 2019-03-29 2022-02-09 ImmunoGen, Inc. Cytotoxic bis-benzodiazepine derivatives and conjugates thereof with cell-binding agents for inhibiting abnormal cell growth or for treating proliferative diseases
HUE065484T2 (hu) 2019-04-26 2024-05-28 Immunogen Inc Camptothecin-származékok
CN114222757A (zh) 2019-06-04 2022-03-22 分子伴侣公司 重组4-1bb结合蛋白及其用途
JP7611173B2 (ja) 2019-06-04 2025-01-09 モレキュラー パートナーズ アクチェンゲゼルシャフト 組換えfap結合タンパク質及びそれらの使用
CA3138805A1 (en) 2019-06-04 2020-12-10 Johannes Schilling Designed ankyrin repeat domain with improved stability
JP2022539248A (ja) 2019-07-02 2022-09-07 フレッド ハッチンソン キャンサー リサーチ センター 組換えad35ベクター及び関連遺伝子治療改善
WO2021116470A2 (en) 2019-12-11 2021-06-17 Molecular Partners Ag Recombinant peptide-mhc complex binding proteins and their generation and use
BR112022011177A2 (pt) 2019-12-11 2022-09-27 Molecular Partners Ag Domínios de repetição de anquirina projetados com resíduos de superfície alterados
US20230142283A1 (en) * 2020-03-05 2023-05-11 University Of Washington Rigid helical junctions for modular repeat protein sculpting and methods of use
WO2021224686A1 (en) 2020-05-06 2021-11-11 Molecular Partners Ag Novel ankyrin repeat binding proteins and their uses
WO2021229076A1 (en) 2020-05-14 2021-11-18 Molecular Partners Ag Recombinant cd40 binding proteins and their use
EP4149959A1 (en) 2020-05-14 2023-03-22 Molecular Partners AG Multispecific proteins
CA3202358A1 (en) 2020-12-16 2022-06-23 Andreas BOSSHART Novel slow-release prodrugs
AU2021403658A1 (en) 2020-12-16 2023-06-29 Molecular Partners Ag Recombinant cd3 binding proteins and their use
JP2024508969A (ja) 2021-03-09 2024-02-28 モレキュラー パートナーズ アクチェンゲゼルシャフト 新規のDARPinに基づくCD33エンゲージャ
JP2024509890A (ja) 2021-03-09 2024-03-05 モレキュラー パートナーズ アクチェンゲゼルシャフト プロテアーゼ切断可能なプロドラッグ
US20240150475A1 (en) 2021-03-09 2024-05-09 Molecular Partners Ag Novel darpin based cd123 engagers
IL305677A (en) 2021-03-09 2023-11-01 Molecular Partners Ag Novel darpin based multi-specific t-cell engagers
EP4447990A1 (en) 2021-12-14 2024-10-23 Molecular Partners AG Designed repeat domains with dual binding specificity and their use
WO2023131707A1 (en) * 2022-01-07 2023-07-13 Universität Zürich Stabilizing n-cap sequences for armadillo repeat proteins
WO2023215725A1 (en) 2022-05-02 2023-11-09 Fred Hutchinson Cancer Center Compositions and methods for cellular immunotherapy
WO2024028278A1 (en) 2022-08-01 2024-02-08 Molecular Partners Ag Charge modified designed repeat domains and their use
EP4673159A1 (en) 2023-02-27 2026-01-07 Molecular Partners AG Darpins for use in reducing renal accumulation of drugs
EP4724473A1 (en) 2023-06-06 2026-04-15 Molecular Partners AG Recombinant cd47 binding proteins and their use
WO2024251628A1 (en) 2023-06-06 2024-12-12 Molecular Partners Ag Recombinant cd16a binding proteins and their use
EP4724486A1 (en) 2023-06-06 2026-04-15 Molecular Partners AG Recombinant cd2 binding proteins and their use
WO2025068607A1 (en) * 2023-09-29 2025-04-03 Universität Zürich Modular armadillo repeat proteins
WO2025101820A1 (en) 2023-11-08 2025-05-15 Fred Hutchinson Cancer Center Compositions and methods for cellular immunotherapy
WO2025146487A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Multispecific binding proteins
WO2025146491A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent
WO2025146490A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Recombinant cd117 binding proteins and their use
WO2025163144A1 (en) 2024-01-31 2025-08-07 Molecular Partners Ag Recombinant mesothelin binding proteins and their use
WO2025163082A1 (en) 2024-01-31 2025-08-07 Molecular Partners Ag Dll3-specific binding constructs and their use in radiotherapy
WO2025181039A1 (en) 2024-03-01 2025-09-04 Molecular Partners Ag Therapeutic combinations comprising a multi-specific t cell engager
WO2025245169A1 (en) 2024-05-21 2025-11-27 Fred Hutchinson Cancer Center Immunotherapy cells equipped with a collagen-targeting payload
WO2026093563A2 (en) 2024-10-31 2026-05-07 Molecular Partners Ag Multispecific binding proteins and their use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004508033A (ja) * 2000-09-08 2004-03-18 ウニヴェルジテート・チューリッヒ 反復モジュールを含む反復タンパク質の集合体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2449272A1 (en) * 2001-06-08 2002-12-19 Incyte Genomics Inc. Intracellular signaling molecules
US7049482B1 (en) * 2004-11-30 2006-05-23 Korea Kumho Petrochemical Co., Ltd. Nucleic acid molecule encoding an armadillo repeat protein, aria and a method utilizing aria to generate salt tolerant plants

