JP2017530099A5 - - Google Patents
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- JP2017530099A5 JP2017530099A5 JP2017510495A JP2017510495A JP2017530099A5 JP 2017530099 A5 JP2017530099 A5 JP 2017530099A5 JP 2017510495 A JP2017510495 A JP 2017510495A JP 2017510495 A JP2017510495 A JP 2017510495A JP 2017530099 A5 JP2017530099 A5 JP 2017530099A5
- Authority
- JP
- Japan
- Prior art keywords
- binding domain
- fzd
- signaling agonist
- signaling
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462049949P | 2014-09-12 | 2014-09-12 | |
| US62/049,949 | 2014-09-12 | ||
| US201562206150P | 2015-08-17 | 2015-08-17 | |
| US62/206,150 | 2015-08-17 | ||
| PCT/US2015/049829 WO2016040895A1 (en) | 2014-09-12 | 2015-09-11 | Wnt signaling agonist molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020138446A Division JP2020186267A (ja) | 2014-09-12 | 2020-08-19 | Ｗｎｔシグナリングアゴニスト分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530099A JP2017530099A (ja) | 2017-10-12 |
| JP2017530099A5 true JP2017530099A5 (enExample) | 2018-09-13 |
| JP6796059B2 JP6796059B2 (ja) | 2020-12-02 |
Family
ID=55459641
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017510495A Active JP6796059B2 (ja) | 2014-09-12 | 2015-09-11 | Ｗｎｔシグナリングアゴニスト分子 |
| JP2020138446A Withdrawn JP2020186267A (ja) | 2014-09-12 | 2020-08-19 | Ｗｎｔシグナリングアゴニスト分子 |
| JP2023080152A Pending JP2023091081A (ja) | 2014-09-12 | 2023-05-15 | Ｗｎｔシグナリングアゴニスト分子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020138446A Withdrawn JP2020186267A (ja) | 2014-09-12 | 2020-08-19 | Ｗｎｔシグナリングアゴニスト分子 |
| JP2023080152A Pending JP2023091081A (ja) | 2014-09-12 | 2023-05-15 | Ｗｎｔシグナリングアゴニスト分子 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US11142577B2 (enExample) |
| EP (2) | EP3191526B1 (enExample) |
| JP (3) | JP6796059B2 (enExample) |
| AU (2) | AU2015314771B2 (enExample) |
| WO (1) | WO2016040895A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3191526B1 (en) | 2014-09-12 | 2023-02-22 | The Board of Trustees of the Leland Stanford Junior University | Wnt signaling agonist molecules |
| US20170349659A1 (en) * | 2016-06-03 | 2017-12-07 | The Board Of Trustees Of The Leland Stanford Junior University | Wnt signaling agonist molecules |
| EP3568158A4 (en) | 2017-01-11 | 2020-11-18 | The Board of Trustees of the Leland Stanford Junior University | R-SPONDIN SUBSTITUTION MOLECULES (RSPO) |
| WO2018140821A1 (en) | 2017-01-26 | 2018-08-02 | Surrozen, Inc. | Tissue-specific wnt signal enhancing molecules and uses thereof |
| KR101966523B1 (ko) * | 2017-05-29 | 2019-04-05 | 차의과학대학교 산학협력단 | 오가노이드 배양을 위한 조성물 및 방법 |
| JP7317016B2 (ja) * | 2017-12-19 | 2023-07-28 | スロゼン オペレーティング， インコーポレイテッド | 抗ｌｒｐ５／６抗体及び使用方法 |
| US11773171B2 (en) * | 2017-12-19 | 2023-10-03 | Surrozen Operating, Inc. | WNT surrogate molecules and uses thereof |
| JP7418332B2 (ja) * | 2017-12-19 | 2024-01-19 | スロゼン オペレーティング， インコーポレイテッド | 抗フリズルド抗体及び使用方法 |
| US20210032352A1 (en) * | 2018-02-14 | 2021-02-04 | Antera Therapeutics Inc. | Multivalent Binding Molecules Activating WNT Signaling and Uses Thereof |
| CN111868078A (zh) | 2018-03-16 | 2020-10-30 | 斯坦福大学托管董事会 | 使用wnt激动剂和生物活性脂质用于生成和扩增心肌细胞的试剂和方法 |
| EP3820906B1 (en) | 2018-07-05 | 2025-10-15 | Surrozen Operating, Inc. | Multi-specific wnt surrogate molecules and uses thereof |
| EP3820499A4 (en) | 2018-07-09 | 2022-07-13 | Surrozen Operating, Inc. | TISSUE SPECIFIC WNT SIGNAL ENHANCEMENT MOLECULES AND USES |
