CA2700391A1 - Designed armadillo repeat proteins - Google Patents
Designed armadillo repeat proteins Download PDFInfo
- Publication number
- CA2700391A1 CA2700391A1 CA2700391A CA2700391A CA2700391A1 CA 2700391 A1 CA2700391 A1 CA 2700391A1 CA 2700391 A CA2700391 A CA 2700391A CA 2700391 A CA2700391 A CA 2700391A CA 2700391 A1 CA2700391 A1 CA 2700391A1
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- Prior art keywords
- repeat
- armadillo
- amino acid
- modules
- proteins
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
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| EP07117059 | 2007-09-24 | ||
| EP07117059.1 | 2007-09-24 | ||
| PCT/EP2008/062671 WO2009040338A1 (en) | 2007-09-24 | 2008-09-23 | Designed armadillo repeat proteins |
Publications (1)
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|---|---|
| CA2700391A1 true CA2700391A1 (en) | 2009-04-02 |
Family
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Family Applications (1)
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|---|---|---|---|
| CA2700391A Abandoned CA2700391A1 (en) | 2007-09-24 | 2008-09-23 | Designed armadillo repeat proteins |
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|---|---|
| US (1) | US9365629B2 (enExample) |
| EP (1) | EP2198022B1 (enExample) |
| JP (1) | JP2010539915A (enExample) |
| CA (1) | CA2700391A1 (enExample) |
| WO (1) | WO2009040338A1 (enExample) |
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| WO2010021718A1 (en) | 2008-08-19 | 2010-02-25 | Nektar Therapeutics | Complexes of small-interfering nucleic acids |
| AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
| CA2818969C (en) | 2010-11-26 | 2020-04-14 | Molecular Partners Ag | Improved n-terminal capping modules for designed ankyrin repeat proteins |
| MY183977A (en) | 2011-02-15 | 2021-03-17 | Immunogen Inc | Cytotoxic benzodiazepine derivatives |
| EP2723389A2 (en) | 2011-06-21 | 2014-04-30 | Immunogen, Inc. | Novel maytansinoid derivatives with peptide linker and conjugates thereof |
| HK1211208A1 (zh) | 2012-08-22 | 2016-05-20 | Immunogen, Inc. | 細胞毒性苯並二氮呯衍生物 |
| EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| WO2014134486A2 (en) | 2013-02-28 | 2014-09-04 | Immunogen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
| WO2014134483A2 (en) | 2013-02-28 | 2014-09-04 | Immunogen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
| CN105209483B (zh) | 2013-05-31 | 2021-07-27 | 分子组合公司 | 与肝细胞生长因子结合的设计锚蛋白重复蛋白 |
| WO2014194030A2 (en) | 2013-05-31 | 2014-12-04 | Immunogen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
| RU2733652C2 (ru) | 2013-10-31 | 2020-10-06 | Фред Хатчинсон Кэнсер Рисерч Сентер | МОДИФИЦИРОВАННЫЕ ГЕМОПОЭТИЧЕСКИЕ СТВОЛОВЫЕ КЛЕТКИ/КЛЕТКИ-ПРЕДШЕСТВЕННИКИ И Не-Т ЭФФЕКТОРНЫЕ КЛЕТКИ, И ИХ ПРИМЕНЕНИЕ |
| ES2837856T3 (es) | 2013-12-20 | 2021-07-01 | Hutchinson Fred Cancer Res | Moléculas efectoras quiméricas etiquetadas y receptores de las mismas |
| CN106605228B (zh) | 2014-07-07 | 2019-08-16 | 耶达研究及发展有限公司 | 计算蛋白质设计的方法 |
| TW201613930A (en) | 2014-09-03 | 2016-04-16 | Immunogen Inc | Cytotoxic benzodiazepine derivatives |
| SG11201701455SA (en) | 2014-09-03 | 2017-03-30 | Immunogen Inc | Cytotoxic benzodiazepine derivatives |
| WO2016141357A1 (en) | 2015-03-05 | 2016-09-09 | Fred Hutchinson Cancer Research Center | Immunomodulatory fusion proteins and uses thereof |
| CN107454904A (zh) | 2015-04-02 | 2017-12-08 | 分子组合公司 | 对血清白蛋白具有结合特异性的经设计的锚蛋白重复结构域 |
