JP2015533164A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015533164A5 JP2015533164A5 JP2015536854A JP2015536854A JP2015533164A5 JP 2015533164 A5 JP2015533164 A5 JP 2015533164A5 JP 2015536854 A JP2015536854 A JP 2015536854A JP 2015536854 A JP2015536854 A JP 2015536854A JP 2015533164 A5 JP2015533164 A5 JP 2015533164A5
- Authority
- JP
- Japan
- Prior art keywords
- polymer
- polymer layer
- coating
- range
- core particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000642 polymer Polymers 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 19
- 238000000576 coating method Methods 0.000 claims description 14
- 239000011248 coating agent Substances 0.000 claims description 13
- 239000002245 particle Substances 0.000 claims description 10
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 4
- 238000005243 fluidization Methods 0.000 claims description 4
- 239000007771 core particle Substances 0.000 claims 5
- 239000011234 nano-particulate material Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000007921 spray Substances 0.000 claims 3
- 239000001856 Ethyl cellulose Substances 0.000 claims 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 229920001249 ethyl cellulose Polymers 0.000 claims 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims 2
- 238000005507 spraying Methods 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 229920003176 water-insoluble polymer Polymers 0.000 claims 1
- 229920003169 water-soluble polymer Polymers 0.000 claims 1
- 239000000843 powder Substances 0.000 description 9
- 239000003814 drug Substances 0.000 description 3
- 238000005054 agglomeration Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/651,829 | 2012-10-15 | ||
| US13/651,829 US8993041B2 (en) | 2012-10-15 | 2012-10-15 | Taste masked active pharmaceutical powder compositions and processes for making them |
| PCT/US2013/064064 WO2014062446A1 (en) | 2012-10-15 | 2013-10-09 | Taste masked active pharmaceutical powder compositions and processes for making them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533164A JP2015533164A (ja) | 2015-11-19 |
| JP2015533164A5 true JP2015533164A5 (enExample) | 2016-11-17 |
| JP6166859B2 JP6166859B2 (ja) | 2017-07-19 |
Family
ID=49447846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015536854A Active JP6166859B2 (ja) | 2012-10-15 | 2013-10-09 | 味マスクされた活性医薬粉末組成物およびその製造方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8993041B2 (enExample) |
| EP (1) | EP2906204B1 (enExample) |
| JP (1) | JP6166859B2 (enExample) |
| CN (1) | CN104902879B (enExample) |
| AR (1) | AR093012A1 (enExample) |
| BR (1) | BR112015008284B1 (enExample) |
| WO (1) | WO2014062446A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9107851B2 (en) * | 2012-10-15 | 2015-08-18 | New Jersey Institute Of Technology | Solventless mixing process for coating pharmaceutical ingredients |
| CN104968332B (zh) * | 2012-11-12 | 2020-10-20 | 新泽西理工学院 | 药用芯-壳复合粉末及其制备方法 |
| CN104587472B (zh) * | 2014-12-31 | 2017-12-15 | 广东国方医药科技有限公司 | 一种含纳米SiO2的包衣剂及其制备方法 |
| JP6067154B1 (ja) * | 2016-01-25 | 2017-01-25 | 株式会社樋口商会 | コーティング粒子の製造方法 |
| IL296490B1 (en) * | 2016-03-15 | 2025-09-01 | Acer Therapeutics Inc | Tasty compositions containing sodium phenylbutyrate and their uses |
| US11794161B1 (en) | 2018-11-21 | 2023-10-24 | Trucapsol, Llc | Reduced permeability microcapsules |
| US12302933B2 (en) | 2021-06-25 | 2025-05-20 | Trucapsol Llc | Flavor delivery system |
| US12187829B2 (en) | 2021-08-12 | 2025-01-07 | Trucapsol Llc | Environmentally biodegradable microcapsules |
| US11878280B2 (en) | 2022-04-19 | 2024-01-23 | Trucapsol Llc | Microcapsules comprising natural materials |
| US11904288B1 (en) | 2023-02-13 | 2024-02-20 | Trucapsol Llc | Environmentally biodegradable microcapsules |
