JP2015506926A5 - - Google Patents
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- Publication number
- JP2015506926A5 JP2015506926A5 JP2014548277A JP2014548277A JP2015506926A5 JP 2015506926 A5 JP2015506926 A5 JP 2015506926A5 JP 2014548277 A JP2014548277 A JP 2014548277A JP 2014548277 A JP2014548277 A JP 2014548277A JP 2015506926 A5 JP2015506926 A5 JP 2015506926A5
- Authority
- JP
- Japan
- Prior art keywords
- process according
- salt
- concentration
- column
- buffer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 18
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 239000000872 buffer Substances 0.000 claims 10
- 239000001488 sodium phosphate Substances 0.000 claims 9
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 9
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 9
- XXMIOPMDWAUFGU-UHFFFAOYSA-N hexane-1,6-diol Chemical compound OCCCCCCO XXMIOPMDWAUFGU-UHFFFAOYSA-N 0.000 claims 6
- 239000011780 sodium chloride Substances 0.000 claims 6
- 238000010828 elution Methods 0.000 claims 5
- 238000011067 equilibration Methods 0.000 claims 4
- 238000005406 washing Methods 0.000 claims 4
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000012149 elution buffer Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 239000011148 porous material Substances 0.000 claims 2
- 230000036316 preload Effects 0.000 claims 2
- 239000012508 resin bead Substances 0.000 claims 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims 1
- 239000004254 Ammonium phosphate Substances 0.000 claims 1
- 239000007995 HEPES buffer Substances 0.000 claims 1
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 1
- 239000007983 Tris buffer Substances 0.000 claims 1
- 229910000148 ammonium phosphate Inorganic materials 0.000 claims 1
- 235000019289 ammonium phosphates Nutrition 0.000 claims 1
- OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 claims 1
- 150000002009 diols Chemical class 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000012160 loading buffer Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical compound [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 claims 1
- 235000018342 monosodium citrate Nutrition 0.000 claims 1
- 239000002524 monosodium citrate Substances 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 229910000160 potassium phosphate Inorganic materials 0.000 claims 1
- 235000011009 potassium phosphates Nutrition 0.000 claims 1
- 235000011008 sodium phosphates Nutrition 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161579609P | 2011-12-22 | 2011-12-22 | |
| US61/579,609 | 2011-12-22 | ||
| US201261644831P | 2012-05-09 | 2012-05-09 | |
| US61/644,831 | 2012-05-09 | ||
| PCT/IB2012/057227 WO2013093720A2 (en) | 2011-12-22 | 2012-12-12 | Anti-diabetic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015506926A JP2015506926A (ja) | 2015-03-05 |
| JP2015506926A5 true JP2015506926A5 (enExample) | 2016-02-04 |
| JP6165168B2 JP6165168B2 (ja) | 2017-07-19 |
Family
ID=47561699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548277A Expired - Fee Related JP6165168B2 (ja) | 2011-12-22 | 2012-12-12 | 抗糖尿病化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9163227B2 (enExample) |
| EP (1) | EP2793928B1 (enExample) |
| JP (1) | JP6165168B2 (enExample) |
| KR (1) | KR101640697B1 (enExample) |
| CN (1) | CN104066438B (enExample) |
| AU (1) | AU2012356219B2 (enExample) |
| BR (1) | BR112014014898A2 (enExample) |