| EP3288569A4 (en) | 2015-04-29 | 2018-12-19 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| US11827904B2 (en) | 2015-04-29 | 2023-11-28 | Fred Hutchinson Cancer Center | Modified stem cells and uses thereof |
| WO2017106728A2 (en) * | 2015-12-16 | 2017-06-22 | University Of Washington | Repeat protein architectures |
| CN109121413A (zh) | 2016-04-14 | 2019-01-01 | 弗莱德哈钦森癌症研究中心 | 使用靶向核酸纳米载体编程治疗性细胞的组合物和方法 |
| US10717772B2 (en) | 2016-09-22 | 2020-07-21 | Molecular Partners Ag | Recombinant binding proteins targeting HER2 and serum albumin, and their uses |
| BR112019017120A8 (pt) | 2017-02-17 | 2023-05-02 | Hutchinson Fred Cancer Res | Terapias de combinação para tratamento de cânceres e distúrbios autoimunes relacionados a bcma |
| KR20250171447A (ko) | 2017-02-28 | 2025-12-08 | 이뮤노젠 아이엔씨 | 자기희생적 펩티드 링커 및 이들의 접합체를 갖는 메이탄시노이드 유도체 |
| US11127483B2 (en) | 2017-03-07 | 2021-09-21 | Igc Bio, Inc. | Computational pipeline for antibody modeling and design |
| JP2020511136A (ja) | 2017-03-17 | 2020-04-16 | フレッド ハッチンソン キャンサー リサーチ センター | 免疫調節性融合タンパク質およびその使用 |
| TW201839001A (zh) | 2017-04-20 | 2018-11-01 | 美商伊繆諾金公司 | 細胞毒性苯并二氮平衍生物及其綴合物 |
| TWI827575B (zh) | 2017-12-28 | 2024-01-01 | 美商伊繆諾金公司 | 苯二氮平衍生物 |
| WO2020056170A1 (en) | 2018-09-12 | 2020-03-19 | Fred Hutchinson Cancer Research Center | Reducing cd33 expression to selectively protect therapeutic cells |
| TW202102270A (zh) | 2019-03-21 | 2021-01-16 | 美商伊繆諾金公司 | 製備細胞結合劑-藥物結合物之方法 |
| TW202102506A (zh) | 2019-03-29 | 2021-01-16 | 美商伊繆諾金公司 | 苯二氮平衍生物 |
| HRP20231619T1 (hr) | 2019-04-26 | 2024-04-26 | Immunogen, Inc. | Derivati kamptotecina |
| CA3138805A1 (en) | 2019-06-04 | 2020-12-10 | Johannes Schilling | Designed ankyrin repeat domain with improved stability |
| US20220298212A1 (en) | 2019-06-04 | 2022-09-22 | Molecular Partners Ag | Recombinant 4-1bb binding proteins and their use |
| KR20220016942A (ko) | 2019-06-04 | 2022-02-10 | 몰리큘라 파트너스 아게 | 재조합 fap 결합 단백질 및 이의 용도 |
| SG11202111943UA (en) | 2019-07-02 | 2021-11-29 | Hutchinson Fred Cancer Res | Recombinant ad35 vectors and related gene therapy improvements |
| EP4073093A2 (en) | 2019-12-11 | 2022-10-19 | Molecular Partners AG | Recombinant peptide-mhc complex binding proteins and their generation and use |
| WO2021116469A2 (en) | 2019-12-11 | 2021-06-17 | Molecular Partners Ag | Recombinant peptide-mhc complex binding proteins and their generation and use |
| US20230142283A1 (en) * | 2020-03-05 | 2023-05-11 | University Of Washington | Rigid helical junctions for modular repeat protein sculpting and methods of use |
| EP4146691A1 (en) | 2020-05-06 | 2023-03-15 | Molecular Partners AG | Novel ankyrin repeat binding proteins and their uses |
| US20240279309A1 (en) | 2020-05-14 | 2024-08-22 | Molecular Partners Ag | Recombinant cd40 binding proteins and their use |
| JP2023528204A (ja) | 2020-05-14 | 2023-07-04 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 多選択性タンパク質 |
| IL303629A (en) | 2020-12-16 | 2023-08-01 | Molecular Partners Ag | Recombinant cd3 binding proteins and their use |
| AU2021403833A1 (en) | 2020-12-16 | 2023-07-27 | Molecular Partners Ag | Novel slow-release prodrugs |
| AU2022233791A1 (en) | 2021-03-09 | 2023-09-28 | Molecular Partners Ag | Novel darpin based cd123 engagers |
| EP4304731A1 (en) | 2021-03-09 | 2024-01-17 | Molecular Partners AG | Novel darpin based multi-specific t-cell engagers |