| CA3106625A1 (en) | 2018-07-16 | 2020-01-23 | The Board Of Trustees Of The Leland Stanford Junior University | Frizzled specific wnt agonists and antagonists |
| US20220064337A1 (en) * | 2018-12-19 | 2022-03-03 | Surrozen, Inc. | Antigen binding formats for receptor complexes |
| WO2020167848A1 (en) * | 2019-02-11 | 2020-08-20 | Surrozen, Inc. | Modulation of wnt signalling in ocular disorders |
| US20220195053A1 (en) * | 2019-03-11 | 2022-06-23 | Surrozen Operating Inc. | Modulation of wnt signaling in gastrointestinal disorders |
| CA3140580A1 (en) * | 2019-06-11 | 2020-12-17 | Antlera Therapeutics Inc. | Multivalent fzd and wnt binding molecules and uses thereof |
| AU2020300618A1 (en) | 2019-07-02 | 2022-01-27 | Surrozen Operating, Inc. | Monospecific anti-frizzled antibodies and methods of use |
| EP3789049A1 (en) | 2019-09-06 | 2021-03-10 | QGel SA | Method for obtaining healthy intestinal organoids |
| CA3198268A1 (en) | 2020-11-16 | 2022-05-19 | Surrozen Operating, Inc. | Liver-specific wnt signal enhancing molecules and uses thereof |
| US20240165165A1 (en) * | 2021-01-26 | 2024-05-23 | The Trustees Of Indiana University | Pharmaceutical compositions and their methods of use |
| JP2024509266A (ja) * | 2021-03-10 | 2024-02-29 | スロゼン オペレーティング， インコーポレイテッド | 胃腸障害におけるｗｎｔシグナル伝達のモジュレーション |
| EP4448009A4 (en) * | 2021-12-17 | 2025-12-10 | Surrozen Operating Inc | WNT SUBSTITUTION AGENTS AND LACRYMAL GLAND REGENERATION METHODS |
| EP4705355A1 (en) * | 2023-04-27 | 2026-03-11 | Surrozen Operating, Inc. | Molecules modulating wnt signaling pathways and uses thereof |
| EP4719454A2 (en) * | 2023-05-29 | 2026-04-08 | Surrozen Operating, Inc. | Wnt surrogate agents and methods for lacrimal gland regeneration |
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| US8461155B2 (en) | 2003-09-22 | 2013-06-11 | University Of Connecticut | Sclerostin and the inhibition of WNT signaling and bone formation |
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| WO2006130076A1 (en) | 2005-05-30 | 2006-12-07 | Astrazeneca Ab | Methods for identifying fzd8 modulators and the use of such modulators for treating osteoarthritis |
| DE102005035568A1 (de) | 2005-07-25 | 2007-02-01 | M-Phasys Gmbh | Frizzled 9 als Biomarker für Substrukturen des humanen Gehirns |
| BRPI0707514A2 (pt) | 2006-02-07 | 2011-05-10 | Wyeth Corp | mÉtodo de identificaÇço de um agente que module ossos ou um lipÍdio; mÉtodo de identificaÇço de um agente que module a atividade de norrin-frizzled4; kit para identificar um agente que module a atividade de lrp5-norrin-frizzled4; cÉlula ou linhagem celular desprovida de norrin nativo e que expresse uma lrp5 nço nativa e uma frizzled4 nço nativa |
| CN105837690A (zh) | 2006-06-12 | 2016-08-10 | 新兴产品开发西雅图有限公司 | 具有效应功能的单链多价结合蛋白 |
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| US20100199362A1 (en) | 2007-04-26 | 2010-08-05 | President And Fellows Of Harvard College | Wnt ligands involved in blood-brain barrier development and uses therefor |
| CN101951954A (zh) | 2007-11-02 | 2011-01-19 | 诺瓦提斯公司 | 调节低密度脂蛋白受体相关蛋白6(lrp6)的分子和方法 |
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| WO2010016766A2 (en) | 2008-08-08 | 2010-02-11 | Koninklijke Nederlandse Akademie Van Wetenschappen | Antibodies recognizing endogenous human lgr5 and/or lgr6 |
| AU2009291747B2 (en) * | 2008-09-10 | 2016-05-26 | Genentech, Inc. | Methods for inhibiting ocular angiogenesis |