| CA (1) | CA2859969A1 (enExample) |
| DK (1) | DK2793928T3 (enExample) |
| ES (1) | ES2623786T3 (enExample) |
| IL (1) | IL233206A (enExample) |
| MX (1) | MX2014007626A (enExample) |
| SG (1) | SG11201402640SA (enExample) |
| TW (1) | TWI560202B (enExample) |
| WO (1) | WO2013093720A2 (enExample) |
| ZA (1) | ZA201403755B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108524919A (zh) | 2012-05-17 | 2018-09-14 | 延伸生物科学股份有限公司 | 用于改进的药物递送的载体 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| HRP20181300T1 (hr) | 2012-12-21 | 2018-10-05 | Sanofi | Derivati eksendina-4 kao dvostruki glp1/gip- ili trostruki glp1/gip/glukagon agonisti |
| TW201609796A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物 |
| EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| US9616109B2 (en) | 2014-10-22 | 2017-04-11 | Extend Biosciences, Inc. | Insulin vitamin D conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| JP7297408B2 (ja) * | 2015-02-06 | 2023-06-26 | セル アイディーエックス， インコーポレイテッド | 抗原をカップリングさせた免疫試薬 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| AR105284A1 (es) * | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
| KR102403089B1 (ko) * | 2017-07-05 | 2022-06-02 | 바이오셀즈(베이징) 바이오테크 코., 엘티디. | 폴리펩타이드의 약학적으로 허용 가능한 염 및 이의 용도 |
| EP3728327A1 (en) * | 2017-12-22 | 2020-10-28 | F. Hoffmann-La Roche AG | Depletion of light chain mispaired antibody variants by hydrophobic interaction chromatography |
| US12226451B2 (en) | 2018-07-03 | 2025-02-18 | Bristol-Myers Squibb Company | FGF-21 formulations |
| WO2021139744A1 (en) | 2020-01-11 | 2021-07-15 | Beijing Ql Biopharmaceutical Co., Ltd. | Conjugates of fusion proteins of glp-1 and fgf21 |
| CN111333714A (zh) * | 2020-03-05 | 2020-06-26 | 成都奥达生物科技有限公司 | 一种长效glp-1化合物 |
| JP2024502740A (ja) * | 2020-12-17 | 2024-01-23 | アイツーオー・セラピューティクス・インコーポレイテッド | 長時間作用型グルカゴン様ポリペプチド－１（ｇｌｐ－１）受容体アゴニスト及び使用方法 |
| CN112986575B (zh) * | 2020-12-29 | 2023-03-17 | 上海药明康德新药开发有限公司 | 一种串联式验证dna编码苗头化合物修饰抗体的方法 |
| TWI837615B (zh) * | 2021-03-23 | 2024-04-01 | 美商美國禮來大藥廠 | 含腸促胰島素(incretin)類似物之組合物及其用途 |
| BR112023022568A2 (pt) * | 2021-04-30 | 2024-02-27 | Innovent Biologics Suzhou Co Ltd | Agente de armazenamento de oxm3, formulação e método de preparação de oxm3 |
| IL319526A (en) | 2022-09-30 | 2025-05-01 | Extend Biosciences Inc | Long-acting parathyroid hormone |
| WO2024238912A1 (en) * | 2023-05-17 | 2024-11-21 | OncoC4, Inc. | Ph-sensitive anti-ctla-4 antibodies and uses thereof |
| CN116804630B (zh) * | 2023-08-03 | 2024-03-05 | 中拓生物有限公司 | 一种血清同型半胱氨酸测定试剂盒 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5733757A (en) | 1995-12-15 | 1998-03-31 | The Scripps Research Institute | Aldolase catalytic antibody |
| UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| US6326176B1 (en) | 1997-12-18 | 2001-12-04 | The Scripps Research Institute | Aldol condensations by catalytic antibodies |
| US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| AU1190101A (en) | 1999-09-27 | 2001-04-30 | Regents Of The University Of California, The | Engineering antibodies that bind irreversibly |
| US6294374B1 (en) | 1999-10-08 | 2001-09-25 | The Scripps Research Institute | Use of catalytic antibodies for synthesizing epothilone |
| ES2335386T3 (es) | 1999-11-18 | 2010-03-26 | Novartis Vaccines And Diagnostics, Inc. | Gen fgf-21 humano y productos de expresion genica. |
| WO2003011213A2 (en) | 2001-07-30 | 2003-02-13 | Eli Lilly And Company | Method for treating diabetes and obesity |