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004508033A (ja) * 2000-09-08 2004-03-18 ウニヴェルジテート・チューリッヒ 反復モジュールを含む反復タンパク質の集合体

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6013030026; Cell, (1997), 90, [5], 871-882 *
JPN6013030027; Curr. Opin. Struct. Biol., (1999), 9, [3], p.383-389 *
JPN6013030028; Trends Cell Biol., (2003), 13, [9], p.463-471 *

Also Published As

Publication number Publication date
WO2009040338A1 (en) 2009-04-02
US20110224100A1 (en) 2011-09-15
EP2198022B1 (en) 2024-03-06
CA2700391A1 (en) 2009-04-02
EP2198022A1 (en) 2010-06-23
US9365629B2 (en) 2016-06-14
EP2198022C0 (en) 2024-03-06

Similar Documents

Publication Publication Date Title
EP2198022B1 (en) Designed armadillo repeat proteins
McKnight et al. A thermostable 35-residue subdomain within villin headpiece
AU2011333666B2 (en) Improved capping modules for designed ankyrin repeat proteins
Januszyk et al. Identification and solution structure of a highly conserved C-terminal domain within ORF1p required for retrotransposition of long interspersed nuclear element-1
Weiser et al. Investigation of N-terminal phospho-regulation of uracil DNA glycosylase using protein semisynthesis
HUE031800T2 (en) Modified Stefin A framework proteins
EP4192851B1 (en) N-terminal capping modules of ankyrin repeat domains
Yang et al. Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair
US20240043481A1 (en) N-Terminal Capping Modules of Ankyrin Repeat Domains
Chen et al. Effects of turn residues in directing the formation of the β‐sheet and in the stability of the β‐sheet
Parker et al. Consensus design of a NOD receptor leucine rich repeat domain with binding affinity for a muramyl dipeptide, a bacterial cell wall fragment
Xian et al. Dissecting the gelsolin–polyphosphoinositide interaction and engineering of a polyphosphoinositide-sensitive gelsolin C-terminal half protein
Ogura et al. Solution structures of yeast Saccharomyces cerevisiae calmodulin in calcium‐and target peptide‐bound states reveal similarities and differences to vertebrate calmodulin
Botuyan et al. Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide
Fernández‐Escamilla et al. Design and NMR conformational study of a β‐sheet peptide based on Betanova and WW domains
US20240247036A1 (en) N-Terminal Capping Modules of Ankyrin Repeat Domains
Jeon et al. Evidence for binary Smc complexes lacking kite subunits in archaea
Kim et al. Designed leucine‐rich repeat proteins bind two muramyl dipeptide ligands
Vetter et al. Phosphorylation of serine residues affects the conformation of the calmodulin binding domain of human protein 4.1
Kocherla et al. Biosynthesis and spectroscopic characterization of 2‐TM fragments encompassing the sequence of a human GPCR, the Y4 receptor
Qian et al. Structure of the adaptor protein p14 reveals a profilin-like fold with distinct function
Jouaux et al. Improving the interaction of Myc‐interfering peptides with Myc using molecular dynamics simulations
Rezaei Araghi et al. A β/γ Motif to Mimic α‐Helical Turns in Proteins
Koscielska‐Kasprzak et al. Importance of α–helix N–capping motif in stabilization of ββα fold
Correa et al. Deciphering the role of the electrostatic interactions in the α‐tropomyosin head‐to‐tail complex

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110826

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110826

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130625

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20131119