JP2016513709A5 - - Google Patents

Info

Publication number

JP2016513709A5

JP2016513709A5 JP2016502520A JP2016502520A JP2016513709A5 JP 2016513709 A5 JP2016513709 A5 JP 2016513709A5 JP 2016502520 A JP2016502520 A JP 2016502520A JP 2016502520 A JP2016502520 A JP 2016502520A JP 2016513709 A5 JP2016513709 A5 JP 2016513709A5

Authority

JP

Japan

Prior art keywords

formula

compound

chloro

phenyl

amino

Prior art date

2014-03-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 14
• -1 acylated aniline compound Chemical class 0.000 claims 10
• PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims 6
• YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 6
• 150000001875 compounds Chemical class 0.000 claims 6
• FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical group [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims 6
• VDLXWVJCSVAOKZ-UHFFFAOYSA-N 1-(2-amino-4-chlorophenyl)-2-chloroethanone Chemical compound NC1=CC(Cl)=CC=C1C(=O)CCl VDLXWVJCSVAOKZ-UHFFFAOYSA-N 0.000 claims 4
• ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 4
• RENMDAKOXSCIGH-UHFFFAOYSA-N Chloroacetonitrile Chemical compound ClCC#N RENMDAKOXSCIGH-UHFFFAOYSA-N 0.000 claims 4
• 108090000790 Enzymes Proteins 0.000 claims 4
• 102000004190 Enzymes Human genes 0.000 claims 4
• 229910052783 alkali metal Inorganic materials 0.000 claims 4
• 230000002152 alkylating effect Effects 0.000 claims 4
• 229910052782 aluminium Inorganic materials 0.000 claims 4
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 4
• 229910052796 boron Inorganic materials 0.000 claims 4
• SBMIBRAEESOEIP-UHFFFAOYSA-N diethyl 2-acetamido-2-[2-(2-amino-4-chlorophenyl)-2-oxoethyl]propanedioate Chemical compound CCOC(=O)C(C(=O)OCC)(NC(C)=O)CC(=O)C1=CC=C(Cl)C=C1N SBMIBRAEESOEIP-UHFFFAOYSA-N 0.000 claims 4
• OVTRJMNZIRSECO-UHFFFAOYSA-N 2-acetamido-4-(2-amino-4-chlorophenyl)-4-oxobutanoic acid Chemical compound CC(=O)NC(C(O)=O)CC(=O)C1=CC=C(Cl)C=C1N OVTRJMNZIRSECO-UHFFFAOYSA-N 0.000 claims 3
• SMNXWBKWPNTECZ-UHFFFAOYSA-N acetamide;diethyl propanedioate Chemical compound CC(N)=O.CCOC(=O)CC(=O)OCC SMNXWBKWPNTECZ-UHFFFAOYSA-N 0.000 claims 2
• 108010003977 aminoacylase I Proteins 0.000 claims 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
• 230000000593 degrading effect Effects 0.000 claims 2
• 238000010438 heat treatment Methods 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 235000009518 sodium iodide Nutrition 0.000 claims 2
• 239000012453 solvate Substances 0.000 claims 2
• HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 claims 1
• PNPCRKVUWYDDST-UHFFFAOYSA-N 3-chloroaniline Chemical compound NC1=CC=CC(Cl)=C1 PNPCRKVUWYDDST-UHFFFAOYSA-N 0.000 claims 1
• 241000228212 Aspergillus Species 0.000 claims 1
• 241000981399 Aspergillus melleus Species 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Substances ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 1
• 229910052736 halogen Inorganic materials 0.000 claims 1
• 150000002367 halogens Chemical group 0.000 claims 1
• 150000002431 hydrogen Chemical group 0.000 claims 1
• 229910052739 hydrogen Inorganic materials 0.000 claims 1
• 239000001257 hydrogen Substances 0.000 claims 1
• 125000000547 substituted alkyl group Chemical group 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• QLOLLPPRFVBYSM-QMMMGPOBSA-N C=Nc1ccccc1C(C[C@@H](C(O)=O)N)=O Chemical compound C=Nc1ccccc1C(C[C@@H](C(O)=O)N)=O QLOLLPPRFVBYSM-QMMMGPOBSA-N 0.000 description 1
• PPIMFXHQDQRWGJ-UHFFFAOYSA-N CC(NC(CC(c1ccccc1N)=O)C(O)=O)=O Chemical compound CC(NC(CC(c1ccccc1N)=O)C(O)=O)=O PPIMFXHQDQRWGJ-UHFFFAOYSA-N 0.000 description 1