CA2700391A1 - Designed armadillo repeat proteins - Google Patents

Designed armadillo repeat proteins Download PDF

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Publication number
CA2700391A1
CA2700391A1 CA2700391A CA2700391A CA2700391A1 CA 2700391 A1 CA2700391 A1 CA 2700391A1 CA 2700391 A CA2700391 A CA 2700391A CA 2700391 A CA2700391 A CA 2700391A CA 2700391 A1 CA2700391 A1 CA 2700391A1
Authority
CA
Canada
Prior art keywords
repeat
armadillo
amino acid
modules
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2700391A
Other languages
English (en)
French (fr)
Inventor
Fabio Parmeggiani
Riccardo Pellarin
Anders Peter Larsen
Gautham Varadamsetty
Michael Tobias Stumpp
Andreas Plueckthun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zurich Universität
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2700391A1 publication Critical patent/CA2700391A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
CA2700391A 2007-09-24 2008-09-23 Designed armadillo repeat proteins Abandoned CA2700391A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07117059 2007-09-24
EP07117059.1 2007-09-24
PCT/EP2008/062671 WO2009040338A1 (en) 2007-09-24 2008-09-23 Designed armadillo repeat proteins

Publications (1)

Publication Number Publication Date
CA2700391A1 true CA2700391A1 (en) 2009-04-02

Family

ID=38962601

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2700391A Abandoned CA2700391A1 (en) 2007-09-24 2008-09-23 Designed armadillo repeat proteins

Country Status (5)

Country Link
US (1) US9365629B2 (enExample)
EP (1) EP2198022B1 (enExample)
JP (1) JP2010539915A (enExample)
CA (1) CA2700391A1 (enExample)
WO (1) WO2009040338A1 (enExample)

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EP4460511A1 (en) * 2022-01-07 2024-11-13 Universität Zürich Stabilizing n-cap sequences for armadillo repeat proteins
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JP2026524079A (ja) 2023-06-06 2026-07-17 モレキュラー パートナーズ アクチェンゲゼルシャフト 組換えｃｄ２結合タンパク質及びその使用
EP4784597A1 (en) * 2023-09-29 2026-08-05 Universität Zürich Modular armadillo repeat proteins
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WO2025181039A1 (en) 2024-03-01 2025-09-04 Molecular Partners Ag Therapeutic combinations comprising a multi-specific t cell engager
WO2025245169A1 (en) 2024-05-21 2025-11-27 Fred Hutchinson Cancer Center Immunotherapy cells equipped with a collagen-targeting payload
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JP2005507242A (ja) * 2001-06-08 2005-03-17 インサイト・ゲノミックス・インコーポレイテッド 細胞内シグナル伝達分子
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Also Published As

Publication number Publication date
US20110224100A1 (en) 2011-09-15
EP2198022B1 (en) 2024-03-06
EP2198022A1 (en) 2010-06-23
EP2198022C0 (en) 2024-03-06
US9365629B2 (en) 2016-06-14
JP2010539915A (ja) 2010-12-24
WO2009040338A1 (en) 2009-04-02

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20140923