| EP1469880A4 (en) | 2002-01-15 | 2006-04-26 | Lilly Co Eli | METHOD FOR REDUCING MORBIDITY AND MORTALITY IN CRITELY SICK PATIENTS |
| BRPI0416683A (pt) | 2003-12-10 | 2007-01-30 | Lilly Co Eli | muteìna de fator de crescimento de fibroblasto de humano 21 (fgf-21), ou um seu peptìdeo biologicamente ativo, polinucleotìdeo, vetor de expressão, célula hospedeira, processo para produzir um polipeptìdeo, composição farmacêutica, método para tratar um paciente, e, uso da muteìna fgf-21 |
| WO2005072769A1 (en) | 2004-01-26 | 2005-08-11 | Eli Lilly And Company | Use of fgf-21 and thiazolidinedione for treating type 2 diabetes |
| JP2007531715A (ja) | 2004-03-17 | 2007-11-08 | イーライ リリー アンド カンパニー | グリコール結合ｆｇｆ−２１化合物 |
| CA2565300A1 (en) | 2004-05-13 | 2005-12-01 | Eli Lilly And Company | Fgf-21 fusion proteins |
| ES2332057T3 (es) | 2004-09-02 | 2010-01-25 | Eli Lilly And Company | Muteinas del factor de crecimiento de fibroblastos 21. |
| EP1789443A1 (en) | 2004-09-02 | 2007-05-30 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
| EP2586456B1 (en) | 2004-10-29 | 2016-01-20 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (FGF) |
| US7655627B2 (en) | 2004-12-14 | 2010-02-02 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
| US20080261875A1 (en) | 2005-01-21 | 2008-10-23 | Eli Lilly And Company | Method For Treating Cardiovascular Disease |
| CA2598833A1 (en) | 2005-03-03 | 2006-09-08 | Curt W. Bradshaw | Anti-angiogenic compounds |
| CN101287485A (zh) * | 2005-03-03 | 2008-10-15 | 爱尔兰考夫克斯科技有限公司 | 抗血管生成化合物 |
| US20090098130A1 (en) | 2007-01-05 | 2009-04-16 | Bradshaw Curt W | Glucagon-like protein-1 receptor (glp-1r) agonist compounds |
| EP2068909B1 (en) | 2007-03-30 | 2012-04-25 | Ambrx, Inc. | Modified fgf-21 polypeptides and their uses |
| WO2009020802A2 (en) * | 2007-08-03 | 2009-02-12 | Eli Lilly And Company | Treatment for obesity |
| CN101993485B (zh) | 2009-08-20 | 2013-04-17 | 重庆富进生物医药有限公司 | 促胰岛素分泌肽类似物同源二聚体及其用途 |
| US20120148586A1 (en) * | 2009-08-27 | 2012-06-14 | Joyce Ching Tsu Chou | Glucagon-like protein-1 receptor (glp-1r) agonists for treating autoimmune disorders |
-
2012
- 2012-12-12 ES ES12816137.9T patent/ES2623786T3/es active Active
- 2012-12-12 WO PCT/IB2012/057227 patent/WO2013093720A2/en not_active Ceased
- 2012-12-12 AU AU2012356219A patent/AU2012356219B2/en not_active Ceased
- 2012-12-12 MX MX2014007626A patent/MX2014007626A/es unknown
- 2012-12-12 SG SG11201402640SA patent/SG11201402640SA/en unknown
- 2012-12-12 CA CA2859969A patent/CA2859969A1/en not_active Abandoned
- 2012-12-12 DK DK12816137.9T patent/DK2793928T3/en active
- 2012-12-12 EP EP12816137.9A patent/EP2793928B1/en not_active Not-in-force
- 2012-12-12 JP JP2014548277A patent/JP6165168B2/ja not_active Expired - Fee Related
- 2012-12-12 TW TW101147080A patent/TWI560202B/zh not_active IP Right Cessation
- 2012-12-12 KR KR1020147020397A patent/KR101640697B1/ko not_active Expired - Fee Related
- 2012-12-12 US US13/712,873 patent/US9163227B2/en not_active Expired - Fee Related
- 2012-12-12 CN CN201280063933.4A patent/CN104066438B/zh not_active Expired - Fee Related
- 2012-12-12 BR BR112014014898-8A patent/BR112014014898A2/pt not_active IP Right Cessation
-
2014
- 2014-05-22 ZA ZA2014/03755A patent/ZA201403755B/en unknown
- 2014-06-17 IL IL233206A patent/IL233206A/en not_active IP Right Cessation
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