CN104902879B - 掩味活性粉末药物组合物及其制备方法 - Google Patents

掩味活性粉末药物组合物及其制备方法 Download PDF

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Publication number
CN104902879B
CN104902879B CN201380053749.6A CN201380053749A CN104902879B CN 104902879 B CN104902879 B CN 104902879B CN 201380053749 A CN201380053749 A CN 201380053749A CN 104902879 B CN104902879 B CN 104902879B
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Prior art keywords
polymer
silica
ibuprofen
coated
coating
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Chinese (zh)
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CN104902879A (zh
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丹尼尔·多
拉杰什·N·戴夫
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New Jersey Institute of Technology
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New Jersey Institute of Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Glanulating (AREA)
CN201380053749.6A 2012-10-15 2013-10-09 掩味活性粉末药物组合物及其制备方法 Active CN104902879B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/651,829 2012-10-15
US13/651,829 US8993041B2 (en) 2012-10-15 2012-10-15 Taste masked active pharmaceutical powder compositions and processes for making them
PCT/US2013/064064 WO2014062446A1 (en) 2012-10-15 2013-10-09 Taste masked active pharmaceutical powder compositions and processes for making them

Publications (2)

Publication Number Publication Date
CN104902879A CN104902879A (zh) 2015-09-09
CN104902879B true CN104902879B (zh) 2018-07-17

Family

ID=49447846

Family Applications (1)

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CN201380053749.6A Active CN104902879B (zh) 2012-10-15 2013-10-09 掩味活性粉末药物组合物及其制备方法

Country Status (7)

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US (1) US8993041B2 (enExample)
EP (1) EP2906204B1 (enExample)
JP (1) JP6166859B2 (enExample)
CN (1) CN104902879B (enExample)
AR (1) AR093012A1 (enExample)
BR (1) BR112015008284B1 (enExample)
WO (1) WO2014062446A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107851B2 (en) * 2012-10-15 2015-08-18 New Jersey Institute Of Technology Solventless mixing process for coating pharmaceutical ingredients
CN104968332B (zh) * 2012-11-12 2020-10-20 新泽西理工学院 药用芯-壳复合粉末及其制备方法
CN104587472B (zh) * 2014-12-31 2017-12-15 广东国方医药科技有限公司 一种含纳米SiO2的包衣剂及其制备方法
JP6067154B1 (ja) * 2016-01-25 2017-01-25 株式会社樋口商会 コーティング粒子の製造方法
IL296490B1 (en) * 2016-03-15 2025-09-01 Acer Therapeutics Inc Tasty compositions containing sodium phenylbutyrate and their uses
US11794161B1 (en) 2018-11-21 2023-10-24 Trucapsol, Llc Reduced permeability microcapsules
US12302933B2 (en) 2021-06-25 2025-05-20 Trucapsol Llc Flavor delivery system
US12187829B2 (en) 2021-08-12 2025-01-07 Trucapsol Llc Environmentally biodegradable microcapsules
US11878280B2 (en) 2022-04-19 2024-01-23 Trucapsol Llc Microcapsules comprising natural materials
US11904288B1 (en) 2023-02-13 2024-02-20 Trucapsol Llc Environmentally biodegradable microcapsules
US11969491B1 (en) 2023-02-22 2024-04-30 Trucapsol Llc pH triggered release particle

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1373658A (zh) * 1999-07-08 2002-10-09 伊西法姆公司 制备遮味的且活性物质即释的包衣颗粒的方法

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JPS63258809A (ja) * 1987-04-16 1988-10-26 Towa Yakuhin Kk 医薬活性成分の放出性にすぐれ、かつ苦味を隠蔽した細粒剤
FI924589A7 (fi) 1990-04-11 1992-10-09 Upjohn Co Ibuprofeenin maun peittäminen leijukerrospäällystyksellä
JPH08333240A (ja) * 1995-06-02 1996-12-17 Shin Etsu Chem Co Ltd 粉末またはペレット状ワックスを用いる無溶媒腸溶性コーティング剤で被覆した腸溶性製剤
GB9515182D0 (en) 1995-07-24 1995-09-20 Co Ordinated Drug Dev Improvements in and relating to powders for use in dry powder inhalers
JP2000053563A (ja) * 1998-08-07 2000-02-22 Bayer Yakuhin Ltd 苦味がマスクされた速放性細粒剤
US6740341B1 (en) * 1998-11-25 2004-05-25 Cima Labs Inc. Taste masking rapid release coating system
GB0010446D0 (en) * 2000-04-28 2000-06-14 Glaxo Wellcome Kk Pharmaceutical formulation
US7276249B2 (en) 2002-05-24 2007-10-02 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
US20040137156A1 (en) * 2002-07-25 2004-07-15 Lee Ernest J Coated solid dosage form and method for preparing same
US8252370B1 (en) 2005-10-20 2012-08-28 The United States Of America As Represented By The Secretary Of The Army Continuous high-speed coating of finely ground particulates
DE102005062270A1 (de) * 2005-12-24 2007-06-28 Bayer Technology Services Gmbh Geschmacksmaskierung von Pulvern
PT2094382E (pt) * 2006-11-10 2012-07-24 New Jersey Tech Inst Sistemas e métodos de leito fluidizado incluindo fluxo gasoso secundário
EP2201939A1 (en) 2008-12-25 2010-06-30 Zentiva Kimyasal Ürünler Sanayi ve Ticaret A.S. Method for producing coated spiramycin and novel formulations containing the same
CN106390129A (zh) * 2009-05-01 2017-02-15 艾戴尔医药公司 含有高剂量和低剂量药物的组合的口腔崩解片组合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1373658A (zh) * 1999-07-08 2002-10-09 伊西法姆公司 制备遮味的且活性物质即释的包衣颗粒的方法

Also Published As

Publication number Publication date
US8993041B2 (en) 2015-03-31
BR112015008284B1 (pt) 2022-05-24
US20140106058A1 (en) 2014-04-17
BR112015008284A2 (pt) 2017-07-04
WO2014062446A1 (en) 2014-04-24
EP2906204B1 (en) 2022-09-28
AR093012A1 (es) 2015-05-13
JP6166859B2 (ja) 2017-07-19
CN104902879A (zh) 2015-09-09
EP2906204A1 (en) 2015-08-19
JP2015533164A (ja) 2015-11-19

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