JP6796059B2 - Ｗｎｔシグナリングアゴニスト分子 - Google Patents

Ｗｎｔシグナリングアゴニスト分子 Download PDF

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JP6796059B2
JP6796059B2 JP2017510495A JP2017510495A JP6796059B2 JP 6796059 B2 JP6796059 B2 JP 6796059B2 JP 2017510495 A JP2017510495 A JP 2017510495A JP 2017510495 A JP2017510495 A JP 2017510495A JP 6796059 B2 JP6796059 B2 JP 6796059B2
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binding domain
wnt
wnt signaling
fzd
cells
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JP2017530099A5 (enExample
JP2017530099A (ja
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クリストファー ガルシア，ケナン
クリストファー ガルシア，ケナン
デイビッド ベイカー，
デイビッド ベイカー，
クラウディア イヴォンヌ ジャンダ，
クラウディア イヴォンヌ ジャンダ，
ルーク ダン，
ルーク ダン，
ジェイムズ ダニエル ムーディー，
ジェイムズ ダニエル ムーディー，
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University of Washington
Leland Stanford Junior University
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University of Washington
Leland Stanford Junior University
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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JP2017510495A 2014-09-12 2015-09-11 Ｗｎｔシグナリングアゴニスト分子 Active JP6796059B2 (ja)

Applications Claiming Priority (5)

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US201462049949P 2014-09-12 2014-09-12
US62/049,949 2014-09-12
US201562206150P 2015-08-17 2015-08-17
US62/206,150 2015-08-17
PCT/US2015/049829 WO2016040895A1 (en) 2014-09-12 2015-09-11 Wnt signaling agonist molecules

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JP2017530099A JP2017530099A (ja) 2017-10-12
JP2017530099A5 JP2017530099A5 (enExample) 2018-09-13
JP6796059B2 true JP6796059B2 (ja) 2020-12-02

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JP2020138446A Withdrawn JP2020186267A (ja) 2014-09-12 2020-08-19 Ｗｎｔシグナリングアゴニスト分子
JP2023080152A Pending JP2023091081A (ja) 2014-09-12 2023-05-15 Ｗｎｔシグナリングアゴニスト分子

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JP2023080152A Pending JP2023091081A (ja) 2014-09-12 2023-05-15 Ｗｎｔシグナリングアゴニスト分子

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US (4) US11142577B2 (enExample)
EP (2) EP4219564A1 (enExample)
JP (3) JP6796059B2 (enExample)
AU (2) AU2015314771B2 (enExample)
WO (1) WO2016040895A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6796059B2 (ja) 2014-09-12 2020-12-02 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Ｗｎｔシグナリングアゴニスト分子
US20170349659A1 (en) * 2016-06-03 2017-12-07 The Board Of Trustees Of The Leland Stanford Junior University Wnt signaling agonist molecules
JP7617603B2 (ja) 2017-01-11 2025-01-20 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Ｒ－スポンジン（ｒｓｐｏ）サロゲート分子
AU2018211985B2 (en) 2017-01-26 2025-02-13 Surrozen Operating, Inc. Tissue-specific Wnt signal enhancing molecules and uses thereof
KR101966523B1 (ko) * 2017-05-29 2019-04-05 차의과학대학교 산학협력단 오가노이드 배양을 위한 조성물 및 방법
CN118271444A (zh) * 2017-12-19 2024-07-02 瑟罗泽恩奥普瑞汀公司 Wnt替代分子和其用途
CN111699003B (zh) * 2017-12-19 2024-05-03 瑟罗泽恩奥普瑞汀公司 抗lrp5/6抗体和使用方法
JP7418332B2 (ja) * 2017-12-19 2024-01-19 スロゼン オペレーティング， インコーポレイテッド 抗フリズルド抗体及び使用方法
US20210032352A1 (en) * 2018-02-14 2021-02-04 Antera Therapeutics Inc. Multivalent Binding Molecules Activating WNT Signaling and Uses Thereof
JP2021518113A (ja) 2018-03-16 2021-08-02 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 心筋細胞を生成及び増殖させるためのｗｎｔアゴニスト、並びに生理活性脂質を用いた試薬及び方法
AU2019297522B2 (en) * 2018-07-05 2026-04-23 Surrozen Operating, Inc. Multi-specific Wnt surrogate molecules and uses thereof
JP2021530223A (ja) 2018-07-09 2021-11-11 スロゼン， インコーポレイテッド 組織特異性Ｗｎｔシグナル増強分子及びその使用
EP3823661A4 (en) * 2018-07-16 2022-05-11 The Board of Trustees of the Leland Stanford Junior University SPECIFIC FRIZZLED WNT AGONISTS AND ANTAGONISTS
US20220064337A1 (en) * 2018-12-19 2022-03-03 Surrozen, Inc. Antigen binding formats for receptor complexes
AU2020221797A1 (en) * 2019-02-11 2021-08-12 Surrozen Operating, Inc. Modulation of WNT signalling in ocular disorders
WO2020185960A1 (en) * 2019-03-11 2020-09-17 Surrozen, Inc. Modulation of wnt signaling in gastrointestinal disorders
KR20220024460A (ko) * 2019-06-11 2022-03-03 안틀라 테라퓨틱스 아이엔씨. 다가 fzd 및 wnt 결합 분자 및 이의 용도
CA3144499A1 (en) 2019-07-02 2021-01-07 Surrozen Operating, Inc. Monospecific anti-frizzled antibodies and methods of use
EP3789049A1 (en) 2019-09-06 2021-03-10 QGel SA Method for obtaining healthy intestinal organoids
WO2022104280A1 (en) 2020-11-16 2022-05-19 Surrozen Operating, Inc. Liver-specific wnt signal enhancing molecules and uses thereof
WO2022164786A1 (en) * 2021-01-26 2022-08-04 The Trustees Of Indiana University Pharmaceutical compositions and their methods of use
JP7891006B2 (ja) * 2021-03-10 2026-07-15 スロゼン オペレーティング， インコーポレイテッド 胃腸障害におけるｗｎｔシグナル伝達のモジュレーション
CA3240866A1 (en) * 2021-12-17 2023-06-22 Surrozen Operating, Inc. Wnt-surrogate agents and methods for lacrimal gland regeneration
WO2024227103A1 (en) * 2023-04-27 2024-10-31 Surrozen Operating, Inc. Molecules modulating wnt signaling pathways and uses thereof
AU2024279826A1 (en) * 2023-05-29 2026-01-08 Surrozen Operating, Inc. Wnt surrogate agents and methods for lacrimal gland regeneration

