JP2016514686A5 - - Google Patents
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- Publication number
- JP2016514686A5 JP2016514686A5 JP2016503003A JP2016503003A JP2016514686A5 JP 2016514686 A5 JP2016514686 A5 JP 2016514686A5 JP 2016503003 A JP2016503003 A JP 2016503003A JP 2016503003 A JP2016503003 A JP 2016503003A JP 2016514686 A5 JP2016514686 A5 JP 2016514686A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- matrix
- dosage form
- wax
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002552 dosage form Substances 0.000 claims 45
- 239000011159 matrix material Substances 0.000 claims 45
- 239000002245 particle Substances 0.000 claims 42
- 239000001993 wax Substances 0.000 claims 32
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 claims 24
- 229960004394 topiramate Drugs 0.000 claims 24
- 239000011230 binding agent Substances 0.000 claims 20
- 239000004094 surface-active agent Substances 0.000 claims 18
- 229920001577 copolymer Polymers 0.000 claims 12
- 239000007788 liquid Substances 0.000 claims 9
- 239000007884 disintegrant Substances 0.000 claims 7
- 239000000843 powder Substances 0.000 claims 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 6
- 235000003599 food sweetener Nutrition 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 6
- 239000003765 sweetening agent Substances 0.000 claims 6
- 239000011248 coating agent Substances 0.000 claims 5
- 238000000576 coating method Methods 0.000 claims 5
- 238000007639 printing Methods 0.000 claims 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 3
- 239000012530 fluid Substances 0.000 claims 3
- 229920000831 ionic polymer Polymers 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 229920000058 polyacrylate Polymers 0.000 claims 3
- 238000010146 3D printing Methods 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229960000913 crospovidone Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 235000012489 doughnuts Nutrition 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791592P | 2013-03-15 | 2013-03-15 | |
| US61/791,592 | 2013-03-15 | ||
| PCT/US2014/029168 WO2014144661A1 (en) | 2013-03-15 | 2014-03-14 | Rapidly dispersible dosage form of topiramate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016514686A JP2016514686A (ja) | 2016-05-23 |
| JP2016514686A5 true JP2016514686A5 (enExample) | 2017-04-06 |
| JP6466399B2 JP6466399B2 (ja) | 2019-02-06 |
Family
ID=51537752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503003A Active JP6466399B2 (ja) | 2013-03-15 | 2014-03-14 | トピラマートの急速分散性の剤形 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9492380B2 (enExample) |
| EP (1) | EP2968181B1 (enExample) |
| JP (1) | JP6466399B2 (enExample) |
| CN (1) | CN105050588B (enExample) |
| AU (2) | AU2014228861B2 (enExample) |
| CA (1) | CA2906172C (enExample) |
| ES (1) | ES2761407T3 (enExample) |
| HK (1) | HK1213473A1 (enExample) |
| MX (1) | MX365914B (enExample) |
| WO (1) | WO2014144661A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105534936B (zh) * | 2007-08-13 | 2020-07-31 | Ohemo 生命科学股份有限公司 | 抗滥用药物、使用方法和制备方法 |
| WO2014144512A1 (en) | 2013-03-15 | 2014-09-18 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
| CN104586871B (zh) * | 2014-12-27 | 2018-01-16 | 北京罗诺强施医药技术研发中心有限公司 | 包含托吡酯的药物组合物 |
| US20160243036A1 (en) * | 2015-02-25 | 2016-08-25 | Intelgenx Corp. | Film dosage forms containing amorphous active agents |
| EP3302442B1 (en) | 2015-06-03 | 2024-10-16 | Triastek, Inc. | Dosage forms and use thereof |