| US11969491B1 (en) | 2023-02-22 | 2024-04-30 | Trucapsol Llc | pH triggered release particle |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63258809A (ja) * | 1987-04-16 | 1988-10-26 | Towa Yakuhin Kk | 医薬活性成分の放出性にすぐれ、かつ苦味を隠蔽した細粒剤 |
| FI924589A7 (fi) | 1990-04-11 | 1992-10-09 | Upjohn Co | Ibuprofeenin maun peittäminen leijukerrospäällystyksellä |
| JPH08333240A (ja) * | 1995-06-02 | 1996-12-17 | Shin Etsu Chem Co Ltd | 粉末またはペレット状ワックスを用いる無溶媒腸溶性コーティング剤で被覆した腸溶性製剤 |
| GB9515182D0 (en) | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
| JP2000053563A (ja) * | 1998-08-07 | 2000-02-22 | Bayer Yakuhin Ltd | 苦味がマスクされた速放性細粒剤 |
| US6740341B1 (en) * | 1998-11-25 | 2004-05-25 | Cima Labs Inc. | Taste masking rapid release coating system |
| FR2795962B1 (fr) * | 1999-07-08 | 2003-05-09 | Prographarm Laboratoires | Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif |
| GB0010446D0 (en) * | 2000-04-28 | 2000-06-14 | Glaxo Wellcome Kk | Pharmaceutical formulation |
| US7276249B2 (en) | 2002-05-24 | 2007-10-02 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
| US20040137156A1 (en) * | 2002-07-25 | 2004-07-15 | Lee Ernest J | Coated solid dosage form and method for preparing same |
| US8252370B1 (en) | 2005-10-20 | 2012-08-28 | The United States Of America As Represented By The Secretary Of The Army | Continuous high-speed coating of finely ground particulates |
| DE102005062270A1 (de) * | 2005-12-24 | 2007-06-28 | Bayer Technology Services Gmbh | Geschmacksmaskierung von Pulvern |
| PT2094382E (pt) * | 2006-11-10 | 2012-07-24 | New Jersey Tech Inst | Sistemas e métodos de leito fluidizado incluindo fluxo gasoso secundário |
| EP2201939A1 (en) | 2008-12-25 | 2010-06-30 | Zentiva Kimyasal Ürünler Sanayi ve Ticaret A.S. | Method for producing coated spiramycin and novel formulations containing the same |
| CN106390129A (zh) * | 2009-05-01 | 2017-02-15 | 艾戴尔医药公司 | 含有高剂量和低剂量药物的组合的口腔崩解片组合物 |
-
2012
- 2012-10-15 US US13/651,829 patent/US8993041B2/en active Active
-
2013
- 2013-10-09 CN CN201380053749.6A patent/CN104902879B/zh active Active
- 2013-10-09 JP JP2015536854A patent/JP6166859B2/ja active Active
- 2013-10-09 EP EP13779706.4A patent/EP2906204B1/en active Active
- 2013-10-09 WO PCT/US2013/064064 patent/WO2014062446A1/en not_active Ceased
- 2013-10-09 BR BR112015008284-0A patent/BR112015008284B1/pt active IP Right Grant
- 2013-10-15 AR ARP130103730A patent/AR093012A1/es not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015533164A5 (enExample) | ||
| CN105813633B (zh) | 匹莫苯的改善的药物组合物 | |
| JP2014516080A5 (enExample) | ||
| JP2016503411A5 (enExample) | ||
| JP2011178784A5 (enExample) | ||
| JP2014005302A5 (enExample) | ||
| JP2002525313A5 (enExample) | ||
| JP2016535777A5 (enExample) | ||
| JP6166859B2 (ja) | 味マスクされた活性医薬粉末組成物およびその製造方法 | |
| JP4234427B2 (ja) | 活性成分をベースとする微小顆粒およびその製造方法 | |
| SA109300166B1 (ar) | أنظمة توصيل عقار تشتمل على عقاقير قاعدية ضعيفة وأحماض عضوية | |
| JP2011503017A (ja) | ヒドロモルホン含有徐放性錠剤 | |
| CN102065691A (zh) | 控制释放的骨骼肌松弛药物剂型的制备 | |
| WO2014030204A1 (ja) | 薬物含有中空粒子 | |
| EP1748764B1 (en) | An amine drug-containing slow-release granule preparation based on particles with a coating layer and the corresponding method of production | |
| JP5405752B2 (ja) | 被覆された薬物含有粒子および該粒子を含む固形製剤 | |
| CN111741744A (zh) | 高单位含量口服紫杉烷组合物和方法 | |
| Albanez et al. | Enteric coating process of diclofenac sodium pellets in a fluid bed coater with a wurster insert: Influence of process variables on coating performance and release profile | |
| JP2025107467A (ja) | 不快な味がマスクされた顆粒剤及びその製造方法 | |
| JP2017122056A (ja) | 医薬含有造粒物の製造方法 | |
| JP2005536527A (ja) | 微結晶セルロースと混合したベンズイミダゾール化合物を含有する医薬製剤およびその製造方法 | |
| JP5615612B2 (ja) | 苦味を有する生理活性物質含有粒子の製造方法 | |
| JP2008013480A (ja) | 薬物含有微粒子およびその製造方法 | |
| US20090192228A1 (en) | Controlled-Release Tolterodine Compositions and Methods | |
| JP5619970B2 (ja) | 生理活性物質含有粒子の製造方法 |