| EP4305063A1 (en) | 2021-03-09 | 2024-01-17 | Molecular Partners AG | Protease cleavable prodrugs |
| CA3211248A1 (en) | 2021-03-09 | 2022-09-15 | Nina RESCHKE | Novel darpin based cd33 engagers |
| WO2023110983A1 (en) | 2021-12-14 | 2023-06-22 | Molecular Partners Ag | Designed repeat domains with dual binding specificity and their use |
| US20250368704A1 (en) * | 2022-01-07 | 2025-12-04 | Universität Zürich | Stabilizing n-cap sequences for armadillo repeat proteins |
| WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| EP4565606A1 (en) | 2022-08-01 | 2025-06-11 | Molecular Partners AG | Charge modified designed repeat domains and their use |
| EP4673159A1 (en) | 2023-02-27 | 2026-01-07 | Molecular Partners AG | Darpins for use in reducing renal accumulation of drugs |
| WO2024251695A1 (en) | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd47 binding proteins and their use |
| CN121263440A (zh) | 2023-06-06 | 2026-01-02 | 分子合作伙伴股份公司 | 重组cd2结合蛋白及其用途 |
| WO2024251628A1 (en) | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd16a binding proteins and their use |
| WO2025068607A1 (en) * | 2023-09-29 | 2025-04-03 | Universität Zürich | Modular armadillo repeat proteins |
| WO2025101820A1 (en) | 2023-11-08 | 2025-05-15 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| WO2025146490A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Recombinant cd117 binding proteins and their use |
| WO2025146487A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Multispecific binding proteins |
| WO2025146491A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent |
| WO2025163083A1 (en) | 2024-01-31 | 2025-08-07 | Molecular Partners Ag | Recobminant dll3 binding proteins and their use |
| WO2025163144A1 (en) | 2024-01-31 | 2025-08-07 | Molecular Partners Ag | Recombinant mesothelin binding proteins and their use |
| WO2025181039A1 (en) | 2024-03-01 | 2025-09-04 | Molecular Partners Ag | Therapeutic combinations comprising a multi-specific t cell engager |
| WO2025245169A1 (en) | 2024-05-21 | 2025-11-27 | Fred Hutchinson Cancer Center | Immunotherapy cells equipped with a collagen-targeting payload |
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| CA2421447C (en) | 2000-09-08 | 2012-05-08 | Universitat Zurich | Collections of repeat proteins comprising repeat modules |
| WO2002101008A2 (en) * | 2001-06-08 | 2002-12-19 | Incyte Genomics Inc. | Intracellular signaling molecules |
| US7049482B1 (en) * | 2004-11-30 | 2006-05-23 | Korea Kumho Petrochemical Co., Ltd. | Nucleic acid molecule encoding an armadillo repeat protein, aria and a method utilizing aria to generate salt tolerant plants |
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2008
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- 2008-09-23 EP EP08804590.1A patent/EP2198022B1/en active Active
- 2008-09-23 CA CA2700391A patent/CA2700391A1/en not_active Abandoned
- 2008-09-23 JP JP2010526268A patent/JP2010539915A/ja active Pending
- 2008-09-23 US US12/733,836 patent/US9365629B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20110224100A1 (en) | 2011-09-15 |
| WO2009040338A1 (en) | 2009-04-02 |
| EP2198022B1 (en) | 2024-03-06 |
| US9365629B2 (en) | 2016-06-14 |
| JP2010539915A (ja) | 2010-12-24 |
| EP2198022C0 (en) | 2024-03-06 |
| EP2198022A1 (en) | 2010-06-23 |
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