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
EP0604552B1 (en) 1991-09-18 1997-02-12 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US6005079A (en) 1992-08-21 1999-12-21 Vrije Universiteit Brussels Immunoglobulins devoid of light chains
HUT72495A (en) 1992-10-01 1996-05-28 Cold Spring Harbor Lab Complex combinatorial chemical libraries encoded with tags
JPH09508353A (ja) 1993-11-02 1997-08-26 アフィマックス テクノロジーズ ナムローゼ フェンノートシャップ 分子多様性の合成及びスクリーニング
JPH10500112A (ja) 1994-05-06 1998-01-06 ファーマコピーア，インコーポレイテッド 組合せ ジヒドロベンゾピラン ライブラリー
US5663046A (en) 1994-06-22 1997-09-02 Pharmacopeia, Inc. Synthesis of combinatorial libraries
US7057017B2 (en) 1997-04-16 2006-06-06 Millennium Pharmaceuticals, Inc. Human dickkopf-related protein and nucleic acid molecules and uses therefor
DE60129799T2 (de) 2000-03-31 2008-04-30 The General Hospital Corp., Boston Verfahren zur steigerung des haarwuchses durch wnt polypeptid
US20030044409A1 (en) 2001-05-01 2003-03-06 Carson Dennis A. Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens
US8637506B2 (en) 2003-09-22 2014-01-28 Enzo Biochem, Inc. Compositions and methods for bone formation and remodeling
US8461155B2 (en) 2003-09-22 2013-06-11 University Of Connecticut Sclerostin and the inhibition of WNT signaling and bone formation
US9046537B2 (en) 2003-09-22 2015-06-02 Enzo Biochem, Inc. Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain
US8367822B2 (en) 2003-09-22 2013-02-05 Enzo Therapeutics, Inc. Compositions and methods for bone formation and remodeling
US8343922B2 (en) 2004-05-19 2013-01-01 Enzo Biochem, Inc. Compositions and methods for the stimulation or enhancement of bone formation and the self-renewal of cells
US9052324B2 (en) 2004-05-19 2015-06-09 Enzo Biochem, Inc. Compounds and assays for controlling Wnt activity
ES2414460T3 (es) 2004-08-04 2013-07-19 Amgen Inc. Anticuerpos para Dkk-1
DE102004050620A1 (de) 2004-10-13 2006-04-20 Eberhard-Karls-Universität Tübingen Monoklonaler Antikörper gegen Frizzled-Rezeptoren
EP1902318A1 (en) 2005-05-30 2008-03-26 AstraZeneca AB Methods for identifying fzd8 modulators and the use of such modulators for treating osteoarthritis
DE102005035568A1 (de) 2005-07-25 2007-02-01 M-Phasys Gmbh Frizzled 9 als Biomarker für Substrukturen des humanen Gehirns
CA2635906A1 (en) 2006-02-07 2007-08-16 Wyeth Materials and methods for identifying agents that modulate norrin. norrin mimetics, and agents identified thereby
CN105837690A (zh) 2006-06-12 2016-08-10 新兴产品开发西雅图有限公司 具有效应功能的单链多价结合蛋白
US8221751B2 (en) 2006-06-21 2012-07-17 Oncotherapy Science, Inc. Tumor-targeting monoclonal antibodies to FZD10 and uses thereof
US20100199362A1 (en) 2007-04-26 2010-08-05 President And Fellows Of Harvard College Wnt ligands involved in blood-brain barrier development and uses therefor
MX2010004761A (es) 2007-11-02 2010-05-19 Novartis Ag Moleculas y metodos para modular la proteina relacionada con el receptor de lipoproteina de baja densidad 6 (lrp6).
EP3211011A1 (en) 2007-11-16 2017-08-30 Nuvelo, Inc. Antibodies to lrp6