| JPWO2017175792A1 (ja) * | 2016-04-06 | 2019-02-14 | アステラス製薬株式会社 | 速溶出性三次元造形物、速溶出性三次元造形物用フィラメント及び速溶出性三次元造形物用材料 |
| ES2908220T3 (es) | 2016-09-02 | 2022-04-28 | Novo Futura Aps | Parrilla desechable y método para fabricar una parrilla desechable |
| AU2018212273B2 (en) | 2017-01-26 | 2023-12-21 | Triastek, Inc. | Dosage forms of controlled release at specific gastrointestinal sites |
| CN107213126B (zh) * | 2017-05-17 | 2020-06-23 | 西安棣加生物科技有限公司 | 一种3d打印技术制备治疗高磷血症的口腔速崩片的方法 |
| CN107252418B (zh) * | 2017-05-17 | 2020-06-23 | 西安棣加生物科技有限公司 | 一种3d打印技术制备治疗低钾血症的口腔速崩片的方法 |
| US10703549B2 (en) * | 2017-06-30 | 2020-07-07 | The Procter And Gamble Company | Water soluble containers and methods of making them |
| CA3080975A1 (en) * | 2017-11-02 | 2019-05-09 | Zambon S.P.A. | Pharmaceutical compositions comprising safinamide |
| JP7360949B2 (ja) * | 2017-12-26 | 2023-10-13 | 東和薬品株式会社 | 環状口腔内崩壊錠 |
| CN111698983B (zh) | 2018-01-09 | 2022-10-18 | 南京三迭纪医药科技有限公司 | 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型 |
| US12544446B2 (en) | 2018-03-02 | 2026-02-10 | Vitiprints, LLC | Printed delivery device having supplements |
| AU2019250911B2 (en) * | 2018-04-10 | 2024-10-24 | Oneful Health, Inc. | Method and system for making personalized nutritional and pharmaceutical formulations using additive manufacturing |
| JP2022500282A (ja) * | 2018-09-14 | 2022-01-04 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | コーティングされた固形医薬投薬形態の調製のためのプロセス |
| KR20250034520A (ko) | 2018-10-15 | 2025-03-11 | 아프레시아 파마슈티칼즈 엘엘씨 | 포장 내에 투여 제형을 형성하는 방법 및 시스템 |
| WO2020104837A1 (en) | 2018-11-21 | 2020-05-28 | Rosemont Pharmaceuticals Limited | Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability |
| CN113490486B (zh) | 2019-02-22 | 2025-10-17 | 康特伦英国斯温顿捷迪斯有限公司 | 最小化团聚、曝气和保持包含布洛芬的药物组合物的包衣 |
| BR112021016485A2 (pt) | 2019-02-22 | 2021-10-13 | Catalent U.K. Swindon Zydis Limited | Minimização de aglomeração de material de revestimento de partícula de fármaco durante armazenamento para estabilizar tempos de desintegração de produtos farmacêuticos |
| AR118418A1 (es) | 2019-02-22 | 2021-10-06 | Catalent Uk Swindon Zydis Ltd | Conservación de partículas ifa revestidas funcionalmente producidas mediante procesos de mezcla sin solvente en suspensión acuosa |
| CA3129383A1 (en) | 2019-02-22 | 2020-08-27 | Catalent U.K. Swindon Zydis Limited | Minimizing aeration of suspensions during in-line mixing |
| AU2020347662B2 (en) * | 2019-09-13 | 2026-07-09 | Meiji Co., Ltd. | Solid food and solid milk |
| AU2021296908A1 (en) | 2020-06-26 | 2023-02-16 | Aprecia Pharmaceuticals LLC | Rapidly-orodispersible tablets having an interior cavity |
| MX2023001004A (es) | 2020-07-31 | 2023-03-01 | Catalent Uk Swindon Zydis Ltd | Composiciones farmaceuticas que comprenden un ingrediente farmaceutico activo (api) recubierto. |
| WO2023200954A1 (en) | 2022-04-13 | 2023-10-19 | Aprecia Pharmaceuticals LLC | System and method for additive manufacturing using an omnidirectional magnetic movement apparatus |
| WO2024108082A1 (en) | 2022-11-18 | 2024-05-23 | Aprecia Pharmaceuticals LLC | Orodispersive dosage forms containing droxidopa |
| GB2643925A (en) | 2024-09-09 | 2026-03-11 | Novumgen Ltd | An orodispersible tablet of topiramate and its process of preparation |
Family Cites Families (47)
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|---|---|---|---|---|
| GB1548022A (en) | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
| US4513006A (en) | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| US4642903A (en) | 1985-03-26 | 1987-02-17 | R. P. Scherer Corporation | Freeze-dried foam dosage form |