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| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| CN102439135B (zh) | 2009-02-03 | 2014-04-30 | 荷兰皇家科学院 | 用于上皮干细胞和包含所述干细胞的类器官的培养基 |
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| BR112012022044A2 (pt) | 2010-03-24 | 2020-08-25 | Genentech Inc | ''anticorpo,imunoconjugado,formulação farmacêutica,uso do anticorpo,método de tratamento,anticorpo biespecifico isolado e célula hospedeira''. |
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| EA201291181A1 (ru) * | 2010-05-06 | 2013-05-30 | Новартис Аг | Композиции и способы применения терапевтических поливалентных антител против белка, родственного рецептору липопротеинов низкой плотности 6 (lrp6) |
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| SG192182A1 (en) * | 2011-01-28 | 2013-08-30 | Univ Leland Stanford Junior | Wnt compositions and methods of use thereof |
| GB201106395D0 (en) * | 2011-04-14 | 2011-06-01 | Hubrecht Inst | Compounds |
| KR20140091031A (ko) | 2011-11-04 | 2014-07-18 | 노파르티스 아게 | 저밀도 지단백질-관련 단백질 6 (lrp6) - 반감기 연장제 구축물 |
| JP6441079B2 (ja) | 2011-12-19 | 2018-12-19 | シンイミューン ゲーエムベーハー | 二重特異性抗体分子 |
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| JP2016510411A (ja) | 2013-02-04 | 2016-04-07 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング |
| JP2016509014A (ja) | 2013-02-08 | 2016-03-24 | ステムセントリックス， インコーポレイテッド | 新規の多特異的構成物 |
| US20150376252A1 (en) * | 2013-02-21 | 2015-12-31 | Van Andel Research Institute | Norrin Mutant Polypeptides, Methods of Making and Uses Thereof |
| BR112015023074A2 (pt) | 2013-03-14 | 2017-11-21 | Oncomed Pharm Inc | agentes de ligação-met e uso dos mesmos |
| GB2518221A (en) | 2013-09-16 | 2015-03-18 | Sergej Michailovic Kiprijanov | Tetravalent antigen-binding protein molecule |
| GB2519786A (en) | 2013-10-30 | 2015-05-06 | Sergej Michailovic Kiprijanov | Multivalent antigen-binding protein molecules |
| EP3191526B1 (en) | 2014-09-12 | 2023-02-22 | The Board of Trustees of the Leland Stanford Junior University | Wnt signaling agonist molecules |
| US9777052B2 (en) | 2014-12-02 | 2017-10-03 | The Board Of Regents Of The University Of Oklahoma | R-spondin variants, compositions, and methods of use |
| US20160312207A1 (en) | 2015-04-21 | 2016-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | R-spondin antagonists and methods of treating cancer associated with aberrant activation of wnt signaling |
-
2015
- 2015-09-11 EP EP15840226.3A patent/EP3191526B1/en active Active
- 2015-09-11 AU AU2015314771A patent/AU2015314771B2/en active Active
- 2015-09-11 WO PCT/US2015/049829 patent/WO2016040895A1/en not_active Ceased
- 2015-09-11 US US15/508,779 patent/US11142577B2/en active Active
- 2015-09-11 JP JP2017510495A patent/JP6796059B2/ja active Active
- 2015-09-11 EP EP23157332.0A patent/EP4219564A1/en not_active Withdrawn
-
2020
- 2020-08-19 JP JP2020138446A patent/JP2020186267A/ja not_active Withdrawn
-
2021
- 2021-05-13 AU AU2021203059A patent/AU2021203059A1/en not_active Abandoned
- 2021-09-08 US US17/469,661 patent/US20210403578A1/en not_active Abandoned
-
2023
- 2023-05-15 JP JP2023080152A patent/JP2023091081A/ja active Pending
-
2024
- 2024-04-04 US US18/627,108 patent/US20250011437A1/en not_active Abandoned
-
2025
- 2025-03-03 US US19/069,060 patent/US20250304702A1/en active Pending
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