WO2010016766A2 (en) 2008-08-08 2010-02-11 Koninklijke Nederlandse Akademie Van Wetenschappen Antibodies recognizing endogenous human lgr5 and/or lgr6
AU2009291747B2 (en) * 2008-09-10 2016-05-26 Genentech, Inc. Methods for inhibiting ocular angiogenesis
EP2331136B1 (en) 2008-09-26 2018-01-10 OncoMed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
US8642339B2 (en) 2009-02-03 2014-02-04 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
US9067986B2 (en) 2009-04-27 2015-06-30 Oncomed Pharmaceuticals, Inc. Method for making heteromultimeric molecules
US20130089554A1 (en) 2009-12-29 2013-04-11 Emergent Product Development Seattle, Llc RON Binding Constructs and Methods of Use Thereof
US8859736B2 (en) 2010-02-19 2014-10-14 The Board Of Regents Of The University Of Oklahoma Monoclonal antibodies that inhibit the wnt signaling pathway and methods of production and use thereof
KR101899835B1 (ko) 2010-03-24 2018-09-19 제넨테크, 인크. 항-ｌｒｐ６ 항체
CN102971337B (zh) 2010-04-01 2016-09-21 昂考梅德药品有限公司 卷曲蛋白结合药剂及其应用
SG185416A1 (en) 2010-05-06 2012-12-28 Novartis Ag Compositions and methods of use for therapeutic low density lipoprotein -related protein 6 (lrp6) antibodies
MX2012012927A (es) 2010-05-06 2013-05-01 Novartis Ag Composiciones y metodos de uso para anticuerpos multivalentes terapeuticos de proteina relacionada con lipoproteina de baja densidad 6 (lrp6).
CN103501799A (zh) * 2011-01-28 2014-01-08 莱兰斯坦福初级大学评议会 Wnt组合物及其使用方法
GB201106395D0 (en) * 2011-04-14 2011-06-01 Hubrecht Inst Compounds
US8883735B2 (en) 2011-11-04 2014-11-11 Novartis Ag Low density lipoprotein-related protein 6 (LRP6)-half life extender constructs
CN104203981A (zh) 2011-12-19 2014-12-10 合成免疫股份有限公司 双特异性抗体分子
SG10201601747XA (en) 2012-01-18 2016-04-28 Genentech Inc Anti-LRP5 Antibodies And Methods Of Use
EP2888279A1 (en) 2012-08-22 2015-07-01 Glaxo Group Limited Anti lrp6 antibodies
WO2014059068A1 (en) 2012-10-11 2014-04-17 The Trustees Of The University Of Pennsylvania Methods for the treatment and prevention of osteoporosis and bone-related disorders
CN105073195A (zh) 2013-02-04 2015-11-18 昂科梅德制药有限公司 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测
HK1218930A1 (zh) 2013-02-08 2017-03-17 Abbvie Stemcentrx Llc 新型多特异性结构
CN105431161A (zh) * 2013-02-21 2016-03-23 范安德尔研究所 Norrin突变体多肽、其制造方法和用途
JP2016512533A (ja) 2013-03-14 2016-04-28 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｍｅｔ結合剤およびその使用
GB2518221A (en) 2013-09-16 2015-03-18 Sergej Michailovic Kiprijanov Tetravalent antigen-binding protein molecule
GB2519786A (en) 2013-10-30 2015-05-06 Sergej Michailovic Kiprijanov Multivalent antigen-binding protein molecules
JP6796059B2 (ja) 2014-09-12 2020-12-02 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Ｗｎｔシグナリングアゴニスト分子
US9777052B2 (en) 2014-12-02 2017-10-03 The Board Of Regents Of The University Of Oklahoma R-spondin variants, compositions, and methods of use
US20160312207A1 (en) 2015-04-21 2016-10-27 The Board Of Trustees Of The Leland Stanford Junior University R-spondin antagonists and methods of treating cancer associated with aberrant activation of wnt signaling

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