| US4855326A (en) | 1987-04-20 | 1989-08-08 | Fuisz Pharmaceutical Ltd. | Rapidly dissoluble medicinal dosage unit and method of manufacture |
| EP0418596A3 (en) | 1989-09-21 | 1991-10-23 | American Cyanamid Company | Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form |
| US5178878A (en) | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
| US5578322A (en) | 1990-11-30 | 1996-11-26 | Yamanouchi Pharmaceutical Co., Ltd. | Quick release coated preparation |
| DE4200821A1 (de) | 1992-01-15 | 1993-07-22 | Bayer Ag | Geschmacksmaskierte pharmazeutische mittel |
| US5518730A (en) | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
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| US5490962A (en) * | 1993-10-18 | 1996-02-13 | Massachusetts Institute Of Technology | Preparation of medical devices by solid free-form fabrication methods |
| US5738875A (en) | 1994-10-28 | 1998-04-14 | R.P. Scherer Corporation | Process for preparing solid pharmaceutical dosage forms |
| US5607697A (en) | 1995-06-07 | 1997-03-04 | Cima Labs, Incorporated | Taste masking microparticles for oral dosage forms |
| ES2318869T3 (es) * | 1997-02-20 | 2009-05-01 | Massachusetts Institute Of Technology | Forma de dosificacion que presenta propiedades de dispersion rapida, metodos de uso y procedimiento para su fabricacion. |
| FR2766089B1 (fr) | 1997-07-21 | 2000-06-02 | Prographarm Lab | Comprime multiparticulaire perfectionne a delitement rapide |
| UA65607C2 (uk) * | 1998-03-04 | 2004-04-15 | Орто-Макнейл Фармацевтикал, Інк. | Фармацевтична композиція (варіанти) та спосіб її приготування |
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| EP2397161B1 (en) | 2009-02-12 | 2019-09-25 | Fuji Chemical Industry Co., Ltd. | Disintegrating particle composition and rapidly disintegrating compression-molded material comprising same |
| US20100285130A1 (en) | 2009-05-06 | 2010-11-11 | Monosol Rx, Llc | Coating of complexed actives in film formulations |
| CN102802614A (zh) | 2009-06-04 | 2012-11-28 | 巴斯夫欧洲公司 | 含有被遮味活性成分的口腔崩解剂型 |
| JP2013502388A (ja) * | 2009-08-19 | 2013-01-24 | バイエル ファーマ アクチエンゲゼルシャフト | 小児科の使用のためのドラッグデリバリーシステム（ウェーハ） |
| AR079862A1 (es) * | 2010-01-08 | 2012-02-22 | Eurand Inc | Composicion de topiramato con sabor enmascarado, un comprimido desintegrable oralmente que comprende la misma y metodo de preparacion |
| JP6133009B2 (ja) * | 2010-08-11 | 2017-05-24 | 協和発酵キリン株式会社 | トピラマート顆粒 |
| US9381154B2 (en) * | 2011-06-09 | 2016-07-05 | Xerox Corporation | Direct inkjet fabrication of drug delivery devices |
-
2014
- 2014-03-14 ES ES14763925T patent/ES2761407T3/es active Active
- 2014-03-14 JP JP2016503003A patent/JP6466399B2/ja active Active
- 2014-03-14 WO PCT/US2014/029168 patent/WO2014144661A1/en not_active Ceased
- 2014-03-14 EP EP14763925.6A patent/EP2968181B1/en active Active
- 2014-03-14 MX MX2015012135A patent/MX365914B/es active IP Right Grant
- 2014-03-14 CA CA2906172A patent/CA2906172C/en active Active
- 2014-03-14 CN CN201480015723.7A patent/CN105050588B/zh active Active
- 2014-03-14 AU AU2014228861A patent/AU2014228861B2/en active Active
- 2014-03-14 HK HK16101295.2A patent/HK1213473A1/zh unknown
-
2015
- 2015-08-27 US US14/837,354 patent/US9492380B2/en active Active
-
2016
- 2016-08-23 US US15/244,563 patent/US10420785B2/en active Active
-
2018
- 2018-08-22 AU AU2018220049A patent/AU2018220049B2/en active Active
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